Putative aspartate aminotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aspartate aminotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMB3_LEIBR

TriTrypDb:

LbrM.34.0810 , LBRM2903_340013800

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB3

PDB structure(s): 4h51_A , 4h51_B

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	13
GO:0006520	amino acid metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009058	biosynthetic process	2	13
GO:0009987	cellular process	1	13
GO:0019752	carboxylic acid metabolic process	5	13
GO:0043436	oxoacid metabolic process	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044281	small molecule metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity	5	13
GO:0005488	binding	1	13
GO:0008483	transaminase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016769	transferase activity, transferring nitrogenous groups	3	13
GO:0019842	vitamin binding	3	13
GO:0030170	pyridoxal phosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0070279	vitamin B6 binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901363	heterocyclic compound binding	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	401	405	PF00656	0.533
CLV_NRD_NRD_1	244	246	PF00675	0.463
CLV_NRD_NRD_1	314	316	PF00675	0.413
CLV_NRD_NRD_1	333	335	PF00675	0.247
CLV_NRD_NRD_1	59	61	PF00675	0.373
CLV_PCSK_KEX2_1	244	246	PF00082	0.462
CLV_PCSK_KEX2_1	29	31	PF00082	0.577
CLV_PCSK_KEX2_1	333	335	PF00082	0.446
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.577
CLV_PCSK_PC7_1	240	246	PF00082	0.472
CLV_PCSK_SKI1_1	119	123	PF00082	0.494
CLV_PCSK_SKI1_1	283	287	PF00082	0.241
CLV_Separin_Metazoa	339	343	PF03568	0.494
DOC_CKS1_1	343	348	PF01111	0.392
DOC_MAPK_gen_1	244	251	PF00069	0.472
DOC_MAPK_gen_1	315	322	PF00069	0.494
DOC_MAPK_gen_1	35	43	PF00069	0.494
DOC_MAPK_gen_1	57	67	PF00069	0.421
DOC_MAPK_MEF2A_6	244	251	PF00069	0.440
DOC_MAPK_MEF2A_6	265	273	PF00069	0.494
DOC_MAPK_MEF2A_6	60	69	PF00069	0.494
DOC_USP7_MATH_1	104	108	PF00917	0.376
DOC_USP7_MATH_1	180	184	PF00917	0.369
DOC_USP7_MATH_1	405	409	PF00917	0.447
DOC_USP7_UBL2_3	274	278	PF12436	0.494
DOC_WW_Pin1_4	127	132	PF00397	0.364
DOC_WW_Pin1_4	342	347	PF00397	0.337
LIG_14-3-3_CanoR_1	328	333	PF00244	0.440
LIG_APCC_ABBA_1	259	264	PF00400	0.345
LIG_APCC_ABBAyCdc20_2	333	339	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_BRCT_BRCA1_1	165	169	PF00533	0.432
LIG_FHA_1	109	115	PF00498	0.358
LIG_FHA_1	162	168	PF00498	0.370
LIG_FHA_1	264	270	PF00498	0.469
LIG_FHA_1	392	398	PF00498	0.274
LIG_FHA_2	156	162	PF00498	0.419
LIG_FHA_2	193	199	PF00498	0.345
LIG_FHA_2	399	405	PF00498	0.537
LIG_FHA_2	6	12	PF00498	0.628
LIG_LIR_Apic_2	156	162	PF02991	0.456
LIG_LIR_Apic_2	292	297	PF02991	0.438
LIG_LIR_Gen_1	11	21	PF02991	0.525
LIG_LIR_Gen_1	202	212	PF02991	0.373
LIG_LIR_Gen_1	348	356	PF02991	0.382
LIG_LIR_Gen_1	72	81	PF02991	0.467
LIG_LIR_Nem_3	11	16	PF02991	0.504
LIG_LIR_Nem_3	156	160	PF02991	0.379
LIG_LIR_Nem_3	202	207	PF02991	0.357
LIG_LIR_Nem_3	221	227	PF02991	0.242
LIG_LIR_Nem_3	348	352	PF02991	0.377
LIG_LIR_Nem_3	360	364	PF02991	0.273
LIG_LIR_Nem_3	72	78	PF02991	0.424
LIG_LIR_Nem_3	79	84	PF02991	0.399
LIG_NRBOX	268	274	PF00104	0.494
LIG_PCNA_PIPBox_1	355	364	PF02747	0.358
LIG_PCNA_yPIPBox_3	355	368	PF02747	0.338
LIG_PTB_Apo_2	67	74	PF02174	0.241
LIG_PTB_Phospho_1	67	73	PF10480	0.241
LIG_SH2_CRK	294	298	PF00017	0.358
LIG_SH2_NCK_1	294	298	PF00017	0.358
LIG_SH2_SRC	75	78	PF00017	0.437
LIG_SH2_STAP1	237	241	PF00017	0.392
LIG_SH2_STAP1	337	341	PF00017	0.494
LIG_SH2_STAT5	123	126	PF00017	0.363
LIG_SH2_STAT5	133	136	PF00017	0.334
LIG_SH2_STAT5	157	160	PF00017	0.350
LIG_SH2_STAT5	294	297	PF00017	0.495
LIG_SH2_STAT5	371	374	PF00017	0.472
LIG_SH2_STAT5	75	78	PF00017	0.357
LIG_SH2_STAT6	80	84	PF00017	0.472
LIG_SH3_3	134	140	PF00018	0.348
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.494
LIG_SUMO_SIM_par_1	100	107	PF11976	0.459
LIG_TRAF2_1	199	202	PF00917	0.474
LIG_TYR_ITIM	335	340	PF00017	0.241
LIG_UBA3_1	24	29	PF00899	0.523
LIG_UBA3_1	358	366	PF00899	0.413
LIG_WRC_WIRS_1	358	363	PF05994	0.472
MOD_CK1_1	135	141	PF00069	0.378
MOD_CK1_1	2	8	PF00069	0.604
MOD_CK1_1	292	298	PF00069	0.299
MOD_CK2_1	281	287	PF00069	0.344
MOD_CK2_1	307	313	PF00069	0.373
MOD_CK2_1	5	11	PF00069	0.593
MOD_GlcNHglycan	1	4	PF01048	0.680
MOD_GlcNHglycan	108	111	PF01048	0.342
MOD_GlcNHglycan	221	224	PF01048	0.365
MOD_GlcNHglycan	228	231	PF01048	0.410
MOD_GlcNHglycan	78	81	PF01048	0.408
MOD_GSK3_1	104	111	PF00069	0.340
MOD_GSK3_1	2	9	PF00069	0.533
MOD_GSK3_1	263	270	PF00069	0.289
MOD_GSK3_1	281	288	PF00069	0.415
MOD_N-GLC_1	180	185	PF02516	0.241
MOD_N-GLC_1	274	279	PF02516	0.241
MOD_NEK2_1	108	113	PF00069	0.336
MOD_NEK2_1	219	224	PF00069	0.382
MOD_NEK2_1	251	256	PF00069	0.373
MOD_NEK2_1	307	312	PF00069	0.395
MOD_NEK2_1	398	403	PF00069	0.545
MOD_NEK2_2	180	185	PF00069	0.472
MOD_PIKK_1	197	203	PF00454	0.494
MOD_Plk_2-3	281	287	PF00069	0.494
MOD_Plk_4	119	125	PF00069	0.356
MOD_Plk_4	141	147	PF00069	0.363
MOD_Plk_4	155	161	PF00069	0.363
MOD_Plk_4	180	186	PF00069	0.373
MOD_Plk_4	267	273	PF00069	0.392
MOD_Plk_4	281	287	PF00069	0.392
MOD_ProDKin_1	127	133	PF00069	0.364
MOD_ProDKin_1	342	348	PF00069	0.337
TRG_DiLeu_BaEn_1	206	211	PF01217	0.446
TRG_DiLeu_BaEn_1	393	398	PF01217	0.241
TRG_DiLeu_BaEn_1	98	103	PF01217	0.490
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.408
TRG_ENDOCYTIC_2	337	340	PF00928	0.392
TRG_ENDOCYTIC_2	73	76	PF00928	0.351
TRG_ENDOCYTIC_2	81	84	PF00928	0.335
TRG_ER_diArg_1	332	334	PF00400	0.437
TRG_NES_CRM1_1	355	367	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0F7CUE9	Hapsidospora irregularis	35%	100%
A0A0N0P7Z5	Leptomonas seymouri	34%	93%
A0A0N1PAS7	Leptomonas seymouri	68%	100%
A0A0S4IPP7	Bodo saltans	40%	100%
A0A0S4JFW4	Bodo saltans	50%	99%
A0A1X0NIT8	Trypanosomatidae	53%	100%
A0A1X0NJG0	Trypanosomatidae	38%	98%
A0A1X0NJN9	Trypanosomatidae	54%	100%
A0A1X0NKG0	Trypanosomatidae	38%	98%
A0A3Q8IG20	Leishmania donovani	86%	99%
A0A3R7MWM6	Trypanosoma rangeli	39%	98%
A0A3S7WY33	Leishmania donovani	35%	95%
A0A422NI78	Trypanosoma rangeli	55%	98%
A4HD93	Leishmania braziliensis	35%	100%
A5A6K8	Pan troglodytes	44%	99%
D0A277	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
D0A706	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9AH48	Leishmania infantum	35%	95%
E9AWM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	95%
E9B5W2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
O42652	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
O85746	Klebsiella pneumoniae	33%	100%
O94320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	94%
P00503	Sus scrofa	45%	99%
P00504	Gallus gallus	44%	99%
P00505	Homo sapiens	42%	95%
P00506	Sus scrofa	42%	95%
P00507	Rattus norvegicus	42%	95%
P00508	Gallus gallus	42%	97%
P00509	Escherichia coli (strain K12)	37%	100%
P04693	Escherichia coli (strain K12)	33%	100%
P05201	Mus musculus	44%	99%
P05202	Mus musculus	43%	95%
P08906	Equus caballus	43%	99%
P08907	Equus caballus	42%	100%
P12344	Bos taurus	42%	95%
P12345	Oryctolagus cuniculus	42%	95%
P13221	Rattus norvegicus	44%	99%
P17174	Homo sapiens	44%	99%
P23542	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	98%
P26563	Lupinus angustifolius	43%	90%
P28011	Medicago sativa	45%	98%
P28734	Daucus carota	44%	100%
P33097	Bos taurus	43%	99%
P37833	Oryza sativa subsp. japonica	45%	100%
P43336	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	36%	100%
P44425	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	37%	100%
P46248	Arabidopsis thaliana	42%	90%
P46643	Arabidopsis thaliana	42%	95%
P46644	Arabidopsis thaliana	45%	91%
P46645	Arabidopsis thaliana	44%	100%
P46646	Arabidopsis thaliana	44%	100%
P58661	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	38%	100%
P72173	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	36%	100%
P74861	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	34%	100%
P95468	Paracoccus denitrificans	35%	100%
Q01802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	91%
Q02636	Rhizobium meliloti (strain 1021)	36%	100%
Q22067	Caenorhabditis elegans	42%	100%
Q28F67	Xenopus tropicalis	42%	96%
Q2PD92	Leishmania infantum	86%	99%
Q2T9S8	Bos taurus	30%	100%
Q4FX34	Leishmania major	85%	100%
Q4QAU4	Leishmania major	36%	100%
Q4R559	Macaca fascicularis	42%	95%
Q4R5L1	Macaca fascicularis	44%	99%
Q54SF7	Dictyostelium discoideum	46%	93%
Q55F21	Dictyostelium discoideum	41%	96%
Q56114	Salmonella typhi	38%	100%
Q5R691	Pongo abelii	44%	99%
Q5REB0	Pongo abelii	42%	95%
Q7SYK7	Danio rerio	41%	96%
Q7TSV6	Mus musculus	28%	100%
Q8NHS2	Homo sapiens	29%	97%
V5BSS0	Trypanosoma cruzi	54%	100%
V5BVY2	Trypanosoma cruzi	38%	98%