Conserved SNF-7-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNF-7-like protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM91_LEIBR

TriTrypDb:

LbrM.34.0580 , LBRM2903_340010800

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM91

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007034	vacuolar transport	4	11
GO:0009987	cellular process	1	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0006900	vesicle budding from membrane	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.308
CLV_C14_Caspase3-7	35	39	PF00656	0.303
CLV_NRD_NRD_1	114	116	PF00675	0.472
CLV_PCSK_KEX2_1	70	72	PF00082	0.326
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.319
CLV_PCSK_SKI1_1	116	120	PF00082	0.320
CLV_PCSK_SKI1_1	52	56	PF00082	0.382
DEG_APCC_KENBOX_2	174	178	PF00400	0.379
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DOC_MAPK_gen_1	115	123	PF00069	0.293
DOC_MAPK_gen_1	58	66	PF00069	0.303
DOC_PP2B_LxvP_1	186	189	PF13499	0.321
DOC_USP7_UBL2_3	108	112	PF12436	0.321
DOC_USP7_UBL2_3	116	120	PF12436	0.325
DOC_WW_Pin1_4	8	13	PF00397	0.573
LIG_14-3-3_CanoR_1	52	59	PF00244	0.293
LIG_Actin_WH2_2	100	117	PF00022	0.379
LIG_FHA_1	138	144	PF00498	0.321
LIG_FHA_1	92	98	PF00498	0.309
LIG_FHA_2	13	19	PF00498	0.320
LIG_FHA_2	94	100	PF00498	0.434
LIG_PCNA_PIPBox_1	130	139	PF02747	0.321
LIG_PCNA_yPIPBox_3	125	137	PF02747	0.356
LIG_PDZ_Class_2	218	223	PF00595	0.561
LIG_SH2_GRB2like	73	76	PF00017	0.263
LIG_SH2_NCK_1	151	155	PF00017	0.315
LIG_SH2_STAP1	215	219	PF00017	0.497
LIG_SH2_STAT3	73	76	PF00017	0.303
LIG_SH2_STAT5	181	184	PF00017	0.303
LIG_SH3_3	191	197	PF00018	0.347
MOD_CDK_SPK_2	8	13	PF00069	0.538
MOD_CK1_1	24	30	PF00069	0.458
MOD_GlcNHglycan	23	26	PF01048	0.350
MOD_GSK3_1	17	24	PF00069	0.395
MOD_GSK3_1	184	191	PF00069	0.301
MOD_GSK3_1	48	55	PF00069	0.373
MOD_GSK3_1	8	15	PF00069	0.552
MOD_GSK3_1	93	100	PF00069	0.397
MOD_N-GLC_1	8	13	PF02516	0.455
MOD_NEK2_1	54	59	PF00069	0.486
MOD_PIKK_1	137	143	PF00454	0.321
MOD_PIKK_1	52	58	PF00454	0.347
MOD_PIKK_1	97	103	PF00454	0.326
MOD_PKA_2	21	27	PF00069	0.426
MOD_PKA_2	32	38	PF00069	0.289
MOD_PKB_1	50	58	PF00069	0.379
MOD_Plk_2-3	208	214	PF00069	0.623
MOD_ProDKin_1	8	14	PF00069	0.569
TRG_NES_CRM1_1	113	127	PF08389	0.382
TRG_NES_CRM1_1	128	142	PF08389	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W8	Leptomonas seymouri	30%	99%
A0A0N1IHV1	Leptomonas seymouri	83%	100%
A0A0S4J9L8	Bodo saltans	60%	100%
A0A1X0NJR2	Trypanosomatidae	72%	100%
A0A1X0P4I7	Trypanosomatidae	25%	98%
A0A3Q8IJN8	Leishmania donovani	27%	99%
A0A3R7K5M7	Trypanosoma rangeli	67%	100%
A0A3R7NQB4	Trypanosoma rangeli	26%	98%
A0A3S7X8S3	Leishmania donovani	90%	100%
A4HPQ2	Leishmania braziliensis	28%	99%
A4IAV5	Leishmania infantum	90%	100%
A4ID11	Leishmania infantum	27%	99%
D0A2A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
D0A8G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	98%
E9AEN3	Leishmania major	91%	100%
E9ATG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E9B5T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O74422	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
Q03390	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	97%
Q4QQV8	Rattus norvegicus	42%	100%
Q54JK4	Dictyostelium discoideum	39%	100%
Q5FW29	Xenopus tropicalis	41%	100%
Q5RBR3	Pongo abelii	42%	100%
Q6DD52	Xenopus laevis	42%	100%
Q7T339	Danio rerio	43%	100%
Q9D7S9	Mus musculus	42%	100%
Q9FMC5	Arabidopsis thaliana	48%	95%
Q9LPN5	Arabidopsis thaliana	45%	95%
Q9NZZ3	Homo sapiens	42%	100%
Q9SZE4	Arabidopsis thaliana	26%	100%
Q9VVI9	Drosophila melanogaster	39%	99%