C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger CCCH domain containing protein 11

Species:

Leishmania braziliensis

UniProt:

A4HMD4_LEIBR

TriTrypDb:

LbrM.34.1030 , LBRM2903_340016400

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HMD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD4

Function

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Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003729	mRNA binding	5	9
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.550
CLV_PCSK_KEX2_1	21	23	PF00082	0.617
CLV_PCSK_KEX2_1	99	101	PF00082	0.542
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.602
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.558
CLV_PCSK_SKI1_1	101	105	PF00082	0.668
CLV_PCSK_SKI1_1	21	25	PF00082	0.593
CLV_PCSK_SKI1_1	35	39	PF00082	0.450
CLV_PCSK_SKI1_1	61	65	PF00082	0.325
DOC_CDC14_PxL_1	230	238	PF14671	0.613

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D6	Leptomonas seymouri	48%	100%
A0A1X0NIQ2	Trypanosomatidae	33%	100%
A0A3Q8IG28	Leishmania donovani	77%	97%
A4IB01	Leishmania infantum	77%	97%
C9ZNK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	84%
E9AES9	Leishmania major	74%	100%
E9B5Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%

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