Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMC9_LEIBR

TriTrypDb:

LbrM.34.0980 , LBRM2903_340015800

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.639
CLV_C14_Caspase3-7	328	332	PF00656	0.608
CLV_C14_Caspase3-7	739	743	PF00656	0.535
CLV_C14_Caspase3-7	81	85	PF00656	0.648
CLV_C14_Caspase3-7	821	825	PF00656	0.809
CLV_NRD_NRD_1	483	485	PF00675	0.508
CLV_NRD_NRD_1	577	579	PF00675	0.511
CLV_NRD_NRD_1	752	754	PF00675	0.524
CLV_NRD_NRD_1	780	782	PF00675	0.657
CLV_NRD_NRD_1	813	815	PF00675	0.663
CLV_PCSK_FUR_1	778	782	PF00082	0.641
CLV_PCSK_KEX2_1	482	484	PF00082	0.529
CLV_PCSK_KEX2_1	577	579	PF00082	0.528
CLV_PCSK_KEX2_1	752	754	PF00082	0.681
CLV_PCSK_KEX2_1	780	782	PF00082	0.657
CLV_PCSK_KEX2_1	813	815	PF00082	0.623
CLV_PCSK_SKI1_1	152	156	PF00082	0.419
CLV_PCSK_SKI1_1	359	363	PF00082	0.550
CLV_PCSK_SKI1_1	587	591	PF00082	0.564
CLV_PCSK_SKI1_1	628	632	PF00082	0.691
CLV_PCSK_SKI1_1	752	756	PF00082	0.507
DEG_COP1_1	130	140	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DEG_SCF_FBW7_1	243	249	PF00400	0.472
DEG_SCF_FBW7_1	361	368	PF00400	0.443
DEG_SPOP_SBC_1	278	282	PF00917	0.486
DEG_SPOP_SBC_1	415	419	PF00917	0.456
DEG_SPOP_SBC_1	496	500	PF00917	0.798
DEG_SPOP_SBC_1	509	513	PF00917	0.677
DEG_SPOP_SBC_1	704	708	PF00917	0.578
DOC_ANK_TNKS_1	301	308	PF00023	0.566
DOC_ANK_TNKS_1	482	489	PF00023	0.482
DOC_CDC14_PxL_1	284	292	PF14671	0.575
DOC_CKS1_1	191	196	PF01111	0.522
DOC_CKS1_1	220	225	PF01111	0.404
DOC_CKS1_1	243	248	PF01111	0.480
DOC_CKS1_1	362	367	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	107	113	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	18	24	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	605	611	PF00134	0.519
DOC_MAPK_MEF2A_6	152	159	PF00069	0.443
DOC_MAPK_MEF2A_6	442	450	PF00069	0.507
DOC_PP1_RVXF_1	376	383	PF00149	0.524
DOC_PP4_FxxP_1	204	207	PF00568	0.508
DOC_PP4_FxxP_1	808	811	PF00568	0.543
DOC_USP7_MATH_1	100	104	PF00917	0.637
DOC_USP7_MATH_1	119	123	PF00917	0.378
DOC_USP7_MATH_1	141	145	PF00917	0.477
DOC_USP7_MATH_1	244	248	PF00917	0.718
DOC_USP7_MATH_1	259	263	PF00917	0.563
DOC_USP7_MATH_1	415	419	PF00917	0.456
DOC_USP7_MATH_1	509	513	PF00917	0.706
DOC_USP7_MATH_1	515	519	PF00917	0.593
DOC_USP7_MATH_1	523	527	PF00917	0.436
DOC_USP7_MATH_1	55	59	PF00917	0.644
DOC_USP7_MATH_1	611	615	PF00917	0.744
DOC_USP7_MATH_1	634	638	PF00917	0.633
DOC_USP7_MATH_1	645	649	PF00917	0.702
DOC_USP7_MATH_1	655	659	PF00917	0.637
DOC_USP7_MATH_1	704	708	PF00917	0.686
DOC_USP7_MATH_1	80	84	PF00917	0.708
DOC_USP7_MATH_1	820	824	PF00917	0.663
DOC_USP7_MATH_1	835	839	PF00917	0.676
DOC_USP7_UBL2_3	403	407	PF12436	0.610
DOC_WW_Pin1_4	174	179	PF00397	0.553
DOC_WW_Pin1_4	190	195	PF00397	0.612
DOC_WW_Pin1_4	209	214	PF00397	0.468
DOC_WW_Pin1_4	219	224	PF00397	0.398
DOC_WW_Pin1_4	239	244	PF00397	0.710
DOC_WW_Pin1_4	246	251	PF00397	0.502
DOC_WW_Pin1_4	311	316	PF00397	0.567
DOC_WW_Pin1_4	348	353	PF00397	0.455
DOC_WW_Pin1_4	361	366	PF00397	0.395
DOC_WW_Pin1_4	398	403	PF00397	0.643
DOC_WW_Pin1_4	497	502	PF00397	0.694
DOC_WW_Pin1_4	51	56	PF00397	0.489
DOC_WW_Pin1_4	607	612	PF00397	0.695
DOC_WW_Pin1_4	656	661	PF00397	0.749
DOC_WW_Pin1_4	757	762	PF00397	0.625
DOC_WW_Pin1_4	828	833	PF00397	0.749
LIG_14-3-3_CanoR_1	293	297	PF00244	0.652
LIG_14-3-3_CanoR_1	442	446	PF00244	0.510
LIG_14-3-3_CanoR_1	530	534	PF00244	0.438
LIG_14-3-3_CanoR_1	577	586	PF00244	0.386
LIG_14-3-3_CanoR_1	596	603	PF00244	0.522
LIG_14-3-3_CanoR_1	668	674	PF00244	0.590
LIG_14-3-3_CanoR_1	688	695	PF00244	0.473
LIG_14-3-3_CanoR_1	752	757	PF00244	0.510
LIG_Actin_WH2_2	585	603	PF00022	0.451
LIG_APCC_ABBA_1	446	451	PF00400	0.573
LIG_BIR_III_4	561	565	PF00653	0.498
LIG_BRCT_BRCA1_1	732	736	PF00533	0.679
LIG_BRCT_BRCA1_1	74	78	PF00533	0.712
LIG_FHA_1	210	216	PF00498	0.492
LIG_FHA_1	279	285	PF00498	0.617
LIG_FHA_1	311	317	PF00498	0.673
LIG_FHA_1	417	423	PF00498	0.695
LIG_FHA_1	44	50	PF00498	0.661
LIG_FHA_1	470	476	PF00498	0.738
LIG_FHA_1	536	542	PF00498	0.420
LIG_FHA_1	581	587	PF00498	0.448
LIG_FHA_1	732	738	PF00498	0.705
LIG_FHA_2	156	162	PF00498	0.489
LIG_FHA_2	23	29	PF00498	0.380
LIG_FHA_2	301	307	PF00498	0.752
LIG_FHA_2	415	421	PF00498	0.641
LIG_FHA_2	425	431	PF00498	0.486
LIG_FHA_2	579	585	PF00498	0.430
LIG_FHA_2	688	694	PF00498	0.565
LIG_FHA_2	89	95	PF00498	0.640
LIG_GBD_Chelix_1	156	164	PF00786	0.492
LIG_LIR_Gen_1	177	188	PF02991	0.564
LIG_LIR_Gen_1	225	235	PF02991	0.496
LIG_LIR_Gen_1	566	576	PF02991	0.517
LIG_LIR_Gen_1	672	681	PF02991	0.616
LIG_LIR_Nem_3	177	183	PF02991	0.550
LIG_LIR_Nem_3	19	23	PF02991	0.493
LIG_LIR_Nem_3	225	230	PF02991	0.497
LIG_LIR_Nem_3	371	376	PF02991	0.417
LIG_LIR_Nem_3	394	399	PF02991	0.584
LIG_LIR_Nem_3	566	571	PF02991	0.479
LIG_LIR_Nem_3	58	63	PF02991	0.641
LIG_LYPXL_yS_3	20	23	PF13949	0.489
LIG_MLH1_MIPbox_1	75	79	PF16413	0.644
LIG_MYND_1	840	844	PF01753	0.540
LIG_Pex14_2	62	66	PF04695	0.484
LIG_PTB_Apo_2	564	571	PF02174	0.436
LIG_RPA_C_Fungi	158	170	PF08784	0.522
LIG_SH2_CRK	227	231	PF00017	0.511
LIG_SH2_GRB2like	565	568	PF00017	0.501
LIG_SH2_NCK_1	227	231	PF00017	0.502
LIG_SH2_NCK_1	5	9	PF00017	0.560
LIG_SH2_STAP1	565	569	PF00017	0.493
LIG_SH2_STAT5	106	109	PF00017	0.457
LIG_SH2_STAT5	268	271	PF00017	0.455
LIG_SH2_STAT5	474	477	PF00017	0.545
LIG_SH2_STAT5	728	731	PF00017	0.711
LIG_SH3_3	135	141	PF00018	0.506
LIG_SH3_3	185	191	PF00018	0.602
LIG_SH3_3	240	246	PF00018	0.533
LIG_SH3_3	314	320	PF00018	0.678
LIG_SH3_3	396	402	PF00018	0.601
LIG_SH3_3	450	456	PF00018	0.632
LIG_SH3_3	498	504	PF00018	0.727
LIG_SH3_3	540	546	PF00018	0.352
LIG_SH3_3	58	64	PF00018	0.480
LIG_SH3_3	605	611	PF00018	0.674
LIG_SH3_3	829	835	PF00018	0.689
LIG_SH3_4	403	410	PF00018	0.574
LIG_SUMO_SIM_anti_2	132	139	PF11976	0.548
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.437
LIG_SUMO_SIM_par_1	19	25	PF11976	0.448
LIG_SUMO_SIM_par_1	212	217	PF11976	0.507
LIG_SUMO_SIM_par_1	601	606	PF11976	0.562
LIG_TRAF2_1	428	431	PF00917	0.490
LIG_TRAF2_1	682	685	PF00917	0.531
LIG_TYR_ITIM	18	23	PF00017	0.492
LIG_UBA3_1	22	29	PF00899	0.494
LIG_WRC_WIRS_1	156	161	PF05994	0.492
LIG_WRC_WIRS_1	253	258	PF05994	0.574
LIG_WRC_WIRS_1	30	35	PF05994	0.624
LIG_WW_3	574	578	PF00397	0.557
MOD_CDK_SPK_2	398	403	PF00069	0.444
MOD_CK1_1	219	225	PF00069	0.516
MOD_CK1_1	242	248	PF00069	0.674
MOD_CK1_1	255	261	PF00069	0.594
MOD_CK1_1	282	288	PF00069	0.662
MOD_CK1_1	295	301	PF00069	0.694
MOD_CK1_1	347	353	PF00069	0.606
MOD_CK1_1	44	50	PF00069	0.748
MOD_CK1_1	469	475	PF00069	0.547
MOD_CK1_1	508	514	PF00069	0.766
MOD_CK1_1	547	553	PF00069	0.608
MOD_CK1_1	580	586	PF00069	0.524
MOD_CK1_1	633	639	PF00069	0.525
MOD_CK1_1	706	712	PF00069	0.825
MOD_CK1_1	74	80	PF00069	0.748
MOD_CK1_1	823	829	PF00069	0.727
MOD_CK1_1	831	837	PF00069	0.721
MOD_CK1_1	838	844	PF00069	0.743
MOD_CK2_1	155	161	PF00069	0.487
MOD_CK2_1	414	420	PF00069	0.588
MOD_CK2_1	424	430	PF00069	0.340
MOD_CK2_1	672	678	PF00069	0.551
MOD_CK2_1	687	693	PF00069	0.554
MOD_CK2_1	711	717	PF00069	0.580
MOD_Cter_Amidation	721	724	PF01082	0.706
MOD_Cter_Amidation	750	753	PF01082	0.759
MOD_Cter_Amidation	811	814	PF01082	0.717
MOD_GlcNHglycan	216	219	PF01048	0.479
MOD_GlcNHglycan	246	249	PF01048	0.653
MOD_GlcNHglycan	257	260	PF01048	0.592
MOD_GlcNHglycan	261	264	PF01048	0.618
MOD_GlcNHglycan	283	287	PF01048	0.674
MOD_GlcNHglycan	43	46	PF01048	0.728
MOD_GlcNHglycan	466	469	PF01048	0.656
MOD_GlcNHglycan	489	492	PF01048	0.711
MOD_GlcNHglycan	507	510	PF01048	0.708
MOD_GlcNHglycan	513	516	PF01048	0.726
MOD_GlcNHglycan	517	520	PF01048	0.662
MOD_GlcNHglycan	521	524	PF01048	0.545
MOD_GlcNHglycan	597	600	PF01048	0.545
MOD_GlcNHglycan	632	635	PF01048	0.502
MOD_GlcNHglycan	782	785	PF01048	0.794
MOD_GlcNHglycan	820	823	PF01048	0.678
MOD_GSK3_1	155	162	PF00069	0.463
MOD_GSK3_1	242	249	PF00069	0.690
MOD_GSK3_1	255	262	PF00069	0.629
MOD_GSK3_1	278	285	PF00069	0.695
MOD_GSK3_1	292	299	PF00069	0.565
MOD_GSK3_1	344	351	PF00069	0.697
MOD_GSK3_1	357	364	PF00069	0.495
MOD_GSK3_1	505	512	PF00069	0.645
MOD_GSK3_1	51	58	PF00069	0.616
MOD_GSK3_1	515	522	PF00069	0.592
MOD_GSK3_1	607	614	PF00069	0.683
MOD_GSK3_1	630	637	PF00069	0.538
MOD_GSK3_1	656	663	PF00069	0.670
MOD_GSK3_1	69	76	PF00069	0.728
MOD_GSK3_1	703	710	PF00069	0.627
MOD_GSK3_1	818	825	PF00069	0.716
MOD_GSK3_1	82	89	PF00069	0.676
MOD_GSK3_1	831	838	PF00069	0.731
MOD_GSK3_1	96	103	PF00069	0.473
MOD_LATS_1	27	33	PF00433	0.580
MOD_N-GLC_1	100	105	PF02516	0.625
MOD_N-GLC_1	111	116	PF02516	0.494
MOD_N-GLC_1	119	124	PF02516	0.393
MOD_NEK2_1	155	160	PF00069	0.426
MOD_NEK2_1	216	221	PF00069	0.492
MOD_NEK2_1	22	27	PF00069	0.431
MOD_NEK2_1	257	262	PF00069	0.588
MOD_NEK2_1	346	351	PF00069	0.625
MOD_NEK2_1	424	429	PF00069	0.387
MOD_NEK2_1	529	534	PF00069	0.499
MOD_NEK2_1	594	599	PF00069	0.479
MOD_NEK2_1	630	635	PF00069	0.562
MOD_NEK2_1	71	76	PF00069	0.521
MOD_NEK2_2	523	528	PF00069	0.459
MOD_PIKK_1	645	651	PF00454	0.518
MOD_PIKK_1	69	75	PF00454	0.525
MOD_PK_1	163	169	PF00069	0.479
MOD_PKA_1	577	583	PF00069	0.553
MOD_PKA_1	752	758	PF00069	0.507
MOD_PKA_1	780	786	PF00069	0.777
MOD_PKA_2	292	298	PF00069	0.702
MOD_PKA_2	41	47	PF00069	0.639
MOD_PKA_2	441	447	PF00069	0.562
MOD_PKA_2	529	535	PF00069	0.446
MOD_PKA_2	577	583	PF00069	0.481
MOD_PKA_2	595	601	PF00069	0.483
MOD_PKA_2	645	651	PF00069	0.639
MOD_PKA_2	687	693	PF00069	0.707
MOD_PKA_2	752	758	PF00069	0.507
MOD_PKA_2	780	786	PF00069	0.676
MOD_PKB_1	778	786	PF00069	0.663
MOD_Plk_1	100	106	PF00069	0.643
MOD_Plk_1	119	125	PF00069	0.377
MOD_Plk_1	523	529	PF00069	0.384
MOD_Plk_4	119	125	PF00069	0.641
MOD_Plk_4	155	161	PF00069	0.505
MOD_Plk_4	165	171	PF00069	0.417
MOD_Plk_4	216	222	PF00069	0.458
MOD_Plk_4	252	258	PF00069	0.636
MOD_Plk_4	29	35	PF00069	0.616
MOD_Plk_4	357	363	PF00069	0.568
MOD_Plk_4	368	374	PF00069	0.509
MOD_Plk_4	441	447	PF00069	0.465
MOD_Plk_4	634	640	PF00069	0.534
MOD_Plk_4	66	72	PF00069	0.616
MOD_Plk_4	74	80	PF00069	0.642
MOD_ProDKin_1	174	180	PF00069	0.552
MOD_ProDKin_1	190	196	PF00069	0.612
MOD_ProDKin_1	209	215	PF00069	0.468
MOD_ProDKin_1	219	225	PF00069	0.394
MOD_ProDKin_1	239	245	PF00069	0.708
MOD_ProDKin_1	246	252	PF00069	0.499
MOD_ProDKin_1	311	317	PF00069	0.569
MOD_ProDKin_1	348	354	PF00069	0.459
MOD_ProDKin_1	361	367	PF00069	0.393
MOD_ProDKin_1	398	404	PF00069	0.644
MOD_ProDKin_1	497	503	PF00069	0.694
MOD_ProDKin_1	51	57	PF00069	0.487
MOD_ProDKin_1	607	613	PF00069	0.700
MOD_ProDKin_1	656	662	PF00069	0.751
MOD_ProDKin_1	757	763	PF00069	0.619
MOD_ProDKin_1	828	834	PF00069	0.748
TRG_DiLeu_BaEn_1	132	137	PF01217	0.541
TRG_DiLeu_BaEn_1	334	339	PF01217	0.443
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.456
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.647
TRG_ENDOCYTIC_2	180	183	PF00928	0.568
TRG_ENDOCYTIC_2	20	23	PF00928	0.489
TRG_ENDOCYTIC_2	227	230	PF00928	0.505
TRG_ENDOCYTIC_2	5	8	PF00928	0.560
TRG_ENDOCYTIC_2	565	568	PF00928	0.501
TRG_ENDOCYTIC_2	673	676	PF00928	0.507
TRG_ER_diArg_1	269	272	PF00400	0.527
TRG_ER_diArg_1	482	484	PF00400	0.529
TRG_ER_diArg_1	576	578	PF00400	0.542
TRG_ER_diArg_1	778	781	PF00400	0.637
TRG_ER_diArg_1	813	815	PF00400	0.663
TRG_ER_diLys_1	847	850	PF00400	0.552
TRG_ER_FFAT_2	251	262	PF00635	0.461
TRG_NES_CRM1_1	6	19	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	587	591	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	813	818	PF00026	0.725

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P319	Leptomonas seymouri	49%	94%
A0A1X0NIZ7	Trypanosomatidae	29%	100%
A0A3R7KEZ9	Trypanosoma rangeli	29%	100%
A0A3S7X8X6	Leishmania donovani	76%	100%
A4IAZ6	Leishmania infantum	76%	100%
E9AES4	Leishmania major	77%	100%
E9B5X9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%