PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell cycle sequence binding phosphoprotein (RBP33), putative

Species:

Leishmania braziliensis

UniProt:

A4HMC6_LEIBR

TriTrypDb:

LbrM.34.0940 , LBRM2903_340015400

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HMC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.522
CLV_C14_Caspase3-7	158	162	PF00656	0.631
CLV_C14_Caspase3-7	179	183	PF00656	0.656
CLV_C14_Caspase3-7	375	379	PF00656	0.584
CLV_NRD_NRD_1	222	224	PF00675	0.377
CLV_NRD_NRD_1	255	257	PF00675	0.394
CLV_PCSK_KEX2_1	218	220	PF00082	0.391
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.391
CLV_PCSK_SKI1_1	42	46	PF00082	0.514
DOC_CYCLIN_RxL_1	309	321	PF00134	0.320
DOC_MAPK_gen_1	309	318	PF00069	0.296
DOC_MAPK_gen_1	7	16	PF00069	0.428
DOC_MAPK_MEF2A_6	312	320	PF00069	0.292
DOC_MAPK_MEF2A_6	7	16	PF00069	0.428
DOC_PP1_RVXF_1	332	339	PF00149	0.285
DOC_USP7_MATH_1	145	149	PF00917	0.736
DOC_USP7_MATH_1	206	210	PF00917	0.509
DOC_USP7_MATH_1	25	29	PF00917	0.631
DOC_USP7_MATH_1	263	267	PF00917	0.418
DOC_USP7_MATH_1	377	381	PF00917	0.560
DOC_USP7_MATH_1	74	78	PF00917	0.657
DOC_WW_Pin1_4	103	108	PF00397	0.583
DOC_WW_Pin1_4	111	116	PF00397	0.595
DOC_WW_Pin1_4	146	151	PF00397	0.627
DOC_WW_Pin1_4	19	24	PF00397	0.544
LIG_14-3-3_CanoR_1	157	163	PF00244	0.580
LIG_14-3-3_CanoR_1	286	293	PF00244	0.306
LIG_14-3-3_CanoR_1	42	47	PF00244	0.483
LIG_14-3-3_CanoR_1	94	98	PF00244	0.588
LIG_APCC_ABBA_1	12	17	PF00400	0.555
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_BIR_III_4	119	123	PF00653	0.526
LIG_BIR_III_4	378	382	PF00653	0.604
LIG_BRCT_BRCA1_1	336	340	PF00533	0.309
LIG_BRCT_BRCA1_1	344	348	PF00533	0.407
LIG_FHA_1	158	164	PF00498	0.582
LIG_FHA_1	260	266	PF00498	0.473
LIG_Integrin_isoDGR_2	281	283	PF01839	0.453
LIG_LIR_Nem_3	345	351	PF02991	0.333
LIG_LIR_Nem_3	354	359	PF02991	0.327
LIG_MLH1_MIPbox_1	336	340	PF16413	0.285
LIG_SH2_GRB2like	189	192	PF00017	0.559
LIG_SH2_PTP2	236	239	PF00017	0.344
LIG_SH2_STAP1	189	193	PF00017	0.657
LIG_SH2_STAT5	225	228	PF00017	0.468
LIG_SH2_STAT5	236	239	PF00017	0.321
LIG_SH2_STAT5	3	6	PF00017	0.546
LIG_TRAF2_1	288	291	PF00917	0.285
LIG_WRC_WIRS_1	356	361	PF05994	0.285
MOD_CK1_1	100	106	PF00069	0.614
MOD_CK1_1	114	120	PF00069	0.549
MOD_CK1_1	128	134	PF00069	0.735
MOD_CK1_1	156	162	PF00069	0.646
MOD_CK1_1	30	36	PF00069	0.583
MOD_CK2_1	377	383	PF00069	0.649
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.573
MOD_GlcNHglycan	102	105	PF01048	0.749
MOD_GlcNHglycan	107	110	PF01048	0.665
MOD_GlcNHglycan	178	181	PF01048	0.579
MOD_GlcNHglycan	19	22	PF01048	0.542
MOD_GlcNHglycan	23	26	PF01048	0.585
MOD_GlcNHglycan	27	30	PF01048	0.607
MOD_GlcNHglycan	378	382	PF01048	0.569
MOD_GlcNHglycan	394	397	PF01048	0.562
MOD_GlcNHglycan	76	79	PF01048	0.671
MOD_GSK3_1	124	131	PF00069	0.572
MOD_GSK3_1	139	146	PF00069	0.597
MOD_GSK3_1	15	22	PF00069	0.531
MOD_GSK3_1	151	158	PF00069	0.693
MOD_GSK3_1	25	32	PF00069	0.590
MOD_GSK3_1	259	266	PF00069	0.446
MOD_GSK3_1	93	100	PF00069	0.585
MOD_LATS_1	40	46	PF00433	0.523
MOD_N-GLC_1	151	156	PF02516	0.659
MOD_N-GLC_1	259	264	PF02516	0.440
MOD_N-GLC_1	392	397	PF02516	0.537
MOD_NEK2_1	15	20	PF00069	0.529
MOD_NEK2_1	176	181	PF00069	0.544
MOD_NEK2_1	355	360	PF00069	0.329
MOD_NEK2_1	97	102	PF00069	0.606
MOD_NEK2_2	307	312	PF00069	0.339
MOD_PK_1	52	58	PF00069	0.463
MOD_PKA_1	334	340	PF00069	0.339
MOD_PKA_2	156	162	PF00069	0.557
MOD_PKA_2	242	248	PF00069	0.365
MOD_PKA_2	6	12	PF00069	0.404
MOD_PKA_2	74	80	PF00069	0.586
MOD_PKA_2	93	99	PF00069	0.426
MOD_Plk_1	259	265	PF00069	0.439
MOD_Plk_1	342	348	PF00069	0.285
MOD_Plk_4	42	48	PF00069	0.623
MOD_Plk_4	52	58	PF00069	0.412
MOD_Plk_4	59	65	PF00069	0.372
MOD_ProDKin_1	103	109	PF00069	0.585
MOD_ProDKin_1	111	117	PF00069	0.592
MOD_ProDKin_1	146	152	PF00069	0.628
MOD_ProDKin_1	19	25	PF00069	0.549
MOD_SUMO_for_1	277	280	PF00179	0.408
MOD_SUMO_rev_2	268	277	PF00179	0.427
MOD_SUMO_rev_2	326	336	PF00179	0.342
TRG_DiLeu_BaEn_2	209	215	PF01217	0.382
TRG_DiLeu_BaEn_4	200	206	PF01217	0.558
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.469
TRG_ENDOCYTIC_2	236	239	PF00928	0.344
TRG_ENDOCYTIC_2	356	359	PF00928	0.287
TRG_ER_diArg_1	219	222	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I362	Leptomonas seymouri	68%	100%
A0A3Q8IEY4	Leishmania donovani	87%	99%
A0A3Q8IJZ1	Leishmania donovani	24%	100%
A4HNG2	Leishmania braziliensis	23%	100%
A4IAZ2	Leishmania infantum	87%	99%
A4IC69	Leishmania infantum	24%	100%
E9AES0	Leishmania major	86%	100%
E9AFX3	Leishmania major	24%	100%
E9B5X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%