PP28 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMC1_LEIBR

TriTrypDb:

LbrM.34.0890 , LBRM2903_340014600

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.620
CLV_NRD_NRD_1	129	131	PF00675	0.591
CLV_NRD_NRD_1	13	15	PF00675	0.594
CLV_NRD_NRD_1	163	165	PF00675	0.521
CLV_NRD_NRD_1	181	183	PF00675	0.621
CLV_NRD_NRD_1	185	187	PF00675	0.536
CLV_NRD_NRD_1	188	190	PF00675	0.539
CLV_NRD_NRD_1	57	59	PF00675	0.638
CLV_PCSK_FUR_1	178	182	PF00082	0.516
CLV_PCSK_KEX2_1	122	124	PF00082	0.620
CLV_PCSK_KEX2_1	128	130	PF00082	0.598
CLV_PCSK_KEX2_1	13	15	PF00082	0.594
CLV_PCSK_KEX2_1	162	164	PF00082	0.553
CLV_PCSK_KEX2_1	180	182	PF00082	0.518
CLV_PCSK_KEX2_1	185	187	PF00082	0.548
CLV_PCSK_KEX2_1	33	35	PF00082	0.434
CLV_PCSK_KEX2_1	57	59	PF00082	0.638
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.587
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.594
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.632
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.434
CLV_PCSK_PC7_1	181	187	PF00082	0.522
CLV_PCSK_SKI1_1	10	14	PF00082	0.644
CLV_PCSK_SKI1_1	15	19	PF00082	0.627
CLV_PCSK_SKI1_1	150	154	PF00082	0.532
CLV_PCSK_SKI1_1	33	37	PF00082	0.464
CLV_PCSK_SKI1_1	85	89	PF00082	0.571
DEG_SCF_SKP2-CKS1_1	101	108	PF00560	0.552
DOC_MAPK_gen_1	108	117	PF00069	0.674
DOC_MAPK_gen_1	162	171	PF00069	0.462
DOC_MAPK_MEF2A_6	110	119	PF00069	0.514
DOC_PIKK_1	195	202	PF02985	0.580
DOC_USP7_UBL2_3	158	162	PF12436	0.617
DOC_USP7_UBL2_3	213	217	PF12436	0.614
DOC_USP7_UBL2_3	5	9	PF12436	0.646
DOC_WW_Pin1_4	102	107	PF00397	0.549
DOC_WW_Pin1_4	25	30	PF00397	0.608
LIG_BIR_II_1	1	5	PF00653	0.622
LIG_FHA_1	166	172	PF00498	0.574
LIG_FHA_2	16	22	PF00498	0.633
LIG_FHA_2	26	32	PF00498	0.552
LIG_FHA_2	75	81	PF00498	0.538
LIG_FHA_2	95	101	PF00498	0.694
LIG_LIR_Gen_1	93	104	PF02991	0.657
LIG_SUMO_SIM_par_1	166	173	PF11976	0.456
LIG_TRAF2_1	170	173	PF00917	0.539
LIG_TRAF2_1	51	54	PF00917	0.616
MOD_CDK_SPxK_1	102	108	PF00069	0.549
MOD_CK1_1	102	108	PF00069	0.534
MOD_CK2_1	74	80	PF00069	0.540
MOD_CK2_1	94	100	PF00069	0.692
MOD_GSK3_1	94	101	PF00069	0.730
MOD_PIKK_1	94	100	PF00454	0.632
MOD_Plk_1	165	171	PF00069	0.578
MOD_Plk_1	94	100	PF00069	0.692
MOD_ProDKin_1	102	108	PF00069	0.549
MOD_ProDKin_1	25	31	PF00069	0.609
MOD_SUMO_for_1	8	11	PF00179	0.524
MOD_SUMO_rev_2	166	176	PF00179	0.531
MOD_SUMO_rev_2	30	35	PF00179	0.549
MOD_SUMO_rev_2	38	48	PF00179	0.672
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.557
TRG_ER_diArg_1	163	165	PF00400	0.526
TRG_ER_diArg_1	180	182	PF00400	0.634
TRG_ER_diArg_1	62	65	PF00400	0.547
TRG_NLS_MonoExtC_3	185	190	PF00514	0.613
TRG_NLS_MonoExtC_3	215	220	PF00514	0.522
TRG_NLS_MonoExtN_4	185	190	PF00514	0.613
TRG_NLS_MonoExtN_4	213	220	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR1	Leptomonas seymouri	70%	100%
A0A3S7X8W2	Leishmania donovani	84%	100%
A4IAY7	Leishmania infantum	85%	100%
E9AER5	Leishmania major	84%	100%
E9B5X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%