Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transmembrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMB5_LEIBR

TriTrypDb:

LbrM.34.0830 , LBRM2903_340014000

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1
GO:0110165	cellular anatomical entity	1	6

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Expansion

Sequence features

A4HMB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB5

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.336
CLV_NRD_NRD_1	43	45	PF00675	0.335
CLV_PCSK_FUR_1	41	45	PF00082	0.340
CLV_PCSK_KEX2_1	40	42	PF00082	0.369
CLV_PCSK_KEX2_1	43	45	PF00082	0.380
CLV_PCSK_KEX2_1	81	83	PF00082	0.471
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.425
CLV_PCSK_SKI1_1	14	18	PF00082	0.402
CLV_PCSK_SKI1_1	315	319	PF00082	0.694
CLV_PCSK_SKI1_1	49	53	PF00082	0.511

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG2	Leptomonas seymouri	44%	95%
A0A3Q8IP51	Leishmania donovani	70%	96%
A4IAY1	Leishmania infantum	70%	96%
E9AEQ9	Leishmania major	67%	100%
E9B5W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	96%

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