Putative proteasome activator protein pa26

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome activator protein pa26, putative

Species:

Leishmania braziliensis

UniProt:

A4HMA7_LEIBR

TriTrypDb:

LbrM.34.0740 , LBRM2903_340012700

Length:

222

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 1
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 3

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0008537	proteasome activator complex	2	11
GO:0032991	protein-containing complex	1	11

Expansion

Sequence features

A4HMA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.692
DOC_MAPK_MEF2A_6	163	171	PF00069	0.626
DOC_MAPK_MEF2A_6	93	102	PF00069	0.568
DOC_USP7_MATH_1	143	147	PF00917	0.597
DOC_USP7_MATH_1	165	169	PF00917	0.638
DOC_USP7_UBL2_3	150	154	PF12436	0.549
LIG_Actin_WH2_2	95	110	PF00022	0.654
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BIR_III_3	1	5	PF00653	0.596
LIG_Clathr_ClatBox_1	181	185	PF01394	0.510
LIG_FHA_1	53	59	PF00498	0.675
LIG_FHA_2	6	12	PF00498	0.562
LIG_LIR_Gen_1	12	20	PF02991	0.433
LIG_LIR_Nem_3	12	18	PF02991	0.437
LIG_PCNA_yPIPBox_3	103	116	PF02747	0.599
LIG_SH2_STAP1	202	206	PF00017	0.505
LIG_SH2_STAP1	48	52	PF00017	0.671
LIG_SH2_STAP1	9	13	PF00017	0.539
LIG_SH2_STAT5	140	143	PF00017	0.504
LIG_SH2_STAT5	48	51	PF00017	0.574
LIG_WRC_WIRS_1	195	200	PF05994	0.587
MOD_CK1_1	214	220	PF00069	0.753
MOD_CK2_1	5	11	PF00069	0.516
MOD_CK2_1	60	66	PF00069	0.668
MOD_GlcNHglycan	119	122	PF01048	0.616
MOD_GlcNHglycan	163	166	PF01048	0.681
MOD_GlcNHglycan	185	189	PF01048	0.543
MOD_GSK3_1	139	146	PF00069	0.475
MOD_GSK3_1	161	168	PF00069	0.595
MOD_GSK3_1	190	197	PF00069	0.509
MOD_GSK3_1	52	59	PF00069	0.633
MOD_GSK3_1	7	14	PF00069	0.519
MOD_N-GLC_1	214	219	PF02516	0.793
MOD_NEK2_1	117	122	PF00069	0.740
MOD_NEK2_1	184	189	PF00069	0.584
MOD_NEK2_2	77	82	PF00069	0.654
MOD_PIKK_1	190	196	PF00454	0.544
MOD_PKA_2	143	149	PF00069	0.543
MOD_PKA_2	31	37	PF00069	0.598
MOD_PKA_2	5	11	PF00069	0.470
MOD_Plk_1	11	17	PF00069	0.570
MOD_Plk_1	184	190	PF00069	0.480
MOD_Plk_2-3	7	13	PF00069	0.552
MOD_Plk_2-3	91	97	PF00069	0.578
MOD_Plk_4	165	171	PF00069	0.565
MOD_Plk_4	56	62	PF00069	0.595
MOD_SUMO_for_1	182	185	PF00179	0.481
MOD_SUMO_for_1	92	95	PF00179	0.581
MOD_SUMO_rev_2	111	118	PF00179	0.622
MOD_SUMO_rev_2	146	152	PF00179	0.551
MOD_SUMO_rev_2	157	162	PF00179	0.758

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3A8	Leptomonas seymouri	73%	97%
A0A0S4JD53	Bodo saltans	37%	100%
A0A1X0NKN6	Trypanosomatidae	46%	89%
A0A3Q8IHQ9	Leishmania donovani	87%	100%
A0A3R7MG26	Trypanosoma rangeli	49%	96%
A4IAX3	Leishmania infantum	87%	100%
D0A282	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	96%
E9AEQ0	Leishmania major	85%	100%
E9B5V5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%