HAP2-GCS1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Generative cell specific 1 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM81_LEIBR

TriTrypDb:

LbrM.34.0480 , LBRM2903_340010000

Length:

905

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	7
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HM81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM81

Function

Biological processes
Term	Name	Level	Count
GO:0007338	single fertilization	3	7
GO:0009566	fertilization	2	7
GO:0022414	reproductive process	1	7

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008289	lipid binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	524	528	PF00656	0.211
CLV_C14_Caspase3-7	550	554	PF00656	0.211
CLV_C14_Caspase3-7	734	738	PF00656	0.630
CLV_C14_Caspase3-7	740	744	PF00656	0.607
CLV_NRD_NRD_1	654	656	PF00675	0.522
CLV_NRD_NRD_1	696	698	PF00675	0.527
CLV_NRD_NRD_1	732	734	PF00675	0.504
CLV_NRD_NRD_1	885	887	PF00675	0.528
CLV_NRD_NRD_1	97	99	PF00675	0.481
CLV_PCSK_KEX2_1	294	296	PF00082	0.411
CLV_PCSK_KEX2_1	654	656	PF00082	0.520
CLV_PCSK_KEX2_1	696	698	PF00082	0.527
CLV_PCSK_KEX2_1	732	734	PF00082	0.495
CLV_PCSK_KEX2_1	885	887	PF00082	0.528
CLV_PCSK_KEX2_1	97	99	PF00082	0.481
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.411
CLV_PCSK_SKI1_1	124	128	PF00082	0.707
CLV_PCSK_SKI1_1	330	334	PF00082	0.560
CLV_PCSK_SKI1_1	375	379	PF00082	0.592
CLV_PCSK_SKI1_1	518	522	PF00082	0.516
CLV_PCSK_SKI1_1	681	685	PF00082	0.263
CLV_PCSK_SKI1_1	747	751	PF00082	0.439
CLV_PCSK_SKI1_1	87	91	PF00082	0.482
DEG_APCC_DBOX_1	200	208	PF00400	0.392
DEG_MDM2_SWIB_1	884	892	PF02201	0.636
DEG_Nend_Nbox_1	1	3	PF02207	0.603
DEG_SCF_FBW7_1	861	867	PF00400	0.821
DEG_SPOP_SBC_1	546	550	PF00917	0.211
DEG_SPOP_SBC_1	611	615	PF00917	0.211
DOC_CKS1_1	3	8	PF01111	0.591
DOC_CKS1_1	794	799	PF01111	0.612
DOC_CKS1_1	861	866	PF01111	0.820
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.657
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.319
DOC_MAPK_gen_1	147	156	PF00069	0.320
DOC_MAPK_gen_1	60	68	PF00069	0.420
DOC_MAPK_gen_1	654	661	PF00069	0.425
DOC_MAPK_HePTP_8	144	156	PF00069	0.211
DOC_MAPK_MEF2A_6	147	156	PF00069	0.320
DOC_MAPK_MEF2A_6	526	534	PF00069	0.233
DOC_PP1_RVXF_1	603	610	PF00149	0.319
DOC_PP2B_LxvP_1	267	270	PF13499	0.211
DOC_PP2B_LxvP_1	377	380	PF13499	0.319
DOC_PP2B_LxvP_1	792	795	PF13499	0.746
DOC_PP2B_LxvP_1	82	85	PF13499	0.572
DOC_PP4_FxxP_1	779	782	PF00568	0.708
DOC_USP7_MATH_1	126	130	PF00917	0.501
DOC_USP7_MATH_1	420	424	PF00917	0.319
DOC_USP7_MATH_1	632	636	PF00917	0.272
DOC_USP7_MATH_1	638	642	PF00917	0.243
DOC_USP7_MATH_1	700	704	PF00917	0.701
DOC_USP7_MATH_1	775	779	PF00917	0.736
DOC_USP7_MATH_1	829	833	PF00917	0.727
DOC_USP7_MATH_1	864	868	PF00917	0.828
DOC_USP7_UBL2_3	143	147	PF12436	0.211
DOC_WW_Pin1_4	184	189	PF00397	0.319
DOC_WW_Pin1_4	2	7	PF00397	0.592
DOC_WW_Pin1_4	338	343	PF00397	0.319
DOC_WW_Pin1_4	473	478	PF00397	0.319
DOC_WW_Pin1_4	482	487	PF00397	0.319
DOC_WW_Pin1_4	628	633	PF00397	0.211
DOC_WW_Pin1_4	747	752	PF00397	0.792
DOC_WW_Pin1_4	771	776	PF00397	0.709
DOC_WW_Pin1_4	784	789	PF00397	0.709
DOC_WW_Pin1_4	793	798	PF00397	0.622
DOC_WW_Pin1_4	825	830	PF00397	0.725
DOC_WW_Pin1_4	857	862	PF00397	0.813
DOC_WW_Pin1_4	869	874	PF00397	0.697
DOC_WW_Pin1_4	877	882	PF00397	0.590
DOC_WW_Pin1_4	90	95	PF00397	0.765
LIG_14-3-3_CanoR_1	190	198	PF00244	0.392
LIG_14-3-3_CanoR_1	283	292	PF00244	0.211
LIG_14-3-3_CanoR_1	317	322	PF00244	0.256
LIG_14-3-3_CanoR_1	35	40	PF00244	0.536
LIG_14-3-3_CanoR_1	444	451	PF00244	0.230
LIG_14-3-3_CanoR_1	482	486	PF00244	0.242
LIG_14-3-3_CanoR_1	535	541	PF00244	0.262
LIG_14-3-3_CanoR_1	605	610	PF00244	0.392
LIG_14-3-3_CanoR_1	866	873	PF00244	0.811
LIG_14-3-3_CanoR_1	885	889	PF00244	0.583
LIG_Actin_WH2_2	667	683	PF00022	0.234
LIG_BIR_III_2	743	747	PF00653	0.630
LIG_BIR_III_4	243	247	PF00653	0.392
LIG_BRCT_BRCA1_1	165	169	PF00533	0.392
LIG_BRCT_BRCA1_1	251	255	PF00533	0.319
LIG_BRCT_BRCA1_1	612	616	PF00533	0.392
LIG_BRCT_BRCA1_1	829	833	PF00533	0.771
LIG_Clathr_ClatBox_1	403	407	PF01394	0.319
LIG_CtBP_PxDLS_1	369	373	PF00389	0.319
LIG_eIF4E_1	663	669	PF01652	0.234
LIG_EVH1_1	785	789	PF00568	0.810
LIG_EVH1_1	892	896	PF00568	0.613
LIG_FHA_1	103	109	PF00498	0.477
LIG_FHA_1	151	157	PF00498	0.392
LIG_FHA_1	235	241	PF00498	0.319
LIG_FHA_1	262	268	PF00498	0.392
LIG_FHA_1	308	314	PF00498	0.319
LIG_FHA_1	331	337	PF00498	0.238
LIG_FHA_1	399	405	PF00498	0.392
LIG_FHA_1	443	449	PF00498	0.319
LIG_FHA_1	501	507	PF00498	0.311
LIG_FHA_1	529	535	PF00498	0.325
LIG_FHA_1	539	545	PF00498	0.241
LIG_FHA_1	560	566	PF00498	0.292
LIG_FHA_1	643	649	PF00498	0.312
LIG_FHA_1	669	675	PF00498	0.234
LIG_FHA_2	346	352	PF00498	0.322
LIG_FHA_2	444	450	PF00498	0.380
LIG_FHA_2	732	738	PF00498	0.620
LIG_GBD_Chelix_1	48	56	PF00786	0.234
LIG_LIR_Apic_2	776	782	PF02991	0.725
LIG_LIR_Gen_1	105	115	PF02991	0.281
LIG_LIR_Gen_1	351	360	PF02991	0.392
LIG_LIR_Gen_1	395	404	PF02991	0.277
LIG_LIR_Gen_1	417	422	PF02991	0.319
LIG_LIR_Gen_1	660	670	PF02991	0.365
LIG_LIR_Gen_1	830	840	PF02991	0.615
LIG_LIR_Nem_3	105	110	PF02991	0.281
LIG_LIR_Nem_3	307	311	PF02991	0.319
LIG_LIR_Nem_3	395	399	PF02991	0.277
LIG_LIR_Nem_3	417	421	PF02991	0.319
LIG_LIR_Nem_3	462	467	PF02991	0.287
LIG_LIR_Nem_3	476	481	PF02991	0.317
LIG_LIR_Nem_3	572	578	PF02991	0.321
LIG_LIR_Nem_3	660	666	PF02991	0.365
LIG_LIR_Nem_3	830	836	PF02991	0.615
LIG_Pex14_1	296	300	PF04695	0.319
LIG_Pex14_2	114	118	PF04695	0.234
LIG_Pex14_2	292	296	PF04695	0.319
LIG_Pex14_2	684	688	PF04695	0.416
LIG_Pex14_2	884	888	PF04695	0.821
LIG_SH2_CRK	200	204	PF00017	0.319
LIG_SH2_CRK	363	367	PF00017	0.211
LIG_SH2_NCK_1	284	288	PF00017	0.319
LIG_SH2_PTP2	107	110	PF00017	0.306
LIG_SH2_SRC	363	366	PF00017	0.392
LIG_SH2_STAP1	215	219	PF00017	0.319
LIG_SH2_STAP1	309	313	PF00017	0.392
LIG_SH2_STAP1	418	422	PF00017	0.319
LIG_SH2_STAT5	107	110	PF00017	0.306
LIG_SH2_STAT5	135	138	PF00017	0.381
LIG_SH2_STAT5	2	5	PF00017	0.679
LIG_SH2_STAT5	206	209	PF00017	0.319
LIG_SH2_STAT5	284	287	PF00017	0.319
LIG_SH2_STAT5	300	303	PF00017	0.319
LIG_SH2_STAT5	305	308	PF00017	0.319
LIG_SH2_STAT5	309	312	PF00017	0.319
LIG_SH2_STAT5	478	481	PF00017	0.319
LIG_SH2_STAT5	502	505	PF00017	0.277
LIG_SH2_STAT5	663	666	PF00017	0.389
LIG_SH2_STAT5	667	670	PF00017	0.381
LIG_SH2_STAT5	689	692	PF00017	0.736
LIG_SH2_STAT5	764	767	PF00017	0.716
LIG_SH2_STAT5	81	84	PF00017	0.758
LIG_SH3_2	861	866	PF14604	0.820
LIG_SH3_3	242	248	PF00018	0.211
LIG_SH3_3	377	383	PF00018	0.270
LIG_SH3_3	471	477	PF00018	0.211
LIG_SH3_3	739	745	PF00018	0.763
LIG_SH3_3	748	754	PF00018	0.746
LIG_SH3_3	783	789	PF00018	0.744
LIG_SH3_3	791	797	PF00018	0.744
LIG_SH3_3	823	829	PF00018	0.742
LIG_SH3_3	858	864	PF00018	0.750
LIG_SH3_3	890	896	PF00018	0.807
LIG_SH3_3	897	903	PF00018	0.745
LIG_Sin3_3	49	56	PF02671	0.234
LIG_SUMO_SIM_par_1	150	155	PF11976	0.319
LIG_SUMO_SIM_par_1	368	374	PF11976	0.317
LIG_SUMO_SIM_par_1	401	407	PF11976	0.319
LIG_SUMO_SIM_par_1	489	494	PF11976	0.279
LIG_SxIP_EBH_1	747	761	PF03271	0.623
LIG_TRAF2_1	162	165	PF00917	0.319
LIG_TRAF2_1	349	352	PF00917	0.211
LIG_TRAF2_1	867	870	PF00917	0.834
LIG_TYR_ITIM	661	666	PF00017	0.281
LIG_WW_2	895	898	PF00397	0.604
LIG_WW_3	744	748	PF00397	0.616
LIG_WW_3	84	88	PF00397	0.583
MOD_CDC14_SPxK_1	187	190	PF00782	0.392
MOD_CDK_SPK_2	877	882	PF00069	0.817
MOD_CDK_SPxK_1	184	190	PF00069	0.392
MOD_CDK_SPxK_1	860	866	PF00069	0.820
MOD_CDK_SPxxK_3	90	97	PF00069	0.695
MOD_CK1_1	131	137	PF00069	0.392
MOD_CK1_1	298	304	PF00069	0.319
MOD_CK1_1	34	40	PF00069	0.545
MOD_CK1_1	341	347	PF00069	0.211
MOD_CK1_1	434	440	PF00069	0.319
MOD_CK1_1	549	555	PF00069	0.257
MOD_CK1_1	582	588	PF00069	0.347
MOD_CK1_1	612	618	PF00069	0.249
MOD_CK1_1	636	642	PF00069	0.319
MOD_CK1_1	701	707	PF00069	0.639
MOD_CK1_1	787	793	PF00069	0.730
MOD_CK1_1	8	14	PF00069	0.745
MOD_CK1_1	832	838	PF00069	0.639
MOD_CK1_1	839	845	PF00069	0.635
MOD_CK1_1	860	866	PF00069	0.775
MOD_CK1_1	887	893	PF00069	0.811
MOD_CK2_1	136	142	PF00069	0.479
MOD_CK2_1	341	347	PF00069	0.300
MOD_CK2_1	435	441	PF00069	0.314
MOD_CK2_1	443	449	PF00069	0.250
MOD_CK2_1	701	707	PF00069	0.711
MOD_CK2_1	864	870	PF00069	0.821
MOD_DYRK1A_RPxSP_1	482	486	PF00069	0.211
MOD_GlcNHglycan	138	141	PF01048	0.682
MOD_GlcNHglycan	171	174	PF01048	0.519
MOD_GlcNHglycan	195	198	PF01048	0.519
MOD_GlcNHglycan	21	24	PF01048	0.514
MOD_GlcNHglycan	27	30	PF01048	0.519
MOD_GlcNHglycan	297	300	PF01048	0.519
MOD_GlcNHglycan	321	324	PF01048	0.530
MOD_GlcNHglycan	326	329	PF01048	0.488
MOD_GlcNHglycan	452	455	PF01048	0.438
MOD_GlcNHglycan	495	498	PF01048	0.549
MOD_GlcNHglycan	507	510	PF01048	0.519
MOD_GlcNHglycan	512	515	PF01048	0.519
MOD_GlcNHglycan	623	626	PF01048	0.562
MOD_GlcNHglycan	635	638	PF01048	0.452
MOD_GlcNHglycan	700	703	PF01048	0.571
MOD_GlcNHglycan	723	727	PF01048	0.596
MOD_GlcNHglycan	829	832	PF01048	0.432
MOD_GlcNHglycan	841	844	PF01048	0.539
MOD_GSK3_1	127	134	PF00069	0.426
MOD_GSK3_1	189	196	PF00069	0.383
MOD_GSK3_1	215	222	PF00069	0.364
MOD_GSK3_1	230	237	PF00069	0.208
MOD_GSK3_1	257	264	PF00069	0.319
MOD_GSK3_1	30	37	PF00069	0.702
MOD_GSK3_1	307	314	PF00069	0.319
MOD_GSK3_1	341	348	PF00069	0.296
MOD_GSK3_1	398	405	PF00069	0.319
MOD_GSK3_1	431	438	PF00069	0.319
MOD_GSK3_1	473	480	PF00069	0.304
MOD_GSK3_1	482	489	PF00069	0.260
MOD_GSK3_1	545	552	PF00069	0.293
MOD_GSK3_1	582	589	PF00069	0.328
MOD_GSK3_1	599	606	PF00069	0.255
MOD_GSK3_1	617	624	PF00069	0.251
MOD_GSK3_1	628	635	PF00069	0.240
MOD_GSK3_1	638	645	PF00069	0.292
MOD_GSK3_1	710	717	PF00069	0.756
MOD_GSK3_1	722	729	PF00069	0.717
MOD_GSK3_1	771	778	PF00069	0.692
MOD_GSK3_1	825	832	PF00069	0.713
MOD_GSK3_1	860	867	PF00069	0.779
MOD_GSK3_1	884	891	PF00069	0.748
MOD_LATS_1	17	23	PF00433	0.792
MOD_N-GLC_1	179	184	PF02516	0.528
MOD_N-GLC_1	311	316	PF02516	0.519
MOD_N-GLC_1	317	322	PF02516	0.519
MOD_N-GLC_1	586	591	PF02516	0.556
MOD_N-GLC_1	617	622	PF02516	0.519
MOD_N-GLC_2	225	227	PF02516	0.519
MOD_N-GLC_2	426	428	PF02516	0.519
MOD_NEK2_1	127	132	PF00069	0.479
MOD_NEK2_1	150	155	PF00069	0.338
MOD_NEK2_1	169	174	PF00069	0.319
MOD_NEK2_1	261	266	PF00069	0.319
MOD_NEK2_1	290	295	PF00069	0.211
MOD_NEK2_1	313	318	PF00069	0.325
MOD_NEK2_1	370	375	PF00069	0.358
MOD_NEK2_1	460	465	PF00069	0.353
MOD_NEK2_1	491	496	PF00069	0.311
MOD_NEK2_1	500	505	PF00069	0.367
MOD_NEK2_1	521	526	PF00069	0.380
MOD_NEK2_1	579	584	PF00069	0.256
MOD_NEK2_1	668	673	PF00069	0.234
MOD_NEK2_1	884	889	PF00069	0.827
MOD_NEK2_2	215	220	PF00069	0.319
MOD_NEK2_2	726	731	PF00069	0.622
MOD_NEK2_2	74	79	PF00069	0.548
MOD_OFUCOSY	428	435	PF10250	0.519
MOD_PIKK_1	249	255	PF00454	0.319
MOD_PIKK_1	330	336	PF00454	0.211
MOD_PIKK_1	420	426	PF00454	0.291
MOD_PIKK_1	435	441	PF00454	0.242
MOD_PIKK_1	617	623	PF00454	0.319
MOD_PIKK_1	865	871	PF00454	0.836
MOD_PK_1	317	323	PF00069	0.239
MOD_PKA_2	189	195	PF00069	0.392
MOD_PKA_2	282	288	PF00069	0.211
MOD_PKA_2	290	296	PF00069	0.189
MOD_PKA_2	34	40	PF00069	0.567
MOD_PKA_2	443	449	PF00069	0.230
MOD_PKA_2	481	487	PF00069	0.211
MOD_PKA_2	731	737	PF00069	0.801
MOD_PKA_2	865	871	PF00069	0.836
MOD_PKA_2	884	890	PF00069	0.582
MOD_PKB_1	714	722	PF00069	0.621
MOD_Plk_1	163	169	PF00069	0.319
MOD_Plk_1	174	180	PF00069	0.319
MOD_Plk_1	215	221	PF00069	0.319
MOD_Plk_1	257	263	PF00069	0.319
MOD_Plk_1	311	317	PF00069	0.319
MOD_Plk_1	500	506	PF00069	0.325
MOD_Plk_1	586	592	PF00069	0.316
MOD_Plk_1	710	716	PF00069	0.773
MOD_Plk_4	102	108	PF00069	0.490
MOD_Plk_4	128	134	PF00069	0.467
MOD_Plk_4	163	169	PF00069	0.319
MOD_Plk_4	219	225	PF00069	0.364
MOD_Plk_4	304	310	PF00069	0.319
MOD_Plk_4	486	492	PF00069	0.367
MOD_Plk_4	5	11	PF00069	0.631
MOD_Plk_4	528	534	PF00069	0.319
MOD_Plk_4	64	70	PF00069	0.286
MOD_Plk_4	657	663	PF00069	0.312
MOD_Plk_4	726	732	PF00069	0.623
MOD_Plk_4	765	771	PF00069	0.607
MOD_Plk_4	787	793	PF00069	0.635
MOD_Plk_4	829	835	PF00069	0.610
MOD_ProDKin_1	184	190	PF00069	0.319
MOD_ProDKin_1	2	8	PF00069	0.592
MOD_ProDKin_1	338	344	PF00069	0.319
MOD_ProDKin_1	473	479	PF00069	0.319
MOD_ProDKin_1	482	488	PF00069	0.319
MOD_ProDKin_1	628	634	PF00069	0.211
MOD_ProDKin_1	747	753	PF00069	0.791
MOD_ProDKin_1	771	777	PF00069	0.710
MOD_ProDKin_1	784	790	PF00069	0.711
MOD_ProDKin_1	793	799	PF00069	0.617
MOD_ProDKin_1	825	831	PF00069	0.726
MOD_ProDKin_1	857	863	PF00069	0.815
MOD_ProDKin_1	869	875	PF00069	0.696
MOD_ProDKin_1	877	883	PF00069	0.589
MOD_ProDKin_1	90	96	PF00069	0.766
MOD_SUMO_for_1	708	711	PF00179	0.762
MOD_SUMO_rev_2	137	144	PF00179	0.330
TRG_DiLeu_BaEn_3	164	170	PF01217	0.392
TRG_ENDOCYTIC_2	107	110	PF00928	0.332
TRG_ENDOCYTIC_2	202	205	PF00928	0.319
TRG_ENDOCYTIC_2	363	366	PF00928	0.392
TRG_ENDOCYTIC_2	418	421	PF00928	0.319
TRG_ENDOCYTIC_2	663	666	PF00928	0.389
TRG_ENDOCYTIC_2	667	670	PF00928	0.381
TRG_ER_diArg_1	731	733	PF00400	0.626
TRG_ER_diArg_1	884	886	PF00400	0.753
TRG_ER_diArg_1	96	98	PF00400	0.690
TRG_NES_CRM1_1	458	472	PF08389	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P372	Leptomonas seymouri	50%	93%
A0A3S7X8Q7	Leishmania donovani	72%	99%
A4GRC6	Chlamydomonas reinhardtii	27%	79%
A4IAU5	Leishmania infantum	72%	99%
E9AEM3	Leishmania major	71%	100%
E9B5T2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	99%
F4JP36	Arabidopsis thaliana	27%	100%