LeishMANIAdb
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Putative vacuolar ATP synthase subunit d

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative vacuolar ATP synthase subunit d
Gene product:
vacuolar ATP synthase subunit d, putative
Species:
Leishmania braziliensis
UniProt:
A4HMA2_LEIBR
TriTrypDb:
LbrM.34.0690 , LBRM2903_340012000
Length:
264

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005774 vacuolar membrane 5 1
GO:0016020 membrane 2 1
GO:0016469 proton-transporting two-sector ATPase complex 3 1
GO:0031090 organelle membrane 3 1
GO:0032991 protein-containing complex 1 1
GO:0033176 proton-transporting V-type ATPase complex 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0098796 membrane protein complex 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HMA2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMA2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0005215 transporter activity 1 12
GO:0008324 monoatomic cation transmembrane transporter activity 4 12
GO:0009678 pyrophosphate hydrolysis-driven proton transmembrane transporter activity 5 12
GO:0015075 monoatomic ion transmembrane transporter activity 3 12
GO:0015078 proton transmembrane transporter activity 5 12
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 12
GO:0015399 primary active transmembrane transporter activity 4 12
GO:0016787 hydrolase activity 2 7
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity 3 12
GO:0022804 active transmembrane transporter activity 3 12
GO:0022853 active monoatomic ion transmembrane transporter activity 4 12
GO:0022857 transmembrane transporter activity 2 12
GO:0022890 inorganic cation transmembrane transporter activity 4 12
GO:0042625 ATPase-coupled ion transmembrane transporter activity 3 12
GO:0042626 ATPase-coupled transmembrane transporter activity 2 12
GO:0044769 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism 4 12
GO:0046961 proton-transporting ATPase activity, rotational mechanism 4 12
GO:0140657 ATP-dependent activity 1 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 178 180 PF00675 0.306
CLV_PCSK_KEX2_1 178 180 PF00082 0.306
CLV_PCSK_PC7_1 174 180 PF00082 0.200
CLV_PCSK_SKI1_1 246 250 PF00082 0.560
DEG_APCC_DBOX_1 149 157 PF00400 0.363
DOC_MAPK_gen_1 34 42 PF00069 0.322
DOC_MAPK_MEF2A_6 150 159 PF00069 0.325
DOC_MAPK_NFAT4_5 150 158 PF00069 0.341
DOC_PP2B_LxvP_1 87 90 PF13499 0.322
DOC_USP7_MATH_1 127 131 PF00917 0.335
DOC_USP7_MATH_1 9 13 PF00917 0.405
DOC_USP7_UBL2_3 20 24 PF12436 0.322
DOC_USP7_UBL2_3 214 218 PF12436 0.306
DOC_USP7_UBL2_3 221 225 PF12436 0.438
LIG_14-3-3_CanoR_1 13 17 PF00244 0.311
LIG_14-3-3_CanoR_1 150 156 PF00244 0.379
LIG_14-3-3_CanoR_1 190 196 PF00244 0.322
LIG_Actin_WH2_2 10 26 PF00022 0.306
LIG_BIR_II_1 1 5 PF00653 0.519
LIG_CaM_IQ_9 213 229 PF13499 0.335
LIG_FHA_1 120 126 PF00498 0.424
LIG_FHA_1 130 136 PF00498 0.402
LIG_FHA_1 150 156 PF00498 0.123
LIG_FHA_1 162 168 PF00498 0.277
LIG_FHA_1 197 203 PF00498 0.354
LIG_FHA_1 233 239 PF00498 0.520
LIG_LIR_Gen_1 164 172 PF02991 0.309
LIG_LIR_Nem_3 144 149 PF02991 0.426
LIG_LIR_Nem_3 164 169 PF02991 0.309
LIG_LIR_Nem_3 208 213 PF02991 0.306
LIG_LIR_Nem_3 4 10 PF02991 0.442
LIG_LIR_Nem_3 65 69 PF02991 0.341
LIG_LYPXL_yS_3 7 10 PF13949 0.443
LIG_REV1ctd_RIR_1 208 218 PF16727 0.306
LIG_RPA_C_Fungi 174 186 PF08784 0.306
LIG_SH2_CRK 44 48 PF00017 0.322
LIG_SH2_STAT5 146 149 PF00017 0.387
LIG_SH2_STAT5 197 200 PF00017 0.306
LIG_SH2_STAT5 66 69 PF00017 0.322
LIG_SH3_2 8 13 PF14604 0.433
LIG_SH3_3 101 107 PF00018 0.306
LIG_SH3_3 183 189 PF00018 0.306
LIG_SH3_3 5 11 PF00018 0.440
LIG_SUMO_SIM_anti_2 152 157 PF11976 0.426
LIG_TRAF2_1 82 85 PF00917 0.306
LIG_TYR_ITIM 42 47 PF00017 0.363
LIG_WRC_WIRS_1 106 111 PF05994 0.341
MOD_CK1_1 108 114 PF00069 0.426
MOD_CK1_1 12 18 PF00069 0.253
MOD_CK1_1 121 127 PF00069 0.426
MOD_CK1_1 130 136 PF00069 0.254
MOD_CK1_1 161 167 PF00069 0.318
MOD_CK1_1 196 202 PF00069 0.354
MOD_CK1_1 65 71 PF00069 0.341
MOD_GlcNHglycan 52 55 PF01048 0.451
MOD_GSK3_1 158 165 PF00069 0.316
MOD_GSK3_1 193 200 PF00069 0.341
MOD_NEK2_1 1 6 PF00069 0.569
MOD_NEK2_1 149 154 PF00069 0.303
MOD_NEK2_1 162 167 PF00069 0.292
MOD_NEK2_1 191 196 PF00069 0.335
MOD_NEK2_1 67 72 PF00069 0.328
MOD_PIKK_1 108 114 PF00454 0.426
MOD_PIKK_1 67 73 PF00454 0.353
MOD_PKA_2 12 18 PF00069 0.311
MOD_PKA_2 149 155 PF00069 0.309
MOD_PKA_2 173 179 PF00069 0.200
MOD_Plk_1 77 83 PF00069 0.341
MOD_Plk_4 12 18 PF00069 0.305
MOD_Plk_4 151 157 PF00069 0.370
MOD_Plk_4 162 168 PF00069 0.228
MOD_Plk_4 193 199 PF00069 0.341
MOD_Plk_4 28 34 PF00069 0.295
MOD_Plk_4 62 68 PF00069 0.329
TRG_DiLeu_BaEn_4 208 214 PF01217 0.322
TRG_ENDOCYTIC_2 146 149 PF00928 0.408
TRG_ENDOCYTIC_2 44 47 PF00928 0.322
TRG_ENDOCYTIC_2 66 69 PF00928 0.322
TRG_ENDOCYTIC_2 7 10 PF00928 0.427
TRG_ER_diArg_1 178 180 PF00400 0.306
TRG_NLS_MonoCore_2 217 222 PF00514 0.316
TRG_NLS_MonoExtN_4 218 223 PF00514 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D6 Leptomonas seymouri 82% 95%
A0A0S4JFL8 Bodo saltans 68% 94%
A0A1X0NIW1 Trypanosomatidae 77% 97%
A0A3S7X8W0 Leishmania donovani 83% 96%
A0A422NBG3 Trypanosoma rangeli 66% 100%
A0PZC8 Clostridium novyi (strain NT) 29% 100%
A2RC99 Streptococcus pyogenes serotype M5 (strain Manfredo) 30% 100%
A3CK50 Streptococcus sanguinis (strain SK36) 31% 100%
A3DHP2 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) 30% 100%
A4FXD2 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 34% 100%
A4IAW7 Leishmania infantum 83% 96%
A4YI07 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 24% 100%
A5UKB0 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 32% 100%
A6UP56 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 35% 100%
A6UT37 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 36% 100%
A6VFZ4 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 33% 100%
A7FWQ5 Clostridium botulinum (strain ATCC 19397 / Type A) 29% 100%
A7GGL2 Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) 29% 100%
A7HDG7 Anaeromyxobacter sp. (strain Fw109-5) 28% 100%
A7IAU6 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 29% 100%
A8AUJ9 Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288) 31% 100%
A9AAQ2 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 33% 100%
B0K5I8 Thermoanaerobacter sp. (strain X514) 31% 100%
B0K8E6 Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E) 31% 100%
B0R751 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 29% 100%
B1ICC7 Streptococcus pneumoniae (strain Hungary19A-6) 30% 100%
B1IJM6 Clostridium botulinum (strain Okra / Type B1) 29% 100%
B1KXT4 Clostridium botulinum (strain Loch Maree / Type A3) 29% 100%
B2IP45 Streptococcus pneumoniae (strain CGSP14) 28% 100%
B2TP89 Clostridium botulinum (strain Eklund 17B / Type B) 28% 100%
B2UWY2 Clostridium botulinum (strain Alaska E43 / Type E3) 28% 100%
B4UH37 Anaeromyxobacter sp. (strain K) 30% 100%
B5E550 Streptococcus pneumoniae serotype 19F (strain G54) 29% 100%
B5XJH5 Streptococcus pyogenes serotype M49 (strain NZ131) 30% 100%
B6YV16 Thermococcus onnurineus (strain NA1) 31% 100%
B8JE33 Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258) 31% 100%
B8ZK29 Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1) 29% 100%
B9K815 Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E) 27% 100%
B9LS43 Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) 29% 100%
C1CES0 Streptococcus pneumoniae (strain JJA) 29% 100%
C1CXU5 Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115) 31% 100%
C1FTN5 Clostridium botulinum (strain Kyoto / Type A2) 29% 100%
C3L1A9 Clostridium botulinum (strain 657 / Type Ba4) 29% 100%
C3MQL3 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 23% 100%
C3MW91 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 23% 100%
C3N6D3 Sulfolobus islandicus (strain M.16.27) 23% 100%
C3NEU1 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 23% 100%
C3NGV3 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 23% 100%
C4KHU8 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 23% 100%
C5A338 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 33% 100%
C6A5E6 Thermococcus sibiricus (strain DSM 12597 / MM 739) 31% 100%
D0A289 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 93%
E9AEP5 Leishmania major 82% 100%
E9B5V0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 96%
O06506 Desulfurococcus sp. (strain SY) 31% 100%
O27034 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 33% 100%
O29099 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 28% 100%
O57731 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 32% 100%
O59823 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 93%
O59941 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 39% 100%
O83539 Treponema pallidum (strain Nichols) 28% 100%
O87880 Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) 32% 100%
O97755 Oryctolagus cuniculus 41% 100%
P0DA00 Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315) 30% 100%
P0DA01 Streptococcus pyogenes serotype M3 (strain SSI-1) 30% 100%
P32610 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
P34462 Caenorhabditis elegans 45% 100%
P39942 Bos taurus 41% 100%
P43435 Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R) 29% 100%
P57746 Mus musculus 43% 100%
P57747 Suberites domuncula 46% 100%
P62017 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 25% 100%
P87220 Candida albicans (strain SC5314 / ATCC MYA-2876) 42% 99%
Q12WK9 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 29% 100%
Q184E4 Clostridioides difficile (strain 630) 29% 100%
Q18FB9 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 27% 100%
Q1IWP5 Deinococcus geothermalis (strain DSM 11300 / AG-3a) 34% 100%
Q2IQ93 Anaeromyxobacter dehalogenans (strain 2CP-C) 31% 100%
Q2NF89 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 31% 100%
Q3IUF7 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 29% 100%
Q4J8L7 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 27% 100%
Q58032 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 32% 100%
Q5JIR1 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 31% 100%
Q5RCS8 Pongo abelii 41% 100%
Q5UXY5 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 27% 100%
Q5XE48 Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) 30% 100%
Q60188 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 30% 100%
Q61IU3 Caenorhabditis briggsae 45% 100%
Q6LYE5 Methanococcus maripaludis (strain S2 / LL) 34% 100%
Q72J74 Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) 32% 100%
Q834X7 Enterococcus faecalis (strain ATCC 700802 / V583) 27% 100%
Q86A77 Dictyostelium discoideum 45% 100%
Q8P2U4 Streptococcus pyogenes serotype M18 (strain MGAS8232) 30% 100%
Q8RI80 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 27% 100%
Q8TII9 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 30% 100%
Q8TUS9 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 31% 100%
Q8U4A4 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 32% 100%
Q97CP8 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 25% 100%
Q97QB0 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 29% 100%
Q9A1Q1 Streptococcus pyogenes serotype M1 30% 100%
Q9HM63 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 25% 100%
Q9HNE7 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 29% 100%
Q9NEF6 Drosophila melanogaster 41% 100%
Q9RWG6 Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) 32% 100%
Q9U0S4 Manduca sexta 43% 100%
Q9UWW9 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 22% 100%
Q9UXU9 Pyrococcus abyssi (strain GE5 / Orsay) 32% 100%
Q9V7D2 Drosophila melanogaster 41% 100%
Q9XGM1 Arabidopsis thaliana 43% 100%
Q9Y5K8 Homo sapiens 41% 100%
V5BSS9 Trypanosoma cruzi 62% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS