C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMD2_LEIBR

TriTrypDb:

LbrM.34.1010 , LBRM2903_340016100

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0003729	mRNA binding	5	6
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.513
CLV_C14_Caspase3-7	24	28	PF00656	0.834
CLV_PCSK_KEX2_1	138	140	PF00082	0.530
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.530
CLV_PCSK_SKI1_1	154	158	PF00082	0.530
CLV_PCSK_SKI1_1	38	42	PF00082	0.572
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DEG_SPOP_SBC_1	341	345	PF00917	0.650
DOC_CKS1_1	34	39	PF01111	0.572
DOC_CKS1_1	394	399	PF01111	0.532
DOC_USP7_MATH_1	121	125	PF00917	0.638
DOC_USP7_MATH_1	127	131	PF00917	0.477
DOC_USP7_MATH_1	174	178	PF00917	0.569
DOC_USP7_MATH_1	232	236	PF00917	0.656
DOC_USP7_MATH_1	247	251	PF00917	0.574
DOC_USP7_MATH_1	282	286	PF00917	0.568
DOC_USP7_MATH_1	292	296	PF00917	0.739
DOC_USP7_MATH_1	304	308	PF00917	0.602
DOC_USP7_MATH_1	422	426	PF00917	0.736
DOC_USP7_UBL2_3	238	242	PF12436	0.592
DOC_WW_Pin1_4	111	116	PF00397	0.818
DOC_WW_Pin1_4	184	189	PF00397	0.590
DOC_WW_Pin1_4	249	254	PF00397	0.721
DOC_WW_Pin1_4	276	281	PF00397	0.564
DOC_WW_Pin1_4	33	38	PF00397	0.632
DOC_WW_Pin1_4	393	398	PF00397	0.533
DOC_WW_Pin1_4	51	56	PF00397	0.658
DOC_WW_Pin1_4	68	73	PF00397	0.755
LIG_14-3-3_CanoR_1	42	50	PF00244	0.577
LIG_BIR_III_4	228	232	PF00653	0.580
LIG_FHA_1	184	190	PF00498	0.707
LIG_FHA_1	212	218	PF00498	0.445
LIG_FHA_1	370	376	PF00498	0.543
LIG_FHA_1	83	89	PF00498	0.558
LIG_FHA_2	171	177	PF00498	0.500
LIG_FHA_2	59	65	PF00498	0.559
LIG_LIR_Apic_2	32	37	PF02991	0.580
LIG_LIR_Gen_1	336	347	PF02991	0.786
LIG_LIR_Gen_1	396	404	PF02991	0.762
LIG_LIR_Nem_3	146	151	PF02991	0.530
LIG_LIR_Nem_3	161	167	PF02991	0.390
LIG_LIR_Nem_3	336	342	PF02991	0.787
LIG_LIR_Nem_3	425	429	PF02991	0.528
LIG_LIR_Nem_3	62	68	PF02991	0.674
LIG_LIR_Nem_3	71	77	PF02991	0.642
LIG_LYPXL_yS_3	65	68	PF13949	0.799
LIG_SH2_GRB2like	398	401	PF00017	0.626
LIG_SH2_SRC	429	432	PF00017	0.513
LIG_SH2_STAP1	205	209	PF00017	0.665
LIG_SH2_STAT3	167	170	PF00017	0.659
LIG_SH2_STAT5	167	170	PF00017	0.594
LIG_SH2_STAT5	392	395	PF00017	0.789
LIG_SH2_STAT5	429	432	PF00017	0.609
LIG_SH3_1	47	53	PF00018	0.566
LIG_SH3_3	115	121	PF00018	0.805
LIG_SH3_3	241	247	PF00018	0.663
LIG_SH3_3	250	256	PF00018	0.667
LIG_SH3_3	391	397	PF00018	0.533
LIG_SH3_3	409	415	PF00018	0.808
LIG_SH3_3	47	53	PF00018	0.566
LIG_SUMO_SIM_par_1	323	328	PF11976	0.804
LIG_TYR_ITIM	63	68	PF00017	0.590
LIG_WW_1	359	362	PF00397	0.554
LIG_WW_3	358	362	PF00397	0.560
MOD_CDK_SPK_2	33	38	PF00069	0.576
MOD_CDK_SPxxK_3	68	75	PF00069	0.556
MOD_CK1_1	111	117	PF00069	0.679
MOD_CK1_1	21	27	PF00069	0.794
MOD_CK1_1	219	225	PF00069	0.546
MOD_CK1_1	260	266	PF00069	0.763
MOD_CK1_1	82	88	PF00069	0.666
MOD_CK2_1	12	18	PF00069	0.660
MOD_CK2_1	174	180	PF00069	0.526
MOD_GlcNHglycan	101	104	PF01048	0.617
MOD_GlcNHglycan	129	132	PF01048	0.618
MOD_GlcNHglycan	144	148	PF01048	0.307
MOD_GlcNHglycan	176	180	PF01048	0.526
MOD_GlcNHglycan	221	224	PF01048	0.627
MOD_GlcNHglycan	262	265	PF01048	0.791
MOD_GlcNHglycan	327	330	PF01048	0.643
MOD_GlcNHglycan	344	347	PF01048	0.538
MOD_GSK3_1	109	116	PF00069	0.775
MOD_GSK3_1	121	128	PF00069	0.679
MOD_GSK3_1	170	177	PF00069	0.489
MOD_GSK3_1	207	214	PF00069	0.455
MOD_GSK3_1	21	28	PF00069	0.660
MOD_GSK3_1	232	239	PF00069	0.677
MOD_GSK3_1	259	266	PF00069	0.768
MOD_GSK3_1	29	36	PF00069	0.649
MOD_GSK3_1	38	45	PF00069	0.561
MOD_GSK3_1	51	58	PF00069	0.534
MOD_GSK3_1	75	82	PF00069	0.786
MOD_GSK3_1	92	99	PF00069	0.706
MOD_N-GLC_1	103	108	PF02516	0.662
MOD_NEK2_1	143	148	PF00069	0.530
MOD_NEK2_1	259	264	PF00069	0.641
MOD_NEK2_1	342	347	PF00069	0.580
MOD_PIKK_1	21	27	PF00454	0.611
MOD_PIKK_1	232	238	PF00454	0.594
MOD_PIKK_1	263	269	PF00454	0.645
MOD_PIKK_1	304	310	PF00454	0.759
MOD_PIKK_1	318	324	PF00454	0.544
MOD_PKA_2	232	238	PF00069	0.594
MOD_Plk_1	103	109	PF00069	0.624
MOD_Plk_2-3	18	24	PF00069	0.583
MOD_Plk_4	29	35	PF00069	0.824
MOD_ProDKin_1	111	117	PF00069	0.818
MOD_ProDKin_1	184	190	PF00069	0.580
MOD_ProDKin_1	249	255	PF00069	0.720
MOD_ProDKin_1	276	282	PF00069	0.561
MOD_ProDKin_1	33	39	PF00069	0.629
MOD_ProDKin_1	393	399	PF00069	0.533
MOD_ProDKin_1	51	57	PF00069	0.659
MOD_ProDKin_1	68	74	PF00069	0.758
MOD_SUMO_rev_2	235	244	PF00179	0.591
TRG_ENDOCYTIC_2	399	402	PF00928	0.788
TRG_ENDOCYTIC_2	65	68	PF00928	0.799
TRG_NLS_MonoExtN_4	136	142	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8W6	Leishmania donovani	56%	100%
A4IAZ9	Leishmania infantum	55%	100%
E9AES7	Leishmania major	55%	99%
E9B5Y2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%