Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMC5_LEIBR

TriTrypDb:

LbrM.34.0930 , LBRM2903_340015300

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HMC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	250	252	PF00675	0.567
CLV_NRD_NRD_1	3	5	PF00675	0.374
CLV_NRD_NRD_1	37	39	PF00675	0.402
CLV_NRD_NRD_1	93	95	PF00675	0.512
CLV_PCSK_KEX2_1	227	229	PF00082	0.357
CLV_PCSK_KEX2_1	250	252	PF00082	0.520
CLV_PCSK_KEX2_1	3	5	PF00082	0.374
CLV_PCSK_KEX2_1	37	39	PF00082	0.464
CLV_PCSK_KEX2_1	93	95	PF00082	0.512
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.412
CLV_PCSK_SKI1_1	205	209	PF00082	0.407
CLV_PCSK_SKI1_1	231	235	PF00082	0.254
DEG_Nend_Nbox_1	1	3	PF02207	0.641
DEG_SPOP_SBC_1	78	82	PF00917	0.663
DOC_MAPK_gen_1	227	235	PF00069	0.470
DOC_PP1_RVXF_1	1	8	PF00149	0.575
DOC_USP7_MATH_1	56	60	PF00917	0.718
DOC_USP7_MATH_1	65	69	PF00917	0.714
DOC_USP7_MATH_1	78	82	PF00917	0.683
DOC_USP7_MATH_2	102	108	PF00917	0.702
DOC_USP7_UBL2_3	112	116	PF12436	0.660
DOC_USP7_UBL2_3	205	209	PF12436	0.626
DOC_WW_Pin1_4	178	183	PF00397	0.632
DOC_WW_Pin1_4	186	191	PF00397	0.641
DOC_WW_Pin1_4	74	79	PF00397	0.654
LIG_14-3-3_CanoR_1	169	175	PF00244	0.615
LIG_14-3-3_CanoR_1	38	47	PF00244	0.662
LIG_14-3-3_CanoR_1	57	62	PF00244	0.648
LIG_14-3-3_CanoR_1	9	15	PF00244	0.585
LIG_Actin_WH2_2	195	211	PF00022	0.546
LIG_BRCT_BRCA1_1	106	110	PF00533	0.635
LIG_BRCT_BRCA1_2	106	112	PF00533	0.617
LIG_FHA_1	116	122	PF00498	0.651
LIG_FHA_1	78	84	PF00498	0.734
LIG_FHA_1	87	93	PF00498	0.670
LIG_FHA_2	19	25	PF00498	0.612
LIG_FHA_2	208	214	PF00498	0.600
LIG_FHA_2	221	227	PF00498	0.547
LIG_LIR_Gen_1	111	121	PF02991	0.594
LIG_LIR_Nem_3	111	117	PF02991	0.601
LIG_LYPXL_yS_3	219	222	PF13949	0.645
LIG_MAD2	206	214	PF02301	0.668
LIG_Pex14_2	110	114	PF04695	0.614
LIG_SH2_STAP1	138	142	PF00017	0.544
LIG_SH2_STAP1	203	207	PF00017	0.633
LIG_SH2_STAT3	138	141	PF00017	0.578
LIG_SH2_STAT5	174	177	PF00017	0.605
LIG_SH2_STAT5	53	56	PF00017	0.629
LIG_SH3_3	184	190	PF00018	0.636
LIG_SH3_3	82	88	PF00018	0.678
LIG_TRAF2_1	223	226	PF00917	0.603
MOD_CDK_SPxxK_3	186	193	PF00069	0.515
MOD_CK1_1	173	179	PF00069	0.524
MOD_CK1_1	36	42	PF00069	0.514
MOD_CK1_1	59	65	PF00069	0.625
MOD_CK1_1	77	83	PF00069	0.629
MOD_CK2_1	18	24	PF00069	0.509
MOD_CK2_1	207	213	PF00069	0.531
MOD_CK2_1	220	226	PF00069	0.470
MOD_GlcNHglycan	106	109	PF01048	0.547
MOD_GlcNHglycan	238	241	PF01048	0.375
MOD_GlcNHglycan	38	41	PF01048	0.629
MOD_GSK3_1	36	43	PF00069	0.616
MOD_GSK3_1	70	77	PF00069	0.566
MOD_NEK2_1	25	30	PF00069	0.575
MOD_NEK2_1	33	38	PF00069	0.521
MOD_NEK2_1	79	84	PF00069	0.560
MOD_PK_1	57	63	PF00069	0.492
MOD_PKA_2	36	42	PF00069	0.498
MOD_PKA_2	56	62	PF00069	0.738
MOD_PKA_2	86	92	PF00069	0.637
MOD_Plk_1	110	116	PF00069	0.509
MOD_Plk_1	220	226	PF00069	0.423
MOD_Plk_4	242	248	PF00069	0.246
MOD_Plk_4	49	55	PF00069	0.580
MOD_ProDKin_1	178	184	PF00069	0.540
MOD_ProDKin_1	186	192	PF00069	0.550
MOD_ProDKin_1	74	80	PF00069	0.571
MOD_SUMO_rev_2	221	229	PF00179	0.348
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.624
TRG_ENDOCYTIC_2	219	222	PF00928	0.517
TRG_ENDOCYTIC_2	230	233	PF00928	0.497
TRG_ER_diArg_1	2	4	PF00400	0.467
TRG_ER_diArg_1	249	251	PF00400	0.383
TRG_ER_diArg_1	92	94	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIS0	Leptomonas seymouri	64%	100%
A0A1X0NKL7	Trypanosomatidae	52%	100%
A0A3S7X940	Leishmania donovani	80%	100%
A4IAZ1	Leishmania infantum	80%	100%
C9ZNI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B5X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%