Conserved RING finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING finger protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM98_LEIBR

TriTrypDb:

LbrM.34.0650 , LBRM2903_340011600

Length:

1272

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HM98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM98

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1060	1064	PF00656	0.413
CLV_C14_Caspase3-7	1070	1074	PF00656	0.418
CLV_C14_Caspase3-7	198	202	PF00656	0.516
CLV_C14_Caspase3-7	426	430	PF00656	0.566
CLV_C14_Caspase3-7	532	536	PF00656	0.467
CLV_C14_Caspase3-7	601	605	PF00656	0.455
CLV_C14_Caspase3-7	696	700	PF00656	0.547
CLV_C14_Caspase3-7	752	756	PF00656	0.514
CLV_C14_Caspase3-7	905	909	PF00656	0.468
CLV_C14_Caspase3-7	989	993	PF00656	0.530

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X911	Leishmania donovani	67%	99%
A4IAW3	Leishmania infantum	67%	99%
E9AEP1	Leishmania major	65%	99%
E9B5U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%

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