GPI transamidase component Tta2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HM95_LEIBR

TriTrypDb:

LbrM.34.0620 , LBRM2903_340011200

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HM95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.391
CLV_C14_Caspase3-7	132	136	PF00656	0.470
CLV_C14_Caspase3-7	163	167	PF00656	0.506
CLV_C14_Caspase3-7	369	373	PF00656	0.469
CLV_NRD_NRD_1	199	201	PF00675	0.610
CLV_NRD_NRD_1	22	24	PF00675	0.428
CLV_NRD_NRD_1	29	31	PF00675	0.382
CLV_NRD_NRD_1	56	58	PF00675	0.614
CLV_NRD_NRD_1	81	83	PF00675	0.689
CLV_PCSK_KEX2_1	190	192	PF00082	0.614
CLV_PCSK_KEX2_1	199	201	PF00082	0.603
CLV_PCSK_KEX2_1	22	24	PF00082	0.428
CLV_PCSK_KEX2_1	28	30	PF00082	0.390
CLV_PCSK_KEX2_1	56	58	PF00082	0.614
CLV_PCSK_KEX2_1	81	83	PF00082	0.689
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.550
CLV_PCSK_SKI1_1	190	194	PF00082	0.586
CLV_PCSK_SKI1_1	200	204	PF00082	0.632
CLV_PCSK_SKI1_1	254	258	PF00082	0.585
CLV_PCSK_SKI1_1	30	34	PF00082	0.272
CLV_PCSK_SKI1_1	64	68	PF00082	0.640
DEG_APCC_DBOX_1	130	138	PF00400	0.466
DEG_APCC_DBOX_1	198	206	PF00400	0.361
DEG_APCC_DBOX_1	63	71	PF00400	0.445
DEG_MDM2_SWIB_1	34	42	PF02201	0.308
DEG_SIAH_1	340	348	PF03145	0.496
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.502
DOC_MAPK_gen_1	173	182	PF00069	0.466
DOC_MAPK_gen_1	190	198	PF00069	0.323
DOC_MAPK_gen_1	199	205	PF00069	0.347
DOC_MAPK_gen_1	28	37	PF00069	0.420
DOC_MAPK_HePTP_8	25	37	PF00069	0.420
DOC_MAPK_MEF2A_6	259	268	PF00069	0.355
DOC_MAPK_MEF2A_6	28	37	PF00069	0.420
DOC_MAPK_MEF2A_6	64	71	PF00069	0.346
DOC_MAPK_NFAT4_5	30	38	PF00069	0.420
DOC_MAPK_NFAT4_5	64	72	PF00069	0.350
DOC_PP2B_LxvP_1	69	72	PF13499	0.467
DOC_PP4_FxxP_1	138	141	PF00568	0.428
DOC_PP4_FxxP_1	46	49	PF00568	0.308
DOC_USP7_MATH_1	103	107	PF00917	0.418
DOC_USP7_MATH_1	307	311	PF00917	0.437
DOC_USP7_UBL2_3	211	215	PF12436	0.387
DOC_WW_Pin1_4	161	166	PF00397	0.403
DOC_WW_Pin1_4	350	355	PF00397	0.487
LIG_14-3-3_CanoR_1	173	178	PF00244	0.429
LIG_14-3-3_CanoR_1	22	26	PF00244	0.598
LIG_14-3-3_CanoR_1	254	261	PF00244	0.379
LIG_14-3-3_CanoR_1	271	281	PF00244	0.359
LIG_14-3-3_CanoR_1	295	303	PF00244	0.472
LIG_14-3-3_CanoR_1	91	98	PF00244	0.497
LIG_Clathr_ClatBox_1	355	359	PF01394	0.460
LIG_FHA_1	22	28	PF00498	0.646
LIG_FHA_1	255	261	PF00498	0.418
LIG_FHA_1	311	317	PF00498	0.410
LIG_FHA_1	71	77	PF00498	0.478
LIG_FHA_2	130	136	PF00498	0.464
LIG_FHA_2	174	180	PF00498	0.425
LIG_FHA_2	208	214	PF00498	0.391
LIG_FHA_2	275	281	PF00498	0.385
LIG_FHA_2	297	303	PF00498	0.387
LIG_FHA_2	367	373	PF00498	0.474
LIG_LIR_Apic_2	135	141	PF02991	0.475
LIG_LIR_Apic_2	44	49	PF02991	0.308
LIG_LIR_Nem_3	300	306	PF02991	0.399
LIG_NRBOX	260	266	PF00104	0.454
LIG_Pex14_2	120	124	PF04695	0.408
LIG_Pex14_2	34	38	PF04695	0.351
LIG_Pex14_2	46	50	PF04695	0.351
LIG_RPA_C_Fungi	170	182	PF08784	0.455
LIG_SH2_CRK	52	56	PF00017	0.535
LIG_SH2_SRC	125	128	PF00017	0.576
LIG_SH2_STAT3	336	339	PF00017	0.439
LIG_SH2_STAT5	125	128	PF00017	0.705
LIG_SH2_STAT5	142	145	PF00017	0.595
LIG_SH2_STAT5	329	332	PF00017	0.530
LIG_SH3_3	13	19	PF00018	0.430
LIG_SH3_3	150	156	PF00018	0.605
LIG_SH3_3	234	240	PF00018	0.648
LIG_SH3_3	335	341	PF00018	0.592
LIG_SUMO_SIM_par_1	72	77	PF11976	0.599
LIG_TRAF2_1	277	280	PF00917	0.613
LIG_TRAF2_1	319	322	PF00917	0.719
LIG_TYR_ITIM	2	7	PF00017	0.481
MOD_CK1_1	129	135	PF00069	0.676
MOD_CK1_1	310	316	PF00069	0.581
MOD_CK1_1	348	354	PF00069	0.599
MOD_CK1_1	366	372	PF00069	0.692
MOD_CK2_1	173	179	PF00069	0.537
MOD_CK2_1	207	213	PF00069	0.475
MOD_CK2_1	274	280	PF00069	0.496
MOD_CK2_1	59	65	PF00069	0.512
MOD_CK2_1	98	104	PF00069	0.589
MOD_GlcNHglycan	104	108	PF01048	0.556
MOD_GlcNHglycan	348	351	PF01048	0.660
MOD_GlcNHglycan	364	368	PF01048	0.475
MOD_GSK3_1	103	110	PF00069	0.583
MOD_GSK3_1	125	132	PF00069	0.606
MOD_GSK3_1	169	176	PF00069	0.512
MOD_GSK3_1	205	212	PF00069	0.494
MOD_GSK3_1	266	273	PF00069	0.458
MOD_GSK3_1	293	300	PF00069	0.565
MOD_GSK3_1	307	314	PF00069	0.581
MOD_GSK3_1	346	353	PF00069	0.649
MOD_GSK3_1	92	99	PF00069	0.623
MOD_LATS_1	272	278	PF00433	0.473
MOD_NEK2_1	126	131	PF00069	0.473
MOD_NEK2_1	222	227	PF00069	0.619
MOD_NEK2_1	266	271	PF00069	0.542
MOD_NEK2_1	293	298	PF00069	0.676
MOD_NEK2_1	363	368	PF00069	0.654
MOD_NEK2_1	41	46	PF00069	0.228
MOD_PIKK_1	274	280	PF00454	0.473
MOD_PIKK_1	331	337	PF00454	0.456
MOD_PKA_2	21	27	PF00069	0.523
MOD_PKA_2	238	244	PF00069	0.539
MOD_PKA_2	270	276	PF00069	0.475
MOD_PKA_2	297	303	PF00069	0.585
MOD_PKA_2	96	102	PF00069	0.548
MOD_PKB_1	173	181	PF00069	0.518
MOD_PKB_1	57	65	PF00069	0.514
MOD_PKB_1	89	97	PF00069	0.520
MOD_Plk_1	107	113	PF00069	0.490
MOD_Plk_2-3	209	215	PF00069	0.474
MOD_Plk_4	260	266	PF00069	0.440
MOD_Plk_4	3	9	PF00069	0.480
MOD_Plk_4	41	47	PF00069	0.323
MOD_ProDKin_1	161	167	PF00069	0.491
MOD_ProDKin_1	350	356	PF00069	0.609
MOD_SUMO_rev_2	208	216	PF00179	0.529
TRG_DiLeu_BaEn_1	214	219	PF01217	0.584
TRG_DiLeu_BaEn_1	65	70	PF01217	0.553
TRG_ENDOCYTIC_2	329	332	PF00928	0.530
TRG_ENDOCYTIC_2	4	7	PF00928	0.512
TRG_ENDOCYTIC_2	52	55	PF00928	0.530
TRG_ER_diArg_1	131	134	PF00400	0.595
TRG_ER_diArg_1	198	200	PF00400	0.483
TRG_ER_diArg_1	27	30	PF00400	0.449
TRG_ER_diArg_1	55	57	PF00400	0.500
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGT9	Leptomonas seymouri	41%	100%
A0A3Q8IEV9	Leishmania donovani	78%	100%
A4IAV9	Leishmania infantum	79%	98%
E9AEN7	Leishmania major	74%	100%
E9B5U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%