Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMA4_LEIBR

TriTrypDb:

LbrM.34.0710 , LBRM2903_340012300

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	325	327	PF00675	0.714
CLV_NRD_NRD_1	402	404	PF00675	0.675
CLV_NRD_NRD_1	470	472	PF00675	0.655
CLV_PCSK_FUR_1	400	404	PF00082	0.670
CLV_PCSK_KEX2_1	325	327	PF00082	0.714
CLV_PCSK_KEX2_1	402	404	PF00082	0.675
CLV_PCSK_KEX2_1	470	472	PF00082	0.653
CLV_PCSK_SKI1_1	103	107	PF00082	0.482
CLV_PCSK_SKI1_1	198	202	PF00082	0.676
CLV_PCSK_SKI1_1	222	226	PF00082	0.482
CLV_PCSK_SKI1_1	92	96	PF00082	0.443
DEG_APCC_DBOX_1	102	110	PF00400	0.534
DEG_APCC_DBOX_1	119	127	PF00400	0.587
DEG_SPOP_SBC_1	438	442	PF00917	0.511
DEG_SPOP_SBC_1	72	76	PF00917	0.483
DOC_CYCLIN_RxL_1	89	98	PF00134	0.408
DOC_CYCLIN_yCln2_LP_2	297	303	PF00134	0.451
DOC_MAPK_FxFP_2	355	358	PF00069	0.512
DOC_MAPK_gen_1	101	109	PF00069	0.592
DOC_MAPK_gen_1	120	128	PF00069	0.573
DOC_MAPK_MEF2A_6	101	109	PF00069	0.586
DOC_MAPK_MEF2A_6	164	172	PF00069	0.478
DOC_MAPK_MEF2A_6	182	191	PF00069	0.490
DOC_PP1_RVXF_1	1	7	PF00149	0.479
DOC_PP1_RVXF_1	456	462	PF00149	0.591
DOC_PP1_RVXF_1	90	97	PF00149	0.565
DOC_PP2B_LxvP_1	107	110	PF13499	0.599
DOC_PP4_FxxP_1	355	358	PF00568	0.512
DOC_USP7_MATH_1	149	153	PF00917	0.481
DOC_USP7_MATH_1	256	260	PF00917	0.631
DOC_USP7_MATH_1	284	288	PF00917	0.651
DOC_USP7_MATH_1	309	313	PF00917	0.710
DOC_USP7_MATH_1	430	434	PF00917	0.734
DOC_USP7_MATH_1	438	442	PF00917	0.741
DOC_USP7_MATH_1	469	473	PF00917	0.677
DOC_USP7_MATH_1	506	510	PF00917	0.695
DOC_USP7_MATH_1	66	70	PF00917	0.639
DOC_USP7_MATH_1	72	76	PF00917	0.686
DOC_WW_Pin1_4	164	169	PF00397	0.608
DOC_WW_Pin1_4	68	73	PF00397	0.587
LIG_14-3-3_CanoR_1	182	188	PF00244	0.482
LIG_14-3-3_CanoR_1	217	222	PF00244	0.650
LIG_14-3-3_CanoR_1	247	252	PF00244	0.689
LIG_14-3-3_CanoR_1	3	7	PF00244	0.474
LIG_14-3-3_CanoR_1	30	36	PF00244	0.384
LIG_14-3-3_CanoR_1	471	477	PF00244	0.638
LIG_14-3-3_CanoR_1	482	487	PF00244	0.549
LIG_14-3-3_CanoR_1	56	61	PF00244	0.318
LIG_14-3-3_CanoR_1	68	72	PF00244	0.385
LIG_FHA_1	227	233	PF00498	0.563
LIG_FHA_1	29	35	PF00498	0.580
LIG_FHA_1	361	367	PF00498	0.753
LIG_FHA_2	113	119	PF00498	0.536
LIG_FHA_2	200	206	PF00498	0.657
LIG_FHA_2	317	323	PF00498	0.605
LIG_FHA_2	347	353	PF00498	0.776
LIG_FHA_2	402	408	PF00498	0.621
LIG_FHA_2	483	489	PF00498	0.734
LIG_FHA_2	57	63	PF00498	0.323
LIG_FHA_2	86	92	PF00498	0.518
LIG_GBD_Chelix_1	187	195	PF00786	0.339
LIG_LIR_Apic_2	352	358	PF02991	0.519
LIG_LIR_Gen_1	20	29	PF02991	0.429
LIG_LIR_Gen_1	220	228	PF02991	0.521
LIG_LIR_Gen_1	406	417	PF02991	0.636
LIG_LIR_Nem_3	18	22	PF02991	0.450
LIG_LIR_Nem_3	219	224	PF02991	0.568
LIG_LIR_Nem_3	322	327	PF02991	0.633
LIG_LIR_Nem_3	354	360	PF02991	0.661
LIG_LIR_Nem_3	373	379	PF02991	0.608
LIG_LIR_Nem_3	406	412	PF02991	0.633
LIG_LIR_Nem_3	5	9	PF02991	0.591
LIG_LYPXL_yS_3	357	360	PF13949	0.755
LIG_PDZ_Class_1	506	511	PF00595	0.687
LIG_Pex14_1	15	19	PF04695	0.470
LIG_Pex14_1	301	305	PF04695	0.456
LIG_Pex14_1	461	465	PF04695	0.632
LIG_SH2_CRK	221	225	PF00017	0.406
LIG_SH2_CRK	409	413	PF00017	0.673
LIG_SH2_CRK	54	58	PF00017	0.462
LIG_SH2_GRB2like	87	90	PF00017	0.385
LIG_SH2_NCK_1	409	413	PF00017	0.673
LIG_SH2_NCK_1	489	493	PF00017	0.725
LIG_SH2_NCK_1	87	91	PF00017	0.383
LIG_SH2_PTP2	223	226	PF00017	0.639
LIG_SH2_PTP2	376	379	PF00017	0.659
LIG_SH2_SRC	320	323	PF00017	0.717
LIG_SH2_SRC	376	379	PF00017	0.659
LIG_SH2_STAP1	316	320	PF00017	0.634
LIG_SH2_STAP1	489	493	PF00017	0.680
LIG_SH2_STAT5	159	162	PF00017	0.446
LIG_SH2_STAT5	223	226	PF00017	0.586
LIG_SH2_STAT5	26	29	PF00017	0.469
LIG_SH2_STAT5	303	306	PF00017	0.553
LIG_SH2_STAT5	376	379	PF00017	0.619
LIG_SH2_STAT5	389	392	PF00017	0.654
LIG_SH2_STAT5	87	90	PF00017	0.449
LIG_SH3_3	162	168	PF00018	0.517
LIG_SH3_3	238	244	PF00018	0.613
LIG_SH3_3	248	254	PF00018	0.713
LIG_SUMO_SIM_par_1	199	208	PF11976	0.680
LIG_TRAF2_1	202	205	PF00917	0.466
LIG_TRAF2_1	404	407	PF00917	0.702
LIG_TYR_ITSM	217	224	PF00017	0.430
MOD_CK1_1	346	352	PF00069	0.704
MOD_CK1_1	472	478	PF00069	0.714
MOD_CK1_1	71	77	PF00069	0.696
MOD_CK2_1	124	130	PF00069	0.532
MOD_CK2_1	199	205	PF00069	0.583
MOD_CK2_1	316	322	PF00069	0.675
MOD_CK2_1	401	407	PF00069	0.663
MOD_CK2_1	482	488	PF00069	0.661
MOD_CK2_1	56	62	PF00069	0.323
MOD_CK2_1	85	91	PF00069	0.565
MOD_DYRK1A_RPxSP_1	164	168	PF00069	0.602
MOD_DYRK1A_RPxSP_1	68	72	PF00069	0.432
MOD_GlcNHglycan	140	143	PF01048	0.700
MOD_GlcNHglycan	151	154	PF01048	0.432
MOD_GlcNHglycan	175	178	PF01048	0.652
MOD_GlcNHglycan	251	254	PF01048	0.681
MOD_GlcNHglycan	286	289	PF01048	0.511
MOD_GlcNHglycan	309	312	PF01048	0.700
MOD_GlcNHglycan	381	384	PF01048	0.674
MOD_GlcNHglycan	421	424	PF01048	0.682
MOD_GlcNHglycan	490	493	PF01048	0.615
MOD_GlcNHglycan	508	511	PF01048	0.437
MOD_GlcNHglycan	75	78	PF01048	0.665
MOD_GSK3_1	138	145	PF00069	0.666
MOD_GSK3_1	164	171	PF00069	0.358
MOD_GSK3_1	199	206	PF00069	0.611
MOD_GSK3_1	222	229	PF00069	0.625
MOD_GSK3_1	307	314	PF00069	0.672
MOD_GSK3_1	401	408	PF00069	0.771
MOD_GSK3_1	419	426	PF00069	0.535
MOD_GSK3_1	52	59	PF00069	0.519
MOD_GSK3_1	67	74	PF00069	0.636
MOD_GSK3_1	81	88	PF00069	0.628
MOD_N-GLC_1	173	178	PF02516	0.398
MOD_N-GLC_1	209	214	PF02516	0.630
MOD_N-GLC_1	226	231	PF02516	0.572
MOD_N-GLC_1	472	477	PF02516	0.504
MOD_NEK2_1	144	149	PF00069	0.566
MOD_NEK2_1	183	188	PF00069	0.540
MOD_NEK2_1	226	231	PF00069	0.627
MOD_NEK2_1	276	281	PF00069	0.706
MOD_NEK2_1	292	297	PF00069	0.435
MOD_NEK2_1	67	72	PF00069	0.434
MOD_NEK2_1	73	78	PF00069	0.490
MOD_PIKK_1	144	150	PF00454	0.590
MOD_PIKK_1	29	35	PF00454	0.344
MOD_PIKK_1	494	500	PF00454	0.682
MOD_PK_1	247	253	PF00069	0.488
MOD_PKA_2	2	8	PF00069	0.469
MOD_PKA_2	216	222	PF00069	0.686
MOD_PKA_2	29	35	PF00069	0.381
MOD_PKA_2	401	407	PF00069	0.638
MOD_PKA_2	469	475	PF00069	0.681
MOD_PKA_2	481	487	PF00069	0.607
MOD_PKA_2	67	73	PF00069	0.538
MOD_PKB_1	247	255	PF00069	0.494
MOD_PKB_1	403	411	PF00069	0.742
MOD_Plk_1	226	232	PF00069	0.622
MOD_Plk_1	351	357	PF00069	0.717
MOD_Plk_1	405	411	PF00069	0.740
MOD_Plk_1	472	478	PF00069	0.593
MOD_Plk_1	81	87	PF00069	0.546
MOD_Plk_4	124	130	PF00069	0.553
MOD_Plk_4	168	174	PF00069	0.391
MOD_Plk_4	2	8	PF00069	0.469
MOD_Plk_4	343	349	PF00069	0.738
MOD_Plk_4	56	62	PF00069	0.469
MOD_Plk_4	81	87	PF00069	0.390
MOD_ProDKin_1	164	170	PF00069	0.607
MOD_ProDKin_1	68	74	PF00069	0.594
MOD_SUMO_rev_2	193	200	PF00179	0.657
TRG_DiLeu_BaEn_1	196	201	PF01217	0.652
TRG_DiLeu_BaEn_1	343	348	PF01217	0.740
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.504
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.528
TRG_ENDOCYTIC_2	22	25	PF00928	0.497
TRG_ENDOCYTIC_2	221	224	PF00928	0.604
TRG_ENDOCYTIC_2	357	360	PF00928	0.653
TRG_ENDOCYTIC_2	376	379	PF00928	0.659
TRG_ENDOCYTIC_2	409	412	PF00928	0.622
TRG_ENDOCYTIC_2	54	57	PF00928	0.418
TRG_ER_diArg_1	246	249	PF00400	0.601
TRG_ER_diArg_1	324	326	PF00400	0.693
TRG_ER_diArg_1	399	402	PF00400	0.685
TRG_ER_diArg_1	469	471	PF00400	0.652
TRG_NES_CRM1_1	118	130	PF08389	0.587
TRG_NES_CRM1_1	190	205	PF08389	0.406
TRG_Pf-PMV_PEXEL_1	386	391	PF00026	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5S8	Leptomonas seymouri	40%	99%
A0A0S4JCU2	Bodo saltans	22%	100%
A0A3S7X8U0	Leishmania donovani	74%	100%
A4IAW9	Leishmania infantum	74%	100%
E9AEP7	Leishmania major	73%	100%
E9B5V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
V5DJL7	Trypanosoma cruzi	27%	100%