Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMB7_LEIBR

TriTrypDb:

LbrM.34.0850 , LBRM2903_340014300

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0009055	electron transfer activity	3	3
GO:0016491	oxidoreductase activity	2	3
GO:0020037	heme binding	4	3
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046906	tetrapyrrole binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.468
CLV_C14_Caspase3-7	139	143	PF00656	0.736
CLV_C14_Caspase3-7	150	154	PF00656	0.704
CLV_C14_Caspase3-7	216	220	PF00656	0.783
CLV_C14_Caspase3-7	286	290	PF00656	0.682
CLV_C14_Caspase3-7	4	8	PF00656	0.760
CLV_NRD_NRD_1	151	153	PF00675	0.700
CLV_NRD_NRD_1	275	277	PF00675	0.563
CLV_NRD_NRD_1	315	317	PF00675	0.642
CLV_NRD_NRD_1	386	388	PF00675	0.490
CLV_PCSK_FUR_1	313	317	PF00082	0.720
CLV_PCSK_KEX2_1	123	125	PF00082	0.749
CLV_PCSK_KEX2_1	151	153	PF00082	0.669
CLV_PCSK_KEX2_1	2	4	PF00082	0.761
CLV_PCSK_KEX2_1	315	317	PF00082	0.642
CLV_PCSK_KEX2_1	386	388	PF00082	0.507
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.777
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.761
CLV_PCSK_PC7_1	147	153	PF00082	0.689
CLV_PCSK_SKI1_1	19	23	PF00082	0.652
CLV_PCSK_SKI1_1	248	252	PF00082	0.485
CLV_PCSK_SKI1_1	276	280	PF00082	0.536
CLV_PCSK_SKI1_1	386	390	PF00082	0.641
DEG_Nend_UBRbox_1	1	4	PF02207	0.741
DEG_SCF_FBW7_1	70	75	PF00400	0.513
DEG_SPOP_SBC_1	212	216	PF00917	0.763
DOC_MAPK_DCC_7	252	262	PF00069	0.302
DOC_MAPK_gen_1	14	22	PF00069	0.601
DOC_MAPK_gen_1	276	283	PF00069	0.567
DOC_MAPK_gen_1	313	323	PF00069	0.582
DOC_MAPK_gen_1	41	50	PF00069	0.504
DOC_MAPK_MEF2A_6	170	177	PF00069	0.440
DOC_MAPK_MEF2A_6	276	283	PF00069	0.534
DOC_MAPK_MEF2A_6	297	306	PF00069	0.706
DOC_MAPK_MEF2A_6	316	325	PF00069	0.484
DOC_MAPK_NFAT4_5	170	178	PF00069	0.554
DOC_MAPK_NFAT4_5	276	284	PF00069	0.542
DOC_MAPK_RevD_3	323	337	PF00069	0.565
DOC_PP1_RVXF_1	295	301	PF00149	0.568
DOC_PP2B_LxvP_1	175	178	PF13499	0.545
DOC_PP2B_LxvP_1	302	305	PF13499	0.467
DOC_SPAK_OSR1_1	352	356	PF12202	0.446
DOC_USP7_MATH_1	107	111	PF00917	0.511
DOC_USP7_MATH_1	122	126	PF00917	0.691
DOC_USP7_MATH_1	145	149	PF00917	0.761
DOC_USP7_MATH_1	206	210	PF00917	0.739
DOC_USP7_MATH_1	211	215	PF00917	0.751
DOC_USP7_MATH_1	230	234	PF00917	0.348
DOC_USP7_MATH_1	305	309	PF00917	0.718
DOC_USP7_MATH_1	339	343	PF00917	0.593
DOC_USP7_MATH_1	357	361	PF00917	0.418
DOC_USP7_MATH_1	94	98	PF00917	0.547
DOC_USP7_UBL2_3	62	66	PF12436	0.526
DOC_WW_Pin1_4	132	137	PF00397	0.790
DOC_WW_Pin1_4	219	224	PF00397	0.603
DOC_WW_Pin1_4	68	73	PF00397	0.626
DOC_WW_Pin1_4	87	92	PF00397	0.642
LIG_14-3-3_CanoR_1	234	240	PF00244	0.588
LIG_14-3-3_CanoR_1	313	319	PF00244	0.594
LIG_14-3-3_CanoR_1	364	368	PF00244	0.430
LIG_14-3-3_CanoR_1	386	394	PF00244	0.602
LIG_14-3-3_CanoR_1	81	87	PF00244	0.730
LIG_BRCT_BRCA1_1	158	162	PF00533	0.672
LIG_Clathr_ClatBox_1	257	261	PF01394	0.278
LIG_CtBP_PxDLS_1	259	263	PF00389	0.283
LIG_FHA_1	223	229	PF00498	0.552
LIG_FHA_1	234	240	PF00498	0.502
LIG_FHA_1	318	324	PF00498	0.582
LIG_FHA_1	343	349	PF00498	0.495
LIG_FHA_1	368	374	PF00498	0.488
LIG_FHA_1	405	411	PF00498	0.591
LIG_FHA_1	52	58	PF00498	0.610
LIG_FHA_2	125	131	PF00498	0.666
LIG_FHA_2	195	201	PF00498	0.657
LIG_FHA_2	214	220	PF00498	0.777
LIG_FHA_2	265	271	PF00498	0.475
LIG_FHA_2	329	335	PF00498	0.494
LIG_LIR_Apic_2	159	164	PF02991	0.662
LIG_LIR_Gen_1	237	247	PF02991	0.495
LIG_LIR_Nem_3	159	165	PF02991	0.650
LIG_LIR_Nem_3	237	243	PF02991	0.441
LIG_NRBOX	274	280	PF00104	0.485
LIG_NRBOX	97	103	PF00104	0.732
LIG_PALB2_WD40_1	157	165	PF16756	0.670
LIG_Pex14_2	251	255	PF04695	0.509
LIG_SH2_STAP1	365	369	PF00017	0.333
LIG_SH2_STAT5	172	175	PF00017	0.469
LIG_SH2_STAT5	365	368	PF00017	0.347
LIG_SH2_STAT5	49	52	PF00017	0.504
LIG_SH3_3	181	187	PF00018	0.577
LIG_SH3_3	224	230	PF00018	0.527
LIG_SH3_3	263	269	PF00018	0.416
LIG_SH3_3	88	94	PF00018	0.745
LIG_SUMO_SIM_par_1	258	263	PF11976	0.284
LIG_TRAF2_1	36	39	PF00917	0.539
LIG_TRFH_1	255	259	PF08558	0.407
MOD_CK1_1	233	239	PF00069	0.549
MOD_CK1_1	342	348	PF00069	0.497
MOD_CK1_1	360	366	PF00069	0.458
MOD_CK1_1	51	57	PF00069	0.617
MOD_CK1_1	68	74	PF00069	0.746
MOD_CK1_1	92	98	PF00069	0.648
MOD_CK2_1	122	128	PF00069	0.600
MOD_CK2_1	194	200	PF00069	0.741
MOD_CK2_1	211	217	PF00069	0.710
MOD_CK2_1	264	270	PF00069	0.479
MOD_CK2_1	328	334	PF00069	0.488
MOD_CK2_1	52	58	PF00069	0.596
MOD_GlcNHglycan	341	344	PF01048	0.505
MOD_GlcNHglycan	407	410	PF01048	0.552
MOD_GlcNHglycan	94	97	PF01048	0.764
MOD_GSK3_1	176	183	PF00069	0.550
MOD_GSK3_1	260	267	PF00069	0.454
MOD_GSK3_1	284	291	PF00069	0.648
MOD_GSK3_1	363	370	PF00069	0.584
MOD_GSK3_1	48	55	PF00069	0.619
MOD_GSK3_1	68	75	PF00069	0.703
MOD_GSK3_1	92	99	PF00069	0.675
MOD_N-GLC_1	180	185	PF02516	0.649
MOD_N-GLC_1	328	333	PF02516	0.469
MOD_N-GLC_1	87	92	PF02516	0.684
MOD_NEK2_1	1	6	PF00069	0.768
MOD_NEK2_1	30	35	PF00069	0.484
MOD_NEK2_1	323	328	PF00069	0.522
MOD_NEK2_1	404	409	PF00069	0.601
MOD_NEK2_1	48	53	PF00069	0.525
MOD_NEK2_2	314	319	PF00069	0.683
MOD_PIKK_1	108	114	PF00454	0.464
MOD_PIKK_1	357	363	PF00454	0.416
MOD_PKA_1	386	392	PF00069	0.586
MOD_PKA_2	156	162	PF00069	0.695
MOD_PKA_2	206	212	PF00069	0.765
MOD_PKA_2	233	239	PF00069	0.591
MOD_PKA_2	314	320	PF00069	0.580
MOD_PKA_2	363	369	PF00069	0.354
MOD_PKA_2	386	392	PF00069	0.586
MOD_PKA_2	80	86	PF00069	0.797
MOD_Plk_1	180	186	PF00069	0.622
MOD_Plk_1	288	294	PF00069	0.730
MOD_Plk_1	328	334	PF00069	0.613
MOD_Plk_1	367	373	PF00069	0.463
MOD_Plk_4	222	228	PF00069	0.509
MOD_Plk_4	97	103	PF00069	0.572
MOD_ProDKin_1	132	138	PF00069	0.792
MOD_ProDKin_1	219	225	PF00069	0.589
MOD_ProDKin_1	68	74	PF00069	0.630
MOD_ProDKin_1	87	93	PF00069	0.641
MOD_SUMO_rev_2	138	145	PF00179	0.563
MOD_SUMO_rev_2	4	10	PF00179	0.748
TRG_ENDOCYTIC_2	172	175	PF00928	0.481
TRG_ER_diArg_1	116	119	PF00400	0.664
TRG_ER_diArg_1	313	316	PF00400	0.664
TRG_NLS_MonoExtC_3	122	128	PF00514	0.772

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGK4	Leptomonas seymouri	65%	99%
A0A0S4J2S0	Bodo saltans	29%	100%
A0A1X0NJH1	Trypanosomatidae	37%	100%
A0A3Q8IHS0	Leishmania donovani	80%	99%
A0A3R7NE95	Trypanosoma rangeli	42%	100%
A4IAY3	Leishmania infantum	80%	99%
D0A272	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AER1	Leishmania major	79%	100%
E9B5W6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%