Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMC7_LEIBR

TriTrypDb:

LbrM.34.0950 , LBRM2903_340015500

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	300	304	PF00656	0.495
CLV_C14_Caspase3-7	410	414	PF00656	0.438
CLV_MEL_PAP_1	432	438	PF00089	0.358
CLV_NRD_NRD_1	11	13	PF00675	0.460
CLV_NRD_NRD_1	129	131	PF00675	0.662
CLV_NRD_NRD_1	587	589	PF00675	0.536
CLV_NRD_NRD_1	615	617	PF00675	0.554
CLV_PCSK_FUR_1	585	589	PF00082	0.517
CLV_PCSK_KEX2_1	10	12	PF00082	0.502
CLV_PCSK_KEX2_1	129	131	PF00082	0.662
CLV_PCSK_KEX2_1	183	185	PF00082	0.468
CLV_PCSK_KEX2_1	587	589	PF00082	0.518
CLV_PCSK_KEX2_1	615	617	PF00082	0.554
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.391
CLV_PCSK_SKI1_1	104	108	PF00082	0.644
CLV_PCSK_SKI1_1	224	228	PF00082	0.474
CLV_PCSK_SKI1_1	340	344	PF00082	0.307
CLV_PCSK_SKI1_1	562	566	PF00082	0.381
CLV_PCSK_SKI1_1	588	592	PF00082	0.388
DEG_APCC_DBOX_1	561	569	PF00400	0.448
DEG_Nend_Nbox_1	1	3	PF02207	0.559
DEG_SPOP_SBC_1	147	151	PF00917	0.722
DEG_SPOP_SBC_1	189	193	PF00917	0.473
DEG_SPOP_SBC_1	279	283	PF00917	0.507
DOC_CDC14_PxL_1	761	769	PF14671	0.356
DOC_CKS1_1	24	29	PF01111	0.511
DOC_CKS1_1	499	504	PF01111	0.417
DOC_CKS1_1	646	651	PF01111	0.428
DOC_CYCLIN_RxL_1	559	567	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.422
DOC_MAPK_gen_1	129	136	PF00069	0.665
DOC_MAPK_gen_1	585	592	PF00069	0.509
DOC_MAPK_gen_1	59	68	PF00069	0.422
DOC_MAPK_MEF2A_6	562	570	PF00069	0.448
DOC_PP1_RVXF_1	63	69	PF00149	0.351
DOC_PP1_RVXF_1	702	708	PF00149	0.534
DOC_PP2B_LxvP_1	134	137	PF13499	0.696
DOC_PP2B_LxvP_1	276	279	PF13499	0.443
DOC_PP2B_LxvP_1	568	571	PF13499	0.452
DOC_USP7_MATH_1	146	150	PF00917	0.690
DOC_USP7_MATH_1	157	161	PF00917	0.609
DOC_USP7_MATH_1	172	176	PF00917	0.698
DOC_USP7_MATH_1	189	193	PF00917	0.480
DOC_USP7_MATH_1	250	254	PF00917	0.575
DOC_USP7_MATH_1	279	283	PF00917	0.642
DOC_USP7_MATH_1	302	306	PF00917	0.509
DOC_USP7_MATH_1	414	418	PF00917	0.498
DOC_USP7_MATH_1	598	602	PF00917	0.607
DOC_USP7_MATH_1	726	730	PF00917	0.632
DOC_USP7_MATH_1	743	747	PF00917	0.459
DOC_WW_Pin1_4	142	147	PF00397	0.634
DOC_WW_Pin1_4	200	205	PF00397	0.767
DOC_WW_Pin1_4	23	28	PF00397	0.461
DOC_WW_Pin1_4	332	337	PF00397	0.558
DOC_WW_Pin1_4	441	446	PF00397	0.653
DOC_WW_Pin1_4	498	503	PF00397	0.426
DOC_WW_Pin1_4	593	598	PF00397	0.438
DOC_WW_Pin1_4	635	640	PF00397	0.562
DOC_WW_Pin1_4	645	650	PF00397	0.516
DOC_WW_Pin1_4	739	744	PF00397	0.485
LIG_14-3-3_CanoR_1	198	205	PF00244	0.579
LIG_14-3-3_CanoR_1	435	440	PF00244	0.574
LIG_14-3-3_CanoR_1	455	459	PF00244	0.634
LIG_14-3-3_CanoR_1	658	662	PF00244	0.378
LIG_14-3-3_CanoR_1	795	801	PF00244	0.441
LIG_14-3-3_CanoR_1	94	102	PF00244	0.511
LIG_APCC_ABBA_1	376	381	PF00400	0.617
LIG_CSL_BTD_1	276	279	PF09270	0.443
LIG_deltaCOP1_diTrp_1	228	238	PF00928	0.375
LIG_EH1_1	678	686	PF00400	0.337
LIG_FHA_1	1	7	PF00498	0.659
LIG_FHA_1	105	111	PF00498	0.641
LIG_FHA_1	165	171	PF00498	0.706
LIG_FHA_1	26	32	PF00498	0.526
LIG_FHA_1	352	358	PF00498	0.467
LIG_FHA_1	413	419	PF00498	0.449
LIG_FHA_1	442	448	PF00498	0.549
LIG_FHA_1	467	473	PF00498	0.584
LIG_FHA_1	530	536	PF00498	0.798
LIG_FHA_1	554	560	PF00498	0.329
LIG_FHA_1	565	571	PF00498	0.356
LIG_FHA_1	641	647	PF00498	0.617
LIG_FHA_1	685	691	PF00498	0.469
LIG_FHA_1	700	706	PF00498	0.575
LIG_FHA_1	96	102	PF00498	0.600
LIG_FHA_2	212	218	PF00498	0.460
LIG_FHA_2	408	414	PF00498	0.423
LIG_FHA_2	483	489	PF00498	0.406
LIG_FHA_2	505	511	PF00498	0.442
LIG_FHA_2	550	556	PF00498	0.429
LIG_FHA_2	570	576	PF00498	0.262
LIG_FHA_2	657	663	PF00498	0.437
LIG_FHA_2	748	754	PF00498	0.418
LIG_LIR_Apic_2	555	560	PF02991	0.335
LIG_LIR_Gen_1	175	182	PF02991	0.558
LIG_LIR_Gen_1	341	350	PF02991	0.328
LIG_LIR_Gen_1	420	429	PF02991	0.454
LIG_LIR_Nem_3	175	179	PF02991	0.505
LIG_LIR_Nem_3	341	345	PF02991	0.278
LIG_LIR_Nem_3	420	426	PF02991	0.471
LIG_LYPXL_yS_3	764	767	PF13949	0.332
LIG_MYND_1	649	653	PF01753	0.368
LIG_NRP_CendR_1	798	801	PF00754	0.406
LIG_SH2_CRK	82	86	PF00017	0.365
LIG_SH2_GRB2like	621	624	PF00017	0.539
LIG_SH2_PTP2	557	560	PF00017	0.428
LIG_SH2_SRC	20	23	PF00017	0.528
LIG_SH2_SRC	54	57	PF00017	0.455
LIG_SH2_SRC	547	550	PF00017	0.436
LIG_SH2_SRC	780	783	PF00017	0.429
LIG_SH2_STAP1	621	625	PF00017	0.637
LIG_SH2_STAP1	661	665	PF00017	0.378
LIG_SH2_STAT5	186	189	PF00017	0.534
LIG_SH2_STAT5	20	23	PF00017	0.447
LIG_SH2_STAT5	344	347	PF00017	0.336
LIG_SH2_STAT5	54	57	PF00017	0.361
LIG_SH2_STAT5	547	550	PF00017	0.405
LIG_SH2_STAT5	557	560	PF00017	0.297
LIG_SH2_STAT5	67	70	PF00017	0.335
LIG_SH2_STAT5	672	675	PF00017	0.511
LIG_SH2_STAT5	775	778	PF00017	0.368
LIG_SH2_STAT5	780	783	PF00017	0.384
LIG_SH3_3	108	114	PF00018	0.622
LIG_SH3_3	120	126	PF00018	0.683
LIG_SH3_3	21	27	PF00018	0.495
LIG_SH3_3	352	358	PF00018	0.438
LIG_SH3_3	393	399	PF00018	0.357
LIG_SH3_3	402	408	PF00018	0.405
LIG_SH3_3	510	516	PF00018	0.580
LIG_SH3_3	644	650	PF00018	0.660
LIG_SH3_3	668	674	PF00018	0.324
LIG_SUMO_SIM_par_1	132	139	PF11976	0.665
LIG_SUMO_SIM_par_1	652	657	PF11976	0.448
LIG_TYR_ITIM	80	85	PF00017	0.395
LIG_WRC_WIRS_1	339	344	PF05994	0.323
MOD_CDK_SPxK_1	23	29	PF00069	0.512
MOD_CK1_1	188	194	PF00069	0.666
MOD_CK1_1	234	240	PF00069	0.457
MOD_CK1_1	282	288	PF00069	0.633
MOD_CK1_1	294	300	PF00069	0.646
MOD_CK1_1	369	375	PF00069	0.629
MOD_CK1_1	479	485	PF00069	0.714
MOD_CK1_1	517	523	PF00069	0.637
MOD_CK1_1	541	547	PF00069	0.606
MOD_CK1_1	657	663	PF00069	0.490
MOD_CK2_1	190	196	PF00069	0.495
MOD_CK2_1	200	206	PF00069	0.619
MOD_CK2_1	482	488	PF00069	0.472
MOD_CK2_1	504	510	PF00069	0.430
MOD_CK2_1	549	555	PF00069	0.433
MOD_CK2_1	569	575	PF00069	0.254
MOD_CK2_1	623	629	PF00069	0.508
MOD_CK2_1	656	662	PF00069	0.489
MOD_CK2_1	747	753	PF00069	0.385
MOD_DYRK1A_RPxSP_1	200	204	PF00069	0.536
MOD_GlcNHglycan	107	110	PF01048	0.648
MOD_GlcNHglycan	150	153	PF01048	0.664
MOD_GlcNHglycan	161	164	PF01048	0.498
MOD_GlcNHglycan	187	190	PF01048	0.663
MOD_GlcNHglycan	246	249	PF01048	0.685
MOD_GlcNHglycan	250	253	PF01048	0.658
MOD_GlcNHglycan	292	296	PF01048	0.658
MOD_GlcNHglycan	351	354	PF01048	0.451
MOD_GlcNHglycan	41	44	PF01048	0.507
MOD_GlcNHglycan	437	440	PF01048	0.630
MOD_GlcNHglycan	481	484	PF01048	0.651
MOD_GlcNHglycan	485	488	PF01048	0.611
MOD_GlcNHglycan	540	543	PF01048	0.640
MOD_GlcNHglycan	600	603	PF01048	0.602
MOD_GlcNHglycan	625	628	PF01048	0.511
MOD_GlcNHglycan	633	636	PF01048	0.535
MOD_GlcNHglycan	724	727	PF01048	0.625
MOD_GSK3_1	136	143	PF00069	0.689
MOD_GSK3_1	157	164	PF00069	0.706
MOD_GSK3_1	185	192	PF00069	0.510
MOD_GSK3_1	211	218	PF00069	0.523
MOD_GSK3_1	233	240	PF00069	0.699
MOD_GSK3_1	244	251	PF00069	0.631
MOD_GSK3_1	278	285	PF00069	0.538
MOD_GSK3_1	287	294	PF00069	0.705
MOD_GSK3_1	297	304	PF00069	0.543
MOD_GSK3_1	412	419	PF00069	0.545
MOD_GSK3_1	472	479	PF00069	0.752
MOD_GSK3_1	531	538	PF00069	0.670
MOD_GSK3_1	549	556	PF00069	0.523
MOD_GSK3_1	623	630	PF00069	0.624
MOD_GSK3_1	631	638	PF00069	0.648
MOD_GSK3_1	722	729	PF00069	0.643
MOD_GSK3_1	739	746	PF00069	0.587
MOD_N-GLC_1	231	236	PF02516	0.456
MOD_N-GLC_1	238	243	PF02516	0.588
MOD_N-GLC_1	374	379	PF02516	0.508
MOD_N-GLC_1	627	632	PF02516	0.506
MOD_N-GLC_1	691	696	PF02516	0.663
MOD_NEK2_1	141	146	PF00069	0.646
MOD_NEK2_1	159	164	PF00069	0.652
MOD_NEK2_1	2	7	PF00069	0.540
MOD_NEK2_1	434	439	PF00069	0.531
MOD_NEK2_1	47	52	PF00069	0.356
MOD_NEK2_1	564	569	PF00069	0.386
MOD_NEK2_1	611	616	PF00069	0.463
MOD_NEK2_1	654	659	PF00069	0.466
MOD_NEK2_2	322	327	PF00069	0.416
MOD_NEK2_2	374	379	PF00069	0.628
MOD_NEK2_2	531	536	PF00069	0.511
MOD_NEK2_2	686	691	PF00069	0.364
MOD_PIKK_1	136	142	PF00454	0.700
MOD_PIKK_1	239	245	PF00454	0.637
MOD_PIKK_1	457	463	PF00454	0.526
MOD_PKA_1	104	110	PF00069	0.646
MOD_PKA_2	434	440	PF00069	0.553
MOD_PKA_2	454	460	PF00069	0.607
MOD_PKA_2	479	485	PF00069	0.712
MOD_PKA_2	609	615	PF00069	0.616
MOD_PKA_2	61	67	PF00069	0.382
MOD_PKA_2	657	663	PF00069	0.380
MOD_PKA_2	93	99	PF00069	0.516
MOD_Plk_1	216	222	PF00069	0.442
MOD_Plk_1	374	380	PF00069	0.624
MOD_Plk_4	351	357	PF00069	0.369
MOD_Plk_4	553	559	PF00069	0.344
MOD_ProDKin_1	142	148	PF00069	0.633
MOD_ProDKin_1	200	206	PF00069	0.767
MOD_ProDKin_1	23	29	PF00069	0.461
MOD_ProDKin_1	332	338	PF00069	0.546
MOD_ProDKin_1	441	447	PF00069	0.655
MOD_ProDKin_1	498	504	PF00069	0.424
MOD_ProDKin_1	593	599	PF00069	0.437
MOD_ProDKin_1	635	641	PF00069	0.565
MOD_ProDKin_1	645	651	PF00069	0.507
MOD_ProDKin_1	739	745	PF00069	0.470
MOD_SUMO_rev_2	201	211	PF00179	0.595
MOD_SUMO_rev_2	228	237	PF00179	0.455
MOD_SUMO_rev_2	251	261	PF00179	0.415
MOD_SUMO_rev_2	364	372	PF00179	0.561
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.557
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.478
TRG_ENDOCYTIC_2	764	767	PF00928	0.332
TRG_ENDOCYTIC_2	82	85	PF00928	0.367
TRG_ER_diArg_1	129	131	PF00400	0.597
TRG_ER_diArg_1	521	524	PF00400	0.504
TRG_ER_diArg_1	585	588	PF00400	0.513
TRG_ER_diArg_1	9	12	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	664	669	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q0	Leptomonas seymouri	47%	96%
A0A3S7X8V4	Leishmania donovani	73%	100%
A0A422N118	Trypanosoma rangeli	30%	100%
A4IAZ3	Leishmania infantum	74%	100%
C9ZNJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AES1	Leishmania major	72%	98%
E9B5X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%