Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Arrestin (or S-antigen), N-terminal domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM80_LEIBR

TriTrypDb:

LbrM.34.0460 , LBRM2903_340009700

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM80

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.656
CLV_C14_Caspase3-7	258	262	PF00656	0.569
CLV_NRD_NRD_1	280	282	PF00675	0.724
CLV_NRD_NRD_1	307	309	PF00675	0.715
CLV_NRD_NRD_1	334	336	PF00675	0.684
CLV_NRD_NRD_1	364	366	PF00675	0.761
CLV_NRD_NRD_1	369	371	PF00675	0.803
CLV_NRD_NRD_1	562	564	PF00675	0.656
CLV_PCSK_FUR_1	560	564	PF00082	0.645
CLV_PCSK_KEX2_1	282	284	PF00082	0.704
CLV_PCSK_KEX2_1	307	309	PF00082	0.697
CLV_PCSK_KEX2_1	334	336	PF00082	0.684
CLV_PCSK_KEX2_1	369	371	PF00082	0.802
CLV_PCSK_KEX2_1	562	564	PF00082	0.656
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.804
CLV_PCSK_PC7_1	365	371	PF00082	0.597
CLV_PCSK_SKI1_1	434	438	PF00082	0.652
CLV_PCSK_SKI1_1	46	50	PF00082	0.549
CLV_PCSK_SKI1_1	521	525	PF00082	0.724
CLV_PCSK_SKI1_1	80	84	PF00082	0.639
DEG_APCC_DBOX_1	509	517	PF00400	0.630
DEG_SIAH_1	112	120	PF03145	0.676
DOC_CKS1_1	453	458	PF01111	0.572
DOC_CKS1_1	482	487	PF01111	0.792
DOC_CKS1_1	523	528	PF01111	0.647
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.826
DOC_CYCLIN_yCln2_LP_2	571	574	PF00134	0.624
DOC_CYCLIN_yCln2_LP_2	622	628	PF00134	0.656
DOC_MAPK_gen_1	508	517	PF00069	0.414
DOC_MAPK_gen_1	562	572	PF00069	0.513
DOC_MAPK_MEF2A_6	25	32	PF00069	0.333
DOC_MAPK_MEF2A_6	288	296	PF00069	0.566
DOC_MAPK_MEF2A_6	5	13	PF00069	0.565
DOC_MAPK_MEF2A_6	508	517	PF00069	0.608
DOC_MAPK_RevD_3	320	335	PF00069	0.480
DOC_PP1_RVXF_1	44	50	PF00149	0.528
DOC_PP2B_LxvP_1	570	573	PF13499	0.643
DOC_PP2B_LxvP_1	622	625	PF13499	0.595
DOC_PP4_FxxP_1	208	211	PF00568	0.411
DOC_USP7_MATH_1	357	361	PF00917	0.737
DOC_USP7_MATH_1	364	368	PF00917	0.772
DOC_USP7_UBL2_3	226	230	PF12436	0.261
DOC_WW_Pin1_4	109	114	PF00397	0.668
DOC_WW_Pin1_4	313	318	PF00397	0.515
DOC_WW_Pin1_4	452	457	PF00397	0.646
DOC_WW_Pin1_4	465	470	PF00397	0.777
DOC_WW_Pin1_4	471	476	PF00397	0.713
DOC_WW_Pin1_4	481	486	PF00397	0.605
DOC_WW_Pin1_4	522	527	PF00397	0.651
LIG_14-3-3_CanoR_1	5	10	PF00244	0.534
LIG_14-3-3_CanoR_1	80	85	PF00244	0.640
LIG_14-3-3_CterR_2	627	629	PF00244	0.650
LIG_Actin_WH2_2	305	323	PF00022	0.518
LIG_BRCT_BRCA1_1	245	249	PF00533	0.793
LIG_BRCT_BRCA1_1	322	326	PF00533	0.447
LIG_BRCT_BRCA1_1	583	587	PF00533	0.563
LIG_CSL_BTD_1	212	215	PF09270	0.411
LIG_DLG_GKlike_1	5	13	PF00625	0.529
LIG_eIF4E_1	42	48	PF01652	0.551
LIG_FHA_1	385	391	PF00498	0.799
LIG_FHA_1	433	439	PF00498	0.653
LIG_FHA_1	490	496	PF00498	0.600
LIG_FHA_1	501	507	PF00498	0.522
LIG_FHA_1	538	544	PF00498	0.528
LIG_FHA_1	612	618	PF00498	0.621
LIG_FHA_2	12	18	PF00498	0.465
LIG_FHA_2	129	135	PF00498	0.699
LIG_FHA_2	156	162	PF00498	0.564
LIG_FHA_2	256	262	PF00498	0.653
LIG_FHA_2	452	458	PF00498	0.570
LIG_FHA_2	595	601	PF00498	0.622
LIG_FHA_2	87	93	PF00498	0.675
LIG_GSK3_LRP6_1	452	457	PF00069	0.567
LIG_IRF3_LxIS_1	317	323	PF10401	0.465
LIG_IRF3_LxIS_1	7	12	PF10401	0.564
LIG_LIR_Apic_2	536	542	PF02991	0.539
LIG_LIR_Gen_1	112	122	PF02991	0.675
LIG_LIR_Gen_1	323	333	PF02991	0.507
LIG_LIR_Gen_1	401	412	PF02991	0.626
LIG_LIR_Gen_1	533	542	PF02991	0.544
LIG_LIR_Gen_1	584	595	PF02991	0.547
LIG_LIR_Gen_1	63	71	PF02991	0.628
LIG_LIR_LC3C_4	427	431	PF02991	0.688
LIG_LIR_Nem_3	112	117	PF02991	0.676
LIG_LIR_Nem_3	125	130	PF02991	0.614
LIG_LIR_Nem_3	191	197	PF02991	0.608
LIG_LIR_Nem_3	217	222	PF02991	0.282
LIG_LIR_Nem_3	323	329	PF02991	0.519
LIG_LIR_Nem_3	340	344	PF02991	0.779
LIG_LIR_Nem_3	401	407	PF02991	0.630
LIG_LIR_Nem_3	455	461	PF02991	0.601
LIG_LIR_Nem_3	518	523	PF02991	0.620
LIG_LIR_Nem_3	528	532	PF02991	0.604
LIG_LIR_Nem_3	533	537	PF02991	0.554
LIG_LIR_Nem_3	584	590	PF02991	0.548
LIG_LIR_Nem_3	63	67	PF02991	0.618
LIG_LYPXL_yS_3	458	461	PF13949	0.576
LIG_MYND_1	195	199	PF01753	0.411
LIG_MYND_1	212	216	PF01753	0.411
LIG_Pex14_2	204	208	PF04695	0.411
LIG_Pex14_2	218	222	PF04695	0.411
LIG_Pex14_2	407	411	PF04695	0.602
LIG_SH2_CRK	114	118	PF00017	0.681
LIG_SH2_CRK	539	543	PF00017	0.528
LIG_SH2_NCK_1	114	118	PF00017	0.681
LIG_SH2_NCK_1	130	134	PF00017	0.567
LIG_SH2_STAP1	114	118	PF00017	0.681
LIG_SH2_STAP1	231	235	PF00017	0.411
LIG_SH2_STAT5	130	133	PF00017	0.613
LIG_SH2_STAT5	539	542	PF00017	0.506
LIG_SH2_STAT5	596	599	PF00017	0.593
LIG_SH2_STAT5	71	74	PF00017	0.649
LIG_SH2_STAT5	77	80	PF00017	0.648
LIG_SH3_1	209	215	PF00018	0.411
LIG_SH3_1	539	545	PF00018	0.529
LIG_SH3_3	116	122	PF00018	0.778
LIG_SH3_3	189	195	PF00018	0.616
LIG_SH3_3	209	215	PF00018	0.183
LIG_SH3_3	447	453	PF00018	0.683
LIG_SH3_3	469	475	PF00018	0.674
LIG_SH3_3	479	485	PF00018	0.692
LIG_SH3_3	539	545	PF00018	0.475
LIG_SH3_3	587	593	PF00018	0.532
LIG_SUMO_SIM_anti_2	327	333	PF11976	0.632
LIG_SUMO_SIM_anti_2	427	432	PF11976	0.593
LIG_SUMO_SIM_par_1	434	441	PF11976	0.690
LIG_SUMO_SIM_par_1	613	620	PF11976	0.620
LIG_TRFH_1	208	212	PF08558	0.411
LIG_TYR_ITIM	40	45	PF00017	0.546
LIG_TYR_ITSM	110	117	PF00017	0.672
LIG_UBA3_1	519	524	PF00899	0.721
LIG_WRC_WIRS_1	219	224	PF05994	0.411
LIG_WRC_WIRS_1	404	409	PF05994	0.611
LIG_WRC_WIRS_1	534	539	PF05994	0.537
MOD_CK1_1	256	262	PF00069	0.657
MOD_CK1_1	489	495	PF00069	0.488
MOD_CK1_1	522	528	PF00069	0.623
MOD_CK1_1	533	539	PF00069	0.450
MOD_CK2_1	128	134	PF00069	0.605
MOD_CK2_1	187	193	PF00069	0.705
MOD_CK2_1	594	600	PF00069	0.613
MOD_CK2_1	86	92	PF00069	0.676
MOD_CK2_1	9	15	PF00069	0.561
MOD_GlcNHglycan	124	127	PF01048	0.645
MOD_GlcNHglycan	184	187	PF01048	0.775
MOD_GlcNHglycan	231	234	PF01048	0.404
MOD_GlcNHglycan	254	258	PF01048	0.755
MOD_GlcNHglycan	275	278	PF01048	0.827
MOD_GlcNHglycan	359	362	PF01048	0.606
MOD_GlcNHglycan	400	403	PF01048	0.525
MOD_GlcNHglycan	488	491	PF01048	0.460
MOD_GSK3_1	1	8	PF00069	0.583
MOD_GSK3_1	143	150	PF00069	0.675
MOD_GSK3_1	178	185	PF00069	0.617
MOD_GSK3_1	214	221	PF00069	0.485
MOD_GSK3_1	229	236	PF00069	0.381
MOD_GSK3_1	311	318	PF00069	0.730
MOD_GSK3_1	364	371	PF00069	0.661
MOD_GSK3_1	380	387	PF00069	0.681
MOD_GSK3_1	533	540	PF00069	0.490
MOD_GSK3_1	576	583	PF00069	0.596
MOD_N-GLC_1	580	585	PF02516	0.584
MOD_N-GLC_2	414	416	PF02516	0.655
MOD_N-GLC_2	499	501	PF02516	0.546
MOD_NEK2_1	136	141	PF00069	0.678
MOD_NEK2_1	218	223	PF00069	0.411
MOD_NEK2_1	229	234	PF00069	0.411
MOD_NEK2_1	255	260	PF00069	0.596
MOD_NEK2_1	398	403	PF00069	0.661
MOD_NEK2_1	537	542	PF00069	0.497
MOD_NEK2_1	588	593	PF00069	0.630
MOD_NEK2_1	9	14	PF00069	0.569
MOD_PIKK_1	364	370	PF00454	0.677
MOD_PIKK_1	442	448	PF00454	0.513
MOD_PIKK_1	500	506	PF00454	0.416
MOD_PIKK_1	86	92	PF00454	0.778
MOD_PKA_2	267	273	PF00069	0.677
MOD_PKA_2	351	357	PF00069	0.790
MOD_PKA_2	364	370	PF00069	0.674
MOD_Plk_1	393	399	PF00069	0.726
MOD_Plk_1	52	58	PF00069	0.587
MOD_Plk_1	537	543	PF00069	0.631
MOD_Plk_2-3	187	193	PF00069	0.542
MOD_Plk_4	214	220	PF00069	0.355
MOD_Plk_4	233	239	PF00069	0.411
MOD_Plk_4	243	249	PF00069	0.459
MOD_Plk_4	295	301	PF00069	0.557
MOD_Plk_4	327	333	PF00069	0.646
MOD_Plk_4	583	589	PF00069	0.459
MOD_Plk_4	594	600	PF00069	0.613
MOD_ProDKin_1	109	115	PF00069	0.669
MOD_ProDKin_1	313	319	PF00069	0.510
MOD_ProDKin_1	452	458	PF00069	0.649
MOD_ProDKin_1	465	471	PF00069	0.779
MOD_ProDKin_1	481	487	PF00069	0.602
MOD_ProDKin_1	522	528	PF00069	0.648
MOD_SUMO_rev_2	314	323	PF00179	0.483
MOD_SUMO_rev_2	600	608	PF00179	0.628
TRG_DiLeu_BaEn_1	193	198	PF01217	0.685
TRG_DiLeu_BaEn_1	425	430	PF01217	0.568
TRG_DiLeu_BaEn_1	43	48	PF01217	0.553
TRG_DiLeu_BaEn_1	63	68	PF01217	0.388
TRG_DiLeu_BaEn_2	101	107	PF01217	0.761
TRG_DiLeu_BaEn_4	102	108	PF01217	0.759
TRG_ENDOCYTIC_2	114	117	PF00928	0.623
TRG_ENDOCYTIC_2	219	222	PF00928	0.355
TRG_ENDOCYTIC_2	341	344	PF00928	0.695
TRG_ENDOCYTIC_2	404	407	PF00928	0.619
TRG_ENDOCYTIC_2	42	45	PF00928	0.551
TRG_ENDOCYTIC_2	458	461	PF00928	0.576
TRG_ENDOCYTIC_2	534	537	PF00928	0.532
TRG_ENDOCYTIC_2	596	599	PF00928	0.621
TRG_ER_diArg_1	281	284	PF00400	0.710
TRG_ER_diArg_1	307	309	PF00400	0.715
TRG_ER_diArg_1	333	335	PF00400	0.668
TRG_ER_diArg_1	493	496	PF00400	0.568
TRG_ER_diArg_1	508	511	PF00400	0.529
TRG_ER_diArg_1	561	563	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.677

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSS5	Leptomonas seymouri	61%	95%
A0A3S5H7Y4	Leishmania donovani	79%	99%
A4IAU3	Leishmania infantum	79%	99%
E9AEM1	Leishmania major	79%	100%
E9B5T0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%