Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM92_LEIBR

TriTrypDb:

LbrM.34.0590 , LBRM2903_340010900

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.685
CLV_C14_Caspase3-7	497	501	PF00656	0.704
CLV_C14_Caspase3-7	76	80	PF00656	0.484
CLV_NRD_NRD_1	163	165	PF00675	0.642
CLV_NRD_NRD_1	286	288	PF00675	0.678
CLV_NRD_NRD_1	290	292	PF00675	0.674
CLV_NRD_NRD_1	298	300	PF00675	0.688
CLV_NRD_NRD_1	307	309	PF00675	0.716
CLV_NRD_NRD_1	449	451	PF00675	0.757
CLV_NRD_NRD_1	670	672	PF00675	0.742
CLV_PCSK_FUR_1	287	291	PF00082	0.676
CLV_PCSK_FUR_1	305	309	PF00082	0.687
CLV_PCSK_KEX2_1	288	290	PF00082	0.675
CLV_PCSK_KEX2_1	298	300	PF00082	0.689
CLV_PCSK_KEX2_1	307	309	PF00082	0.707
CLV_PCSK_KEX2_1	448	450	PF00082	0.767
CLV_PCSK_KEX2_1	470	472	PF00082	0.525
CLV_PCSK_KEX2_1	670	672	PF00082	0.742
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.671
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.489
CLV_PCSK_SKI1_1	165	169	PF00082	0.682
CLV_PCSK_SKI1_1	419	423	PF00082	0.664
CLV_PCSK_SKI1_1	449	453	PF00082	0.748
DEG_APCC_DBOX_1	142	150	PF00400	0.744
DEG_APCC_DBOX_1	290	298	PF00400	0.523
DEG_APCC_DBOX_1	448	456	PF00400	0.743
DEG_SCF_FBW7_1	72	78	PF00400	0.497
DEG_SPOP_SBC_1	333	337	PF00917	0.663
DOC_CKS1_1	29	34	PF01111	0.509
DOC_CKS1_1	653	658	PF01111	0.536
DOC_CKS1_1	72	77	PF01111	0.560
DOC_MAPK_gen_1	448	457	PF00069	0.644
DOC_MAPK_MEF2A_6	677	686	PF00069	0.712
DOC_MAPK_NFAT4_5	677	685	PF00069	0.712
DOC_PP2B_LxvP_1	422	425	PF13499	0.653
DOC_USP7_MATH_1	230	234	PF00917	0.523
DOC_USP7_MATH_1	310	314	PF00917	0.645
DOC_USP7_MATH_1	327	331	PF00917	0.715
DOC_USP7_MATH_1	333	337	PF00917	0.669
DOC_USP7_MATH_1	339	343	PF00917	0.611
DOC_USP7_MATH_1	390	394	PF00917	0.623
DOC_USP7_MATH_1	417	421	PF00917	0.737
DOC_USP7_MATH_1	43	47	PF00917	0.574
DOC_USP7_MATH_1	432	436	PF00917	0.654
DOC_USP7_MATH_1	475	479	PF00917	0.478
DOC_USP7_MATH_1	584	588	PF00917	0.497
DOC_USP7_MATH_1	626	630	PF00917	0.684
DOC_USP7_MATH_1	662	666	PF00917	0.731
DOC_USP7_MATH_1	73	77	PF00917	0.508
DOC_USP7_MATH_1	92	96	PF00917	0.639
DOC_USP7_UBL2_3	258	262	PF12436	0.546
DOC_WW_Pin1_4	251	256	PF00397	0.730
DOC_WW_Pin1_4	28	33	PF00397	0.643
DOC_WW_Pin1_4	386	391	PF00397	0.683
DOC_WW_Pin1_4	487	492	PF00397	0.750
DOC_WW_Pin1_4	639	644	PF00397	0.575
DOC_WW_Pin1_4	652	657	PF00397	0.524
DOC_WW_Pin1_4	71	76	PF00397	0.566
LIG_14-3-3_CanoR_1	116	126	PF00244	0.641
LIG_14-3-3_CanoR_1	164	170	PF00244	0.570
LIG_14-3-3_CanoR_1	217	225	PF00244	0.594
LIG_14-3-3_CanoR_1	317	325	PF00244	0.764
LIG_14-3-3_CanoR_1	392	401	PF00244	0.520
LIG_14-3-3_CanoR_1	515	523	PF00244	0.480
LIG_BRCT_BRCA1_1	193	197	PF00533	0.757
LIG_BRCT_BRCA1_1	472	476	PF00533	0.487
LIG_CSL_BTD_1	8	11	PF09270	0.522
LIG_deltaCOP1_diTrp_1	154	157	PF00928	0.577
LIG_FHA_1	105	111	PF00498	0.630
LIG_FHA_1	164	170	PF00498	0.586
LIG_FHA_1	266	272	PF00498	0.759
LIG_FHA_1	329	335	PF00498	0.633
LIG_FHA_1	431	437	PF00498	0.688
LIG_FHA_1	459	465	PF00498	0.604
LIG_FHA_1	500	506	PF00498	0.725
LIG_FHA_2	246	252	PF00498	0.780
LIG_FHA_2	336	342	PF00498	0.692
LIG_LIR_Gen_1	107	117	PF02991	0.648
LIG_LIR_Gen_1	153	159	PF02991	0.770
LIG_LIR_Gen_1	409	417	PF02991	0.464
LIG_LIR_Gen_1	511	520	PF02991	0.716
LIG_LIR_Gen_1	554	563	PF02991	0.532
LIG_LIR_Nem_3	107	112	PF02991	0.639
LIG_LIR_Nem_3	153	158	PF02991	0.672
LIG_LIR_Nem_3	194	200	PF02991	0.741
LIG_LIR_Nem_3	409	414	PF02991	0.463
LIG_LIR_Nem_3	473	479	PF02991	0.479
LIG_LIR_Nem_3	511	516	PF02991	0.610
LIG_LIR_Nem_3	521	526	PF02991	0.663
LIG_LIR_Nem_3	554	558	PF02991	0.518
LIG_MLH1_MIPbox_1	193	197	PF16413	0.757
LIG_PCNA_PIPBox_1	190	199	PF02747	0.648
LIG_PDZ_Wminus1_1	705	707	PF00595	0.504
LIG_Pex14_1	672	676	PF04695	0.722
LIG_SH2_CRK	267	271	PF00017	0.551
LIG_SH2_NCK_1	654	658	PF00017	0.534
LIG_SH2_STAP1	151	155	PF00017	0.757
LIG_SH2_STAP1	267	271	PF00017	0.551
LIG_SH2_STAP1	407	411	PF00017	0.674
LIG_SH2_STAP1	611	615	PF00017	0.584
LIG_SH2_STAT5	267	270	PF00017	0.552
LIG_SH2_STAT5	347	350	PF00017	0.635
LIG_SH2_STAT5	411	414	PF00017	0.557
LIG_SH2_STAT5	523	526	PF00017	0.518
LIG_SH2_STAT5	654	657	PF00017	0.535
LIG_SH3_2	570	575	PF14604	0.489
LIG_SH3_3	267	273	PF00018	0.800
LIG_SH3_3	5	11	PF00018	0.660
LIG_SH3_3	564	570	PF00018	0.766
LIG_SH3_3	63	69	PF00018	0.577
LIG_TRAF2_1	160	163	PF00917	0.732
LIG_TRAF2_1	451	454	PF00917	0.739
LIG_TRAF2_1	689	692	PF00917	0.488
LIG_UBA3_1	348	352	PF00899	0.748
LIG_WRC_WIRS_1	193	198	PF05994	0.755
MOD_CDC14_SPxK_1	389	392	PF00782	0.543
MOD_CDK_SPxK_1	386	392	PF00069	0.546
MOD_CDK_SPxxK_3	251	258	PF00069	0.728
MOD_CK1_1	101	107	PF00069	0.715
MOD_CK1_1	328	334	PF00069	0.725
MOD_CK1_1	406	412	PF00069	0.482
MOD_CK1_1	551	557	PF00069	0.499
MOD_CK1_1	621	627	PF00069	0.742
MOD_CK2_1	157	163	PF00069	0.674
MOD_CK2_1	315	321	PF00069	0.550
MOD_CK2_1	39	45	PF00069	0.776
MOD_CK2_1	390	396	PF00069	0.674
MOD_CK2_1	662	668	PF00069	0.652
MOD_CMANNOS	139	142	PF00535	0.772
MOD_GlcNHglycan	130	133	PF01048	0.778
MOD_GlcNHglycan	318	321	PF01048	0.640
MOD_GlcNHglycan	325	328	PF01048	0.611
MOD_GlcNHglycan	360	363	PF01048	0.788
MOD_GlcNHglycan	41	44	PF01048	0.753
MOD_GlcNHglycan	419	422	PF01048	0.748
MOD_GlcNHglycan	45	48	PF01048	0.716
MOD_GlcNHglycan	472	475	PF01048	0.487
MOD_GlcNHglycan	526	529	PF01048	0.697
MOD_GlcNHglycan	619	623	PF01048	0.780
MOD_GlcNHglycan	628	631	PF01048	0.671
MOD_GlcNHglycan	664	667	PF01048	0.629
MOD_GlcNHglycan	75	78	PF01048	0.533
MOD_GlcNHglycan	95	98	PF01048	0.614
MOD_GSK3_1	128	135	PF00069	0.593
MOD_GSK3_1	241	248	PF00069	0.819
MOD_GSK3_1	321	328	PF00069	0.713
MOD_GSK3_1	335	342	PF00069	0.618
MOD_GSK3_1	380	387	PF00069	0.753
MOD_GSK3_1	39	46	PF00069	0.711
MOD_GSK3_1	402	409	PF00069	0.482
MOD_GSK3_1	440	447	PF00069	0.581
MOD_GSK3_1	495	502	PF00069	0.671
MOD_GSK3_1	514	521	PF00069	0.538
MOD_GSK3_1	522	529	PF00069	0.591
MOD_GSK3_1	547	554	PF00069	0.592
MOD_GSK3_1	584	591	PF00069	0.638
MOD_GSK3_1	635	642	PF00069	0.695
MOD_GSK3_1	662	669	PF00069	0.597
MOD_GSK3_1	71	78	PF00069	0.572
MOD_LATS_1	39	45	PF00433	0.523
MOD_N-GLC_1	101	106	PF02516	0.664
MOD_N-GLC_1	444	449	PF02516	0.517
MOD_N-GLC_1	666	671	PF02516	0.492
MOD_N-GLC_2	540	542	PF02516	0.704
MOD_N-GLC_2	80	82	PF02516	0.485
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	157	162	PF00069	0.670
MOD_NEK2_1	283	288	PF00069	0.690
MOD_NEK2_1	315	320	PF00069	0.693
MOD_NEK2_1	325	330	PF00069	0.810
MOD_NEK2_1	384	389	PF00069	0.637
MOD_NEK2_1	401	406	PF00069	0.585
MOD_NEK2_1	494	499	PF00069	0.758
MOD_NEK2_1	524	529	PF00069	0.661
MOD_NEK2_2	192	197	PF00069	0.754
MOD_NEK2_2	347	352	PF00069	0.551
MOD_NEK2_2	380	385	PF00069	0.553
MOD_PIKK_1	157	163	PF00454	0.772
MOD_PIKK_1	245	251	PF00454	0.575
MOD_PIKK_1	292	298	PF00454	0.776
MOD_PIKK_1	384	390	PF00454	0.547
MOD_PIKK_1	514	520	PF00454	0.704
MOD_PIKK_1	532	538	PF00454	0.598
MOD_PIKK_1	624	630	PF00454	0.569
MOD_PK_1	641	647	PF00069	0.685
MOD_PKA_1	470	476	PF00069	0.522
MOD_PKA_2	163	169	PF00069	0.567
MOD_PKA_2	216	222	PF00069	0.720
MOD_PKA_2	316	322	PF00069	0.788
MOD_PKA_2	391	397	PF00069	0.535
MOD_PKA_2	470	476	PF00069	0.619
MOD_PKA_2	514	520	PF00069	0.466
MOD_PKA_2	662	668	PF00069	0.696
MOD_PKB_1	143	151	PF00069	0.762
MOD_Plk_1	499	505	PF00069	0.733
MOD_Plk_1	518	524	PF00069	0.430
MOD_Plk_4	145	151	PF00069	0.653
MOD_Plk_4	192	198	PF00069	0.753
MOD_Plk_4	230	236	PF00069	0.607
MOD_Plk_4	266	272	PF00069	0.799
MOD_Plk_4	406	412	PF00069	0.510
MOD_Plk_4	499	505	PF00069	0.698
MOD_ProDKin_1	251	257	PF00069	0.728
MOD_ProDKin_1	28	34	PF00069	0.644
MOD_ProDKin_1	386	392	PF00069	0.685
MOD_ProDKin_1	487	493	PF00069	0.751
MOD_ProDKin_1	639	645	PF00069	0.575
MOD_ProDKin_1	652	658	PF00069	0.523
MOD_ProDKin_1	71	77	PF00069	0.563
MOD_SUMO_for_1	180	183	PF00179	0.782
MOD_SUMO_rev_2	160	167	PF00179	0.709
TRG_ENDOCYTIC_2	267	270	PF00928	0.552
TRG_ENDOCYTIC_2	411	414	PF00928	0.616
TRG_ENDOCYTIC_2	523	526	PF00928	0.518
TRG_ER_diArg_1	142	145	PF00400	0.772
TRG_ER_diArg_1	287	290	PF00400	0.677
TRG_ER_diArg_1	297	299	PF00400	0.686
TRG_ER_diArg_1	305	308	PF00400	0.697
TRG_ER_diArg_1	448	450	PF00400	0.756
TRG_ER_diArg_1	670	672	PF00400	0.640
TRG_NLS_MonoCore_2	286	291	PF00514	0.673
TRG_NLS_MonoExtC_3	286	291	PF00514	0.677
TRG_NLS_MonoExtN_4	287	292	PF00514	0.686
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.745

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A3	Leptomonas seymouri	29%	100%
A0A3S7X8U8	Leishmania donovani	63%	99%
A4IAV6	Leishmania infantum	63%	99%
E9AEN4	Leishmania major	64%	100%
E9B5U0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	99%