Enoyl-CoA hydratase/isomerase family protein,conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase family protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM74_LEIBR

TriTrypDb:

LbrM.34.0400 , LBRM2903_340008900

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM74

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006635	fatty acid beta-oxidation	6	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009062	fatty acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016042	lipid catabolic process	4	1
GO:0016054	organic acid catabolic process	4	1
GO:0019395	fatty acid oxidation	5	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0030258	lipid modification	4	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0034440	lipid oxidation	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044242	cellular lipid catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0072329	monocarboxylic acid catabolic process	6	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	10
GO:0004300	enoyl-CoA hydratase activity	5	1
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0004490	methylglutaconyl-CoA hydratase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.309
CLV_NRD_NRD_1	288	290	PF00675	0.335
CLV_NRD_NRD_1	47	49	PF00675	0.401
CLV_PCSK_KEX2_1	288	290	PF00082	0.206
CLV_PCSK_SKI1_1	21	25	PF00082	0.414
DEG_Nend_UBRbox_1	1	4	PF02207	0.582
DEG_SPOP_SBC_1	74	78	PF00917	0.417
DOC_ANK_TNKS_1	157	164	PF00023	0.426
DOC_ANK_TNKS_1	47	54	PF00023	0.378
DOC_CYCLIN_RxL_1	190	200	PF00134	0.343
DOC_MAPK_gen_1	105	112	PF00069	0.322
DOC_MAPK_gen_1	234	243	PF00069	0.341
DOC_MAPK_gen_1	256	264	PF00069	0.403
DOC_MAPK_gen_1	45	54	PF00069	0.482
DOC_MAPK_MEF2A_6	48	56	PF00069	0.475
DOC_PP2B_LxvP_1	132	135	PF13499	0.206
DOC_USP7_MATH_1	13	17	PF00917	0.460
DOC_USP7_MATH_1	220	224	PF00917	0.426
DOC_USP7_MATH_1	249	253	PF00917	0.406
DOC_WW_Pin1_4	287	292	PF00397	0.453
LIG_14-3-3_CanoR_1	123	127	PF00244	0.362
LIG_BRCT_BRCA1_1	114	118	PF00533	0.331
LIG_FHA_1	1	7	PF00498	0.585
LIG_FHA_2	255	261	PF00498	0.426
LIG_FHA_2	76	82	PF00498	0.237
LIG_IRF3_LxIS_1	229	236	PF10401	0.375
LIG_IRF3_LxIS_1	84	91	PF10401	0.200
LIG_LIR_Gen_1	125	134	PF02991	0.324
LIG_LIR_Gen_1	267	273	PF02991	0.342
LIG_LIR_Nem_3	125	129	PF02991	0.324
LIG_LIR_Nem_3	18	23	PF02991	0.522
LIG_LIR_Nem_3	267	272	PF02991	0.342
LIG_RPA_C_Fungi	111	123	PF08784	0.341
LIG_SH2_NCK_1	32	36	PF00017	0.475
LIG_SH2_STAP1	269	273	PF00017	0.322
LIG_SH3_3	163	169	PF00018	0.426
LIG_SH3_3	180	186	PF00018	0.426
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.464
MOD_CDK_SPxxK_3	287	294	PF00069	0.414
MOD_CK1_1	73	79	PF00069	0.526
MOD_CK2_1	108	114	PF00069	0.354
MOD_CK2_1	124	130	PF00069	0.241
MOD_CK2_1	220	226	PF00069	0.453
MOD_CK2_1	254	260	PF00069	0.382
MOD_GlcNHglycan	204	207	PF01048	0.426
MOD_GlcNHglycan	222	225	PF01048	0.426
MOD_GlcNHglycan	226	229	PF01048	0.200
MOD_GlcNHglycan	251	254	PF01048	0.336
MOD_GlcNHglycan	72	75	PF01048	0.604
MOD_GlcNHglycan	91	94	PF01048	0.123
MOD_GSK3_1	108	115	PF00069	0.320
MOD_GSK3_1	220	227	PF00069	0.344
MOD_GSK3_1	70	77	PF00069	0.609
MOD_NEK2_1	122	127	PF00069	0.327
MOD_NEK2_1	189	194	PF00069	0.309
MOD_NEK2_1	233	238	PF00069	0.453
MOD_NEK2_1	6	11	PF00069	0.541
MOD_NEK2_1	88	93	PF00069	0.367
MOD_NEK2_2	179	184	PF00069	0.423
MOD_PIKK_1	33	39	PF00454	0.479
MOD_PK_1	108	114	PF00069	0.391
MOD_PKA_2	122	128	PF00069	0.349
MOD_PKA_2	233	239	PF00069	0.453
MOD_Plk_1	108	114	PF00069	0.397
MOD_Plk_4	52	58	PF00069	0.383
MOD_ProDKin_1	287	293	PF00069	0.453
MOD_SUMO_rev_2	103	110	PF00179	0.391
TRG_DiLeu_BaEn_2	113	119	PF01217	0.391
TRG_ENDOCYTIC_2	269	272	PF00928	0.322

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z0	Leptomonas seymouri	34%	100%
A0A0N1HVP1	Leptomonas seymouri	28%	95%
A0A0N1PCQ9	Leptomonas seymouri	79%	100%
A0A0S4IKH3	Bodo saltans	28%	86%
A0A0S4IPV6	Bodo saltans	36%	100%
A0A0S4JWH0	Bodo saltans	52%	100%
A0A1X0NJ83	Trypanosomatidae	58%	100%
A0A1X0P9A2	Trypanosomatidae	34%	100%
A0A3Q8IIZ5	Leishmania donovani	36%	100%
A0A3Q8IV04	Leishmania donovani	88%	100%
A0A3R7KI60	Trypanosoma rangeli	55%	100%
A0A3R7N7B2	Trypanosoma rangeli	37%	100%
A0A3S7X4R5	Leishmania donovani	26%	87%
A0A3S7X4T7	Leishmania donovani	28%	87%
A0A422NUW6	Trypanosoma rangeli	28%	100%
A0PJR5	Danio rerio	28%	100%
A0R4Q3	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	32%	100%
A4HH09	Leishmania braziliensis	30%	100%
A4HHN0	Leishmania braziliensis	36%	100%
A4I4U5	Leishmania infantum	36%	100%
A4I708	Leishmania infantum	26%	87%
A4YI89	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	36%	100%
A8ALR7	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	37%	100%
A9JS71	Xenopus laevis	30%	100%
A9MR28	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	37%	100%
A9MYJ5	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	36%	100%
B1IRE0	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	37%	100%
B1LFW9	Escherichia coli (strain SMS-3-5 / SECEC)	37%	100%
B4EY26	Proteus mirabilis (strain HI4320)	39%	100%
B4T6J5	Salmonella newport (strain SL254)	37%	100%
B4TIG9	Salmonella heidelberg (strain SL476)	37%	100%
B4TWR3	Salmonella schwarzengrund (strain CVM19633)	37%	100%
B5BL54	Salmonella paratyphi A (strain AKU_12601)	36%	100%
B5F749	Salmonella agona (strain SL483)	36%	100%
B5FHG4	Salmonella dublin (strain CT_02021853)	36%	100%
B5R1Q9	Salmonella enteritidis PT4 (strain P125109)	36%	100%
B5RGA4	Salmonella gallinarum (strain 287/91 / NCTC 13346)	36%	100%
C0Q4L2	Salmonella paratyphi C (strain RKS4594)	36%	100%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A2C1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AE93	Leishmania major	35%	100%
E9AEL3	Leishmania major	88%	100%
E9AHU0	Leishmania infantum	88%	100%
E9ALJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B233	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	87%
E9B5S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
F1LU71	Rattus norvegicus	39%	94%
F4JML5	Arabidopsis thaliana	46%	98%
F9XMX6	Zymoseptoria tritici (strain CBS 115943 / IPO323)	39%	97%
G4V4T7	Amycolatopsis orientalis	34%	100%
O07137	Mycobacterium leprae (strain TN)	33%	100%
O07533	Bacillus subtilis (strain 168)	25%	100%
O34893	Bacillus subtilis (strain 168)	40%	100%
O35459	Mus musculus	27%	91%
O53561	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	100%
O69762	Pseudomonas fluorescens	26%	100%
O75521	Homo sapiens	22%	75%
O87873	Thauera aromatica	26%	100%
P0ABU0	Escherichia coli (strain K12)	25%	100%
P0ABU1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	25%	100%
P14604	Rattus norvegicus	34%	100%
P23966	Bacillus subtilis (strain 168)	27%	100%
P24162	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	26%	100%
P30084	Homo sapiens	33%	100%
P31551	Escherichia coli (strain K12)	37%	100%
P34559	Caenorhabditis elegans	38%	100%
P44960	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P52045	Escherichia coli (strain K12)	27%	100%
P52046	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	40%	100%
P53526	Mycobacterium leprae (strain TN)	28%	100%
P59395	Shigella flexneri	37%	100%
P64015	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	28%	100%
P64017	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	100%
P76082	Escherichia coli (strain K12)	35%	100%
P77467	Escherichia coli (strain K12)	33%	100%
P94549	Bacillus subtilis (strain 168)	34%	100%
P9WNN6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	29%	100%
P9WNN7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
P9WNN8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	100%
P9WNN9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	100%
P9WNP0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	28%	100%
P9WNP1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
Q0AVM1	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	35%	100%
Q0TLV3	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	37%	100%
Q13011	Homo sapiens	32%	90%
Q13825	Homo sapiens	39%	87%
Q1ZXF1	Dictyostelium discoideum	32%	100%
Q2HJD5	Bos taurus	26%	97%
Q2TBT3	Bos taurus	40%	100%
Q3MIE0	Rattus norvegicus	29%	99%
Q3TLP5	Mus musculus	41%	100%
Q49WG8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	25%	100%
Q4L549	Staphylococcus haemolyticus (strain JCSC1435)	26%	100%
Q4PEN0	Ustilago maydis (strain 521 / FGSC 9021)	44%	100%
Q4Q636	Leishmania major	26%	78%
Q4WF54	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
Q50130	Mycobacterium leprae (strain TN)	26%	100%
Q52995	Rhizobium meliloti (strain 1021)	33%	100%
Q54HG7	Dictyostelium discoideum	41%	98%
Q57TJ1	Salmonella choleraesuis (strain SC-B67)	36%	100%
Q589W8	Alternaria alternata	29%	100%
Q58DM8	Bos taurus	38%	100%
Q5HH38	Staphylococcus aureus (strain COL)	26%	100%
Q5HQC3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	26%	100%
Q5PIL1	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	36%	100%
Q5R4W0	Pongo abelii	26%	98%
Q5R646	Pongo abelii	33%	100%
Q5RFG0	Pongo abelii	32%	90%
Q5XIC0	Rattus norvegicus	24%	76%
Q62651	Rattus norvegicus	28%	91%
Q6AYG5	Rattus norvegicus	26%	99%
Q6GAG7	Staphylococcus aureus (strain MSSA476)	26%	100%
Q6GI37	Staphylococcus aureus (strain MRSA252)	26%	100%
Q6NL24	Arabidopsis thaliana	30%	100%
Q78JN3	Mus musculus	25%	93%
Q7A6A9	Staphylococcus aureus (strain N315)	26%	100%
Q7CQ56	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
Q7U004	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	29%	100%
Q869N6	Dictyostelium discoideum	33%	99%
Q86YB7	Homo sapiens	46%	100%
Q8BH95	Mus musculus	34%	100%
Q8CPQ4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	26%	100%
Q8DR19	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	27%	100%
Q8DSN0	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	28%	100%
Q8FLA6	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	37%	100%
Q8GB17	Proteus sp. (strain LE138)	39%	100%
Q8GYN9	Arabidopsis thaliana	24%	88%
Q8NXA0	Staphylococcus aureus (strain MW2)	26%	100%
Q8XA35	Escherichia coli O157:H7	36%	100%
Q8Z9L5	Salmonella typhi	37%	100%
Q8ZRX5	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	37%	100%
Q96DC8	Homo sapiens	29%	98%
Q96VB3	Alternaria alternata	29%	100%
Q99V48	Staphylococcus aureus (strain Mu50 / ATCC 700699)	26%	100%
Q9CLV5	Pasteurella multocida (strain Pm70)	27%	100%
Q9D7J9	Mus musculus	29%	99%
Q9D9V3	Mus musculus	27%	92%
Q9FHR8	Arabidopsis thaliana	26%	100%
Q9JLZ3	Mus musculus	40%	94%
Q9NTX5	Homo sapiens	27%	96%
Q9P4U7	Alternaria alternata	27%	100%
Q9P4U9	Alternaria alternata	29%	100%
Q9TM10	Cyanidium caldarium	26%	100%
Q9WUR2	Mus musculus	23%	76%
V5BNA5	Trypanosoma cruzi	53%	100%
V5BWB9	Trypanosoma cruzi	26%	81%
V5DTT7	Trypanosoma cruzi	33%	100%