Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP65, putative

Species:

Leishmania braziliensis

UniProt:

A4HM96_LEIBR

TriTrypDb:

LbrM.34.0630 , LBRM2903_340011300

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HM96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM96

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.543
CLV_C14_Caspase3-7	541	545	PF00656	0.603
CLV_NRD_NRD_1	12	14	PF00675	0.699
CLV_NRD_NRD_1	16	18	PF00675	0.740
CLV_NRD_NRD_1	198	200	PF00675	0.615
CLV_NRD_NRD_1	411	413	PF00675	0.537
CLV_NRD_NRD_1	445	447	PF00675	0.406
CLV_PCSK_FUR_1	13	17	PF00082	0.698
CLV_PCSK_FUR_1	195	199	PF00082	0.578
CLV_PCSK_FUR_1	443	447	PF00082	0.459
CLV_PCSK_KEX2_1	12	14	PF00082	0.699
CLV_PCSK_KEX2_1	15	17	PF00082	0.736
CLV_PCSK_KEX2_1	197	199	PF00082	0.609
CLV_PCSK_KEX2_1	411	413	PF00082	0.537
CLV_PCSK_KEX2_1	445	447	PF00082	0.409
CLV_PCSK_KEX2_1	561	563	PF00082	0.376
CLV_PCSK_PC1ET2_1	561	563	PF00082	0.376
CLV_PCSK_PC7_1	12	18	PF00082	0.755
CLV_PCSK_PC7_1	193	199	PF00082	0.565
CLV_PCSK_PC7_1	407	413	PF00082	0.488
CLV_PCSK_PC7_1	441	447	PF00082	0.419
CLV_PCSK_SKI1_1	198	202	PF00082	0.625
CLV_PCSK_SKI1_1	41	45	PF00082	0.690
CLV_PCSK_SKI1_1	501	505	PF00082	0.479
DEG_Nend_Nbox_1	1	3	PF02207	0.436
DEG_SPOP_SBC_1	142	146	PF00917	0.441
DEG_SPOP_SBC_1	215	219	PF00917	0.438
DEG_SPOP_SBC_1	361	365	PF00917	0.428
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.318
DOC_MAPK_DCC_7	561	571	PF00069	0.574
DOC_MAPK_gen_1	172	181	PF00069	0.509
DOC_MAPK_gen_1	501	509	PF00069	0.661
DOC_MAPK_gen_1	561	568	PF00069	0.628
DOC_MAPK_MEF2A_6	125	132	PF00069	0.260
DOC_MAPK_MEF2A_6	172	181	PF00069	0.446
DOC_MAPK_MEF2A_6	561	570	PF00069	0.637
DOC_MAPK_MEF2A_6	580	588	PF00069	0.281
DOC_PP1_SILK_1	37	42	PF00149	0.533
DOC_PP2B_LxvP_1	229	232	PF13499	0.436
DOC_PP4_FxxP_1	132	135	PF00568	0.300
DOC_PP4_FxxP_1	358	361	PF00568	0.448
DOC_SPAK_OSR1_1	379	383	PF12202	0.403
DOC_USP7_MATH_1	215	219	PF00917	0.520
DOC_USP7_MATH_1	235	239	PF00917	0.408
DOC_USP7_MATH_1	243	247	PF00917	0.487
DOC_USP7_MATH_1	276	280	PF00917	0.462
DOC_USP7_MATH_1	294	298	PF00917	0.518
DOC_USP7_MATH_1	35	39	PF00917	0.488
DOC_USP7_MATH_1	361	365	PF00917	0.428
DOC_USP7_MATH_1	397	401	PF00917	0.695
DOC_USP7_MATH_1	437	441	PF00917	0.692
DOC_USP7_MATH_2	460	466	PF00917	0.648
DOC_WW_Pin1_4	131	136	PF00397	0.279
DOC_WW_Pin1_4	21	26	PF00397	0.568
DOC_WW_Pin1_4	227	232	PF00397	0.504
DOC_WW_Pin1_4	233	238	PF00397	0.478
DOC_WW_Pin1_4	272	277	PF00397	0.460
DOC_WW_Pin1_4	285	290	PF00397	0.460
DOC_WW_Pin1_4	362	367	PF00397	0.475
DOC_WW_Pin1_4	428	433	PF00397	0.732
DOC_WW_Pin1_4	456	461	PF00397	0.612
DOC_WW_Pin1_4	490	495	PF00397	0.673
DOC_WW_Pin1_4	70	75	PF00397	0.411
LIG_14-3-3_CanoR_1	143	148	PF00244	0.445
LIG_14-3-3_CanoR_1	161	170	PF00244	0.408
LIG_14-3-3_CanoR_1	172	178	PF00244	0.381
LIG_14-3-3_CanoR_1	271	276	PF00244	0.505
LIG_14-3-3_CanoR_1	291	297	PF00244	0.450
LIG_14-3-3_CanoR_1	349	355	PF00244	0.423
LIG_14-3-3_CanoR_1	419	429	PF00244	0.637
LIG_14-3-3_CanoR_1	443	449	PF00244	0.619
LIG_14-3-3_CanoR_1	580	585	PF00244	0.403
LIG_APCC_ABBAyCdc20_2	185	191	PF00400	0.424
LIG_BRCT_BRCA1_1	145	149	PF00533	0.435
LIG_BRCT_BRCA1_1	355	359	PF00533	0.444
LIG_BRCT_BRCA1_1	399	403	PF00533	0.583
LIG_BRCT_BRCA1_2	399	405	PF00533	0.590
LIG_eIF4E_1	581	587	PF01652	0.318
LIG_FHA_1	217	223	PF00498	0.515
LIG_FHA_1	34	40	PF00498	0.531
LIG_FHA_1	369	375	PF00498	0.355
LIG_FHA_1	516	522	PF00498	0.662
LIG_FHA_1	85	91	PF00498	0.340
LIG_FHA_2	122	128	PF00498	0.312
LIG_FHA_2	153	159	PF00498	0.454
LIG_FHA_2	281	287	PF00498	0.536
LIG_FHA_2	3	9	PF00498	0.450
LIG_FHA_2	536	542	PF00498	0.717
LIG_FHA_2	550	556	PF00498	0.617
LIG_FHA_2	71	77	PF00498	0.522
LIG_LIR_Apic_2	356	361	PF02991	0.445
LIG_LIR_Gen_1	126	136	PF02991	0.279
LIG_LIR_Gen_1	387	397	PF02991	0.235
LIG_LIR_Gen_1	459	469	PF02991	0.596
LIG_LIR_Gen_1	487	496	PF02991	0.614
LIG_LIR_Gen_1	534	543	PF02991	0.705
LIG_LIR_Gen_1	585	594	PF02991	0.348
LIG_LIR_Gen_1	86	96	PF02991	0.234
LIG_LIR_Nem_3	104	109	PF02991	0.191
LIG_LIR_Nem_3	126	132	PF02991	0.279
LIG_LIR_Nem_3	319	325	PF02991	0.523
LIG_LIR_Nem_3	338	344	PF02991	0.381
LIG_LIR_Nem_3	371	376	PF02991	0.316
LIG_LIR_Nem_3	387	392	PF02991	0.193
LIG_LIR_Nem_3	459	464	PF02991	0.597
LIG_LIR_Nem_3	465	469	PF02991	0.574
LIG_LIR_Nem_3	487	491	PF02991	0.614
LIG_LIR_Nem_3	534	540	PF02991	0.683
LIG_LIR_Nem_3	585	590	PF02991	0.348
LIG_LIR_Nem_3	86	91	PF02991	0.234
LIG_MLH1_MIPbox_1	355	359	PF16413	0.444
LIG_PCNA_yPIPBox_3	71	84	PF02747	0.482
LIG_Pex14_1	577	581	PF04695	0.318
LIG_REV1ctd_RIR_1	401	411	PF16727	0.603
LIG_SH2_CRK	469	473	PF00017	0.585
LIG_SH2_CRK	581	585	PF00017	0.318
LIG_SH2_NCK_1	325	329	PF00017	0.511
LIG_SH2_STAP1	147	151	PF00017	0.372
LIG_SH2_STAT3	495	498	PF00017	0.678
LIG_SH2_STAT5	105	108	PF00017	0.346
LIG_SH2_STAT5	109	112	PF00017	0.316
LIG_SH2_STAT5	117	120	PF00017	0.271
LIG_SH2_STAT5	129	132	PF00017	0.312
LIG_SH2_STAT5	471	474	PF00017	0.629
LIG_SH2_STAT5	72	75	PF00017	0.522
LIG_SH3_1	470	476	PF00018	0.592
LIG_SH3_2	170	175	PF14604	0.489
LIG_SH3_3	167	173	PF00018	0.534
LIG_SH3_3	202	208	PF00018	0.388
LIG_SH3_3	260	266	PF00018	0.510
LIG_SH3_3	426	432	PF00018	0.708
LIG_SH3_3	470	476	PF00018	0.592
LIG_SH3_3	49	55	PF00018	0.423
LIG_SH3_3	568	574	PF00018	0.568
LIG_SH3_3	64	70	PF00018	0.425
LIG_SH3_CIN85_PxpxPR_1	414	419	PF14604	0.624
LIG_SUMO_SIM_anti_2	176	181	PF11976	0.350
LIG_SUMO_SIM_par_1	381	387	PF11976	0.315
LIG_SUMO_SIM_par_1	97	104	PF11976	0.279
LIG_TYR_ITIM	467	472	PF00017	0.462
LIG_WRC_WIRS_1	160	165	PF05994	0.521
LIG_WRC_WIRS_1	341	346	PF05994	0.511
LIG_WRC_WIRS_1	463	468	PF05994	0.548
LIG_WW_1	69	72	PF00397	0.530
LIG_WW_3	172	176	PF00397	0.594
LIG_WW_3	68	72	PF00397	0.537
MOD_CDC14_SPxK_1	288	291	PF00782	0.534
MOD_CDK_SPK_2	362	367	PF00069	0.440
MOD_CDK_SPxK_1	285	291	PF00069	0.542
MOD_CDK_SPxxK_3	362	369	PF00069	0.597
MOD_CK1_1	145	151	PF00069	0.538
MOD_CK1_1	230	236	PF00069	0.816
MOD_CK1_1	238	244	PF00069	0.636
MOD_CK1_1	274	280	PF00069	0.670
MOD_CK1_1	290	296	PF00069	0.669
MOD_CK1_1	297	303	PF00069	0.577
MOD_CK1_1	431	437	PF00069	0.516
MOD_CK1_1	515	521	PF00069	0.568
MOD_CK1_1	582	588	PF00069	0.332
MOD_CK1_1	86	92	PF00069	0.268
MOD_CK2_1	121	127	PF00069	0.261
MOD_CK2_1	152	158	PF00069	0.553
MOD_CK2_1	280	286	PF00069	0.664
MOD_CK2_1	456	462	PF00069	0.495
MOD_CK2_1	535	541	PF00069	0.651
MOD_CK2_1	549	555	PF00069	0.516
MOD_CK2_1	70	76	PF00069	0.669
MOD_CMANNOS	386	389	PF00535	0.403
MOD_GlcNHglycan	163	166	PF01048	0.579
MOD_GlcNHglycan	233	236	PF01048	0.721
MOD_GlcNHglycan	240	244	PF01048	0.828
MOD_GlcNHglycan	276	279	PF01048	0.704
MOD_GlcNHglycan	292	295	PF01048	0.747
MOD_GlcNHglycan	296	299	PF01048	0.656
MOD_GlcNHglycan	304	307	PF01048	0.601
MOD_GlcNHglycan	310	313	PF01048	0.614
MOD_GlcNHglycan	456	459	PF01048	0.507
MOD_GlcNHglycan	91	94	PF01048	0.403
MOD_GSK3_1	116	123	PF00069	0.373
MOD_GSK3_1	141	148	PF00069	0.446
MOD_GSK3_1	216	223	PF00069	0.731
MOD_GSK3_1	227	234	PF00069	0.710
MOD_GSK3_1	235	242	PF00069	0.559
MOD_GSK3_1	270	277	PF00069	0.691
MOD_GSK3_1	280	287	PF00069	0.611
MOD_GSK3_1	29	36	PF00069	0.602
MOD_GSK3_1	290	297	PF00069	0.613
MOD_GSK3_1	420	427	PF00069	0.674
MOD_GSK3_1	531	538	PF00069	0.631
MOD_N-GLC_1	152	157	PF02516	0.442
MOD_NEK2_1	120	125	PF00069	0.429
MOD_NEK2_1	239	244	PF00069	0.650
MOD_NEK2_1	292	297	PF00069	0.713
MOD_NEK2_1	308	313	PF00069	0.524
MOD_NEK2_1	340	345	PF00069	0.678
MOD_NEK2_1	384	389	PF00069	0.403
MOD_NEK2_1	444	449	PF00069	0.540
MOD_NEK2_1	503	508	PF00069	0.518
MOD_NEK2_1	83	88	PF00069	0.562
MOD_PIKK_1	424	430	PF00454	0.702
MOD_PKA_2	142	148	PF00069	0.541
MOD_PKA_2	243	249	PF00069	0.595
MOD_PKA_2	270	276	PF00069	0.730
MOD_PKA_2	290	296	PF00069	0.591
MOD_PKA_2	368	374	PF00069	0.658
MOD_PKA_2	444	450	PF00069	0.579
MOD_PKA_2	549	555	PF00069	0.652
MOD_PKA_2	579	585	PF00069	0.403
MOD_PKB_1	269	277	PF00069	0.564
MOD_Plk_1	532	538	PF00069	0.599
MOD_Plk_4	35	41	PF00069	0.672
MOD_Plk_4	350	356	PF00069	0.620
MOD_Plk_4	397	403	PF00069	0.457
MOD_Plk_4	503	509	PF00069	0.522
MOD_Plk_4	582	588	PF00069	0.318
MOD_ProDKin_1	131	137	PF00069	0.318
MOD_ProDKin_1	21	27	PF00069	0.723
MOD_ProDKin_1	227	233	PF00069	0.634
MOD_ProDKin_1	272	278	PF00069	0.571
MOD_ProDKin_1	285	291	PF00069	0.571
MOD_ProDKin_1	362	368	PF00069	0.580
MOD_ProDKin_1	428	434	PF00069	0.672
MOD_ProDKin_1	456	462	PF00069	0.495
MOD_ProDKin_1	490	496	PF00069	0.585
MOD_ProDKin_1	70	76	PF00069	0.496
TRG_DiLeu_BaEn_1	565	570	PF01217	0.537
TRG_DiLeu_BaEn_2	461	467	PF01217	0.461
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.642
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.553
TRG_ENDOCYTIC_2	117	120	PF00928	0.401
TRG_ENDOCYTIC_2	129	132	PF00928	0.257
TRG_ENDOCYTIC_2	341	344	PF00928	0.515
TRG_ENDOCYTIC_2	375	378	PF00928	0.318
TRG_ENDOCYTIC_2	469	472	PF00928	0.467
TRG_ENDOCYTIC_2	581	584	PF00928	0.318
TRG_ENDOCYTIC_2	72	75	PF00928	0.657
TRG_ER_diArg_1	12	15	PF00400	0.632
TRG_ER_diArg_1	195	198	PF00400	0.487
TRG_ER_diArg_1	266	269	PF00400	0.615
TRG_ER_diArg_1	366	369	PF00400	0.420
TRG_ER_diArg_1	442	445	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRZ6	Leptomonas seymouri	46%	100%
A0A3S7X8T0	Leishmania donovani	79%	100%
A4IAW0	Leishmania infantum	79%	100%
E9AEN8	Leishmania major	77%	100%
E9B5U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%