Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania braziliensis

UniProt:

A4HMD0_LEIBR

TriTrypDb:

LbrM.34.0990 , LBRM2903_340015900

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HMD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMD0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	18
GO:0006793	phosphorus metabolic process	3	18
GO:0006796	phosphate-containing compound metabolic process	4	18
GO:0006807	nitrogen compound metabolic process	2	18
GO:0008152	metabolic process	1	18
GO:0009987	cellular process	1	18
GO:0016310	phosphorylation	5	18
GO:0019538	protein metabolic process	3	18
GO:0036211	protein modification process	4	18
GO:0043170	macromolecule metabolic process	3	18
GO:0043412	macromolecule modification	4	18
GO:0044237	cellular metabolic process	2	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18
GO:1901564	organonitrogen compound metabolic process	3	18
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0004672	protein kinase activity	3	18
GO:0004674	protein serine/threonine kinase activity	4	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016301	kinase activity	4	18
GO:0016740	transferase activity	2	18
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	18
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	18
GO:0017076	purine nucleotide binding	4	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:0140096	catalytic activity, acting on a protein	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	172	174	PF00675	0.283
CLV_NRD_NRD_1	211	213	PF00675	0.336
CLV_NRD_NRD_1	29	31	PF00675	0.440
CLV_NRD_NRD_1	292	294	PF00675	0.497
CLV_NRD_NRD_1	310	312	PF00675	0.331
CLV_NRD_NRD_1	320	322	PF00675	0.649
CLV_PCSK_FUR_1	321	325	PF00082	0.392
CLV_PCSK_KEX2_1	211	213	PF00082	0.336
CLV_PCSK_KEX2_1	29	31	PF00082	0.440
CLV_PCSK_KEX2_1	292	294	PF00082	0.414
CLV_PCSK_KEX2_1	320	322	PF00082	0.537
CLV_PCSK_KEX2_1	323	325	PF00082	0.572
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.575
CLV_PCSK_PC7_1	288	294	PF00082	0.481
CLV_PCSK_SKI1_1	10	14	PF00082	0.360
CLV_PCSK_SKI1_1	146	150	PF00082	0.337
CLV_PCSK_SKI1_1	190	194	PF00082	0.336
CLV_PCSK_SKI1_1	288	292	PF00082	0.385
DEG_SCF_FBW7_1	251	257	PF00400	0.348
DOC_CKS1_1	251	256	PF01111	0.401
DOC_CYCLIN_RxL_1	271	280	PF00134	0.405
DOC_CYCLIN_RxL_1	288	298	PF00134	0.390
DOC_MAPK_gen_1	159	166	PF00069	0.332
DOC_MAPK_JIP1_4	149	155	PF00069	0.217
DOC_PP1_RVXF_1	272	279	PF00149	0.403
DOC_SPAK_OSR1_1	24	28	PF12202	0.413
DOC_USP7_MATH_1	254	258	PF00917	0.358
DOC_USP7_MATH_2	263	269	PF00917	0.417
DOC_USP7_UBL2_3	328	332	PF12436	0.620
DOC_WW_Pin1_4	250	255	PF00397	0.386
LIG_14-3-3_CanoR_1	118	122	PF00244	0.344
LIG_Actin_WH2_2	214	229	PF00022	0.349
LIG_Clathr_ClatBox_1	98	102	PF01394	0.217
LIG_FHA_1	122	128	PF00498	0.356
LIG_FHA_1	9	15	PF00498	0.449
LIG_FHA_1	98	104	PF00498	0.231
LIG_FHA_2	251	257	PF00498	0.417
LIG_GBD_Chelix_1	127	135	PF00786	0.217
LIG_GBD_Chelix_1	218	226	PF00786	0.454
LIG_HCF-1_HBM_1	240	243	PF13415	0.217
LIG_LIR_Gen_1	195	205	PF02991	0.336
LIG_LIR_Gen_1	240	251	PF02991	0.364
LIG_LIR_Gen_1	265	272	PF02991	0.441
LIG_LIR_Gen_1	38	44	PF02991	0.217
LIG_LIR_Gen_1	69	80	PF02991	0.320
LIG_LIR_Gen_1	93	104	PF02991	0.337
LIG_LIR_Nem_3	195	201	PF02991	0.349
LIG_LIR_Nem_3	229	235	PF02991	0.336
LIG_LIR_Nem_3	240	246	PF02991	0.363
LIG_LIR_Nem_3	265	269	PF02991	0.348
LIG_LIR_Nem_3	283	287	PF02991	0.388
LIG_LIR_Nem_3	35	39	PF02991	0.352
LIG_LIR_Nem_3	93	99	PF02991	0.217
LIG_Pex14_2	291	295	PF04695	0.393
LIG_Pex14_2	36	40	PF04695	0.365
LIG_SH2_CRK	243	247	PF00017	0.336
LIG_SH2_CRK	284	288	PF00017	0.379
LIG_SH2_NCK_1	243	247	PF00017	0.348
LIG_SH2_PTP2	220	223	PF00017	0.320
LIG_SH2_STAP1	243	247	PF00017	0.256
LIG_SH2_STAP1	272	276	PF00017	0.337
LIG_SH2_STAP1	306	310	PF00017	0.369
LIG_SH2_STAT5	165	168	PF00017	0.333
LIG_SH2_STAT5	220	223	PF00017	0.336
LIG_SH2_STAT5	224	227	PF00017	0.336
LIG_SH2_STAT5	286	289	PF00017	0.379
LIG_SH2_STAT5	304	307	PF00017	0.400
LIG_SH2_STAT5	90	93	PF00017	0.217
LIG_SUMO_SIM_par_1	123	129	PF11976	0.336
LIG_SUMO_SIM_par_1	49	56	PF11976	0.217
LIG_TYR_ITIM	218	223	PF00017	0.384
MOD_CK1_1	120	126	PF00069	0.345
MOD_CK1_1	200	206	PF00069	0.336
MOD_CK1_1	73	79	PF00069	0.235
MOD_CK2_1	250	256	PF00069	0.407
MOD_CK2_1	32	38	PF00069	0.384
MOD_Cter_Amidation	157	160	PF01082	0.349
MOD_Cter_Amidation	27	30	PF01082	0.440
MOD_Cter_Amidation	329	332	PF01082	0.684
MOD_GSK3_1	117	124	PF00069	0.339
MOD_GSK3_1	188	195	PF00069	0.354
MOD_GSK3_1	250	257	PF00069	0.400
MOD_GSK3_1	60	67	PF00069	0.287
MOD_NEK2_1	121	126	PF00069	0.363
MOD_NEK2_1	137	142	PF00069	0.359
MOD_NEK2_1	192	197	PF00069	0.343
MOD_NEK2_1	226	231	PF00069	0.349
MOD_NEK2_1	313	318	PF00069	0.494
MOD_NEK2_1	66	71	PF00069	0.441
MOD_NEK2_2	234	239	PF00069	0.217
MOD_PIKK_1	42	48	PF00454	0.431
MOD_PIKK_1	60	66	PF00454	0.457
MOD_PIKK_1	73	79	PF00454	0.427
MOD_PK_1	197	203	PF00069	0.349
MOD_PK_1	70	76	PF00069	0.217
MOD_PKA_2	117	123	PF00069	0.365
MOD_PKA_2	226	232	PF00069	0.349
MOD_Plk_4	121	127	PF00069	0.336
MOD_Plk_4	265	271	PF00069	0.382
MOD_Plk_4	313	319	PF00069	0.338
MOD_Plk_4	70	76	PF00069	0.316
MOD_Plk_4	83	89	PF00069	0.220
MOD_ProDKin_1	250	256	PF00069	0.393
MOD_SUMO_for_1	53	56	PF00179	0.349
MOD_SUMO_rev_2	273	282	PF00179	0.324
TRG_DiLeu_BaEn_1	265	270	PF01217	0.236
TRG_ENDOCYTIC_2	220	223	PF00928	0.336
TRG_ENDOCYTIC_2	243	246	PF00928	0.336
TRG_ENDOCYTIC_2	284	287	PF00928	0.381
TRG_ENDOCYTIC_2	72	75	PF00928	0.335
TRG_ER_diArg_1	29	31	PF00400	0.440
TRG_ER_diArg_1	291	293	PF00400	0.500
TRG_ER_diLys_1	331	334	PF00400	0.571
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	64%	94%
A0A0N0P4J7	Leptomonas seymouri	26%	75%
A0A0N1HU44	Leptomonas seymouri	68%	100%
A0A0N1HU45	Leptomonas seymouri	40%	87%
A0A0N1I2H3	Leptomonas seymouri	39%	91%
A0A0S4IVY6	Bodo saltans	44%	81%
A0A0S4J7K4	Bodo saltans	22%	69%
A0A0S4JA30	Bodo saltans	45%	92%
A0A0S4JCG2	Bodo saltans	26%	75%
A0A0S4JN06	Bodo saltans	62%	93%
A0A0S4JP58	Bodo saltans	47%	78%
A0A0S4JQP0	Bodo saltans	26%	68%
A0A0S4JU73	Bodo saltans	27%	70%
A0A0S4JXJ0	Bodo saltans	43%	100%
A0A1X0NIT3	Trypanosomatidae	58%	100%
A0A1X0NXJ1	Trypanosomatidae	39%	91%
A0A1X0NZS9	Trypanosomatidae	46%	76%
A0A1X0P176	Trypanosomatidae	48%	86%
A0A3Q8IJ66	Leishmania donovani	64%	95%
A0A3Q8ISA0	Leishmania donovani	46%	89%
A0A3R7K5P9	Trypanosoma rangeli	22%	89%
A0A3R7K7W6	Trypanosoma rangeli	28%	81%
A0A3R7KRP1	Trypanosoma rangeli	24%	70%
A0A3S7WNZ6	Leishmania donovani	39%	91%
A0A3S7X8X3	Leishmania donovani	78%	100%
A0A422MSV5	Trypanosoma rangeli	41%	92%
A0A422N5C9	Trypanosoma rangeli	61%	100%
A0A422NL83	Trypanosoma rangeli	43%	84%
A0A8I3S724	Canis lupus familiaris	24%	82%
A4H436	Leishmania braziliensis	37%	91%
A4HCD7	Leishmania braziliensis	22%	78%
A4HIT6	Leishmania braziliensis	44%	85%
A4HMD1	Leishmania braziliensis	64%	94%
A4HSC0	Leishmania infantum	39%	91%
A4I638	Leishmania infantum	46%	89%
A4IAZ7	Leishmania infantum	77%	100%
A4IAZ8	Leishmania infantum	64%	95%
A4IGM9	Xenopus tropicalis	25%	93%
A5GFW1	Sus scrofa	24%	83%
A7E3X2	Bos taurus	51%	73%
A8XJQ6	Caenorhabditis briggsae	24%	87%
B9VVJ6	Trypanosoma brucei brucei	60%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	84%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	82%
C9ZNJ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
C9ZNJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	76%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	85%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	84%
D0A1R2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	88%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	91%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	85%
E9B5Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	94%
O14965	Homo sapiens	23%	83%
O15726	Plasmodium falciparum (isolate Dd2)	51%	100%
O57252	Vaccinia virus (strain Ankara)	24%	100%
O57259	Vaccinia virus (strain Ankara)	24%	100%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	94%
O74135	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	76%
O76324	Drosophila melanogaster	52%	76%
O96999	Leishmania major	38%	100%
P16913	Vaccinia virus (strain Western Reserve)	24%	100%
P20505	Vaccinia virus (strain Copenhagen)	24%	100%
P21098	Vaccinia virus (strain Copenhagen)	24%	100%
P24362	Vaccinia virus (strain Western Reserve)	24%	100%
P29295	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	46%	68%
P33800	Variola virus (isolate Human/India/Ind3/1967)	24%	100%
P34516	Caenorhabditis elegans	29%	97%
P34635	Caenorhabditis elegans	28%	89%
P35507	Bos taurus	51%	99%
P35508	Bos taurus	57%	80%
P35509	Bos taurus	48%	100%
P40233	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	75%
P40234	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	77%
P40235	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	53%	92%
P40236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	52%	84%
P41279	Homo sapiens	25%	72%
P42158	Arabidopsis thaliana	54%	74%
P42168	Caenorhabditis elegans	50%	98%
P42169	Caenorhabditis elegans	26%	98%
P42685	Homo sapiens	23%	66%
P42818	Arabidopsis thaliana	24%	72%
P48729	Homo sapiens	53%	99%
P48730	Homo sapiens	57%	80%
P49674	Homo sapiens	56%	80%
P54367	Drosophila melanogaster	49%	99%
P67827	Bos taurus	53%	100%
P67828	Oryctolagus cuniculus	53%	100%
P67829	Ovis aries	53%	100%
P67962	Gallus gallus	53%	99%
P67963	Xenopus laevis	53%	99%
P78368	Homo sapiens	45%	80%
P97633	Rattus norvegicus	52%	100%
Q06486	Rattus norvegicus	57%	80%
Q07174	Mus musculus	27%	72%
Q09503	Caenorhabditis elegans	25%	100%
Q20347	Caenorhabditis elegans	23%	92%
Q20471	Caenorhabditis elegans	51%	67%
Q2YDN8	Bos taurus	24%	74%
Q32PI1	Bos taurus	30%	84%
Q39050	Arabidopsis thaliana	55%	73%
Q4Q6U1	Leishmania major	46%	100%
Q4Q9T3	Leishmania major	42%	66%
Q4R9A9	Macaca fascicularis	51%	88%
Q54DF7	Dictyostelium discoideum	33%	67%
Q54L81	Dictyostelium discoideum	24%	72%
Q54QD5	Dictyostelium discoideum	22%	69%
Q556Y4	Dictyostelium discoideum	55%	78%
Q5BP74	Xenopus laevis	57%	80%
Q5PRD4	Danio rerio	50%	79%
Q5R4V3	Pongo abelii	49%	73%
Q5RC72	Pongo abelii	57%	80%
Q5SUV5	Mus musculus	27%	87%
Q5XF24	Arabidopsis thaliana	56%	71%
Q5ZJS0	Gallus gallus	51%	73%
Q5ZLL1	Gallus gallus	56%	80%
Q61RA2	Caenorhabditis briggsae	24%	68%
Q62761	Rattus norvegicus	51%	86%
Q62762	Rattus norvegicus	46%	80%
Q62763	Rattus norvegicus	51%	75%
Q63562	Rattus norvegicus	26%	72%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	93%
Q6DE08	Xenopus laevis	25%	93%
Q6GPL3	Xenopus laevis	25%	91%
Q6K9N1	Oryza sativa subsp. japonica	57%	72%
Q6NRT0	Xenopus laevis	51%	73%
Q6P3K7	Danio rerio	57%	82%
Q6P647	Xenopus tropicalis	57%	80%
Q6QNL9	Eimeria tenella	56%	100%
Q6QNM1	Toxoplasma gondii	54%	100%
Q7JP68	Caenorhabditis elegans	25%	84%
Q7RBX5	Plasmodium yoelii yoelii	52%	100%
Q7T2E3	Danio rerio	57%	83%
Q7YRC6	Bos taurus	25%	97%
Q7ZUS1	Danio rerio	28%	79%
Q80X41	Mus musculus	31%	76%
Q8BK63	Mus musculus	53%	99%
Q8BN21	Mus musculus	29%	66%
Q8BTH8	Mus musculus	51%	73%
Q8BVP5	Mus musculus	46%	80%
Q8C4X2	Mus musculus	51%	79%
Q8IHZ9	Plasmodium falciparum (isolate 3D7)	52%	100%
Q8LG64	Arabidopsis thaliana	27%	100%
Q8LPI7	Arabidopsis thaliana	55%	81%
Q8LPJ1	Arabidopsis thaliana	56%	70%
Q8N752	Homo sapiens	53%	99%
Q8NU97	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	27%	71%
Q8SQR2	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
Q8SS96	Encephalitozoon cuniculi (strain GB-M1)	42%	100%
Q8VYK9	Arabidopsis thaliana	54%	77%
Q8W490	Arabidopsis thaliana	25%	71%
Q8WQ99	Caenorhabditis elegans	44%	82%
Q90ZY4	Danio rerio	25%	87%
Q91820	Xenopus laevis	24%	82%
Q91FD5	Invertebrate iridescent virus 6	28%	81%
Q93Z18	Arabidopsis thaliana	55%	80%
Q95PZ9	Caenorhabditis elegans	29%	88%
Q99986	Homo sapiens	30%	84%
Q9CAI5	Arabidopsis thaliana	54%	72%
Q9DC28	Mus musculus	57%	80%
Q9FFH8	Arabidopsis thaliana	56%	70%
Q9HCP0	Homo sapiens	51%	79%
Q9J509	Fowlpox virus (strain NVSL)	27%	100%
Q9J523	Fowlpox virus (strain NVSL)	25%	100%
Q9JJX8	Mus musculus	24%	81%
Q9JMK2	Mus musculus	56%	80%
Q9LSX4	Arabidopsis thaliana	56%	70%
Q9LW62	Arabidopsis thaliana	56%	76%
Q9N0X0	Sus scrofa	24%	97%
Q9NHE1	Leishmania major	64%	100%
Q9NHE2	Leishmania major	77%	100%
Q9NY57	Homo sapiens	24%	81%
Q9UQB9	Homo sapiens	25%	100%
Q9VKN7	Drosophila melanogaster	21%	100%
Q9Y6M4	Homo sapiens	49%	75%
Q9ZUP4	Arabidopsis thaliana	54%	77%
Q9ZWB3	Arabidopsis thaliana	56%	71%
V5AIW9	Trypanosoma cruzi	42%	91%
V5AX03	Trypanosoma cruzi	26%	79%
V5BC61	Trypanosoma cruzi	25%	100%
V5BLT9	Trypanosoma cruzi	29%	80%
V5BMQ3	Trypanosoma cruzi	45%	84%