Aldose 1-epimerase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HMC8_LEIBR

TriTrypDb:

LbrM.34.0970 , LBRM2903_340015700

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC8

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0008152	metabolic process	1	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0016853	isomerase activity	2	2
GO:0030246	carbohydrate binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.421
CLV_NRD_NRD_1	218	220	PF00675	0.421
CLV_PCSK_KEX2_1	218	220	PF00082	0.421
CLV_PCSK_KEX2_1	63	65	PF00082	0.421
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.421
CLV_PCSK_SKI1_1	113	117	PF00082	0.421
CLV_PCSK_SKI1_1	144	148	PF00082	0.421
DEG_Nend_UBRbox_2	1	3	PF02207	0.521
DOC_MAPK_gen_1	188	197	PF00069	0.621
DOC_MAPK_gen_1	60	69	PF00069	0.621
DOC_PP2B_LxvP_1	79	82	PF13499	0.621
DOC_USP7_MATH_1	28	32	PF00917	0.621
DOC_USP7_MATH_2	6	12	PF00917	0.621
DOC_WW_Pin1_4	102	107	PF00397	0.621
DOC_WW_Pin1_4	150	155	PF00397	0.621
DOC_WW_Pin1_4	34	39	PF00397	0.621
LIG_14-3-3_CanoR_1	223	229	PF00244	0.621
LIG_Actin_WH2_2	10	28	PF00022	0.621
LIG_APCC_ABBA_1	145	150	PF00400	0.621
LIG_APCC_ABBAyCdc20_2	144	150	PF00400	0.621
LIG_BIR_III_2	40	44	PF00653	0.621
LIG_FHA_1	12	18	PF00498	0.621
LIG_FHA_1	153	159	PF00498	0.621
LIG_FHA_1	223	229	PF00498	0.621
LIG_FHA_2	103	109	PF00498	0.621
LIG_FHA_2	25	31	PF00498	0.621
LIG_LIR_Apic_2	65	71	PF02991	0.621
LIG_LIR_Gen_1	221	232	PF02991	0.621
LIG_LIR_Gen_1	96	107	PF02991	0.621
LIG_LIR_Nem_3	221	227	PF02991	0.621
LIG_LIR_Nem_3	27	32	PF02991	0.621
LIG_LIR_Nem_3	96	102	PF02991	0.621
LIG_PDZ_Class_1	235	240	PF00595	0.734
LIG_Pex14_2	166	170	PF04695	0.621
LIG_PTB_Apo_2	45	52	PF02174	0.621
LIG_PTB_Phospho_1	45	51	PF10480	0.621
LIG_SH2_GRB2like	51	54	PF00017	0.621
LIG_SH2_SRC	131	134	PF00017	0.621
LIG_SH2_STAP1	29	33	PF00017	0.621
LIG_SH2_STAT5	172	175	PF00017	0.621
LIG_SH2_STAT5	201	204	PF00017	0.621
LIG_SH2_STAT5	32	35	PF00017	0.621
LIG_SH2_STAT5	99	102	PF00017	0.621
LIG_SH3_3	207	213	PF00018	0.621
LIG_SUMO_SIM_par_1	132	138	PF11976	0.621
MOD_CK1_1	11	17	PF00069	0.621
MOD_CK1_1	153	159	PF00069	0.621
MOD_Cter_Amidation	61	64	PF01082	0.421
MOD_GlcNHglycan	181	184	PF01048	0.421
MOD_GlcNHglycan	204	207	PF01048	0.421
MOD_GlcNHglycan	234	237	PF01048	0.670
MOD_GSK3_1	230	237	PF00069	0.633
MOD_GSK3_1	24	31	PF00069	0.621
MOD_GSK3_1	98	105	PF00069	0.621
MOD_N-GLC_2	157	159	PF02516	0.421
MOD_NEK2_1	232	237	PF00069	0.649
MOD_PKA_2	190	196	PF00069	0.621
MOD_PKA_2	222	228	PF00069	0.621
MOD_Plk_1	230	236	PF00069	0.621
MOD_Plk_2-3	98	104	PF00069	0.621
MOD_Plk_4	28	34	PF00069	0.621
MOD_ProDKin_1	102	108	PF00069	0.621
MOD_ProDKin_1	150	156	PF00069	0.621
MOD_ProDKin_1	34	40	PF00069	0.621
TRG_DiLeu_BaEn_1	141	146	PF01217	0.621
TRG_ENDOCYTIC_2	163	166	PF00928	0.621
TRG_ENDOCYTIC_2	51	54	PF00928	0.621
TRG_ENDOCYTIC_2	99	102	PF00928	0.621
TRG_ER_diArg_1	217	219	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P0A9C3	Escherichia coli (strain K12)	31%	69%
P0A9C4	Shigella flexneri	31%	69%
P31765	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	71%
Q5EA79	Bos taurus	29%	70%
Q5R8U1	Pongo abelii	30%	70%
Q66HG4	Rattus norvegicus	30%	70%
Q8K157	Mus musculus	30%	70%
Q96C23	Homo sapiens	31%	70%
Q9GKX6	Sus scrofa	28%	70%