Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear transmembrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMB5_LEIBR

TriTrypDb:

LbrM.34.0830 , LBRM2903_340014000

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

A4HMB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	40	42	PF00675	0.336
CLV_NRD_NRD_1	43	45	PF00675	0.335
CLV_PCSK_FUR_1	41	45	PF00082	0.340
CLV_PCSK_KEX2_1	40	42	PF00082	0.369
CLV_PCSK_KEX2_1	43	45	PF00082	0.380
CLV_PCSK_KEX2_1	81	83	PF00082	0.471
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.425
CLV_PCSK_SKI1_1	14	18	PF00082	0.402
CLV_PCSK_SKI1_1	315	319	PF00082	0.694
CLV_PCSK_SKI1_1	49	53	PF00082	0.511
CLV_PCSK_SKI1_1	81	85	PF00082	0.524
CLV_Separin_Metazoa	230	234	PF03568	0.533
DEG_APCC_DBOX_1	386	394	PF00400	0.290
DEG_Nend_UBRbox_2	1	3	PF02207	0.527
DEG_SPOP_SBC_1	105	109	PF00917	0.643
DEG_SPOP_SBC_1	317	321	PF00917	0.521
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.411
DOC_CYCLIN_yCln2_LP_2	26	32	PF00134	0.474
DOC_MAPK_gen_1	196	206	PF00069	0.577
DOC_MAPK_gen_1	40	50	PF00069	0.545
DOC_PP2B_LxvP_1	258	261	PF13499	0.513
DOC_PP2B_LxvP_1	26	29	PF13499	0.474
DOC_USP7_MATH_1	105	109	PF00917	0.636
DOC_USP7_MATH_1	112	116	PF00917	0.663
DOC_USP7_MATH_1	125	129	PF00917	0.747
DOC_USP7_MATH_1	156	160	PF00917	0.602
DOC_USP7_MATH_1	186	190	PF00917	0.695
DOC_USP7_MATH_1	317	321	PF00917	0.466
DOC_USP7_MATH_1	357	361	PF00917	0.693
DOC_USP7_MATH_1	362	366	PF00917	0.489
DOC_USP7_MATH_1	367	371	PF00917	0.411
DOC_USP7_MATH_1	63	67	PF00917	0.683
DOC_USP7_MATH_1	77	81	PF00917	0.651
DOC_USP7_UBL2_3	199	203	PF12436	0.582
DOC_WW_Pin1_4	118	123	PF00397	0.750
DOC_WW_Pin1_4	126	131	PF00397	0.786
DOC_WW_Pin1_4	152	157	PF00397	0.630
DOC_WW_Pin1_4	306	311	PF00397	0.492
DOC_WW_Pin1_4	89	94	PF00397	0.716
LIG_14-3-3_CanoR_1	245	255	PF00244	0.466
LIG_14-3-3_CanoR_1	82	88	PF00244	0.629
LIG_Clathr_ClatBox_1	373	377	PF01394	0.513
LIG_FHA_1	2	8	PF00498	0.466
LIG_FHA_1	247	253	PF00498	0.494
LIG_FHA_1	287	293	PF00498	0.408
LIG_FHA_1	307	313	PF00498	0.494
LIG_FHA_1	330	336	PF00498	0.481
LIG_FHA_1	361	367	PF00498	0.411
LIG_FHA_2	145	151	PF00498	0.791
LIG_FHA_2	217	223	PF00498	0.583
LIG_GBD_Chelix_1	292	300	PF00786	0.756
LIG_GBD_Chelix_1	368	376	PF00786	0.402
LIG_LIR_Apic_2	212	218	PF02991	0.698
LIG_LIR_Gen_1	249	259	PF02991	0.513
LIG_LIR_Gen_1	339	347	PF02991	0.346
LIG_LIR_Gen_1	370	379	PF02991	0.513
LIG_LIR_Nem_3	222	226	PF02991	0.639
LIG_LIR_Nem_3	249	254	PF02991	0.443
LIG_LIR_Nem_3	339	343	PF02991	0.346
LIG_LIR_Nem_3	370	374	PF02991	0.513
LIG_Pex14_2	392	396	PF04695	0.474
LIG_Pex14_2	96	100	PF04695	0.753
LIG_REV1ctd_RIR_1	9	18	PF16727	0.476
LIG_SH2_CRK	201	205	PF00017	0.762
LIG_SH2_PTP2	340	343	PF00017	0.474
LIG_SH2_STAP1	19	23	PF00017	0.402
LIG_SH2_STAP1	31	35	PF00017	0.402
LIG_SH2_STAT3	301	304	PF00017	0.386
LIG_SH2_STAT5	193	196	PF00017	0.694
LIG_SH2_STAT5	215	218	PF00017	0.696
LIG_SH2_STAT5	340	343	PF00017	0.474
LIG_SH3_3	116	122	PF00018	0.780
LIG_SH3_3	69	75	PF00018	0.666
LIG_SH3_3	92	98	PF00018	0.599
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.339
LIG_SUMO_SIM_anti_2	365	370	PF11976	0.411
LIG_SUMO_SIM_par_1	370	378	PF11976	0.416
LIG_TRAF2_1	147	150	PF00917	0.821
LIG_TRAF2_1	219	222	PF00917	0.688
LIG_TRFH_1	33	37	PF08558	0.613
LIG_TYR_ITIM	338	343	PF00017	0.238
LIG_WRC_WIRS_1	368	373	PF05994	0.513
MOD_CDK_SPxK_1	126	132	PF00069	0.640
MOD_CK1_1	135	141	PF00069	0.823
MOD_CK1_1	159	165	PF00069	0.588
MOD_CK1_1	246	252	PF00069	0.261
MOD_CK1_1	264	270	PF00069	0.467
MOD_CK1_1	305	311	PF00069	0.492
MOD_CK1_1	360	366	PF00069	0.465
MOD_CK1_1	76	82	PF00069	0.751
MOD_CK2_1	144	150	PF00069	0.790
MOD_CK2_1	216	222	PF00069	0.606
MOD_GlcNHglycan	102	105	PF01048	0.523
MOD_GlcNHglycan	134	137	PF01048	0.624
MOD_GlcNHglycan	161	164	PF01048	0.530
MOD_GlcNHglycan	176	179	PF01048	0.508
MOD_GlcNHglycan	180	183	PF01048	0.508
MOD_GlcNHglycan	188	191	PF01048	0.488
MOD_GlcNHglycan	377	380	PF01048	0.411
MOD_GlcNHglycan	75	78	PF01048	0.563
MOD_GSK3_1	100	107	PF00069	0.756
MOD_GSK3_1	135	142	PF00069	0.707
MOD_GSK3_1	152	159	PF00069	0.612
MOD_GSK3_1	174	181	PF00069	0.769
MOD_GSK3_1	302	309	PF00069	0.571
MOD_GSK3_1	73	80	PF00069	0.724
MOD_N-GLC_1	204	209	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.467
MOD_NEK2_1	100	105	PF00069	0.597
MOD_NEK2_1	139	144	PF00069	0.701
MOD_NEK2_1	21	26	PF00069	0.261
MOD_NEK2_1	237	242	PF00069	0.556
MOD_NEK2_1	295	300	PF00069	0.554
MOD_NEK2_1	311	316	PF00069	0.521
MOD_NEK2_1	318	323	PF00069	0.564
MOD_NEK2_1	350	355	PF00069	0.433
MOD_NEK2_1	83	88	PF00069	0.689
MOD_NEK2_2	64	69	PF00069	0.628
MOD_OFUCOSY	348	354	PF10250	0.411
MOD_PIKK_1	154	160	PF00454	0.766
MOD_PIKK_1	264	270	PF00454	0.455
MOD_PK_1	243	249	PF00069	0.438
MOD_PKA_2	112	118	PF00069	0.755
MOD_PKA_2	216	222	PF00069	0.513
MOD_PKA_2	237	243	PF00069	0.536
MOD_PKA_2	305	311	PF00069	0.569
MOD_PKA_2	357	363	PF00069	0.546
MOD_PKA_2	73	79	PF00069	0.727
MOD_Plk_1	1	7	PF00069	0.488
MOD_Plk_1	207	213	PF00069	0.640
MOD_Plk_1	283	289	PF00069	0.478
MOD_Plk_4	156	162	PF00069	0.597
MOD_Plk_4	21	27	PF00069	0.468
MOD_Plk_4	339	345	PF00069	0.405
MOD_Plk_4	367	373	PF00069	0.513
MOD_Plk_4	399	405	PF00069	0.375
MOD_Plk_4	83	89	PF00069	0.703
MOD_ProDKin_1	118	124	PF00069	0.751
MOD_ProDKin_1	126	132	PF00069	0.787
MOD_ProDKin_1	152	158	PF00069	0.625
MOD_ProDKin_1	306	312	PF00069	0.494
MOD_ProDKin_1	89	95	PF00069	0.712
TRG_DiLeu_BaEn_1	2	7	PF01217	0.358
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.623
TRG_ENDOCYTIC_2	201	204	PF00928	0.722
TRG_ENDOCYTIC_2	340	343	PF00928	0.513
TRG_ER_diArg_1	168	171	PF00400	0.728
TRG_ER_diArg_1	235	238	PF00400	0.615
TRG_ER_diArg_1	39	41	PF00400	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG2	Leptomonas seymouri	44%	95%
A0A3Q8IP51	Leishmania donovani	70%	96%
A4IAY1	Leishmania infantum	70%	96%
E9AEQ9	Leishmania major	67%	100%
E9B5W4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	96%