Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMB1_LEIBR

TriTrypDb:

LbrM.34.0790 , LBRM2903_340013600

Length:

973

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMB1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.588
CLV_C14_Caspase3-7	358	362	PF00656	0.668
CLV_C14_Caspase3-7	579	583	PF00656	0.687
CLV_C14_Caspase3-7	654	658	PF00656	0.664
CLV_C14_Caspase3-7	889	893	PF00656	0.859
CLV_NRD_NRD_1	155	157	PF00675	0.667
CLV_NRD_NRD_1	23	25	PF00675	0.716
CLV_NRD_NRD_1	303	305	PF00675	0.613
CLV_NRD_NRD_1	622	624	PF00675	0.475
CLV_NRD_NRD_1	720	722	PF00675	0.592
CLV_NRD_NRD_1	781	783	PF00675	0.609
CLV_NRD_NRD_1	919	921	PF00675	0.606
CLV_NRD_NRD_1	925	927	PF00675	0.593
CLV_PCSK_FUR_1	300	304	PF00082	0.613
CLV_PCSK_FUR_1	388	392	PF00082	0.518
CLV_PCSK_FUR_1	916	920	PF00082	0.590
CLV_PCSK_KEX2_1	117	119	PF00082	0.627
CLV_PCSK_KEX2_1	155	157	PF00082	0.667
CLV_PCSK_KEX2_1	23	25	PF00082	0.716
CLV_PCSK_KEX2_1	302	304	PF00082	0.613
CLV_PCSK_KEX2_1	390	392	PF00082	0.523
CLV_PCSK_KEX2_1	397	399	PF00082	0.505
CLV_PCSK_KEX2_1	622	624	PF00082	0.551
CLV_PCSK_KEX2_1	720	722	PF00082	0.626
CLV_PCSK_KEX2_1	781	783	PF00082	0.609
CLV_PCSK_KEX2_1	918	920	PF00082	0.681
CLV_PCSK_KEX2_1	925	927	PF00082	0.718
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.589
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.523
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.505
CLV_PCSK_SKI1_1	42	46	PF00082	0.671
CLV_PCSK_SKI1_1	824	828	PF00082	0.850
CLV_PCSK_SKI1_1	965	969	PF00082	0.743
DEG_SCF_FBW7_1	179	186	PF00400	0.581
DEG_SCF_TRCP1_1	296	301	PF00400	0.598
DEG_SCF_TRCP1_1	361	367	PF00400	0.581
DEG_SPOP_SBC_1	174	178	PF00917	0.716
DOC_CKS1_1	148	153	PF01111	0.702
DOC_CKS1_1	464	469	PF01111	0.816
DOC_CYCLIN_RxL_1	36	49	PF00134	0.647
DOC_CYCLIN_RxL_1	648	657	PF00134	0.569
DOC_CYCLIN_yCln2_LP_2	544	550	PF00134	0.654
DOC_CYCLIN_yCln2_LP_2	594	597	PF00134	0.583
DOC_MAPK_DCC_7	491	501	PF00069	0.558
DOC_MAPK_DCC_7	875	885	PF00069	0.798
DOC_MAPK_MEF2A_6	878	885	PF00069	0.790
DOC_PP1_RVXF_1	649	656	PF00149	0.568
DOC_PP2B_LxvP_1	594	597	PF13499	0.583
DOC_PP4_FxxP_1	452	455	PF00568	0.551
DOC_PP4_FxxP_1	546	549	PF00568	0.566
DOC_PP4_MxPP_1	874	877	PF00568	0.585
DOC_USP7_MATH_1	111	115	PF00917	0.693
DOC_USP7_MATH_1	135	139	PF00917	0.830
DOC_USP7_MATH_1	174	178	PF00917	0.833
DOC_USP7_MATH_1	183	187	PF00917	0.682
DOC_USP7_MATH_1	329	333	PF00917	0.555
DOC_USP7_MATH_1	348	352	PF00917	0.664
DOC_USP7_MATH_1	355	359	PF00917	0.766
DOC_USP7_MATH_1	537	541	PF00917	0.586
DOC_USP7_MATH_1	599	603	PF00917	0.827
DOC_USP7_MATH_1	642	646	PF00917	0.827
DOC_USP7_MATH_1	672	676	PF00917	0.670
DOC_USP7_MATH_1	702	706	PF00917	0.809
DOC_USP7_MATH_1	74	78	PF00917	0.566
DOC_USP7_MATH_1	755	759	PF00917	0.763
DOC_USP7_MATH_1	884	888	PF00917	0.787
DOC_WW_Pin1_4	147	152	PF00397	0.702
DOC_WW_Pin1_4	179	184	PF00397	0.630
DOC_WW_Pin1_4	238	243	PF00397	0.691
DOC_WW_Pin1_4	304	309	PF00397	0.800
DOC_WW_Pin1_4	431	436	PF00397	0.567
DOC_WW_Pin1_4	440	445	PF00397	0.515
DOC_WW_Pin1_4	463	468	PF00397	0.813
DOC_WW_Pin1_4	480	485	PF00397	0.524
DOC_WW_Pin1_4	522	527	PF00397	0.663
DOC_WW_Pin1_4	535	540	PF00397	0.756
DOC_WW_Pin1_4	611	616	PF00397	0.519
DOC_WW_Pin1_4	675	680	PF00397	0.733
DOC_WW_Pin1_4	683	688	PF00397	0.780
DOC_WW_Pin1_4	829	834	PF00397	0.594
DOC_WW_Pin1_4	876	881	PF00397	0.811
LIG_14-3-3_CanoR_1	155	161	PF00244	0.577
LIG_14-3-3_CanoR_1	223	227	PF00244	0.709
LIG_14-3-3_CanoR_1	235	242	PF00244	0.489
LIG_14-3-3_CanoR_1	342	348	PF00244	0.808
LIG_14-3-3_CanoR_1	366	374	PF00244	0.560
LIG_14-3-3_CanoR_1	600	606	PF00244	0.634
LIG_14-3-3_CanoR_1	651	656	PF00244	0.780
LIG_14-3-3_CanoR_1	677	687	PF00244	0.805
LIG_14-3-3_CanoR_1	720	730	PF00244	0.630
LIG_14-3-3_CanoR_1	781	785	PF00244	0.604
LIG_14-3-3_CanoR_1	918	924	PF00244	0.698
LIG_14-3-3_CanoR_1	95	99	PF00244	0.636
LIG_Actin_WH2_2	8	25	PF00022	0.726
LIG_BIR_II_1	1	5	PF00653	0.830
LIG_BIR_III_3	1	5	PF00653	0.830
LIG_BIR_III_4	269	273	PF00653	0.803
LIG_BIR_III_4	788	792	PF00653	0.822
LIG_BRCT_BRCA1_1	242	246	PF00533	0.556
LIG_BRCT_BRCA1_1	433	437	PF00533	0.567
LIG_BRCT_BRCA1_1	745	749	PF00533	0.792
LIG_BRCT_BRCA1_1	946	950	PF00533	0.731
LIG_deltaCOP1_diTrp_1	372	380	PF00928	0.768
LIG_deltaCOP1_diTrp_1	744	749	PF00928	0.795
LIG_FHA_1	174	180	PF00498	0.718
LIG_FHA_1	243	249	PF00498	0.572
LIG_FHA_1	344	350	PF00498	0.553
LIG_FHA_1	36	42	PF00498	0.700
LIG_FHA_1	420	426	PF00498	0.573
LIG_FHA_1	467	473	PF00498	0.580
LIG_FHA_1	492	498	PF00498	0.804
LIG_FHA_1	52	58	PF00498	0.460
LIG_FHA_1	633	639	PF00498	0.550
LIG_FHA_1	661	667	PF00498	0.573
LIG_FHA_1	752	758	PF00498	0.600
LIG_FHA_1	823	829	PF00498	0.594
LIG_FHA_1	91	97	PF00498	0.832
LIG_FHA_2	148	154	PF00498	0.777
LIG_FHA_2	16	22	PF00498	0.472
LIG_FHA_2	317	323	PF00498	0.574
LIG_FHA_2	731	737	PF00498	0.581
LIG_FHA_2	897	903	PF00498	0.630
LIG_Integrin_RGD_1	734	736	PF01839	0.834
LIG_LIR_Apic_2	494	498	PF02991	0.552
LIG_LIR_Apic_2	545	549	PF02991	0.569
LIG_LIR_Apic_2	697	702	PF02991	0.600
LIG_LIR_Apic_2	871	876	PF02991	0.746
LIG_LIR_Gen_1	18	26	PF02991	0.470
LIG_LIR_Gen_1	195	204	PF02991	0.581
LIG_LIR_Gen_1	243	253	PF02991	0.560
LIG_LIR_Gen_1	434	444	PF02991	0.562
LIG_LIR_Gen_1	744	755	PF02991	0.797
LIG_LIR_Gen_1	775	784	PF02991	0.594
LIG_LIR_Nem_3	143	148	PF02991	0.643
LIG_LIR_Nem_3	18	22	PF02991	0.472
LIG_LIR_Nem_3	195	200	PF02991	0.579
LIG_LIR_Nem_3	243	249	PF02991	0.559
LIG_LIR_Nem_3	346	350	PF02991	0.681
LIG_LIR_Nem_3	372	377	PF02991	0.771
LIG_LIR_Nem_3	434	440	PF02991	0.571
LIG_LIR_Nem_3	744	750	PF02991	0.796
LIG_LIR_Nem_3	775	779	PF02991	0.587
LIG_LYPXL_yS_3	347	350	PF13949	0.549
LIG_PAM2_1	864	876	PF00658	0.583
LIG_PCNA_PIPBox_1	692	701	PF02747	0.565
LIG_Pex14_2	946	950	PF04695	0.692
LIG_RPA_C_Fungi	914	926	PF08784	0.595
LIG_SH2_CRK	776	780	PF00017	0.590
LIG_SH2_GRB2like	266	269	PF00017	0.560
LIG_SH2_GRB2like	37	40	PF00017	0.704
LIG_SH2_STAP1	266	270	PF00017	0.688
LIG_SH2_STAP1	37	41	PF00017	0.693
LIG_SH2_STAT3	228	231	PF00017	0.821
LIG_SH2_STAT5	115	118	PF00017	0.590
LIG_SH2_STAT5	323	326	PF00017	0.645
LIG_SH2_STAT5	37	40	PF00017	0.704
LIG_SH2_STAT5	456	459	PF00017	0.715
LIG_SH2_STAT5	51	54	PF00017	0.467
LIG_SH3_1	311	317	PF00018	0.837
LIG_SH3_3	307	313	PF00018	0.819
LIG_SH3_3	464	470	PF00018	0.668
LIG_SH3_3	54	60	PF00018	0.744
LIG_SH3_3	593	599	PF00018	0.732
LIG_SH3_3	681	687	PF00018	0.816
LIG_SH3_3	874	880	PF00018	0.674
LIG_SH3_3	93	99	PF00018	0.583
LIG_TRAF2_1	124	127	PF00917	0.595
LIG_TRAF2_1	909	912	PF00917	0.649
LIG_TYR_ITIM	774	779	PF00017	0.585
LIG_UBA3_1	620	629	PF00899	0.591
LIG_WRC_WIRS_1	377	382	PF05994	0.638
LIG_WW_3	875	879	PF00397	0.593
MOD_CDC14_SPxK_1	614	617	PF00782	0.495
MOD_CDK_SPK_2	444	449	PF00069	0.538
MOD_CDK_SPxK_1	611	617	PF00069	0.515
MOD_CDK_SPxxK_3	304	311	PF00069	0.614
MOD_CK1_1	103	109	PF00069	0.746
MOD_CK1_1	134	140	PF00069	0.778
MOD_CK1_1	193	199	PF00069	0.796
MOD_CK1_1	211	217	PF00069	0.533
MOD_CK1_1	222	228	PF00069	0.716
MOD_CK1_1	241	247	PF00069	0.786
MOD_CK1_1	277	283	PF00069	0.718
MOD_CK1_1	291	297	PF00069	0.610
MOD_CK1_1	343	349	PF00069	0.662
MOD_CK1_1	459	465	PF00069	0.799
MOD_CK1_1	538	544	PF00069	0.637
MOD_CK1_1	633	639	PF00069	0.643
MOD_CK1_1	67	73	PF00069	0.568
MOD_CK1_1	675	681	PF00069	0.674
MOD_CK1_1	686	692	PF00069	0.719
MOD_CK1_1	713	719	PF00069	0.596
MOD_CK1_1	722	728	PF00069	0.554
MOD_CK1_1	780	786	PF00069	0.758
MOD_CK1_1	822	828	PF00069	0.590
MOD_CK1_1	847	853	PF00069	0.829
MOD_CK1_1	855	861	PF00069	0.702
MOD_CK2_1	121	127	PF00069	0.591
MOD_CK2_1	147	153	PF00069	0.777
MOD_CK2_1	15	21	PF00069	0.470
MOD_CK2_1	195	201	PF00069	0.563
MOD_CK2_1	380	386	PF00069	0.582
MOD_CK2_1	721	727	PF00069	0.724
MOD_CK2_1	904	910	PF00069	0.825
MOD_Cter_Amidation	923	926	PF01082	0.736
MOD_GlcNHglycan	102	105	PF01048	0.587
MOD_GlcNHglycan	109	112	PF01048	0.716
MOD_GlcNHglycan	133	136	PF01048	0.607
MOD_GlcNHglycan	137	140	PF01048	0.783
MOD_GlcNHglycan	142	145	PF01048	0.692
MOD_GlcNHglycan	168	171	PF01048	0.649
MOD_GlcNHglycan	185	188	PF01048	0.588
MOD_GlcNHglycan	192	195	PF01048	0.565
MOD_GlcNHglycan	279	282	PF01048	0.637
MOD_GlcNHglycan	293	296	PF01048	0.593
MOD_GlcNHglycan	31	34	PF01048	0.469
MOD_GlcNHglycan	335	338	PF01048	0.814
MOD_GlcNHglycan	361	364	PF01048	0.709
MOD_GlcNHglycan	408	411	PF01048	0.625
MOD_GlcNHglycan	429	432	PF01048	0.754
MOD_GlcNHglycan	540	543	PF01048	0.564
MOD_GlcNHglycan	601	604	PF01048	0.813
MOD_GlcNHglycan	640	643	PF01048	0.808
MOD_GlcNHglycan	644	647	PF01048	0.780
MOD_GlcNHglycan	670	673	PF01048	0.722
MOD_GlcNHglycan	680	683	PF01048	0.679
MOD_GlcNHglycan	714	718	PF01048	0.832
MOD_GlcNHglycan	757	760	PF01048	0.561
MOD_GlcNHglycan	796	802	PF01048	0.701
MOD_GlcNHglycan	854	857	PF01048	0.575
MOD_GlcNHglycan	888	891	PF01048	0.765
MOD_GlcNHglycan	946	949	PF01048	0.692
MOD_GlcNHglycan	951	954	PF01048	0.583
MOD_GSK3_1	103	110	PF00069	0.769
MOD_GSK3_1	11	18	PF00069	0.608
MOD_GSK3_1	127	134	PF00069	0.730
MOD_GSK3_1	174	181	PF00069	0.648
MOD_GSK3_1	192	199	PF00069	0.706
MOD_GSK3_1	227	234	PF00069	0.818
MOD_GSK3_1	238	245	PF00069	0.592
MOD_GSK3_1	294	301	PF00069	0.595
MOD_GSK3_1	3	10	PF00069	0.801
MOD_GSK3_1	329	336	PF00069	0.617
MOD_GSK3_1	355	362	PF00069	0.621
MOD_GSK3_1	376	383	PF00069	0.733
MOD_GSK3_1	427	434	PF00069	0.684
MOD_GSK3_1	440	447	PF00069	0.595
MOD_GSK3_1	456	463	PF00069	0.737
MOD_GSK3_1	487	494	PF00069	0.726
MOD_GSK3_1	538	545	PF00069	0.689
MOD_GSK3_1	628	635	PF00069	0.631
MOD_GSK3_1	638	645	PF00069	0.654
MOD_GSK3_1	668	675	PF00069	0.826
MOD_GSK3_1	702	709	PF00069	0.779
MOD_GSK3_1	719	726	PF00069	0.708
MOD_GSK3_1	751	758	PF00069	0.661
MOD_GSK3_1	763	770	PF00069	0.722
MOD_GSK3_1	792	799	PF00069	0.609
MOD_GSK3_1	822	829	PF00069	0.613
MOD_GSK3_1	864	871	PF00069	0.596
MOD_GSK3_1	884	891	PF00069	0.614
MOD_GSK3_1	90	97	PF00069	0.704
MOD_GSK3_1	944	951	PF00069	0.827
MOD_N-GLC_1	131	136	PF02516	0.733
MOD_N-GLC_1	710	715	PF02516	0.595
MOD_N-GLC_1	822	827	PF02516	0.587
MOD_N-GLC_1	904	909	PF02516	0.825
MOD_NEK2_1	165	170	PF00069	0.643
MOD_NEK2_1	192	197	PF00069	0.818
MOD_NEK2_1	227	232	PF00069	0.820
MOD_NEK2_1	380	385	PF00069	0.585
MOD_NEK2_1	628	633	PF00069	0.762
MOD_NEK2_1	82	87	PF00069	0.718
MOD_NEK2_1	868	873	PF00069	0.596
MOD_NEK2_1	90	95	PF00069	0.800
MOD_NEK2_1	966	971	PF00069	0.761
MOD_NEK2_2	175	180	PF00069	0.718
MOD_NEK2_2	329	334	PF00069	0.556
MOD_PIKK_1	121	127	PF00454	0.591
MOD_PIKK_1	227	233	PF00454	0.818
MOD_PIKK_1	587	593	PF00454	0.572
MOD_PIKK_1	933	939	PF00454	0.753
MOD_PIKK_1	94	100	PF00454	0.797
MOD_PK_1	156	162	PF00069	0.578
MOD_PKA_1	155	161	PF00069	0.577
MOD_PKA_1	919	925	PF00069	0.604
MOD_PKA_2	135	141	PF00069	0.576
MOD_PKA_2	155	161	PF00069	0.752
MOD_PKA_2	222	228	PF00069	0.568
MOD_PKA_2	291	297	PF00069	0.588
MOD_PKA_2	329	335	PF00069	0.597
MOD_PKA_2	35	41	PF00069	0.637
MOD_PKA_2	365	371	PF00069	0.575
MOD_PKA_2	426	432	PF00069	0.566
MOD_PKA_2	599	605	PF00069	0.676
MOD_PKA_2	719	725	PF00069	0.627
MOD_PKA_2	780	786	PF00069	0.855
MOD_PKA_2	919	925	PF00069	0.737
MOD_PKA_2	94	100	PF00069	0.694
MOD_Plk_1	11	17	PF00069	0.490
MOD_Plk_2-3	274	280	PF00069	0.803
MOD_Plk_2-3	7	13	PF00069	0.517
MOD_Plk_2-3	792	798	PF00069	0.610
MOD_Plk_4	111	117	PF00069	0.579
MOD_Plk_4	222	228	PF00069	0.821
MOD_Plk_4	242	248	PF00069	0.607
MOD_Plk_4	329	335	PF00069	0.544
MOD_Plk_4	376	382	PF00069	0.639
MOD_Plk_4	580	586	PF00069	0.611
MOD_Plk_4	864	870	PF00069	0.824
MOD_ProDKin_1	147	153	PF00069	0.702
MOD_ProDKin_1	179	185	PF00069	0.631
MOD_ProDKin_1	238	244	PF00069	0.691
MOD_ProDKin_1	304	310	PF00069	0.801
MOD_ProDKin_1	431	437	PF00069	0.567
MOD_ProDKin_1	440	446	PF00069	0.515
MOD_ProDKin_1	463	469	PF00069	0.815
MOD_ProDKin_1	480	486	PF00069	0.526
MOD_ProDKin_1	522	528	PF00069	0.666
MOD_ProDKin_1	535	541	PF00069	0.755
MOD_ProDKin_1	611	617	PF00069	0.515
MOD_ProDKin_1	675	681	PF00069	0.734
MOD_ProDKin_1	683	689	PF00069	0.779
MOD_ProDKin_1	829	835	PF00069	0.597
MOD_ProDKin_1	876	882	PF00069	0.814
MOD_SUMO_rev_2	722	730	PF00179	0.707
TRG_DiLeu_BaEn_1	616	621	PF01217	0.618
TRG_DiLeu_BaEn_1	956	961	PF01217	0.706
TRG_DiLeu_BaEn_2	375	381	PF01217	0.755
TRG_DiLeu_BaEn_2	77	83	PF01217	0.553
TRG_DiLeu_BaEn_4	910	916	PF01217	0.564
TRG_ENDOCYTIC_2	19	22	PF00928	0.471
TRG_ENDOCYTIC_2	347	350	PF00928	0.549
TRG_ENDOCYTIC_2	776	779	PF00928	0.590
TRG_ER_diArg_1	22	24	PF00400	0.733
TRG_ER_diArg_1	299	302	PF00400	0.718
TRG_ER_diArg_1	621	623	PF00400	0.477
TRG_ER_diArg_1	87	90	PF00400	0.807
TRG_ER_diArg_1	915	918	PF00400	0.825
TRG_ER_diArg_1	963	966	PF00400	0.727
TRG_ER_FFAT_2	947	956	PF00635	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8V2	Leishmania donovani	57%	97%
A4IAX7	Leishmania infantum	57%	97%
E9AEQ5	Leishmania major	59%	100%
E9B5W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	96%