Thioredoxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

thioredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4HM75_LEIBR

TriTrypDb:

LbrM.34.0410 , LBRM2903_340009100

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.468
CLV_C14_Caspase3-7	31	35	PF00656	0.507
CLV_NRD_NRD_1	254	256	PF00675	0.596
CLV_NRD_NRD_1	593	595	PF00675	0.411
CLV_PCSK_FUR_1	252	256	PF00082	0.646
CLV_PCSK_KEX2_1	16	18	PF00082	0.613
CLV_PCSK_KEX2_1	236	238	PF00082	0.667
CLV_PCSK_KEX2_1	254	256	PF00082	0.683
CLV_PCSK_KEX2_1	593	595	PF00082	0.411
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.613
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.636
CLV_PCSK_SKI1_1	13	17	PF00082	0.668
CLV_PCSK_SKI1_1	216	220	PF00082	0.388
CLV_PCSK_SKI1_1	433	437	PF00082	0.446
CLV_PCSK_SKI1_1	448	452	PF00082	0.328
CLV_PCSK_SKI1_1	478	482	PF00082	0.365
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DEG_SCF_FBW7_1	121	128	PF00400	0.653
DEG_SCF_SKP2-CKS1_1	229	236	PF00560	0.462
DOC_ANK_TNKS_1	236	243	PF00023	0.542
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.354
DOC_MAPK_gen_1	183	192	PF00069	0.352
DOC_MAPK_gen_1	476	483	PF00069	0.390
DOC_MAPK_HePTP_8	182	194	PF00069	0.435
DOC_MAPK_MEF2A_6	175	184	PF00069	0.654
DOC_MAPK_MEF2A_6	185	194	PF00069	0.263
DOC_USP7_MATH_1	125	129	PF00917	0.650
DOC_USP7_MATH_1	178	182	PF00917	0.539
DOC_USP7_MATH_1	23	27	PF00917	0.647
DOC_USP7_MATH_1	247	251	PF00917	0.726
DOC_USP7_MATH_1	297	301	PF00917	0.655
DOC_USP7_MATH_1	309	313	PF00917	0.640
DOC_USP7_MATH_1	357	361	PF00917	0.584
DOC_USP7_MATH_1	567	571	PF00917	0.441
DOC_WW_Pin1_4	105	110	PF00397	0.585
DOC_WW_Pin1_4	121	126	PF00397	0.655
DOC_WW_Pin1_4	19	24	PF00397	0.599
DOC_WW_Pin1_4	230	235	PF00397	0.489
DOC_WW_Pin1_4	243	248	PF00397	0.676
DOC_WW_Pin1_4	71	76	PF00397	0.547
LIG_14-3-3_CanoR_1	112	121	PF00244	0.513
LIG_14-3-3_CanoR_1	131	140	PF00244	0.754
LIG_14-3-3_CanoR_1	216	221	PF00244	0.413
LIG_14-3-3_CanoR_1	422	431	PF00244	0.440
LIG_14-3-3_CanoR_1	448	454	PF00244	0.390
LIG_14-3-3_CanoR_1	594	600	PF00244	0.349
LIG_APCC_ABBA_1	192	197	PF00400	0.414
LIG_BIR_III_4	248	252	PF00653	0.541
LIG_BRCT_BRCA1_1	605	609	PF00533	0.393
LIG_CAP-Gly_1	610	613	PF01302	0.534
LIG_Clathr_ClatBox_1	193	197	PF01394	0.418
LIG_FHA_1	116	122	PF00498	0.634
LIG_FHA_1	131	137	PF00498	0.665
LIG_FHA_1	187	193	PF00498	0.415
LIG_FHA_1	207	213	PF00498	0.266
LIG_FHA_1	217	223	PF00498	0.365
LIG_FHA_1	297	303	PF00498	0.657
LIG_FHA_1	533	539	PF00498	0.362
LIG_FHA_1	62	68	PF00498	0.609
LIG_FHA_2	268	274	PF00498	0.713
LIG_FHA_2	318	324	PF00498	0.514
LIG_FHA_2	412	418	PF00498	0.572
LIG_FHA_2	434	440	PF00498	0.381
LIG_FHA_2	5	11	PF00498	0.650
LIG_GBD_Chelix_1	510	518	PF00786	0.404
LIG_LIR_Apic_2	486	490	PF02991	0.356
LIG_LIR_Gen_1	535	544	PF02991	0.345
LIG_LIR_Nem_3	445	450	PF02991	0.329
LIG_LIR_Nem_3	454	460	PF02991	0.327
LIG_LIR_Nem_3	526	530	PF02991	0.354
LIG_LIR_Nem_3	535	539	PF02991	0.315
LIG_MYND_1	380	384	PF01753	0.447
LIG_PDZ_Class_3	608	613	PF00595	0.521
LIG_Pex14_2	447	451	PF04695	0.393
LIG_Pex14_2	609	613	PF04695	0.525
LIG_SH2_NCK_1	548	552	PF00017	0.324
LIG_SH2_SRC	38	41	PF00017	0.514
LIG_SH2_STAP1	572	576	PF00017	0.446
LIG_SH2_STAT3	407	410	PF00017	0.598
LIG_SH2_STAT5	195	198	PF00017	0.323
LIG_SH2_STAT5	38	41	PF00017	0.514
LIG_SH2_STAT5	482	485	PF00017	0.314
LIG_SH2_STAT5	527	530	PF00017	0.397
LIG_SH3_3	397	403	PF00018	0.517
LIG_SH3_5	226	230	PF00018	0.490
LIG_SH3_5	523	527	PF00018	0.398
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.349
LIG_SUMO_SIM_par_1	347	353	PF11976	0.481
LIG_SUMO_SIM_par_1	428	434	PF11976	0.441
LIG_TRAF2_1	395	398	PF00917	0.487
LIG_TRAF2_1	575	578	PF00917	0.440
LIG_TRAF2_1	74	77	PF00917	0.515
LIG_TRAF2_1	9	12	PF00917	0.754
LIG_WRC_WIRS_1	533	538	PF05994	0.304
LIG_WRC_WIRS_1	596	601	PF05994	0.416
MOD_CDK_SPxK_1	230	236	PF00069	0.478
MOD_CDK_SPxxK_3	105	112	PF00069	0.631
MOD_CDK_SPxxK_3	230	237	PF00069	0.488
MOD_CK1_1	115	121	PF00069	0.791
MOD_CK1_1	168	174	PF00069	0.579
MOD_CK1_1	200	206	PF00069	0.504
MOD_CK1_1	325	331	PF00069	0.495
MOD_CK1_1	33	39	PF00069	0.641
MOD_CK1_1	557	563	PF00069	0.559
MOD_CK1_1	56	62	PF00069	0.509
MOD_CK1_1	601	607	PF00069	0.463
MOD_CK1_1	83	89	PF00069	0.684
MOD_CK2_1	271	277	PF00069	0.710
MOD_CK2_1	317	323	PF00069	0.517
MOD_CK2_1	4	10	PF00069	0.788
MOD_CK2_1	411	417	PF00069	0.577
MOD_CK2_1	578	584	PF00069	0.402
MOD_CK2_1	605	611	PF00069	0.513
MOD_CK2_1	62	68	PF00069	0.520
MOD_CK2_1	71	77	PF00069	0.502
MOD_GlcNHglycan	172	175	PF01048	0.584
MOD_GlcNHglycan	23	26	PF01048	0.651
MOD_GlcNHglycan	248	252	PF01048	0.684
MOD_GlcNHglycan	298	302	PF01048	0.567
MOD_GlcNHglycan	315	318	PF01048	0.674
MOD_GlcNHglycan	556	559	PF01048	0.592
MOD_GlcNHglycan	563	566	PF01048	0.708
MOD_GlcNHglycan	64	67	PF01048	0.694
MOD_GSK3_1	115	122	PF00069	0.763
MOD_GSK3_1	126	133	PF00069	0.625
MOD_GSK3_1	151	158	PF00069	0.429
MOD_GSK3_1	161	168	PF00069	0.411
MOD_GSK3_1	19	26	PF00069	0.522
MOD_GSK3_1	196	203	PF00069	0.437
MOD_GSK3_1	206	213	PF00069	0.340
MOD_GSK3_1	243	250	PF00069	0.668
MOD_GSK3_1	264	271	PF00069	0.693
MOD_GSK3_1	30	37	PF00069	0.573
MOD_GSK3_1	309	316	PF00069	0.602
MOD_GSK3_1	322	329	PF00069	0.474
MOD_GSK3_1	335	342	PF00069	0.509
MOD_GSK3_1	456	463	PF00069	0.366
MOD_GSK3_1	470	477	PF00069	0.433
MOD_GSK3_1	506	513	PF00069	0.425
MOD_GSK3_1	52	59	PF00069	0.658
MOD_GSK3_1	553	560	PF00069	0.459
MOD_GSK3_1	561	568	PF00069	0.447
MOD_GSK3_1	594	601	PF00069	0.430
MOD_GSK3_1	76	83	PF00069	0.648
MOD_N-GLC_1	34	39	PF02516	0.513
MOD_N-GLC_1	561	566	PF02516	0.445
MOD_N-GLC_1	81	86	PF02516	0.696
MOD_NEK2_1	126	131	PF00069	0.511
MOD_NEK2_1	165	170	PF00069	0.508
MOD_NEK2_1	196	201	PF00069	0.402
MOD_NEK2_1	282	287	PF00069	0.593
MOD_NEK2_1	289	294	PF00069	0.513
MOD_NEK2_1	4	9	PF00069	0.640
MOD_NEK2_1	456	461	PF00069	0.325
MOD_NEK2_1	483	488	PF00069	0.382
MOD_NEK2_1	588	593	PF00069	0.433
MOD_NEK2_1	595	600	PF00069	0.424
MOD_NEK2_1	80	85	PF00069	0.534
MOD_NEK2_2	152	157	PF00069	0.365
MOD_PIKK_1	210	216	PF00454	0.404
MOD_PIKK_1	264	270	PF00454	0.670
MOD_PIKK_1	357	363	PF00454	0.620
MOD_PIKK_1	406	412	PF00454	0.598
MOD_PIKK_1	565	571	PF00454	0.525
MOD_PIKK_1	601	607	PF00454	0.437
MOD_PKA_2	119	125	PF00069	0.640
MOD_PKA_2	130	136	PF00069	0.544
MOD_PKA_2	168	174	PF00069	0.451
MOD_PKA_2	421	427	PF00069	0.455
MOD_PKA_2	470	476	PF00069	0.512
MOD_PKA_2	554	560	PF00069	0.384
MOD_PKB_1	85	93	PF00069	0.675
MOD_Plk_1	196	202	PF00069	0.448
MOD_Plk_1	210	216	PF00069	0.345
MOD_Plk_1	297	303	PF00069	0.515
MOD_Plk_1	322	328	PF00069	0.458
MOD_Plk_1	33	39	PF00069	0.511
MOD_Plk_1	76	82	PF00069	0.530
MOD_Plk_4	161	167	PF00069	0.408
MOD_Plk_4	186	192	PF00069	0.364
MOD_Plk_4	34	40	PF00069	0.528
MOD_Plk_4	350	356	PF00069	0.504
MOD_Plk_4	442	448	PF00069	0.333
MOD_Plk_4	506	512	PF00069	0.430
MOD_Plk_4	532	538	PF00069	0.313
MOD_Plk_4	595	601	PF00069	0.423
MOD_ProDKin_1	105	111	PF00069	0.582
MOD_ProDKin_1	121	127	PF00069	0.654
MOD_ProDKin_1	19	25	PF00069	0.601
MOD_ProDKin_1	230	236	PF00069	0.501
MOD_ProDKin_1	243	249	PF00069	0.676
MOD_ProDKin_1	71	77	PF00069	0.548
MOD_SUMO_for_1	528	531	PF00179	0.415
TRG_DiLeu_BaEn_1	188	193	PF01217	0.406
TRG_DiLeu_BaEn_1	497	502	PF01217	0.407
TRG_DiLeu_BaEn_4	279	285	PF01217	0.529
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.515
TRG_ENDOCYTIC_2	525	528	PF00928	0.391
TRG_ENDOCYTIC_2	548	551	PF00928	0.433
TRG_ER_diArg_1	252	255	PF00400	0.625
TRG_ER_diArg_1	593	595	PF00400	0.423
TRG_ER_diArg_1	85	88	PF00400	0.557
TRG_NES_CRM1_1	339	352	PF08389	0.474
TRG_NES_CRM1_1	519	531	PF08389	0.350
TRG_NLS_MonoExtC_3	15	21	PF00514	0.597
TRG_NLS_MonoExtN_4	13	20	PF00514	0.655
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA84	Leptomonas seymouri	57%	97%
A0A1X0NIY2	Trypanosomatidae	33%	100%
A0A3S7X8S7	Leishmania donovani	79%	100%
A4IAT8	Leishmania infantum	79%	100%
E9AEL5	Leishmania major	78%	100%
E9B5S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%