Cupin_5 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania braziliensis

UniProt:

A4HMD3_LEIBR

TriTrypDb:

LbrM.34.1020 , LBRM2903_340016300

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD3

PDB structure(s): 3m3i_A , 3m3i_B , 3m3i_C , 3m3i_D , 3m3i_E , 3m3i_F , 3m3i_G , 3m3i_H

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.345
CLV_C14_Caspase3-7	196	200	PF00656	0.393
CLV_NRD_NRD_1	165	167	PF00675	0.417
CLV_NRD_NRD_1	89	91	PF00675	0.435
CLV_PCSK_KEX2_1	165	167	PF00082	0.417
CLV_PCSK_KEX2_1	89	91	PF00082	0.435
CLV_PCSK_KEX2_1	9	11	PF00082	0.567
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.567
CLV_PCSK_SKI1_1	165	169	PF00082	0.417
DEG_Nend_UBRbox_4	1	3	PF02207	0.552
DEG_ODPH_VHL_1	63	75	PF01847	0.260
DOC_USP7_MATH_1	23	27	PF00917	0.577
DOC_WW_Pin1_4	101	106	PF00397	0.483
DOC_WW_Pin1_4	194	199	PF00397	0.387
DOC_WW_Pin1_4	209	214	PF00397	0.326
DOC_WW_Pin1_4	30	35	PF00397	0.603
DOC_WW_Pin1_4	50	55	PF00397	0.410
LIG_14-3-3_CanoR_1	110	118	PF00244	0.357
LIG_14-3-3_CanoR_1	90	99	PF00244	0.375
LIG_APCC_ABBA_1	63	68	PF00400	0.375
LIG_BRCT_BRCA1_1	211	215	PF00533	0.341
LIG_LIR_Gen_1	216	223	PF02991	0.354
LIG_LIR_Gen_1	26	36	PF02991	0.509
LIG_LIR_Nem_3	216	220	PF02991	0.375
LIG_LIR_Nem_3	26	32	PF02991	0.512
LIG_SH2_CRK	164	168	PF00017	0.435
LIG_SH2_CRK	181	185	PF00017	0.435
LIG_SH2_CRK	204	208	PF00017	0.435
LIG_SH2_CRK	93	97	PF00017	0.341
LIG_SH2_NCK_1	181	185	PF00017	0.435
LIG_SH2_NCK_1	204	208	PF00017	0.425
LIG_SH2_NCK_1	93	97	PF00017	0.375
LIG_SH2_PTP2	72	75	PF00017	0.260
LIG_SH2_SRC	72	75	PF00017	0.260
LIG_SH2_STAP1	93	97	PF00017	0.409
LIG_SH2_STAT5	181	184	PF00017	0.435
LIG_SH2_STAT5	29	32	PF00017	0.515
LIG_SH2_STAT5	52	55	PF00017	0.371
LIG_SH2_STAT5	72	75	PF00017	0.396
LIG_SH2_STAT5	93	96	PF00017	0.341
LIG_SH2_STAT5	97	100	PF00017	0.341
LIG_TYR_ITIM	91	96	PF00017	0.314
LIG_WW_1	49	52	PF00397	0.431
LIG_WW_3	48	52	PF00397	0.438
MOD_CDK_SPxxK_3	194	201	PF00069	0.260
MOD_CK1_1	113	119	PF00069	0.435
MOD_CK1_1	192	198	PF00069	0.456
MOD_CK1_1	205	211	PF00069	0.353
MOD_CK1_1	40	46	PF00069	0.585
MOD_GlcNHglycan	77	80	PF01048	0.417
MOD_GSK3_1	205	212	PF00069	0.366
MOD_GSK3_1	30	37	PF00069	0.539
MOD_GSK3_1	99	106	PF00069	0.260
MOD_NEK2_1	179	184	PF00069	0.435
MOD_NEK2_1	202	207	PF00069	0.463
MOD_NEK2_1	38	43	PF00069	0.520
MOD_NEK2_1	91	96	PF00069	0.272
MOD_NEK2_2	92	97	PF00069	0.375
MOD_PIKK_1	12	18	PF00454	0.552
MOD_Plk_1	113	119	PF00069	0.435
MOD_Plk_4	113	119	PF00069	0.435
MOD_Plk_4	202	208	PF00069	0.435
MOD_Plk_4	92	98	PF00069	0.375
MOD_ProDKin_1	101	107	PF00069	0.483
MOD_ProDKin_1	194	200	PF00069	0.387
MOD_ProDKin_1	209	215	PF00069	0.326
MOD_ProDKin_1	30	36	PF00069	0.603
MOD_ProDKin_1	50	56	PF00069	0.406
MOD_SUMO_rev_2	194	202	PF00179	0.260
TRG_ENDOCYTIC_2	164	167	PF00928	0.409
TRG_ENDOCYTIC_2	204	207	PF00928	0.390
TRG_ENDOCYTIC_2	29	32	PF00928	0.515
TRG_ENDOCYTIC_2	72	75	PF00928	0.402
TRG_ENDOCYTIC_2	93	96	PF00928	0.341
TRG_ER_diArg_1	164	166	PF00400	0.417
TRG_ER_diArg_1	89	91	PF00400	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB1	Leptomonas seymouri	69%	100%
A0A1X0NZ51	Trypanosomatidae	40%	100%
A0A3Q8IIT6	Leishmania donovani	77%	100%
A0A422P1M2	Trypanosoma rangeli	38%	100%
A4IB00	Leishmania infantum	78%	100%
E9AES8	Leishmania major	78%	100%
E9B5Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%