Dolichyl-diphosphooligosaccharide--protein glycotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligosaccharyl transferase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HMD5_LEIBR

TriTrypDb:

LbrM.34.1050 , LBRM2903_340016700

Length:

772

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 26
NetGPI	no	yes: 0, no: 26

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27
GO:0005635	nuclear envelope	4	4
GO:0005783	endoplasmic reticulum	5	4
GO:0031967	organelle envelope	3	4
GO:0031975	envelope	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4

Expansion

Sequence features

A4HMD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD5

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	27
GO:0006807	nitrogen compound metabolic process	2	27
GO:0008152	metabolic process	1	27
GO:0019538	protein metabolic process	3	27
GO:0036211	protein modification process	4	27
GO:0043170	macromolecule metabolic process	3	27
GO:0043412	macromolecule modification	4	27
GO:0043413	macromolecule glycosylation	3	27
GO:0044238	primary metabolic process	2	27
GO:0070085	glycosylation	2	27
GO:0071704	organic substance metabolic process	2	27
GO:1901564	organonitrogen compound metabolic process	3	27

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	27
GO:0004576	oligosaccharyl transferase activity	5	27
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	6	27
GO:0005488	binding	1	27
GO:0016740	transferase activity	2	27
GO:0016757	glycosyltransferase activity	3	27
GO:0016758	hexosyltransferase activity	4	27
GO:0043167	ion binding	2	27
GO:0043169	cation binding	3	27
GO:0046872	metal ion binding	4	27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	574	578	PF00656	0.297
CLV_NRD_NRD_1	338	340	PF00675	0.375
CLV_NRD_NRD_1	372	374	PF00675	0.283
CLV_NRD_NRD_1	436	438	PF00675	0.450
CLV_PCSK_KEX2_1	448	450	PF00082	0.516
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.509
CLV_PCSK_SKI1_1	318	322	PF00082	0.434
CLV_PCSK_SKI1_1	521	525	PF00082	0.552
CLV_PCSK_SKI1_1	591	595	PF00082	0.496
CLV_PCSK_SKI1_1	697	701	PF00082	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.230
DEG_SPOP_SBC_1	61	65	PF00917	0.411
DOC_AGCK_PIF_1	349	354	PF00069	0.210
DOC_AGCK_PIF_2	46	51	PF00069	0.280
DOC_CKS1_1	498	503	PF01111	0.210
DOC_CYCLIN_RxL_1	315	325	PF00134	0.242
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.239
DOC_MAPK_gen_1	166	175	PF00069	0.351
DOC_MAPK_gen_1	270	277	PF00069	0.471
DOC_MAPK_gen_1	373	382	PF00069	0.392
DOC_MAPK_gen_1	464	473	PF00069	0.662
DOC_MAPK_gen_1	9	17	PF00069	0.164
DOC_MAPK_MEF2A_6	486	493	PF00069	0.481
DOC_MAPK_RevD_3	361	374	PF00069	0.157
DOC_PP1_RVXF_1	519	525	PF00149	0.372
DOC_PP1_RVXF_1	553	560	PF00149	0.288
DOC_PP2B_LxvP_1	413	416	PF13499	0.180
DOC_PP4_FxxP_1	517	520	PF00568	0.360
DOC_USP7_MATH_1	244	248	PF00917	0.266
DOC_USP7_MATH_1	369	373	PF00917	0.437
DOC_USP7_MATH_1	430	434	PF00917	0.601
DOC_USP7_MATH_1	672	676	PF00917	0.380
DOC_WW_Pin1_4	240	245	PF00397	0.266
DOC_WW_Pin1_4	302	307	PF00397	0.181
DOC_WW_Pin1_4	426	431	PF00397	0.499
DOC_WW_Pin1_4	497	502	PF00397	0.468
DOC_WW_Pin1_4	547	552	PF00397	0.312
DOC_WW_Pin1_4	592	597	PF00397	0.290
DOC_WW_Pin1_4	621	626	PF00397	0.332
LIG_14-3-3_CanoR_1	11	16	PF00244	0.266
LIG_14-3-3_CanoR_1	166	172	PF00244	0.290
LIG_14-3-3_CanoR_1	212	216	PF00244	0.521
LIG_14-3-3_CanoR_1	288	293	PF00244	0.445
LIG_14-3-3_CanoR_1	452	456	PF00244	0.611
LIG_14-3-3_CanoR_1	464	474	PF00244	0.583
LIG_14-3-3_CanoR_1	509	519	PF00244	0.353
LIG_14-3-3_CanoR_1	555	560	PF00244	0.254
LIG_14-3-3_CanoR_1	572	576	PF00244	0.317
LIG_14-3-3_CanoR_1	629	635	PF00244	0.310
LIG_14-3-3_CanoR_1	662	666	PF00244	0.355
LIG_14-3-3_CanoR_1	765	770	PF00244	0.502
LIG_Actin_WH2_2	516	531	PF00022	0.222
LIG_AP2alpha_2	26	28	PF02296	0.266
LIG_BRCT_BRCA1_1	42	46	PF00533	0.336
LIG_BRCT_BRCA1_1	513	517	PF00533	0.270
LIG_deltaCOP1_diTrp_1	418	427	PF00928	0.581
LIG_FHA_1	119	125	PF00498	0.294
LIG_FHA_1	155	161	PF00498	0.259
LIG_FHA_1	312	318	PF00498	0.381
LIG_FHA_1	466	472	PF00498	0.525
LIG_FHA_1	498	504	PF00498	0.489
LIG_FHA_1	531	537	PF00498	0.292
LIG_FHA_1	592	598	PF00498	0.296
LIG_FHA_2	103	109	PF00498	0.271
LIG_FHA_2	455	461	PF00498	0.596
LIG_FHA_2	474	480	PF00498	0.494
LIG_FHA_2	548	554	PF00498	0.296
LIG_FHA_2	766	772	PF00498	0.387
LIG_GBD_Chelix_1	103	111	PF00786	0.240
LIG_LIR_Apic_2	307	312	PF02991	0.293
LIG_LIR_Apic_2	425	430	PF02991	0.545
LIG_LIR_Apic_2	514	520	PF02991	0.364
LIG_LIR_Apic_2	652	657	PF02991	0.360
LIG_LIR_Apic_2	725	729	PF02991	0.426
LIG_LIR_Gen_1	157	165	PF02991	0.313
LIG_LIR_Gen_1	347	356	PF02991	0.218
LIG_LIR_Gen_1	418	428	PF02991	0.533
LIG_LIR_Gen_1	43	52	PF02991	0.323
LIG_LIR_Gen_1	541	551	PF02991	0.289
LIG_LIR_Gen_1	609	615	PF02991	0.338
LIG_LIR_Gen_1	633	643	PF02991	0.388
LIG_LIR_Gen_1	683	693	PF02991	0.405
LIG_LIR_Nem_3	157	162	PF02991	0.298
LIG_LIR_Nem_3	243	248	PF02991	0.260
LIG_LIR_Nem_3	26	31	PF02991	0.266
LIG_LIR_Nem_3	307	313	PF02991	0.287
LIG_LIR_Nem_3	347	352	PF02991	0.237
LIG_LIR_Nem_3	418	424	PF02991	0.482
LIG_LIR_Nem_3	43	49	PF02991	0.261
LIG_LIR_Nem_3	53	57	PF02991	0.249
LIG_LIR_Nem_3	541	546	PF02991	0.298
LIG_LIR_Nem_3	558	562	PF02991	0.244
LIG_LIR_Nem_3	609	613	PF02991	0.276
LIG_LIR_Nem_3	63	69	PF02991	0.235
LIG_LIR_Nem_3	633	638	PF02991	0.314
LIG_LIR_Nem_3	683	688	PF02991	0.343
LIG_LIR_Nem_3	690	696	PF02991	0.287
LIG_LYPXL_yS_3	66	69	PF13949	0.358
LIG_MLH1_MIPbox_1	42	46	PF16413	0.336
LIG_NRBOX	253	259	PF00104	0.365
LIG_Pex14_1	42	46	PF04695	0.266
LIG_Pex14_1	560	564	PF04695	0.278
LIG_Pex14_2	25	29	PF04695	0.245
LIG_Pex14_2	45	49	PF04695	0.202
LIG_PTB_Apo_2	629	636	PF02174	0.305
LIG_PTB_Phospho_1	629	635	PF10480	0.300
LIG_SH2_CRK	100	104	PF00017	0.181
LIG_SH2_CRK	18	22	PF00017	0.280
LIG_SH2_CRK	654	658	PF00017	0.392
LIG_SH2_CRK	693	697	PF00017	0.276
LIG_SH2_NCK_1	383	387	PF00017	0.186
LIG_SH2_PTP2	191	194	PF00017	0.333
LIG_SH2_PTP2	610	613	PF00017	0.268
LIG_SH2_SRC	20	23	PF00017	0.281
LIG_SH2_SRC	539	542	PF00017	0.274
LIG_SH2_STAP1	223	227	PF00017	0.333
LIG_SH2_STAP1	346	350	PF00017	0.234
LIG_SH2_STAP1	354	358	PF00017	0.207
LIG_SH2_STAP1	417	421	PF00017	0.440
LIG_SH2_STAP1	515	519	PF00017	0.234
LIG_SH2_STAP1	689	693	PF00017	0.329
LIG_SH2_STAT3	502	505	PF00017	0.459
LIG_SH2_STAT3	562	565	PF00017	0.270
LIG_SH2_STAT5	159	162	PF00017	0.358
LIG_SH2_STAT5	191	194	PF00017	0.333
LIG_SH2_STAT5	2	5	PF00017	0.307
LIG_SH2_STAT5	20	23	PF00017	0.336
LIG_SH2_STAT5	227	230	PF00017	0.424
LIG_SH2_STAT5	309	312	PF00017	0.253
LIG_SH2_STAT5	348	351	PF00017	0.238
LIG_SH2_STAT5	389	392	PF00017	0.304
LIG_SH2_STAT5	502	505	PF00017	0.326
LIG_SH2_STAT5	539	542	PF00017	0.305
LIG_SH2_STAT5	610	613	PF00017	0.281
LIG_SH3_3	300	306	PF00018	0.306
LIG_SH3_3	495	501	PF00018	0.473
LIG_SH3_3	637	643	PF00018	0.395
LIG_SH3_3	709	715	PF00018	0.346
LIG_SH3_3	716	722	PF00018	0.358
LIG_SH3_3	91	97	PF00018	0.358
LIG_SUMO_SIM_anti_2	395	401	PF11976	0.199
LIG_SUMO_SIM_par_1	532	538	PF11976	0.264
LIG_TYR_ITSM	155	162	PF00017	0.298
LIG_WRC_WIRS_1	155	160	PF05994	0.298
MOD_CDC14_SPxK_1	243	246	PF00782	0.336
MOD_CDK_SPxK_1	240	246	PF00069	0.266
MOD_CK1_1	118	124	PF00069	0.366
MOD_CK1_1	164	170	PF00069	0.333
MOD_CK1_1	384	390	PF00069	0.210
MOD_CK1_1	429	435	PF00069	0.606
MOD_CK1_1	513	519	PF00069	0.336
MOD_CK1_1	705	711	PF00069	0.319
MOD_CK2_1	102	108	PF00069	0.157
MOD_CK2_1	331	337	PF00069	0.234
MOD_CK2_1	369	375	PF00069	0.392
MOD_CK2_1	430	436	PF00069	0.572
MOD_CK2_1	473	479	PF00069	0.490
MOD_CK2_1	765	771	PF00069	0.401
MOD_Cter_Amidation	751	754	PF01082	0.568
MOD_GlcNHglycan	117	120	PF01048	0.318
MOD_GlcNHglycan	37	40	PF01048	0.497
MOD_GlcNHglycan	42	45	PF01048	0.527
MOD_GlcNHglycan	432	435	PF01048	0.377
MOD_GlcNHglycan	674	677	PF01048	0.598
MOD_GlcNHglycan	704	707	PF01048	0.552
MOD_GSK3_1	211	218	PF00069	0.509
MOD_GSK3_1	228	235	PF00069	0.201
MOD_GSK3_1	240	247	PF00069	0.284
MOD_GSK3_1	384	391	PF00069	0.257
MOD_GSK3_1	40	47	PF00069	0.341
MOD_GSK3_1	422	429	PF00069	0.624
MOD_GSK3_1	523	530	PF00069	0.348
MOD_N-GLC_1	115	120	PF02516	0.354
MOD_N-GLC_1	430	435	PF02516	0.291
MOD_N-GLC_1	570	575	PF02516	0.492
MOD_N-GLC_1	702	707	PF02516	0.515
MOD_N-GLC_2	146	148	PF02516	0.266
MOD_N-GLC_2	91	93	PF02516	0.424
MOD_NEK2_1	136	141	PF00069	0.337
MOD_NEK2_1	154	159	PF00069	0.203
MOD_NEK2_1	322	327	PF00069	0.277
MOD_NEK2_1	331	336	PF00069	0.239
MOD_NEK2_1	350	355	PF00069	0.333
MOD_NEK2_1	473	478	PF00069	0.667
MOD_NEK2_1	523	528	PF00069	0.322
MOD_NEK2_1	661	666	PF00069	0.303
MOD_NEK2_1	69	74	PF00069	0.313
MOD_NEK2_1	763	768	PF00069	0.394
MOD_NEK2_2	161	166	PF00069	0.298
MOD_PIKK_1	419	425	PF00454	0.415
MOD_PIKK_1	523	529	PF00454	0.285
MOD_PK_1	11	17	PF00069	0.302
MOD_PK_1	288	294	PF00069	0.403
MOD_PKA_2	167	173	PF00069	0.303
MOD_PKA_2	211	217	PF00069	0.521
MOD_PKA_2	338	344	PF00069	0.234
MOD_PKA_2	392	398	PF00069	0.473
MOD_PKA_2	436	442	PF00069	0.601
MOD_PKA_2	451	457	PF00069	0.753
MOD_PKA_2	465	471	PF00069	0.626
MOD_PKA_2	571	577	PF00069	0.296
MOD_PKA_2	661	667	PF00069	0.351
MOD_PKB_1	286	294	PF00069	0.481
MOD_PKB_1	9	17	PF00069	0.154
MOD_Plk_1	350	356	PF00069	0.213
MOD_Plk_1	570	576	PF00069	0.292
MOD_Plk_4	154	160	PF00069	0.298
MOD_Plk_4	203	209	PF00069	0.410
MOD_Plk_4	215	221	PF00069	0.413
MOD_Plk_4	352	358	PF00069	0.301
MOD_Plk_4	384	390	PF00069	0.301
MOD_Plk_4	50	56	PF00069	0.266
MOD_Plk_4	530	536	PF00069	0.351
MOD_Plk_4	555	561	PF00069	0.240
MOD_Plk_4	599	605	PF00069	0.350
MOD_Plk_4	630	636	PF00069	0.290
MOD_Plk_4	661	667	PF00069	0.349
MOD_Plk_4	680	686	PF00069	0.259
MOD_Plk_4	722	728	PF00069	0.365
MOD_ProDKin_1	240	246	PF00069	0.266
MOD_ProDKin_1	302	308	PF00069	0.181
MOD_ProDKin_1	426	432	PF00069	0.501
MOD_ProDKin_1	497	503	PF00069	0.468
MOD_ProDKin_1	547	553	PF00069	0.313
MOD_ProDKin_1	592	598	PF00069	0.296
MOD_ProDKin_1	621	627	PF00069	0.329
MOD_SUMO_rev_2	433	439	PF00179	0.562
TRG_DiLeu_BaEn_1	599	604	PF01217	0.306
TRG_DiLeu_BaEn_2	374	380	PF01217	0.392
TRG_ENDOCYTIC_2	100	103	PF00928	0.181
TRG_ENDOCYTIC_2	159	162	PF00928	0.298
TRG_ENDOCYTIC_2	18	21	PF00928	0.280
TRG_ENDOCYTIC_2	181	184	PF00928	0.298
TRG_ENDOCYTIC_2	191	194	PF00928	0.298
TRG_ENDOCYTIC_2	223	226	PF00928	0.298
TRG_ENDOCYTIC_2	346	349	PF00928	0.248
TRG_ENDOCYTIC_2	543	546	PF00928	0.290
TRG_ENDOCYTIC_2	610	613	PF00928	0.281
TRG_ENDOCYTIC_2	635	638	PF00928	0.325
TRG_ENDOCYTIC_2	66	69	PF00928	0.406
TRG_ENDOCYTIC_2	693	696	PF00928	0.271
TRG_ER_diArg_1	165	168	PF00400	0.332
TRG_ER_diArg_1	269	272	PF00400	0.484
TRG_ER_diArg_1	277	280	PF00400	0.454
TRG_ER_diArg_1	285	288	PF00400	0.401
TRG_ER_diArg_1	8	11	PF00400	0.291
TRG_NES_CRM1_1	249	264	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ72	Bodo saltans	51%	94%
A0A1X0NFU7	Trypanosomatidae	57%	91%
A0A3Q8IHT0	Leishmania donovani	72%	89%
A0A3Q8II34	Leishmania donovani	54%	97%
A0A3Q8ILY7	Leishmania donovani	82%	98%
A0A3Q8IV37	Leishmania donovani	71%	92%
A0A422MX14	Trypanosoma rangeli	57%	93%
A4HFF9	Leishmania braziliensis	76%	100%
A4HMD6	Leishmania braziliensis	59%	94%
A4HMD7	Leishmania braziliensis	74%	90%
A4IB08	Leishmania infantum	73%	89%
A4IB09	Leishmania infantum	83%	98%
A4IB10	Leishmania infantum	54%	97%
C9ZNL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	94%
C9ZQ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E2RG47	Canis lupus familiaris	31%	93%
E9AET6	Leishmania major	72%	100%
E9AET7	Leishmania major	82%	100%
E9AET8	Leishmania major	54%	100%
E9AET9	Leishmania major	71%	100%
E9AHU4	Leishmania infantum	71%	92%
E9B5Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	89%
E9B5Z3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	92%
E9B5Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	97%
E9B5Z5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	91%
F1PJP5	Canis lupus familiaris	29%	100%
O94335	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P39007	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P46975	Caenorhabditis elegans	31%	100%
P46977	Homo sapiens	29%	100%
P46978	Mus musculus	29%	100%
Q2KJI2	Bos taurus	29%	100%
Q3TDQ1	Mus musculus	31%	94%
Q54NM9	Dictyostelium discoideum	30%	100%
Q5RCE2	Pongo abelii	29%	100%
Q6F2Z1	Oryza sativa subsp. japonica	29%	98%
Q7XQ88	Oryza sativa subsp. japonica	32%	100%
Q8TCJ2	Homo sapiens	31%	93%
Q93ZY3	Arabidopsis thaliana	31%	99%
Q9FX21	Arabidopsis thaliana	31%	100%
V5BDM6	Trypanosoma cruzi	56%	93%