SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMA5_LEIBR

TriTrypDb:

LbrM.34.0720 , LBRM2903_340012400

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	4

Expansion

Sequence features

A4HMA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	407	411	PF00656	0.451
CLV_C14_Caspase3-7	548	552	PF00656	0.670
CLV_NRD_NRD_1	2	4	PF00675	0.504
CLV_NRD_NRD_1	206	208	PF00675	0.432
CLV_NRD_NRD_1	227	229	PF00675	0.469
CLV_NRD_NRD_1	244	246	PF00675	0.436
CLV_NRD_NRD_1	326	328	PF00675	0.336
CLV_NRD_NRD_1	440	442	PF00675	0.242
CLV_NRD_NRD_1	677	679	PF00675	0.656
CLV_NRD_NRD_1	681	683	PF00675	0.628
CLV_PCSK_FUR_1	207	211	PF00082	0.439
CLV_PCSK_KEX2_1	2	4	PF00082	0.504
CLV_PCSK_KEX2_1	206	208	PF00082	0.432
CLV_PCSK_KEX2_1	209	211	PF00082	0.455
CLV_PCSK_KEX2_1	326	328	PF00082	0.336
CLV_PCSK_KEX2_1	440	442	PF00082	0.252
CLV_PCSK_KEX2_1	676	678	PF00082	0.634
CLV_PCSK_KEX2_1	681	683	PF00082	0.613
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.448
CLV_PCSK_PC1ET2_1	676	678	PF00082	0.537
CLV_PCSK_PC7_1	677	683	PF00082	0.651
CLV_PCSK_SKI1_1	158	162	PF00082	0.456
CLV_PCSK_SKI1_1	206	210	PF00082	0.453
CLV_PCSK_SKI1_1	320	324	PF00082	0.242
CLV_PCSK_SKI1_1	327	331	PF00082	0.249
CLV_PCSK_SKI1_1	635	639	PF00082	0.602
DEG_APCC_DBOX_1	681	689	PF00400	0.473
DEG_Nend_UBRbox_1	1	4	PF02207	0.708
DEG_SPOP_SBC_1	131	135	PF00917	0.613
DEG_SPOP_SBC_1	392	396	PF00917	0.450
DEG_SPOP_SBC_1	504	508	PF00917	0.764
DEG_SPOP_SBC_1	54	58	PF00917	0.731
DOC_CDC14_PxL_1	1	9	PF14671	0.591
DOC_CDC14_PxL_1	541	549	PF14671	0.698
DOC_CDC14_PxL_1	610	618	PF14671	0.530
DOC_CKS1_1	22	27	PF01111	0.604
DOC_CYCLIN_yClb3_PxF_3	221	229	PF00134	0.688
DOC_MAPK_DCC_7	608	618	PF00069	0.555
DOC_MAPK_gen_1	185	194	PF00069	0.734
DOC_MAPK_gen_1	2	9	PF00069	0.659
DOC_MAPK_gen_1	206	216	PF00069	0.651
DOC_MAPK_gen_1	228	235	PF00069	0.673
DOC_MAPK_gen_1	326	337	PF00069	0.505
DOC_MAPK_gen_1	608	618	PF00069	0.594
DOC_MAPK_gen_1	676	685	PF00069	0.436
DOC_MAPK_gen_1	93	103	PF00069	0.719
DOC_MAPK_HePTP_8	606	618	PF00069	0.522
DOC_MAPK_MEF2A_6	2	9	PF00069	0.657
DOC_MAPK_MEF2A_6	209	218	PF00069	0.688
DOC_MAPK_MEF2A_6	609	618	PF00069	0.570
DOC_MAPK_MEF2A_6	78	86	PF00069	0.752
DOC_MAPK_RevD_3	665	679	PF00069	0.436
DOC_PIKK_1	653	660	PF02985	0.449
DOC_PP1_RVXF_1	528	535	PF00149	0.635
DOC_PP2B_LxvP_1	233	236	PF13499	0.735
DOC_PP2B_LxvP_1	33	36	PF13499	0.613
DOC_USP7_MATH_1	125	129	PF00917	0.636
DOC_USP7_MATH_1	131	135	PF00917	0.643
DOC_USP7_MATH_1	136	140	PF00917	0.745
DOC_USP7_MATH_1	34	38	PF00917	0.715
DOC_USP7_MATH_1	392	396	PF00917	0.535
DOC_USP7_MATH_1	504	508	PF00917	0.764
DOC_USP7_MATH_1	54	58	PF00917	0.778
DOC_USP7_MATH_1	649	653	PF00917	0.456
DOC_USP7_MATH_1	76	80	PF00917	0.740
DOC_USP7_UBL2_3	209	213	PF12436	0.714
DOC_WW_Pin1_4	144	149	PF00397	0.690
DOC_WW_Pin1_4	199	204	PF00397	0.670
DOC_WW_Pin1_4	21	26	PF00397	0.799
DOC_WW_Pin1_4	245	250	PF00397	0.662
DOC_WW_Pin1_4	493	498	PF00397	0.653
DOC_WW_Pin1_4	600	605	PF00397	0.674
LIG_14-3-3_CanoR_1	19	25	PF00244	0.713
LIG_14-3-3_CanoR_1	291	295	PF00244	0.659
LIG_14-3-3_CanoR_1	522	532	PF00244	0.582
LIG_14-3-3_CanoR_1	87	95	PF00244	0.701
LIG_APCC_ABBA_1	253	258	PF00400	0.677
LIG_BIR_III_4	401	405	PF00653	0.496
LIG_BRCT_BRCA1_1	201	205	PF00533	0.712
LIG_CaM_IQ_9	334	349	PF13499	0.536
LIG_FHA_1	10	16	PF00498	0.795
LIG_FHA_1	265	271	PF00498	0.667
LIG_FHA_1	323	329	PF00498	0.442
LIG_FHA_1	331	337	PF00498	0.442
LIG_FHA_1	356	362	PF00498	0.536
LIG_FHA_1	36	42	PF00498	0.713
LIG_FHA_1	394	400	PF00498	0.466
LIG_FHA_1	459	465	PF00498	0.445
LIG_FHA_2	100	106	PF00498	0.696
LIG_FHA_2	482	488	PF00498	0.729
LIG_FHA_2	497	503	PF00498	0.612
LIG_FHA_2	546	552	PF00498	0.677
LIG_FHA_2	87	93	PF00498	0.744
LIG_Integrin_isoDGR_2	302	304	PF01839	0.440
LIG_KLC1_Yacidic_2	474	478	PF13176	0.615
LIG_LIR_Apic_2	574	578	PF02991	0.521
LIG_LIR_Gen_1	461	470	PF02991	0.528
LIG_LIR_Gen_1	607	618	PF02991	0.579
LIG_LIR_Gen_1	99	108	PF02991	0.684
LIG_LIR_Nem_3	202	208	PF02991	0.646
LIG_LIR_Nem_3	220	226	PF02991	0.559
LIG_LIR_Nem_3	284	288	PF02991	0.696
LIG_LIR_Nem_3	538	544	PF02991	0.657
LIG_LIR_Nem_3	607	613	PF02991	0.628
LIG_LIR_Nem_3	642	648	PF02991	0.453
LIG_LIR_Nem_3	74	80	PF02991	0.654
LIG_LIR_Nem_3	99	103	PF02991	0.679
LIG_LYPXL_S_1	80	84	PF13949	0.534
LIG_LYPXL_yS_3	544	547	PF13949	0.697
LIG_LYPXL_yS_3	81	84	PF13949	0.653
LIG_NRP_CendR_1	717	720	PF00754	0.709
LIG_PCNA_yPIPBox_3	633	641	PF02747	0.285
LIG_PTB_Apo_2	581	588	PF02174	0.531
LIG_PTB_Phospho_1	581	587	PF10480	0.532
LIG_SH2_CRK	22	26	PF00017	0.604
LIG_SH2_CRK	285	289	PF00017	0.766
LIG_SH2_CRK	610	614	PF00017	0.600
LIG_SH2_CRK	645	649	PF00017	0.299
LIG_SH2_CRK	77	81	PF00017	0.727
LIG_SH2_NCK_1	22	26	PF00017	0.596
LIG_SH2_NCK_1	610	614	PF00017	0.638
LIG_SH2_PTP2	575	578	PF00017	0.509
LIG_SH2_SRC	575	578	PF00017	0.509
LIG_SH2_STAT5	374	377	PF00017	0.503
LIG_SH2_STAT5	445	448	PF00017	0.474
LIG_SH2_STAT5	476	479	PF00017	0.603
LIG_SH2_STAT5	555	558	PF00017	0.475
LIG_SH2_STAT5	575	578	PF00017	0.403
LIG_SH2_STAT5	587	590	PF00017	0.508
LIG_SH3_1	2	8	PF00018	0.590
LIG_SH3_1	246	252	PF00018	0.655
LIG_SH3_3	192	198	PF00018	0.656
LIG_SH3_3	2	8	PF00018	0.658
LIG_SH3_3	215	221	PF00018	0.674
LIG_SH3_3	246	252	PF00018	0.733
LIG_SH3_5	219	223	PF00018	0.703
LIG_SUMO_SIM_anti_2	332	340	PF11976	0.442
LIG_SUMO_SIM_par_1	424	430	PF11976	0.548
LIG_SUMO_SIM_par_1	619	624	PF11976	0.410
LIG_TRAF2_1	102	105	PF00917	0.690
LIG_TRAF2_1	237	240	PF00917	0.655
LIG_TRAF2_1	509	512	PF00917	0.604
LIG_TRAF2_1	652	655	PF00917	0.409
LIG_TRAF2_1	89	92	PF00917	0.790
LIG_WRC_WIRS_1	100	105	PF05994	0.680
LIG_WRC_WIRS_1	223	228	PF05994	0.751
LIG_WRC_WIRS_1	428	433	PF05994	0.442
MOD_CDK_SPxxK_3	199	206	PF00069	0.685
MOD_CK1_1	127	133	PF00069	0.646
MOD_CK1_1	37	43	PF00069	0.801
MOD_CK1_1	435	441	PF00069	0.533
MOD_CK1_1	496	502	PF00069	0.692
MOD_CK1_1	505	511	PF00069	0.625
MOD_CK2_1	113	119	PF00069	0.765
MOD_CK2_1	273	279	PF00069	0.724
MOD_CK2_1	383	389	PF00069	0.455
MOD_CK2_1	433	439	PF00069	0.498
MOD_CK2_1	481	487	PF00069	0.689
MOD_CK2_1	505	511	PF00069	0.604
MOD_CK2_1	649	655	PF00069	0.415
MOD_CK2_1	86	92	PF00069	0.749
MOD_CK2_1	99	105	PF00069	0.676
MOD_DYRK1A_RPxSP_1	144	148	PF00069	0.616
MOD_GlcNHglycan	127	130	PF01048	0.539
MOD_GlcNHglycan	134	137	PF01048	0.573
MOD_GlcNHglycan	507	510	PF01048	0.456
MOD_GlcNHglycan	514	517	PF01048	0.511
MOD_GlcNHglycan	57	60	PF01048	0.548
MOD_GlcNHglycan	62	65	PF01048	0.546
MOD_GSK3_1	113	120	PF00069	0.756
MOD_GSK3_1	127	134	PF00069	0.690
MOD_GSK3_1	142	149	PF00069	0.714
MOD_GSK3_1	311	318	PF00069	0.563
MOD_GSK3_1	37	44	PF00069	0.702
MOD_GSK3_1	378	385	PF00069	0.442
MOD_GSK3_1	498	505	PF00069	0.669
MOD_GSK3_1	60	67	PF00069	0.808
MOD_N-GLC_1	452	457	PF02516	0.255
MOD_N-GLC_1	458	463	PF02516	0.247
MOD_N-GLC_1	539	544	PF02516	0.406
MOD_NEK2_1	315	320	PF00069	0.575
MOD_NEK2_1	432	437	PF00069	0.464
MOD_NEK2_1	452	457	PF00069	0.468
MOD_NEK2_1	86	91	PF00069	0.741
MOD_NEK2_2	393	398	PF00069	0.384
MOD_NEK2_2	76	81	PF00069	0.703
MOD_PIKK_1	523	529	PF00454	0.789
MOD_PIKK_1	87	93	PF00454	0.749
MOD_PKA_2	20	26	PF00069	0.698
MOD_PKA_2	290	296	PF00069	0.708
MOD_PKA_2	470	476	PF00069	0.672
MOD_PKA_2	481	487	PF00069	0.723
MOD_PKA_2	692	698	PF00069	0.470
MOD_PKA_2	86	92	PF00069	0.728
MOD_Plk_1	117	123	PF00069	0.746
MOD_Plk_1	273	279	PF00069	0.724
MOD_Plk_1	433	439	PF00069	0.463
MOD_Plk_1	458	464	PF00069	0.451
MOD_Plk_1	539	545	PF00069	0.583
MOD_Plk_2-3	273	279	PF00069	0.724
MOD_Plk_2-3	99	105	PF00069	0.611
MOD_Plk_4	330	336	PF00069	0.473
MOD_Plk_4	383	389	PF00069	0.442
MOD_Plk_4	427	433	PF00069	0.442
MOD_ProDKin_1	144	150	PF00069	0.690
MOD_ProDKin_1	199	205	PF00069	0.669
MOD_ProDKin_1	21	27	PF00069	0.799
MOD_ProDKin_1	245	251	PF00069	0.661
MOD_ProDKin_1	493	499	PF00069	0.655
MOD_ProDKin_1	600	606	PF00069	0.681
MOD_SUMO_for_1	214	217	PF00179	0.712
MOD_SUMO_for_1	329	332	PF00179	0.496
MOD_SUMO_for_1	346	349	PF00179	0.455
MOD_SUMO_rev_2	603	611	PF00179	0.629
MOD_SUMO_rev_2	642	648	PF00179	0.294
TRG_DiLeu_BaEn_1	156	161	PF01217	0.606
TRG_DiLeu_BaEn_2	168	174	PF01217	0.603
TRG_ENDOCYTIC_2	223	226	PF00928	0.686
TRG_ENDOCYTIC_2	285	288	PF00928	0.749
TRG_ENDOCYTIC_2	462	465	PF00928	0.442
TRG_ENDOCYTIC_2	544	547	PF00928	0.669
TRG_ENDOCYTIC_2	610	613	PF00928	0.587
TRG_ENDOCYTIC_2	645	648	PF00928	0.442
TRG_ENDOCYTIC_2	77	80	PF00928	0.652
TRG_ENDOCYTIC_2	81	84	PF00928	0.644
TRG_ER_diArg_1	1	3	PF00400	0.697
TRG_ER_diArg_1	205	207	PF00400	0.626
TRG_ER_diArg_1	326	328	PF00400	0.536
TRG_ER_diArg_1	632	635	PF00400	0.435
TRG_ER_diArg_1	660	663	PF00400	0.396
TRG_ER_diArg_1	681	683	PF00400	0.446
TRG_NLS_MonoCore_2	675	680	PF00514	0.368
TRG_NLS_MonoExtC_3	677	682	PF00514	0.411
TRG_NLS_MonoExtN_4	676	682	PF00514	0.408
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	304	308	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5D5	Leptomonas seymouri	62%	98%
A0A0S4JG56	Bodo saltans	44%	100%
A0A1X0NIV0	Trypanosomatidae	48%	93%
A0A3S5H7Y5	Leishmania donovani	80%	99%
A4IAX0	Leishmania infantum	80%	99%
D0A284	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AEP8	Leishmania major	79%	99%
E9B5V3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
V5B354	Trypanosoma cruzi	58%	100%