Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMA6_LEIBR

TriTrypDb:

LbrM.34.0730 , LBRM2903_340012600

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	369	373	PF00656	0.540
CLV_C14_Caspase3-7	792	796	PF00656	0.795
CLV_NRD_NRD_1	2	4	PF00675	0.724
CLV_NRD_NRD_1	309	311	PF00675	0.668
CLV_NRD_NRD_1	440	442	PF00675	0.505
CLV_NRD_NRD_1	477	479	PF00675	0.632
CLV_NRD_NRD_1	702	704	PF00675	0.687
CLV_NRD_NRD_1	821	823	PF00675	0.738
CLV_NRD_NRD_1	825	827	PF00675	0.707
CLV_NRD_NRD_1	833	835	PF00675	0.677
CLV_NRD_NRD_1	836	838	PF00675	0.659
CLV_NRD_NRD_1	875	877	PF00675	0.604
CLV_PCSK_FUR_1	521	525	PF00082	0.562
CLV_PCSK_FUR_1	822	826	PF00082	0.811
CLV_PCSK_FUR_1	834	838	PF00082	0.600
CLV_PCSK_KEX2_1	309	311	PF00082	0.668
CLV_PCSK_KEX2_1	440	442	PF00082	0.505
CLV_PCSK_KEX2_1	476	478	PF00082	0.623
CLV_PCSK_KEX2_1	523	525	PF00082	0.796
CLV_PCSK_KEX2_1	702	704	PF00082	0.687
CLV_PCSK_KEX2_1	823	825	PF00082	0.747
CLV_PCSK_KEX2_1	835	837	PF00082	0.784
CLV_PCSK_KEX2_1	875	877	PF00082	0.604
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.796
CLV_PCSK_PC1ET2_1	823	825	PF00082	0.747
CLV_PCSK_PC1ET2_1	835	837	PF00082	0.784
CLV_PCSK_SKI1_1	427	431	PF00082	0.489
CLV_PCSK_SKI1_1	441	445	PF00082	0.422
CLV_PCSK_SKI1_1	463	467	PF00082	0.655
CLV_PCSK_SKI1_1	510	514	PF00082	0.564
CLV_PCSK_SKI1_1	589	593	PF00082	0.509
CLV_Separin_Metazoa	814	818	PF03568	0.578
DEG_APCC_DBOX_1	467	475	PF00400	0.585
DEG_SPOP_SBC_1	178	182	PF00917	0.418
DEG_SPOP_SBC_1	288	292	PF00917	0.771
DEG_SPOP_SBC_1	720	724	PF00917	0.562
DOC_CKS1_1	430	435	PF01111	0.727
DOC_CKS1_1	51	56	PF01111	0.685
DOC_CYCLIN_RxL_1	634	644	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.618
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.672
DOC_CYCLIN_yCln2_LP_2	516	522	PF00134	0.563
DOC_CYCLIN_yCln2_LP_2	613	616	PF00134	0.801
DOC_CYCLIN_yCln2_LP_2	777	783	PF00134	0.564
DOC_MAPK_gen_1	689	697	PF00069	0.684
DOC_MAPK_JIP1_4	691	697	PF00069	0.779
DOC_MAPK_MEF2A_6	691	699	PF00069	0.678
DOC_MAPK_RevD_3	688	703	PF00069	0.781
DOC_PP2B_LxvP_1	613	616	PF13499	0.801
DOC_PP4_FxxP_1	195	198	PF00568	0.636
DOC_PP4_FxxP_1	553	556	PF00568	0.582
DOC_SPAK_OSR1_1	552	556	PF12202	0.812
DOC_USP7_MATH_1	13	17	PF00917	0.697
DOC_USP7_MATH_1	269	273	PF00917	0.623
DOC_USP7_MATH_1	286	290	PF00917	0.585
DOC_USP7_MATH_1	371	375	PF00917	0.546
DOC_USP7_MATH_1	385	389	PF00917	0.495
DOC_USP7_MATH_1	401	405	PF00917	0.725
DOC_USP7_MATH_1	487	491	PF00917	0.703
DOC_USP7_MATH_1	577	581	PF00917	0.730
DOC_USP7_MATH_1	69	73	PF00917	0.638
DOC_USP7_MATH_1	720	724	PF00917	0.572
DOC_USP7_MATH_1	737	741	PF00917	0.715
DOC_USP7_MATH_1	77	81	PF00917	0.584
DOC_USP7_MATH_1	781	785	PF00917	0.702
DOC_USP7_MATH_1	874	878	PF00917	0.594
DOC_USP7_UBL2_3	5	9	PF12436	0.720
DOC_WW_Pin1_4	245	250	PF00397	0.560
DOC_WW_Pin1_4	397	402	PF00397	0.831
DOC_WW_Pin1_4	429	434	PF00397	0.733
DOC_WW_Pin1_4	455	460	PF00397	0.672
DOC_WW_Pin1_4	481	486	PF00397	0.780
DOC_WW_Pin1_4	488	493	PF00397	0.758
DOC_WW_Pin1_4	496	501	PF00397	0.595
DOC_WW_Pin1_4	50	55	PF00397	0.555
DOC_WW_Pin1_4	539	544	PF00397	0.775
DOC_WW_Pin1_4	570	575	PF00397	0.621
DOC_WW_Pin1_4	701	706	PF00397	0.694
DOC_WW_Pin1_4	722	727	PF00397	0.819
DOC_WW_Pin1_4	73	78	PF00397	0.598
DOC_WW_Pin1_4	768	773	PF00397	0.794
DOC_WW_Pin1_4	776	781	PF00397	0.689
DOC_WW_Pin1_4	9	14	PF00397	0.834
LIG_14-3-3_CanoR_1	287	294	PF00244	0.764
LIG_14-3-3_CanoR_1	3	13	PF00244	0.570
LIG_14-3-3_CanoR_1	327	333	PF00244	0.654
LIG_14-3-3_CanoR_1	341	347	PF00244	0.513
LIG_14-3-3_CanoR_1	413	418	PF00244	0.650
LIG_14-3-3_CanoR_1	478	487	PF00244	0.616
LIG_14-3-3_CanoR_1	836	843	PF00244	0.686
LIG_14-3-3_CanoR_1	864	874	PF00244	0.677
LIG_14-3-3_CanoR_1	875	881	PF00244	0.786
LIG_14-3-3_CanoR_1	94	102	PF00244	0.499
LIG_APCC_Cbox_2	340	346	PF00515	0.546
LIG_BIR_III_2	527	531	PF00653	0.569
LIG_BIR_III_2	642	646	PF00653	0.802
LIG_CtBP_PxDLS_1	615	619	PF00389	0.557
LIG_deltaCOP1_diTrp_1	467	472	PF00928	0.682
LIG_EVH1_1	132	136	PF00568	0.641
LIG_EVH1_2	175	179	PF00568	0.651
LIG_FHA_1	119	125	PF00498	0.355
LIG_FHA_1	294	300	PF00498	0.564
LIG_FHA_1	306	312	PF00498	0.461
LIG_FHA_1	327	333	PF00498	0.602
LIG_FHA_1	430	436	PF00498	0.720
LIG_FHA_1	51	57	PF00498	0.571
LIG_FHA_1	511	517	PF00498	0.807
LIG_FHA_1	582	588	PF00498	0.513
LIG_FHA_1	608	614	PF00498	0.706
LIG_FHA_1	739	745	PF00498	0.782
LIG_FHA_1	810	816	PF00498	0.557
LIG_FHA_2	246	252	PF00498	0.760
LIG_FHA_2	258	264	PF00498	0.623
LIG_FHA_2	381	387	PF00498	0.667
LIG_FHA_2	491	497	PF00498	0.555
LIG_GBD_Chelix_1	435	443	PF00786	0.613
LIG_LIR_Apic_2	194	198	PF02991	0.599
LIG_LIR_Apic_2	551	556	PF02991	0.584
LIG_LIR_Apic_2	885	890	PF02991	0.589
LIG_LIR_Gen_1	181	191	PF02991	0.495
LIG_LIR_Gen_1	271	281	PF02991	0.531
LIG_LIR_Gen_1	801	809	PF02991	0.780
LIG_LIR_Nem_3	180	186	PF02991	0.482
LIG_LIR_Nem_3	245	250	PF02991	0.619
LIG_LIR_Nem_3	271	277	PF02991	0.772
LIG_LIR_Nem_3	58	64	PF02991	0.594
LIG_LIR_Nem_3	801	806	PF02991	0.779
LIG_LYPXL_yS_3	132	135	PF13949	0.626
LIG_Pex14_1	78	82	PF04695	0.526
LIG_PTB_Apo_2	189	196	PF02174	0.626
LIG_SH2_CRK	102	106	PF00017	0.373
LIG_SH2_NCK_1	247	251	PF00017	0.561
LIG_SH2_STAP1	64	68	PF00017	0.651
LIG_SH2_STAT5	118	121	PF00017	0.505
LIG_SH2_STAT5	184	187	PF00017	0.475
LIG_SH2_STAT5	247	250	PF00017	0.562
LIG_SH2_STAT5	342	345	PF00017	0.546
LIG_SH2_STAT5	698	701	PF00017	0.680
LIG_SH2_STAT5	710	713	PF00017	0.709
LIG_SH2_STAT5	750	753	PF00017	0.569
LIG_SH3_1	130	136	PF00018	0.649
LIG_SH3_2	871	876	PF14604	0.572
LIG_SH3_3	130	136	PF00018	0.569
LIG_SH3_3	170	176	PF00018	0.627
LIG_SH3_3	23	29	PF00018	0.783
LIG_SH3_3	344	350	PF00018	0.561
LIG_SH3_3	362	368	PF00018	0.653
LIG_SH3_3	453	459	PF00018	0.783
LIG_SH3_3	46	52	PF00018	0.552
LIG_SH3_3	486	492	PF00018	0.714
LIG_SH3_3	571	577	PF00018	0.557
LIG_SH3_3	632	638	PF00018	0.615
LIG_SH3_3	676	682	PF00018	0.696
LIG_SH3_3	868	874	PF00018	0.658
LIG_Sin3_3	462	469	PF02671	0.707
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.687
LIG_SUMO_SIM_par_1	153	158	PF11976	0.687
LIG_SUMO_SIM_par_1	248	253	PF11976	0.555
LIG_Vh1_VBS_1	576	594	PF01044	0.526
LIG_WRC_WIRS_1	214	219	PF05994	0.514
LIG_WW_2	133	136	PF00397	0.653
LIG_WW_3	872	876	PF00397	0.573
MOD_CDC14_SPxK_1	76	79	PF00782	0.642
MOD_CDK_SPxK_1	73	79	PF00069	0.573
MOD_CK1_1	245	251	PF00069	0.656
MOD_CK1_1	258	264	PF00069	0.467
MOD_CK1_1	289	295	PF00069	0.741
MOD_CK1_1	374	380	PF00069	0.581
MOD_CK1_1	392	398	PF00069	0.745
MOD_CK1_1	399	405	PF00069	0.711
MOD_CK1_1	407	413	PF00069	0.560
MOD_CK1_1	490	496	PF00069	0.560
MOD_CK1_1	542	548	PF00069	0.751
MOD_CK1_1	564	570	PF00069	0.713
MOD_CK1_1	580	586	PF00069	0.448
MOD_CK1_1	606	612	PF00069	0.725
MOD_CK1_1	675	681	PF00069	0.541
MOD_CK1_1	715	721	PF00069	0.739
MOD_CK1_1	72	78	PF00069	0.590
MOD_CK1_1	722	728	PF00069	0.681
MOD_CK1_1	768	774	PF00069	0.726
MOD_CK1_1	779	785	PF00069	0.698
MOD_CK1_1	818	824	PF00069	0.583
MOD_CK2_1	213	219	PF00069	0.513
MOD_CK2_1	257	263	PF00069	0.675
MOD_CK2_1	380	386	PF00069	0.668
MOD_CK2_1	538	544	PF00069	0.789
MOD_CK2_1	841	847	PF00069	0.653
MOD_Cter_Amidation	826	829	PF01082	0.807
MOD_DYRK1A_RPxSP_1	703	707	PF00069	0.689
MOD_GlcNHglycan	137	140	PF01048	0.478
MOD_GlcNHglycan	15	18	PF01048	0.564
MOD_GlcNHglycan	21	24	PF01048	0.525
MOD_GlcNHglycan	291	294	PF01048	0.697
MOD_GlcNHglycan	359	362	PF01048	0.629
MOD_GlcNHglycan	379	382	PF01048	0.504
MOD_GlcNHglycan	390	394	PF01048	0.756
MOD_GlcNHglycan	409	412	PF01048	0.491
MOD_GlcNHglycan	481	484	PF01048	0.549
MOD_GlcNHglycan	544	547	PF01048	0.653
MOD_GlcNHglycan	584	587	PF01048	0.598
MOD_GlcNHglycan	661	664	PF01048	0.768
MOD_GlcNHglycan	741	744	PF01048	0.628
MOD_GlcNHglycan	761	764	PF01048	0.747
MOD_GlcNHglycan	781	784	PF01048	0.573
MOD_GlcNHglycan	817	820	PF01048	0.691
MOD_GlcNHglycan	843	846	PF01048	0.639
MOD_GlcNHglycan	95	98	PF01048	0.499
MOD_GSK3_1	137	144	PF00069	0.639
MOD_GSK3_1	15	22	PF00069	0.701
MOD_GSK3_1	174	181	PF00069	0.567
MOD_GSK3_1	187	194	PF00069	0.322
MOD_GSK3_1	288	295	PF00069	0.691
MOD_GSK3_1	366	373	PF00069	0.619
MOD_GSK3_1	376	383	PF00069	0.684
MOD_GSK3_1	385	392	PF00069	0.522
MOD_GSK3_1	397	404	PF00069	0.652
MOD_GSK3_1	409	416	PF00069	0.719
MOD_GSK3_1	5	12	PF00069	0.580
MOD_GSK3_1	538	545	PF00069	0.759
MOD_GSK3_1	576	583	PF00069	0.774
MOD_GSK3_1	603	610	PF00069	0.794
MOD_GSK3_1	649	656	PF00069	0.747
MOD_GSK3_1	659	666	PF00069	0.680
MOD_GSK3_1	671	678	PF00069	0.749
MOD_GSK3_1	69	76	PF00069	0.706
MOD_GSK3_1	708	715	PF00069	0.807
MOD_GSK3_1	720	727	PF00069	0.615
MOD_GSK3_1	735	742	PF00069	0.718
MOD_GSK3_1	764	771	PF00069	0.688
MOD_GSK3_1	775	782	PF00069	0.746
MOD_GSK3_1	789	796	PF00069	0.593
MOD_LATS_1	19	25	PF00433	0.592
MOD_N-GLC_1	187	192	PF02516	0.507
MOD_N-GLC_1	19	24	PF02516	0.584
MOD_N-GLC_1	561	566	PF02516	0.550
MOD_N-GLC_1	596	601	PF02516	0.564
MOD_N-GLC_1	650	655	PF02516	0.604
MOD_N-GLC_2	38	40	PF02516	0.566
MOD_NEK2_1	179	184	PF00069	0.642
MOD_NEK2_1	537	542	PF00069	0.824
MOD_NEK2_1	561	566	PF00069	0.713
MOD_NEK2_1	581	586	PF00069	0.708
MOD_NEK2_1	650	655	PF00069	0.565
MOD_NEK2_1	670	675	PF00069	0.563
MOD_NEK2_2	69	74	PF00069	0.704
MOD_OFUCOSY	382	389	PF10250	0.549
MOD_PIKK_1	327	333	PF00454	0.751
MOD_PIKK_1	404	410	PF00454	0.832
MOD_PIKK_1	498	504	PF00454	0.553
MOD_PIKK_1	607	613	PF00454	0.588
MOD_PIKK_1	663	669	PF00454	0.821
MOD_PK_1	413	419	PF00069	0.643
MOD_PKA_1	3	9	PF00069	0.809
MOD_PKA_1	836	842	PF00069	0.688
MOD_PKA_2	286	292	PF00069	0.740
MOD_PKA_2	326	332	PF00069	0.747
MOD_PKA_2	479	485	PF00069	0.601
MOD_PKA_2	670	676	PF00069	0.801
MOD_PKA_2	759	765	PF00069	0.568
MOD_PKA_2	836	842	PF00069	0.781
MOD_PKA_2	863	869	PF00069	0.580
MOD_PKA_2	874	880	PF00069	0.550
MOD_PKA_2	93	99	PF00069	0.481
MOD_PKB_1	834	842	PF00069	0.783
MOD_Plk_1	371	377	PF00069	0.656
MOD_Plk_1	561	567	PF00069	0.651
MOD_Plk_1	663	669	PF00069	0.776
MOD_Plk_1	671	677	PF00069	0.493
MOD_Plk_1	712	718	PF00069	0.812
MOD_Plk_2-3	213	219	PF00069	0.513
MOD_Plk_4	174	180	PF00069	0.647
MOD_Plk_4	191	197	PF00069	0.412
MOD_Plk_4	213	219	PF00069	0.615
MOD_Plk_4	269	275	PF00069	0.720
MOD_Plk_4	413	419	PF00069	0.564
MOD_Plk_4	724	730	PF00069	0.675
MOD_Plk_4	838	844	PF00069	0.548
MOD_ProDKin_1	245	251	PF00069	0.560
MOD_ProDKin_1	397	403	PF00069	0.830
MOD_ProDKin_1	429	435	PF00069	0.727
MOD_ProDKin_1	455	461	PF00069	0.664
MOD_ProDKin_1	481	487	PF00069	0.782
MOD_ProDKin_1	488	494	PF00069	0.756
MOD_ProDKin_1	496	502	PF00069	0.595
MOD_ProDKin_1	50	56	PF00069	0.553
MOD_ProDKin_1	539	545	PF00069	0.774
MOD_ProDKin_1	570	576	PF00069	0.621
MOD_ProDKin_1	701	707	PF00069	0.697
MOD_ProDKin_1	722	728	PF00069	0.820
MOD_ProDKin_1	73	79	PF00069	0.595
MOD_ProDKin_1	768	774	PF00069	0.796
MOD_ProDKin_1	776	782	PF00069	0.690
MOD_ProDKin_1	9	15	PF00069	0.832
MOD_SUMO_rev_2	617	624	PF00179	0.569
MOD_SUMO_rev_2	844	851	PF00179	0.650
TRG_DiLeu_BaEn_2	190	196	PF01217	0.530
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.382
TRG_ENDOCYTIC_2	102	105	PF00928	0.367
TRG_ENDOCYTIC_2	132	135	PF00928	0.626
TRG_ENDOCYTIC_2	183	186	PF00928	0.448
TRG_ENDOCYTIC_2	247	250	PF00928	0.562
TRG_ER_diArg_1	309	311	PF00400	0.672
TRG_ER_diArg_1	439	441	PF00400	0.504
TRG_ER_diArg_1	475	478	PF00400	0.610
TRG_ER_diArg_1	822	825	PF00400	0.759
TRG_ER_diArg_1	834	837	PF00400	0.643
TRG_ER_diArg_1	874	876	PF00400	0.593
TRG_NLS_Bipartite_1	822	839	PF00514	0.797
TRG_NLS_MonoCore_2	821	826	PF00514	0.811
TRG_NLS_MonoCore_2	833	838	PF00514	0.602
TRG_NLS_MonoExtC_3	821	826	PF00514	0.786
TRG_NLS_MonoExtC_3	834	840	PF00514	0.607
TRG_NLS_MonoExtN_4	2	7	PF00514	0.641
TRG_NLS_MonoExtN_4	822	827	PF00514	0.745
TRG_NLS_MonoExtN_4	834	839	PF00514	0.762
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	637	642	PF00026	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDY7	Leptomonas seymouri	35%	100%
A0A3Q8IP33	Leishmania donovani	66%	97%
A4IAX1	Leishmania infantum	71%	96%
E9AEP9	Leishmania major	66%	100%
E9B5V4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	96%