Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMC4_LEIBR

TriTrypDb:

LbrM.34.0920 , LBRM2903_340015200

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HMC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.402
CLV_NRD_NRD_1	163	165	PF00675	0.451
CLV_NRD_NRD_1	208	210	PF00675	0.450
CLV_PCSK_KEX2_1	118	120	PF00082	0.402
CLV_PCSK_KEX2_1	163	165	PF00082	0.451
CLV_PCSK_KEX2_1	207	209	PF00082	0.458
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.433
CLV_PCSK_PC7_1	204	210	PF00082	0.440
CLV_PCSK_SKI1_1	164	168	PF00082	0.391
CLV_PCSK_SKI1_1	218	222	PF00082	0.388
CLV_PCSK_SKI1_1	23	27	PF00082	0.459
CLV_PCSK_SKI1_1	6	10	PF00082	0.427
CLV_Separin_Metazoa	160	164	PF03568	0.620
DOC_MAPK_MEF2A_6	67	76	PF00069	0.599
DOC_USP7_MATH_1	41	45	PF00917	0.658
DOC_USP7_MATH_1	80	84	PF00917	0.705
DOC_USP7_MATH_1	91	95	PF00917	0.784
DOC_USP7_UBL2_3	187	191	PF12436	0.648
DOC_WW_Pin1_4	164	169	PF00397	0.629
DOC_WW_Pin1_4	193	198	PF00397	0.643
DOC_WW_Pin1_4	37	42	PF00397	0.638
DOC_WW_Pin1_4	43	48	PF00397	0.612
DOC_WW_Pin1_4	94	99	PF00397	0.718
LIG_14-3-3_CanoR_1	163	167	PF00244	0.627
LIG_14-3-3_CanoR_1	30	34	PF00244	0.645
LIG_14-3-3_CanoR_1	50	57	PF00244	0.585
LIG_14-3-3_CanoR_1	6	15	PF00244	0.643
LIG_14-3-3_CanoR_1	67	73	PF00244	0.566
LIG_14-3-3_CanoR_1	99	107	PF00244	0.699
LIG_BRCT_BRCA1_1	228	232	PF00533	0.388
LIG_deltaCOP1_diTrp_1	215	220	PF00928	0.681
LIG_eIF4E_1	217	223	PF01652	0.438
LIG_FHA_1	217	223	PF00498	0.534
LIG_FHA_1	228	234	PF00498	0.358
LIG_FHA_1	51	57	PF00498	0.629
LIG_FHA_2	126	132	PF00498	0.636
LIG_LIR_Gen_1	219	227	PF02991	0.451
LIG_LIR_Nem_3	170	174	PF02991	0.667
LIG_LIR_Nem_3	215	220	PF02991	0.642
LIG_LIR_Nem_3	235	240	PF02991	0.393
LIG_LIR_Nem_3	59	65	PF02991	0.694
LIG_Pex14_1	216	220	PF04695	0.515
LIG_Pex14_1	64	68	PF04695	0.602
LIG_REV1ctd_RIR_1	237	241	PF16727	0.531
LIG_RPA_C_Fungi	143	155	PF08784	0.385
LIG_SH2_STAT3	139	142	PF00017	0.519
LIG_SUMO_SIM_anti_2	158	163	PF11976	0.506
LIG_TRAF2_1	128	131	PF00917	0.533
LIG_TRFH_1	37	41	PF08558	0.535
LIG_UBA3_1	233	241	PF00899	0.388
LIG_WRC_WIRS_1	217	222	PF05994	0.361
MOD_CDK_SPK_2	94	99	PF00069	0.543
MOD_CDK_SPxxK_3	43	50	PF00069	0.517
MOD_CK1_1	94	100	PF00069	0.700
MOD_CK2_1	125	131	PF00069	0.547
MOD_CK2_1	167	173	PF00069	0.592
MOD_CK2_1	193	199	PF00069	0.655
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.520
MOD_GlcNHglycan	103	106	PF01048	0.653
MOD_GlcNHglycan	149	153	PF01048	0.439
MOD_GlcNHglycan	82	85	PF01048	0.602
MOD_GlcNHglycan	89	92	PF01048	0.676
MOD_GlcNHglycan	93	96	PF01048	0.673
MOD_GSK3_1	2	9	PF00069	0.572
MOD_GSK3_1	222	229	PF00069	0.339
MOD_GSK3_1	29	36	PF00069	0.588
MOD_GSK3_1	37	44	PF00069	0.568
MOD_GSK3_1	51	58	PF00069	0.603
MOD_GSK3_1	87	94	PF00069	0.764
MOD_GSK3_1	97	104	PF00069	0.711
MOD_NEK2_1	101	106	PF00069	0.609
MOD_NEK2_1	162	167	PF00069	0.559
MOD_NEK2_1	221	226	PF00069	0.348
MOD_NEK2_1	232	237	PF00069	0.466
MOD_NEK2_1	26	31	PF00069	0.552
MOD_NEK2_1	49	54	PF00069	0.578
MOD_NEK2_1	56	61	PF00069	0.581
MOD_NEK2_2	227	232	PF00069	0.253
MOD_PIKK_1	125	131	PF00454	0.490
MOD_PIKK_1	134	140	PF00454	0.444
MOD_PKA_2	134	140	PF00069	0.379
MOD_PKA_2	162	168	PF00069	0.515
MOD_PKA_2	29	35	PF00069	0.540
MOD_PKA_2	49	55	PF00069	0.463
MOD_Plk_4	216	222	PF00069	0.388
MOD_Plk_4	227	233	PF00069	0.284
MOD_Plk_4	57	63	PF00069	0.490
MOD_ProDKin_1	164	170	PF00069	0.517
MOD_ProDKin_1	193	199	PF00069	0.541
MOD_ProDKin_1	37	43	PF00069	0.527
MOD_ProDKin_1	94	100	PF00069	0.647
MOD_SUMO_for_1	186	189	PF00179	0.548
MOD_SUMO_rev_2	188	193	PF00179	0.541
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.519
TRG_ENDOCYTIC_2	217	220	PF00928	0.435
TRG_ER_diArg_1	117	119	PF00400	0.531
TRG_ER_diArg_1	162	164	PF00400	0.511
TRG_NLS_MonoCore_2	205	210	PF00514	0.526
TRG_NLS_MonoExtN_4	204	211	PF00514	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IV31	Leishmania donovani	75%	100%
A4IAZ0	Leishmania infantum	76%	100%
E9AER8	Leishmania major	78%	100%
E9B5X3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%