Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM76_LEIBR

TriTrypDb:

LbrM.34.0420 , LBRM2903_340009300

Length:

547

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.513
CLV_C14_Caspase3-7	185	189	PF00656	0.674
CLV_C14_Caspase3-7	450	454	PF00656	0.736
CLV_NRD_NRD_1	118	120	PF00675	0.547
CLV_NRD_NRD_1	173	175	PF00675	0.751
CLV_NRD_NRD_1	405	407	PF00675	0.457
CLV_NRD_NRD_1	487	489	PF00675	0.691
CLV_PCSK_KEX2_1	118	120	PF00082	0.517
CLV_PCSK_KEX2_1	17	19	PF00082	0.483
CLV_PCSK_KEX2_1	171	173	PF00082	0.633
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.512
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.633
CLV_PCSK_SKI1_1	324	328	PF00082	0.660
CLV_PCSK_SKI1_1	410	414	PF00082	0.537
CLV_PCSK_SKI1_1	84	88	PF00082	0.462
DEG_SCF_FBW7_1	123	129	PF00400	0.446
DEG_SPOP_SBC_1	126	130	PF00917	0.711
DOC_ANK_TNKS_1	44	51	PF00023	0.722
DOC_CKS1_1	123	128	PF01111	0.551
DOC_CKS1_1	141	146	PF01111	0.493
DOC_CKS1_1	190	195	PF01111	0.596
DOC_PP4_FxxP_1	165	168	PF00568	0.507
DOC_USP7_MATH_1	108	112	PF00917	0.531
DOC_USP7_MATH_1	196	200	PF00917	0.455
DOC_USP7_MATH_1	30	34	PF00917	0.621
DOC_USP7_MATH_1	309	313	PF00917	0.602
DOC_USP7_MATH_1	39	43	PF00917	0.578
DOC_WW_Pin1_4	122	127	PF00397	0.568
DOC_WW_Pin1_4	140	145	PF00397	0.455
DOC_WW_Pin1_4	189	194	PF00397	0.604
DOC_WW_Pin1_4	480	485	PF00397	0.663
DOC_WW_Pin1_4	73	78	PF00397	0.700
LIG_14-3-3_CanoR_1	198	208	PF00244	0.720
LIG_14-3-3_CanoR_1	263	267	PF00244	0.600
LIG_14-3-3_CanoR_1	372	378	PF00244	0.532
LIG_14-3-3_CanoR_1	410	420	PF00244	0.462
LIG_14-3-3_CanoR_1	508	514	PF00244	0.667
LIG_14-3-3_CanoR_1	84	91	PF00244	0.517
LIG_14-3-3_CanoR_1	95	99	PF00244	0.475
LIG_Actin_WH2_2	404	421	PF00022	0.561
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BRCT_BRCA1_1	1	5	PF00533	0.649
LIG_BRCT_BRCA1_1	161	165	PF00533	0.475
LIG_BRCT_BRCA1_1	215	219	PF00533	0.729
LIG_CSL_BTD_1	123	126	PF09270	0.633
LIG_CSL_BTD_1	190	193	PF09270	0.613
LIG_EH_1	387	391	PF12763	0.557
LIG_eIF4E_1	253	259	PF01652	0.572
LIG_FHA_1	149	155	PF00498	0.538
LIG_FHA_1	177	183	PF00498	0.654
LIG_FHA_1	275	281	PF00498	0.507
LIG_FHA_1	289	295	PF00498	0.302
LIG_FHA_1	372	378	PF00498	0.550
LIG_FHA_1	455	461	PF00498	0.544
LIG_FHA_1	494	500	PF00498	0.537
LIG_FHA_1	55	61	PF00498	0.803
LIG_FHA_1	86	92	PF00498	0.416
LIG_FHA_2	128	134	PF00498	0.751
LIG_FHA_2	298	304	PF00498	0.467
LIG_FHA_2	488	494	PF00498	0.539
LIG_FHA_2	61	67	PF00498	0.756
LIG_LIR_Apic_2	162	168	PF02991	0.498
LIG_LIR_Apic_2	97	102	PF02991	0.642
LIG_LIR_Gen_1	2	13	PF02991	0.595
LIG_LIR_Gen_1	251	261	PF02991	0.544
LIG_LIR_Nem_3	188	194	PF02991	0.511
LIG_LIR_Nem_3	2	8	PF02991	0.602
LIG_LIR_Nem_3	251	256	PF02991	0.497
LIG_MAD2	119	127	PF02301	0.627
LIG_MYND_1	366	370	PF01753	0.647
LIG_PCNA_PIPBox_1	117	126	PF02747	0.625
LIG_Pex14_2	155	159	PF04695	0.536
LIG_Pex14_2	408	412	PF04695	0.567
LIG_Rb_LxCxE_1	237	255	PF01857	0.346
LIG_Rb_pABgroove_1	296	304	PF01858	0.479
LIG_SH2_CRK	99	103	PF00017	0.402
LIG_SH2_GRB2like	99	102	PF00017	0.390
LIG_SH2_NCK_1	99	103	PF00017	0.655
LIG_SH2_STAP1	317	321	PF00017	0.608
LIG_SH2_STAT3	317	320	PF00017	0.610
LIG_SH2_STAT5	20	23	PF00017	0.608
LIG_SH2_STAT5	420	423	PF00017	0.545
LIG_SH2_STAT5	99	102	PF00017	0.390
LIG_SH3_1	99	105	PF00018	0.658
LIG_SH3_2	193	198	PF14604	0.356
LIG_SH3_2	367	372	PF14604	0.640
LIG_SH3_3	138	144	PF00018	0.424
LIG_SH3_3	190	196	PF00018	0.564
LIG_SH3_3	276	282	PF00018	0.569
LIG_SH3_3	301	307	PF00018	0.528
LIG_SH3_3	361	367	PF00018	0.694
LIG_SH3_3	495	501	PF00018	0.538
LIG_SH3_3	99	105	PF00018	0.629
LIG_SUMO_SIM_par_1	119	125	PF11976	0.407
LIG_SUMO_SIM_par_1	245	251	PF11976	0.428
LIG_SUMO_SIM_par_1	290	295	PF11976	0.554
LIG_SUMO_SIM_par_1	308	315	PF11976	0.601
LIG_UBA3_1	445	451	PF00899	0.664
LIG_Vh1_VBS_1	411	429	PF01044	0.557
LIG_Vh1_VBS_1	448	466	PF01044	0.720
LIG_WRC_WIRS_1	72	77	PF05994	0.514
MOD_CK1_1	129	135	PF00069	0.640
MOD_CK1_1	148	154	PF00069	0.550
MOD_CK1_1	199	205	PF00069	0.699
MOD_CK1_1	210	216	PF00069	0.600
MOD_CK1_1	217	223	PF00069	0.483
MOD_CK1_1	424	430	PF00069	0.559
MOD_CK1_1	514	520	PF00069	0.617
MOD_CK2_1	157	163	PF00069	0.519
MOD_CK2_1	236	242	PF00069	0.629
MOD_CK2_1	245	251	PF00069	0.507
MOD_CK2_1	309	315	PF00069	0.615
MOD_CK2_1	487	493	PF00069	0.654
MOD_CK2_1	60	66	PF00069	0.766
MOD_CK2_1	73	79	PF00069	0.692
MOD_GlcNHglycan	110	113	PF01048	0.543
MOD_GlcNHglycan	159	162	PF01048	0.633
MOD_GlcNHglycan	307	310	PF01048	0.568
MOD_GlcNHglycan	32	35	PF01048	0.677
MOD_GlcNHglycan	91	94	PF01048	0.589
MOD_GSK3_1	122	129	PF00069	0.574
MOD_GSK3_1	157	164	PF00069	0.510
MOD_GSK3_1	196	203	PF00069	0.582
MOD_GSK3_1	207	214	PF00069	0.632
MOD_GSK3_1	234	241	PF00069	0.599
MOD_GSK3_1	262	269	PF00069	0.608
MOD_GSK3_1	270	277	PF00069	0.439
MOD_GSK3_1	30	37	PF00069	0.638
MOD_GSK3_1	305	312	PF00069	0.607
MOD_GSK3_1	449	456	PF00069	0.679
MOD_GSK3_1	504	511	PF00069	0.657
MOD_GSK3_1	71	78	PF00069	0.759
MOD_GSK3_1	85	92	PF00069	0.524
MOD_N-GLC_1	68	73	PF02516	0.534
MOD_NEK2_1	208	213	PF00069	0.646
MOD_NEK2_1	219	224	PF00069	0.635
MOD_NEK2_1	234	239	PF00069	0.582
MOD_NEK2_1	29	34	PF00069	0.604
MOD_NEK2_1	373	378	PF00069	0.573
MOD_NEK2_1	411	416	PF00069	0.511
MOD_NEK2_1	509	514	PF00069	0.689
MOD_NEK2_2	297	302	PF00069	0.424
MOD_NEK2_2	501	506	PF00069	0.711
MOD_PIKK_1	113	119	PF00454	0.543
MOD_PIKK_1	39	45	PF00454	0.720
MOD_PKA_2	13	19	PF00069	0.657
MOD_PKA_2	197	203	PF00069	0.660
MOD_PKA_2	262	268	PF00069	0.570
MOD_PKA_2	371	377	PF00069	0.539
MOD_PKA_2	487	493	PF00069	0.561
MOD_PKA_2	507	513	PF00069	0.672
MOD_PKA_2	94	100	PF00069	0.511
MOD_PKB_1	506	514	PF00069	0.626
MOD_Plk_1	68	74	PF00069	0.534
MOD_Plk_4	150	156	PF00069	0.559
MOD_Plk_4	214	220	PF00069	0.685
MOD_Plk_4	262	268	PF00069	0.475
MOD_Plk_4	288	294	PF00069	0.435
MOD_Plk_4	297	303	PF00069	0.382
MOD_Plk_4	413	419	PF00069	0.510
MOD_Plk_4	514	520	PF00069	0.484
MOD_Plk_4	94	100	PF00069	0.570
MOD_ProDKin_1	122	128	PF00069	0.574
MOD_ProDKin_1	140	146	PF00069	0.442
MOD_ProDKin_1	189	195	PF00069	0.599
MOD_ProDKin_1	480	486	PF00069	0.665
MOD_ProDKin_1	73	79	PF00069	0.696
MOD_SUMO_rev_2	170	179	PF00179	0.525
TRG_DiLeu_BaEn_1	242	247	PF01217	0.326
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.493
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.691
TRG_DiLeu_BaLyEn_6	441	446	PF01217	0.621
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.387
TRG_ENDOCYTIC_2	253	256	PF00928	0.559
TRG_ER_diArg_1	118	120	PF00400	0.547
TRG_ER_diArg_1	172	174	PF00400	0.746
TRG_ER_diArg_1	505	508	PF00400	0.631
TRG_NLS_MonoExtC_3	472	477	PF00514	0.698
TRG_NLS_MonoExtN_4	473	478	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	84	89	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II05	Leptomonas seymouri	55%	96%
A0A0S4JU63	Bodo saltans	25%	100%
A0A1X0NIV1	Trypanosomatidae	32%	100%
A0A3S7X8R0	Leishmania donovani	77%	100%
A4IAT9	Leishmania infantum	77%	100%
D0A2B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AEL6	Leishmania major	77%	100%
E9B5S7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5BNA1	Trypanosoma cruzi	29%	100%