Endo/exonuclease/phosphatase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endonuclease/Exonuclease/phosphatase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HMA3_LEIBR

TriTrypDb:

LbrM.34.0700 , LBRM2903_340012200

Length:

522

Annotations

LeishMANIAdb annotations

A tail-anchored nuclease (hydrolase) domain protein

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HMA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	2
GO:0004519	endonuclease activity	5	2
GO:0004527	exonuclease activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.248
CLV_C14_Caspase3-7	401	405	PF00656	0.461
CLV_C14_Caspase3-7	432	436	PF00656	0.396
CLV_NRD_NRD_1	189	191	PF00675	0.501
CLV_NRD_NRD_1	299	301	PF00675	0.489
CLV_NRD_NRD_1	81	83	PF00675	0.501
CLV_PCSK_KEX2_1	148	150	PF00082	0.435
CLV_PCSK_KEX2_1	189	191	PF00082	0.500
CLV_PCSK_KEX2_1	81	83	PF00082	0.485
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.457
CLV_PCSK_SKI1_1	11	15	PF00082	0.660
CLV_PCSK_SKI1_1	160	164	PF00082	0.514
CLV_PCSK_SKI1_1	193	197	PF00082	0.487
CLV_PCSK_SKI1_1	300	304	PF00082	0.492
CLV_PCSK_SKI1_1	330	334	PF00082	0.597
CLV_PCSK_SKI1_1	493	497	PF00082	0.497
CLV_PCSK_SKI1_1	94	98	PF00082	0.400
DEG_APCC_DBOX_1	382	390	PF00400	0.366
DEG_SPOP_SBC_1	488	492	PF00917	0.371
DOC_CKS1_1	113	118	PF01111	0.217
DOC_CYCLIN_RxL_1	283	294	PF00134	0.415
DOC_CYCLIN_yCln2_LP_2	113	119	PF00134	0.377
DOC_MAPK_gen_1	189	200	PF00069	0.347
DOC_MAPK_gen_1	383	391	PF00069	0.339
DOC_MAPK_gen_1	81	88	PF00069	0.281
DOC_MAPK_gen_1	94	102	PF00069	0.297
DOC_MAPK_MEF2A_6	193	200	PF00069	0.362
DOC_PP1_RVXF_1	273	279	PF00149	0.388
DOC_PP1_RVXF_1	282	288	PF00149	0.327
DOC_PP1_RVXF_1	383	389	PF00149	0.316
DOC_PP1_RVXF_1	42	49	PF00149	0.316
DOC_USP7_MATH_1	443	447	PF00917	0.310
DOC_USP7_UBL2_3	90	94	PF12436	0.362
DOC_WW_Pin1_4	112	117	PF00397	0.266
DOC_WW_Pin1_4	130	135	PF00397	0.310
LIG_14-3-3_CanoR_1	160	165	PF00244	0.339
LIG_14-3-3_CanoR_1	190	200	PF00244	0.335
LIG_14-3-3_CanoR_1	205	213	PF00244	0.288
LIG_14-3-3_CanoR_1	244	250	PF00244	0.266
LIG_14-3-3_CanoR_1	275	279	PF00244	0.296
LIG_14-3-3_CanoR_1	286	291	PF00244	0.368
LIG_BRCT_BRCA1_1	317	321	PF00533	0.424
LIG_BRCT_BRCA1_1	39	43	PF00533	0.416
LIG_CtBP_PxDLS_1	408	412	PF00389	0.346
LIG_FHA_1	171	177	PF00498	0.215
LIG_FHA_1	280	286	PF00498	0.384
LIG_FHA_1	40	46	PF00498	0.384
LIG_FHA_1	500	506	PF00498	0.341
LIG_FHA_2	161	167	PF00498	0.290
LIG_FHA_2	345	351	PF00498	0.423
LIG_FHA_2	399	405	PF00498	0.393
LIG_FHA_2	458	464	PF00498	0.395
LIG_FHA_2	52	58	PF00498	0.380
LIG_GBD_Chelix_1	92	100	PF00786	0.513
LIG_Integrin_isoDGR_2	475	477	PF01839	0.631
LIG_LIR_Gen_1	105	113	PF02991	0.276
LIG_LIR_Gen_1	337	346	PF02991	0.383
LIG_LIR_Gen_1	387	396	PF02991	0.300
LIG_LIR_Gen_1	450	459	PF02991	0.360
LIG_LIR_Gen_1	69	78	PF02991	0.354
LIG_LIR_Gen_1	83	93	PF02991	0.296
LIG_LIR_Nem_3	105	109	PF02991	0.276
LIG_LIR_Nem_3	318	324	PF02991	0.382
LIG_LIR_Nem_3	337	343	PF02991	0.225
LIG_LIR_Nem_3	387	391	PF02991	0.294
LIG_LIR_Nem_3	40	46	PF02991	0.343
LIG_LIR_Nem_3	450	455	PF02991	0.361
LIG_LIR_Nem_3	69	73	PF02991	0.320
LIG_LIR_Nem_3	83	88	PF02991	0.213
LIG_NRP_CendR_1	519	522	PF00754	0.437
LIG_PCNA_yPIPBox_3	330	343	PF02747	0.378
LIG_Pex14_1	340	344	PF04695	0.336
LIG_Pex14_2	102	106	PF04695	0.254
LIG_PTB_Apo_2	372	379	PF02174	0.391
LIG_PTB_Apo_2	453	460	PF02174	0.348
LIG_PTB_Phospho_1	372	378	PF10480	0.434
LIG_PTB_Phospho_1	453	459	PF10480	0.405
LIG_SH2_CRK	319	323	PF00017	0.400
LIG_SH2_GRB2like	85	88	PF00017	0.362
LIG_SH2_PTP2	85	88	PF00017	0.297
LIG_SH2_SRC	342	345	PF00017	0.384
LIG_SH2_SRC	362	365	PF00017	0.168
LIG_SH2_SRC	429	432	PF00017	0.424
LIG_SH2_SRC	85	88	PF00017	0.358
LIG_SH2_STAP1	324	328	PF00017	0.389
LIG_SH2_STAP1	425	429	PF00017	0.415
LIG_SH2_STAT5	101	104	PF00017	0.285
LIG_SH2_STAT5	214	217	PF00017	0.277
LIG_SH2_STAT5	342	345	PF00017	0.400
LIG_SH2_STAT5	425	428	PF00017	0.395
LIG_SH2_STAT5	429	432	PF00017	0.396
LIG_SH2_STAT5	452	455	PF00017	0.321
LIG_SH2_STAT5	459	462	PF00017	0.337
LIG_SH2_STAT5	489	492	PF00017	0.394
LIG_SH2_STAT5	85	88	PF00017	0.292
LIG_SH3_3	83	89	PF00018	0.297
LIG_SUMO_SIM_anti_2	410	415	PF11976	0.437
LIG_TYR_ITIM	317	322	PF00017	0.444
LIG_UBA3_1	59	64	PF00899	0.329
LIG_WRC_WIRS_1	266	271	PF05994	0.200
MOD_CK1_1	133	139	PF00069	0.333
MOD_CK1_1	419	425	PF00069	0.357
MOD_CK2_1	160	166	PF00069	0.342
MOD_CK2_1	286	292	PF00069	0.340
MOD_CK2_1	344	350	PF00069	0.342
MOD_CK2_1	51	57	PF00069	0.380
MOD_GlcNHglycan	110	113	PF01048	0.491
MOD_GlcNHglycan	135	138	PF01048	0.524
MOD_GlcNHglycan	193	196	PF01048	0.560
MOD_GlcNHglycan	206	209	PF01048	0.567
MOD_GlcNHglycan	32	35	PF01048	0.601
MOD_GSK3_1	108	115	PF00069	0.269
MOD_GSK3_1	136	143	PF00069	0.382
MOD_GSK3_1	156	163	PF00069	0.259
MOD_GSK3_1	362	369	PF00069	0.334
MOD_GSK3_1	416	423	PF00069	0.357
MOD_GSK3_1	429	436	PF00069	0.379
MOD_N-GLC_1	250	255	PF02516	0.406
MOD_N-GLC_1	334	339	PF02516	0.558
MOD_N-GLC_1	416	421	PF02516	0.596
MOD_N-GLC_1	457	462	PF02516	0.614
MOD_NEK2_1	144	149	PF00069	0.354
MOD_NEK2_1	389	394	PF00069	0.258
MOD_NEK2_1	39	44	PF00069	0.435
MOD_NEK2_1	421	426	PF00069	0.392
MOD_NEK2_1	467	472	PF00069	0.407
MOD_NEK2_1	499	504	PF00069	0.346
MOD_PIKK_1	121	127	PF00454	0.319
MOD_PIKK_1	434	440	PF00454	0.348
MOD_PK_1	367	373	PF00069	0.329
MOD_PK_1	416	422	PF00069	0.416
MOD_PKA_2	204	210	PF00069	0.368
MOD_PKA_2	274	280	PF00069	0.277
MOD_PKA_2	51	57	PF00069	0.200
MOD_PKA_2	80	86	PF00069	0.301
MOD_PKB_1	242	250	PF00069	0.200
MOD_PKB_1	284	292	PF00069	0.344
MOD_Plk_1	334	340	PF00069	0.412
MOD_Plk_4	165	171	PF00069	0.362
MOD_Plk_4	245	251	PF00069	0.217
MOD_Plk_4	334	340	PF00069	0.354
MOD_Plk_4	416	422	PF00069	0.412
MOD_ProDKin_1	112	118	PF00069	0.266
MOD_ProDKin_1	130	136	PF00069	0.310
MOD_SUMO_for_1	96	99	PF00179	0.297
MOD_SUMO_rev_2	57	66	PF00179	0.362
MOD_SUMO_rev_2	7	13	PF00179	0.452
TRG_ENDOCYTIC_2	319	322	PF00928	0.431
TRG_ENDOCYTIC_2	378	381	PF00928	0.396
TRG_ENDOCYTIC_2	452	455	PF00928	0.325
TRG_ENDOCYTIC_2	85	88	PF00928	0.287
TRG_ER_diArg_1	188	190	PF00400	0.337
TRG_ER_diArg_1	196	199	PF00400	0.336
TRG_ER_diArg_1	284	287	PF00400	0.271
TRG_ER_diLys_1	517	522	PF00400	0.534
TRG_NES_CRM1_1	62	75	PF08389	0.339
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWC2	Leptomonas seymouri	66%	99%
A0A0S4JD46	Bodo saltans	40%	100%
A0A1X0NIT2	Trypanosomatidae	48%	97%
A0A3Q8IG08	Leishmania donovani	78%	98%
A0A3R7MBG8	Trypanosoma rangeli	46%	100%
A4IAW8	Leishmania infantum	78%	98%
D0A288	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AEP6	Leishmania major	79%	100%
E9B5V1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	98%
V5BN83	Trypanosoma cruzi	46%	100%