C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger CCCH domain containing protein 11

Species:

Leishmania braziliensis

UniProt:

A4HMD4_LEIBR

TriTrypDb:

LbrM.34.1030 , LBRM2903_340016400

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD4

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0009266	response to temperature stimulus	3	1
GO:0009408	response to heat	3	1
GO:0009628	response to abiotic stimulus	2	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050896	response to stimulus	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003729	mRNA binding	5	9
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	100	102	PF00675	0.550
CLV_PCSK_KEX2_1	21	23	PF00082	0.617
CLV_PCSK_KEX2_1	99	101	PF00082	0.542
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.602
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.558
CLV_PCSK_SKI1_1	101	105	PF00082	0.668
CLV_PCSK_SKI1_1	21	25	PF00082	0.593
CLV_PCSK_SKI1_1	35	39	PF00082	0.450
CLV_PCSK_SKI1_1	61	65	PF00082	0.325
DOC_CDC14_PxL_1	230	238	PF14671	0.613
DOC_CKS1_1	162	167	PF01111	0.584
DOC_USP7_MATH_1	2	6	PF00917	0.701
DOC_USP7_MATH_1	257	261	PF00917	0.660
DOC_USP7_MATH_1	292	296	PF00917	0.574
DOC_WW_Pin1_4	161	166	PF00397	0.579
LIG_14-3-3_CanoR_1	124	132	PF00244	0.557
LIG_14-3-3_CanoR_1	149	154	PF00244	0.473
LIG_14-3-3_CanoR_1	285	292	PF00244	0.648
LIG_14-3-3_CanoR_1	72	78	PF00244	0.524
LIG_Actin_WH2_2	56	74	PF00022	0.325
LIG_APCC_ABBA_1	197	202	PF00400	0.605
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_DLG_GKlike_1	149	156	PF00625	0.477
LIG_FHA_1	11	17	PF00498	0.583
LIG_FHA_2	104	110	PF00498	0.444
LIG_FHA_2	285	291	PF00498	0.649
LIG_FHA_2	71	77	PF00498	0.516
LIG_FHA_2	81	87	PF00498	0.518
LIG_IBAR_NPY_1	183	185	PF08397	0.508
LIG_LIR_Apic_2	219	224	PF02991	0.642
LIG_LIR_Nem_3	238	244	PF02991	0.655
LIG_SH2_STAT5	180	183	PF00017	0.525
LIG_SH2_STAT5	185	188	PF00017	0.509
LIG_SH2_STAT5	222	225	PF00017	0.636
LIG_SH2_STAT5	50	53	PF00017	0.415
LIG_SH3_3	159	165	PF00018	0.630
LIG_SH3_3	212	218	PF00018	0.597
LIG_SH3_3	228	234	PF00018	0.625
LIG_SH3_3	239	245	PF00018	0.652
LIG_SH3_3	298	304	PF00018	0.650
LIG_TRAF2_1	263	266	PF00917	0.646
LIG_TRAF2_1	83	86	PF00917	0.463
LIG_TRFH_1	187	191	PF08558	0.593
MOD_CK1_1	10	16	PF00069	0.514
MOD_CK1_1	117	123	PF00069	0.645
MOD_CK1_1	161	167	PF00069	0.506
MOD_CK1_1	174	180	PF00069	0.561
MOD_CK1_1	235	241	PF00069	0.719
MOD_CK1_1	260	266	PF00069	0.753
MOD_CK1_1	272	278	PF00069	0.437
MOD_CK2_1	103	109	PF00069	0.430
MOD_CK2_1	260	266	PF00069	0.764
MOD_CK2_1	284	290	PF00069	0.606
MOD_CK2_1	80	86	PF00069	0.490
MOD_GlcNHglycan	191	194	PF01048	0.438
MOD_GlcNHglycan	262	265	PF01048	0.654
MOD_GlcNHglycan	273	277	PF01048	0.644
MOD_GSK3_1	174	181	PF00069	0.493
MOD_GSK3_1	271	278	PF00069	0.627
MOD_LATS_1	147	153	PF00433	0.472
MOD_N-GLC_1	260	265	PF02516	0.556
MOD_NEK2_1	279	284	PF00069	0.478
MOD_NEK2_1	7	12	PF00069	0.604
MOD_PIKK_1	174	180	PF00454	0.507
MOD_PIKK_1	235	241	PF00454	0.699
MOD_PIKK_1	244	250	PF00454	0.622
MOD_PKA_2	284	290	PF00069	0.596
MOD_PKA_2	71	77	PF00069	0.516
MOD_Plk_2-3	135	141	PF00069	0.505
MOD_Plk_4	171	177	PF00069	0.627
MOD_Plk_4	232	238	PF00069	0.641
MOD_Plk_4	275	281	PF00069	0.500
MOD_ProDKin_1	161	167	PF00069	0.581
MOD_SUMO_for_1	52	55	PF00179	0.356
MOD_SUMO_rev_2	29	37	PF00179	0.598
TRG_DiLeu_BaEn_3	32	38	PF01217	0.553
TRG_DiLeu_BaEn_4	33	39	PF01217	0.535
TRG_ENDOCYTIC_2	200	203	PF00928	0.629
TRG_ENDOCYTIC_2	280	283	PF00928	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D6	Leptomonas seymouri	48%	100%
A0A1X0NIQ2	Trypanosomatidae	33%	100%
A0A3Q8IG28	Leishmania donovani	77%	97%
A4IB01	Leishmania infantum	77%	97%
C9ZNK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	84%
E9AES9	Leishmania major	74%	100%
E9B5Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%