Glycerophosphocholine acyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2838), putative

Species:

Leishmania braziliensis

UniProt:

A4HMB6_LEIBR

TriTrypDb:

LbrM.34.0840 , LBRM2903_340014200

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HMB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0008610	lipid biosynthetic process	4	7
GO:0008654	phospholipid biosynthetic process	5	7
GO:0009058	biosynthetic process	2	7
GO:0009987	cellular process	1	7
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006656	phosphatidylcholine biosynthetic process	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046470	phosphatidylcholine metabolic process	4	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.372
CLV_C14_Caspase3-7	255	259	PF00656	0.375
CLV_C14_Caspase3-7	380	384	PF00656	0.580
CLV_NRD_NRD_1	216	218	PF00675	0.634
CLV_NRD_NRD_1	321	323	PF00675	0.671
CLV_NRD_NRD_1	351	353	PF00675	0.417
CLV_NRD_NRD_1	357	359	PF00675	0.446
CLV_NRD_NRD_1	370	372	PF00675	0.461
CLV_NRD_NRD_1	418	420	PF00675	0.507
CLV_PCSK_FUR_1	355	359	PF00082	0.323
CLV_PCSK_KEX2_1	216	218	PF00082	0.642
CLV_PCSK_KEX2_1	321	323	PF00082	0.671
CLV_PCSK_KEX2_1	351	353	PF00082	0.417
CLV_PCSK_KEX2_1	357	359	PF00082	0.446
CLV_PCSK_KEX2_1	361	363	PF00082	0.446
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.519
CLV_PCSK_PC7_1	357	363	PF00082	0.358
CLV_PCSK_SKI1_1	180	184	PF00082	0.594
CLV_PCSK_SKI1_1	210	214	PF00082	0.591
CLV_PCSK_SKI1_1	322	326	PF00082	0.654
CLV_PCSK_SKI1_1	362	366	PF00082	0.507
CLV_PCSK_SKI1_1	371	375	PF00082	0.531
CLV_PCSK_SKI1_1	420	424	PF00082	0.379
CLV_PCSK_SKI1_1	425	429	PF00082	0.357
CLV_PCSK_SKI1_1	494	498	PF00082	0.308
CLV_PCSK_SKI1_1	525	529	PF00082	0.352
DOC_CYCLIN_yCln2_LP_2	386	392	PF00134	0.582
DOC_MAPK_gen_1	124	133	PF00069	0.523
DOC_MAPK_MEF2A_6	110	119	PF00069	0.390
DOC_MAPK_MEF2A_6	127	135	PF00069	0.419
DOC_PP1_RVXF_1	329	335	PF00149	0.513
DOC_PP2B_LxvP_1	117	120	PF13499	0.545
DOC_PP2B_LxvP_1	238	241	PF13499	0.342
DOC_PP2B_PxIxI_1	457	463	PF00149	0.397
DOC_USP7_MATH_1	241	245	PF00917	0.381
DOC_USP7_MATH_1	391	395	PF00917	0.742
DOC_USP7_UBL2_3	361	365	PF12436	0.654
DOC_USP7_UBL2_3	494	498	PF12436	0.689
DOC_USP7_UBL2_3	525	529	PF12436	0.552
DOC_USP7_UBL2_3	56	60	PF12436	0.327
DOC_WW_Pin1_4	104	109	PF00397	0.463
DOC_WW_Pin1_4	397	402	PF00397	0.696
LIG_14-3-3_CanoR_1	190	198	PF00244	0.372
LIG_14-3-3_CanoR_1	210	219	PF00244	0.249
LIG_14-3-3_CanoR_1	280	286	PF00244	0.572
LIG_14-3-3_CanoR_1	321	327	PF00244	0.396
LIG_14-3-3_CanoR_1	371	379	PF00244	0.562
LIG_14-3-3_CanoR_1	404	409	PF00244	0.611
LIG_14-3-3_CanoR_1	434	440	PF00244	0.605
LIG_Actin_WH2_2	282	299	PF00022	0.536
LIG_APCC_ABBA_1	427	432	PF00400	0.683
LIG_BRCT_BRCA1_1	282	286	PF00533	0.380
LIG_EH1_1	8	16	PF00400	0.302
LIG_eIF4E_1	9	15	PF01652	0.290
LIG_FHA_1	266	272	PF00498	0.532
LIG_FHA_1	302	308	PF00498	0.521
LIG_FHA_1	380	386	PF00498	0.606
LIG_FHA_1	442	448	PF00498	0.559
LIG_FHA_1	526	532	PF00498	0.647
LIG_FHA_2	148	154	PF00498	0.634
LIG_FHA_2	344	350	PF00498	0.483
LIG_FHA_2	378	384	PF00498	0.727
LIG_LIR_Apic_2	98	102	PF02991	0.580
LIG_LIR_Gen_1	112	122	PF02991	0.513
LIG_LIR_Gen_1	136	145	PF02991	0.499
LIG_LIR_Gen_1	156	166	PF02991	0.619
LIG_LIR_Gen_1	187	196	PF02991	0.362
LIG_LIR_Gen_1	283	291	PF02991	0.549
LIG_LIR_Gen_1	35	44	PF02991	0.411
LIG_LIR_Gen_1	370	379	PF02991	0.662
LIG_LIR_Gen_1	406	416	PF02991	0.535
LIG_LIR_Nem_3	112	117	PF02991	0.499
LIG_LIR_Nem_3	129	135	PF02991	0.375
LIG_LIR_Nem_3	136	140	PF02991	0.482
LIG_LIR_Nem_3	156	161	PF02991	0.589
LIG_LIR_Nem_3	168	172	PF02991	0.333
LIG_LIR_Nem_3	18	24	PF02991	0.411
LIG_LIR_Nem_3	192	198	PF02991	0.399
LIG_LIR_Nem_3	283	289	PF02991	0.555
LIG_LIR_Nem_3	325	329	PF02991	0.371
LIG_LIR_Nem_3	35	39	PF02991	0.411
LIG_LIR_Nem_3	370	376	PF02991	0.660
LIG_LIR_Nem_3	454	460	PF02991	0.454
LIG_LIR_Nem_3	469	474	PF02991	0.330
LIG_LIR_Nem_3	71	75	PF02991	0.455
LIG_LYPXL_yS_3	457	460	PF13949	0.411
LIG_NRBOX	44	50	PF00104	0.261
LIG_PCNA_yPIPBox_3	236	246	PF02747	0.517
LIG_PCNA_yPIPBox_3	41	51	PF02747	0.513
LIG_Pex14_1	340	344	PF04695	0.411
LIG_Pex14_2	158	162	PF04695	0.411
LIG_Pex14_2	29	33	PF04695	0.438
LIG_Pex14_2	343	347	PF04695	0.482
LIG_Pex14_2	426	430	PF04695	0.605
LIG_PTB_Apo_2	93	100	PF02174	0.409
LIG_PTB_Phospho_1	93	99	PF10480	0.407
LIG_SH2_CRK	19	23	PF00017	0.261
LIG_SH2_CRK	313	317	PF00017	0.509
LIG_SH2_CRK	326	330	PF00017	0.300
LIG_SH2_NCK_1	228	232	PF00017	0.505
LIG_SH2_SRC	132	135	PF00017	0.513
LIG_SH2_SRC	228	231	PF00017	0.507
LIG_SH2_STAP1	408	412	PF00017	0.538
LIG_SH2_STAP1	466	470	PF00017	0.312
LIG_SH2_STAT3	24	27	PF00017	0.619
LIG_SH2_STAT5	132	135	PF00017	0.472
LIG_SH2_STAT5	144	147	PF00017	0.427
LIG_SH2_STAT5	195	198	PF00017	0.365
LIG_SH2_STAT5	21	24	PF00017	0.411
LIG_SH2_STAT5	31	34	PF00017	0.511
LIG_SH2_STAT5	36	39	PF00017	0.336
LIG_SH2_STAT5	408	411	PF00017	0.511
LIG_SH2_STAT5	466	469	PF00017	0.348
LIG_SH2_STAT5	9	12	PF00017	0.411
LIG_SH3_3	128	134	PF00018	0.419
LIG_TYR_ITIM	324	329	PF00017	0.380
LIG_UBA3_1	13	20	PF00899	0.404
LIG_UBA3_1	48	56	PF00899	0.554
LIG_WRC_WIRS_1	155	160	PF05994	0.619
LIG_WRC_WIRS_1	185	190	PF05994	0.346
LIG_WRC_WIRS_1	344	349	PF05994	0.476
MOD_CDK_SPxK_1	104	110	PF00069	0.503
MOD_CDK_SPxxK_3	397	404	PF00069	0.663
MOD_CK1_1	248	254	PF00069	0.443
MOD_CK1_1	257	263	PF00069	0.394
MOD_CK1_1	284	290	PF00069	0.522
MOD_CK1_1	64	70	PF00069	0.381
MOD_CK2_1	147	153	PF00069	0.638
MOD_CK2_1	343	349	PF00069	0.479
MOD_CK2_1	397	403	PF00069	0.671
MOD_CK2_1	508	514	PF00069	0.526
MOD_Cter_Amidation	417	420	PF01082	0.512
MOD_GlcNHglycan	213	216	PF01048	0.592
MOD_GlcNHglycan	258	262	PF01048	0.628
MOD_GlcNHglycan	41	44	PF01048	0.261
MOD_GlcNHglycan	468	471	PF01048	0.572
MOD_GlcNHglycan	91	94	PF01048	0.628
MOD_GSK3_1	241	248	PF00069	0.386
MOD_GSK3_1	280	287	PF00069	0.449
MOD_GSK3_1	430	437	PF00069	0.558
MOD_GSK3_1	64	71	PF00069	0.351
MOD_N-GLC_1	265	270	PF02516	0.704
MOD_N-GLC_1	80	85	PF02516	0.723
MOD_N-GLC_1	95	100	PF02516	0.617
MOD_NEK2_1	165	170	PF00069	0.460
MOD_NEK2_1	211	216	PF00069	0.477
MOD_NEK2_1	252	257	PF00069	0.500
MOD_NEK2_1	281	286	PF00069	0.541
MOD_NEK2_1	296	301	PF00069	0.341
MOD_NEK2_1	343	348	PF00069	0.478
MOD_NEK2_1	39	44	PF00069	0.513
MOD_NEK2_1	430	435	PF00069	0.551
MOD_NEK2_1	441	446	PF00069	0.534
MOD_NEK2_1	451	456	PF00069	0.403
MOD_NEK2_1	464	469	PF00069	0.299
MOD_NEK2_1	515	520	PF00069	0.591
MOD_PIKK_1	296	302	PF00454	0.514
MOD_PIKK_1	371	377	PF00454	0.560
MOD_PIKK_1	441	447	PF00454	0.558
MOD_PIKK_1	508	514	PF00454	0.526
MOD_PKA_1	371	377	PF00069	0.560
MOD_PKA_2	189	195	PF00069	0.346
MOD_PKA_2	296	302	PF00069	0.514
MOD_PKA_2	403	409	PF00069	0.630
MOD_PKA_2	68	74	PF00069	0.474
MOD_Plk_1	95	101	PF00069	0.489
MOD_Plk_2-3	218	224	PF00069	0.444
MOD_Plk_4	110	116	PF00069	0.435
MOD_Plk_4	154	160	PF00069	0.619
MOD_Plk_4	202	208	PF00069	0.403
MOD_Plk_4	241	247	PF00069	0.504
MOD_Plk_4	248	254	PF00069	0.451
MOD_Plk_4	281	287	PF00069	0.519
MOD_Plk_4	406	412	PF00069	0.534
MOD_Plk_4	435	441	PF00069	0.608
MOD_ProDKin_1	104	110	PF00069	0.466
MOD_ProDKin_1	397	403	PF00069	0.696
MOD_SUMO_for_1	364	367	PF00179	0.705
MOD_SUMO_rev_2	367	374	PF00179	0.548
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.543
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.592
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.264
TRG_ENDOCYTIC_2	132	135	PF00928	0.411
TRG_ENDOCYTIC_2	19	22	PF00928	0.379
TRG_ENDOCYTIC_2	195	198	PF00928	0.365
TRG_ENDOCYTIC_2	228	231	PF00928	0.507
TRG_ENDOCYTIC_2	31	34	PF00928	0.565
TRG_ENDOCYTIC_2	313	316	PF00928	0.494
TRG_ENDOCYTIC_2	326	329	PF00928	0.310
TRG_ENDOCYTIC_2	344	347	PF00928	0.460
TRG_ENDOCYTIC_2	36	39	PF00928	0.451
TRG_ENDOCYTIC_2	408	411	PF00928	0.589
TRG_ENDOCYTIC_2	457	460	PF00928	0.411
TRG_ER_diArg_1	320	322	PF00400	0.466
TRG_ER_diArg_1	350	352	PF00400	0.689
TRG_ER_diArg_1	355	358	PF00400	0.643
TRG_ER_diLys_1	529	532	PF00400	0.590
TRG_NLS_MonoExtN_4	357	364	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8X9	Leishmania donovani	82%	100%
A0A422NIA4	Trypanosoma rangeli	37%	97%
A4IAY2	Leishmania infantum	82%	100%
E9AER0	Leishmania major	83%	100%
E9B5W5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%