Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMB9_LEIBR

TriTrypDb:

LbrM.34.0870 , LBRM2903_340014400

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.501
CLV_C14_Caspase3-7	421	425	PF00656	0.513
CLV_NRD_NRD_1	107	109	PF00675	0.561
CLV_NRD_NRD_1	116	118	PF00675	0.627
CLV_NRD_NRD_1	303	305	PF00675	0.676
CLV_NRD_NRD_1	379	381	PF00675	0.698
CLV_NRD_NRD_1	443	445	PF00675	0.629
CLV_NRD_NRD_1	510	512	PF00675	0.569
CLV_NRD_NRD_1	61	63	PF00675	0.474
CLV_PCSK_FUR_1	387	391	PF00082	0.537
CLV_PCSK_FUR_1	506	510	PF00082	0.631
CLV_PCSK_KEX2_1	107	109	PF00082	0.573
CLV_PCSK_KEX2_1	148	150	PF00082	0.606
CLV_PCSK_KEX2_1	159	161	PF00082	0.534
CLV_PCSK_KEX2_1	302	304	PF00082	0.661
CLV_PCSK_KEX2_1	32	34	PF00082	0.544
CLV_PCSK_KEX2_1	379	381	PF00082	0.698
CLV_PCSK_KEX2_1	389	391	PF00082	0.515
CLV_PCSK_KEX2_1	443	445	PF00082	0.622
CLV_PCSK_KEX2_1	451	453	PF00082	0.574
CLV_PCSK_KEX2_1	508	510	PF00082	0.567
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.589
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.534
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.467
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.515
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.662
CLV_PCSK_PC7_1	506	512	PF00082	0.673
CLV_PCSK_SKI1_1	100	104	PF00082	0.572
CLV_PCSK_SKI1_1	159	163	PF00082	0.398
CLV_PCSK_SKI1_1	359	363	PF00082	0.675
CLV_PCSK_SKI1_1	42	46	PF00082	0.636
CLV_PCSK_SKI1_1	487	491	PF00082	0.623
CLV_PCSK_SKI1_1	502	506	PF00082	0.583
CLV_Separin_Metazoa	114	118	PF03568	0.466
DEG_APCC_DBOX_1	13	21	PF00400	0.604
DEG_APCC_DBOX_1	139	147	PF00400	0.606
DEG_APCC_DBOX_1	378	386	PF00400	0.677
DEG_SPOP_SBC_1	132	136	PF00917	0.400
DEG_SPOP_SBC_1	5	9	PF00917	0.635
DOC_CYCLIN_yCln2_LP_2	459	465	PF00134	0.476
DOC_MAPK_gen_1	457	465	PF00069	0.469
DOC_MAPK_RevD_3	290	303	PF00069	0.654
DOC_PP2B_LxvP_1	227	230	PF13499	0.494
DOC_PP4_FxxP_1	490	493	PF00568	0.572
DOC_USP7_MATH_1	132	136	PF00917	0.529
DOC_USP7_MATH_1	167	171	PF00917	0.755
DOC_USP7_MATH_1	232	236	PF00917	0.566
DOC_USP7_MATH_1	333	337	PF00917	0.743
DOC_USP7_MATH_1	6	10	PF00917	0.571
DOC_USP7_MATH_1	98	102	PF00917	0.698
DOC_WW_Pin1_4	133	138	PF00397	0.617
DOC_WW_Pin1_4	331	336	PF00397	0.541
DOC_WW_Pin1_4	434	439	PF00397	0.781
DOC_WW_Pin1_4	463	468	PF00397	0.620
LIG_14-3-3_CanoR_1	160	167	PF00244	0.612
LIG_14-3-3_CanoR_1	379	383	PF00244	0.585
LIG_14-3-3_CterR_2	517	520	PF00244	0.699
LIG_Actin_WH2_2	364	381	PF00022	0.558
LIG_APCC_ABBA_1	219	224	PF00400	0.380
LIG_BRCT_BRCA1_1	363	367	PF00533	0.551
LIG_CtBP_PxDLS_1	291	295	PF00389	0.708
LIG_DLG_GKlike_1	65	72	PF00625	0.704
LIG_FHA_1	276	282	PF00498	0.575
LIG_FHA_1	440	446	PF00498	0.632
LIG_FHA_1	5	11	PF00498	0.623
LIG_FHA_1	68	74	PF00498	0.643
LIG_FHA_2	192	198	PF00498	0.590
LIG_FHA_2	240	246	PF00498	0.749
LIG_FHA_2	278	284	PF00498	0.622
LIG_FHA_2	308	314	PF00498	0.586
LIG_FHA_2	390	396	PF00498	0.621
LIG_FHA_2	496	502	PF00498	0.700
LIG_FHA_2	6	12	PF00498	0.572
LIG_LIR_Gen_1	125	133	PF02991	0.513
LIG_LIR_Gen_1	220	230	PF02991	0.475
LIG_LIR_Gen_1	76	83	PF02991	0.615
LIG_LIR_Nem_3	125	131	PF02991	0.495
LIG_LIR_Nem_3	220	225	PF02991	0.394
LIG_LIR_Nem_3	76	80	PF02991	0.642
LIG_NBox_RRM_1	398	408	PF00076	0.568
LIG_SH2_CRK	128	132	PF00017	0.585
LIG_SH2_CRK	77	81	PF00017	0.626
LIG_SH2_SRC	320	323	PF00017	0.626
LIG_SH2_STAP1	320	324	PF00017	0.686
LIG_SH2_STAT3	267	270	PF00017	0.590
LIG_SH2_STAT5	267	270	PF00017	0.494
LIG_SH2_STAT5	475	478	PF00017	0.594
LIG_SH3_3	347	353	PF00018	0.707
LIG_SH3_3	464	470	PF00018	0.608
LIG_SUMO_SIM_par_1	177	184	PF11976	0.446
LIG_SUMO_SIM_par_1	216	224	PF11976	0.628
LIG_TRAF2_1	27	30	PF00917	0.574
LIG_TRAF2_1	407	410	PF00917	0.510
LIG_WW_3	484	488	PF00397	0.523
MOD_CDK_SPxK_1	434	440	PF00069	0.520
MOD_CDK_SPxxK_3	133	140	PF00069	0.610
MOD_CK1_1	122	128	PF00069	0.616
MOD_CK1_1	220	226	PF00069	0.615
MOD_CK1_1	466	472	PF00069	0.632
MOD_CK2_1	132	138	PF00069	0.558
MOD_CK2_1	191	197	PF00069	0.515
MOD_CK2_1	24	30	PF00069	0.525
MOD_CK2_1	277	283	PF00069	0.570
MOD_CK2_1	307	313	PF00069	0.517
MOD_CK2_1	326	332	PF00069	0.636
MOD_CK2_1	495	501	PF00069	0.588
MOD_Cter_Amidation	506	509	PF01082	0.667
MOD_GlcNHglycan	162	165	PF01048	0.433
MOD_GlcNHglycan	176	179	PF01048	0.593
MOD_GlcNHglycan	26	29	PF01048	0.608
MOD_GlcNHglycan	321	325	PF01048	0.661
MOD_GlcNHglycan	335	338	PF01048	0.583
MOD_GSK3_1	165	172	PF00069	0.635
MOD_GSK3_1	181	188	PF00069	0.466
MOD_GSK3_1	277	284	PF00069	0.624
MOD_GSK3_1	294	301	PF00069	0.590
MOD_GSK3_1	333	340	PF00069	0.635
MOD_LATS_1	416	422	PF00433	0.505
MOD_N-GLC_1	120	125	PF02516	0.673
MOD_N-GLC_1	174	179	PF02516	0.636
MOD_N-GLC_1	307	312	PF02516	0.632
MOD_N-GLC_1	326	331	PF02516	0.643
MOD_NEK2_1	131	136	PF00069	0.553
MOD_NEK2_1	326	331	PF00069	0.609
MOD_NEK2_1	439	444	PF00069	0.647
MOD_PIKK_1	122	128	PF00454	0.408
MOD_PIKK_1	165	171	PF00454	0.695
MOD_PIKK_1	185	191	PF00454	0.473
MOD_PIKK_1	239	245	PF00454	0.568
MOD_PKA_1	159	165	PF00069	0.412
MOD_PKA_1	389	395	PF00069	0.621
MOD_PKA_2	159	165	PF00069	0.639
MOD_PKA_2	24	30	PF00069	0.512
MOD_PKA_2	281	287	PF00069	0.730
MOD_PKA_2	378	384	PF00069	0.592
MOD_PKA_2	389	395	PF00069	0.621
MOD_PKA_2	439	445	PF00069	0.711
MOD_Plk_1	223	229	PF00069	0.691
MOD_Plk_1	320	326	PF00069	0.678
MOD_Plk_1	409	415	PF00069	0.530
MOD_Plk_1	65	71	PF00069	0.556
MOD_Plk_1	75	81	PF00069	0.625
MOD_Plk_2-3	197	203	PF00069	0.426
MOD_Plk_2-3	307	313	PF00069	0.585
MOD_Plk_4	191	197	PF00069	0.537
MOD_Plk_4	214	220	PF00069	0.540
MOD_Plk_4	294	300	PF00069	0.585
MOD_Plk_4	389	395	PF00069	0.621
MOD_ProDKin_1	133	139	PF00069	0.616
MOD_ProDKin_1	331	337	PF00069	0.542
MOD_ProDKin_1	434	440	PF00069	0.777
MOD_ProDKin_1	463	469	PF00069	0.617
MOD_SUMO_for_1	343	346	PF00179	0.781
MOD_SUMO_for_1	388	391	PF00179	0.634
MOD_SUMO_for_1	44	47	PF00179	0.362
MOD_SUMO_rev_2	258	265	PF00179	0.524
MOD_SUMO_rev_2	27	34	PF00179	0.615
MOD_SUMO_rev_2	421	431	PF00179	0.706
MOD_SUMO_rev_2	432	437	PF00179	0.692
TRG_ENDOCYTIC_2	128	131	PF00928	0.537
TRG_ENDOCYTIC_2	477	480	PF00928	0.559
TRG_ENDOCYTIC_2	77	80	PF00928	0.606
TRG_ER_diArg_1	107	109	PF00400	0.523
TRG_ER_diArg_1	302	304	PF00400	0.598
TRG_ER_diArg_1	378	380	PF00400	0.686
TRG_ER_diArg_1	443	445	PF00400	0.501
TRG_ER_diArg_1	505	508	PF00400	0.597
TRG_ER_diArg_1	509	511	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	315	319	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0N1	Leptomonas seymouri	53%	90%
A0A1X0NJ03	Trypanosomatidae	30%	89%
A0A3S7X8Y2	Leishmania donovani	78%	100%
A0A422NI80	Trypanosoma rangeli	33%	92%
A4IAY5	Leishmania infantum	78%	100%
C9ZNI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
E9AER3	Leishmania major	77%	100%
E9B5W8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%