Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM73_LEIBR

TriTrypDb:

LbrM.34.0390 , LBRM2903_340008800

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.553
CLV_NRD_NRD_1	149	151	PF00675	0.380
CLV_NRD_NRD_1	257	259	PF00675	0.526
CLV_NRD_NRD_1	649	651	PF00675	0.449
CLV_NRD_NRD_1	668	670	PF00675	0.416
CLV_PCSK_FUR_1	147	151	PF00082	0.329
CLV_PCSK_FUR_1	647	651	PF00082	0.470
CLV_PCSK_KEX2_1	149	151	PF00082	0.499
CLV_PCSK_KEX2_1	257	259	PF00082	0.581
CLV_PCSK_KEX2_1	649	651	PF00082	0.452
CLV_PCSK_KEX2_1	668	670	PF00082	0.416
CLV_PCSK_PC1ET2_1	668	670	PF00082	0.416
CLV_PCSK_SKI1_1	239	243	PF00082	0.313
CLV_PCSK_SKI1_1	26	30	PF00082	0.361
CLV_PCSK_SKI1_1	287	291	PF00082	0.543
CLV_PCSK_SKI1_1	295	299	PF00082	0.485
CLV_PCSK_SKI1_1	412	416	PF00082	0.454
CLV_PCSK_SKI1_1	45	49	PF00082	0.163
CLV_PCSK_SKI1_1	557	561	PF00082	0.371
CLV_PCSK_SKI1_1	585	589	PF00082	0.444
DEG_APCC_DBOX_1	238	246	PF00400	0.321
DEG_APCC_DBOX_1	261	269	PF00400	0.338
DEG_MDM2_SWIB_1	626	634	PF02201	0.442
DOC_ANK_TNKS_1	155	162	PF00023	0.432
DOC_ANK_TNKS_1	603	610	PF00023	0.300
DOC_ANK_TNKS_1	648	655	PF00023	0.531
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.459
DOC_MAPK_FxFP_2	550	553	PF00069	0.321
DOC_MAPK_gen_1	257	265	PF00069	0.388
DOC_MAPK_gen_1	668	680	PF00069	0.350
DOC_MAPK_MEF2A_6	215	223	PF00069	0.376
DOC_MAPK_MEF2A_6	257	265	PF00069	0.388
DOC_MAPK_MEF2A_6	26	34	PF00069	0.263
DOC_MAPK_MEF2A_6	383	392	PF00069	0.352
DOC_MAPK_MEF2A_6	628	636	PF00069	0.309
DOC_MAPK_MEF2A_6	673	680	PF00069	0.322
DOC_MAPK_NFAT4_5	258	266	PF00069	0.370
DOC_PP2B_LxvP_1	98	101	PF13499	0.445
DOC_PP2B_PxIxI_1	29	35	PF00149	0.208
DOC_PP4_FxxP_1	234	237	PF00568	0.416
DOC_PP4_FxxP_1	550	553	PF00568	0.328
DOC_USP7_MATH_1	10	14	PF00917	0.410
DOC_USP7_MATH_1	109	113	PF00917	0.458
DOC_USP7_MATH_1	120	124	PF00917	0.587
DOC_USP7_MATH_1	138	142	PF00917	0.455
DOC_USP7_MATH_1	357	361	PF00917	0.561
DOC_USP7_MATH_1	515	519	PF00917	0.649
DOC_WW_Pin1_4	105	110	PF00397	0.385
DOC_WW_Pin1_4	180	185	PF00397	0.572
DOC_WW_Pin1_4	469	474	PF00397	0.638
LIG_14-3-3_CanoR_1	287	294	PF00244	0.301
LIG_14-3-3_CanoR_1	447	455	PF00244	0.633
LIG_Actin_WH2_2	673	688	PF00022	0.395
LIG_APCC_ABBA_1	676	681	PF00400	0.304
LIG_BIR_II_1	1	5	PF00653	0.368
LIG_BRCT_BRCA1_1	111	115	PF00533	0.440
LIG_BRCT_BRCA1_1	140	144	PF00533	0.489
LIG_BRCT_BRCA1_1	308	312	PF00533	0.389
LIG_CaM_IQ_9	148	164	PF13499	0.486
LIG_Clathr_ClatBox_1	33	37	PF01394	0.290
LIG_deltaCOP1_diTrp_1	362	367	PF00928	0.418
LIG_FHA_1	114	120	PF00498	0.579
LIG_FHA_1	191	197	PF00498	0.341
LIG_FHA_1	353	359	PF00498	0.424
LIG_FHA_1	525	531	PF00498	0.334
LIG_FHA_1	544	550	PF00498	0.346
LIG_FHA_1	566	572	PF00498	0.378
LIG_FHA_1	694	700	PF00498	0.367
LIG_FHA_1	76	82	PF00498	0.670
LIG_FHA_2	377	383	PF00498	0.640
LIG_FHA_2	622	628	PF00498	0.321
LIG_FHA_2	78	84	PF00498	0.615
LIG_IBAR_NPY_1	611	613	PF08397	0.447
LIG_LIR_Apic_2	548	553	PF02991	0.325
LIG_LIR_Gen_1	133	139	PF02991	0.455
LIG_LIR_Gen_1	14	25	PF02991	0.232
LIG_LIR_Gen_1	199	208	PF02991	0.463
LIG_LIR_Gen_1	362	372	PF02991	0.470
LIG_LIR_Gen_1	48	58	PF02991	0.442
LIG_LIR_Gen_1	483	488	PF02991	0.470
LIG_LIR_Gen_1	586	594	PF02991	0.425
LIG_LIR_Nem_3	14	20	PF02991	0.278
LIG_LIR_Nem_3	199	204	PF02991	0.457
LIG_LIR_Nem_3	362	367	PF02991	0.385
LIG_LIR_Nem_3	450	455	PF02991	0.518
LIG_LIR_Nem_3	48	54	PF02991	0.436
LIG_LIR_Nem_3	554	559	PF02991	0.465
LIG_LIR_Nem_3	586	590	PF02991	0.434
LIG_LIR_Nem_3	97	102	PF02991	0.454
LIG_LYPXL_yS_3	552	555	PF13949	0.354
LIG_MYND_1	206	210	PF01753	0.386
LIG_PCNA_yPIPBox_3	684	697	PF02747	0.462
LIG_Pex14_1	230	234	PF04695	0.429
LIG_Pex14_2	197	201	PF04695	0.418
LIG_Pex14_2	25	29	PF04695	0.236
LIG_Pex14_2	626	630	PF04695	0.315
LIG_Pex14_2	691	695	PF04695	0.308
LIG_PTAP_UEV_1	184	189	PF05743	0.468
LIG_PTB_Apo_2	423	430	PF02174	0.323
LIG_PTB_Phospho_1	423	429	PF10480	0.322
LIG_REV1ctd_RIR_1	152	160	PF16727	0.469
LIG_SH2_NCK_1	430	434	PF00017	0.446
LIG_SH2_NCK_1	452	456	PF00017	0.570
LIG_SH2_PTP2	613	616	PF00017	0.472
LIG_SH2_STAP1	430	434	PF00017	0.446
LIG_SH2_STAT3	58	61	PF00017	0.492
LIG_SH2_STAT5	434	437	PF00017	0.473
LIG_SH2_STAT5	484	487	PF00017	0.472
LIG_SH2_STAT5	51	54	PF00017	0.328
LIG_SH2_STAT5	602	605	PF00017	0.306
LIG_SH2_STAT5	613	616	PF00017	0.341
LIG_SH2_STAT5	65	68	PF00017	0.424
LIG_SH3_3	116	122	PF00018	0.353
LIG_SH3_3	182	188	PF00018	0.619
LIG_SH3_3	396	402	PF00018	0.353
LIG_SH3_3	492	498	PF00018	0.649
LIG_SH3_3	659	665	PF00018	0.385
LIG_SH3_3	98	104	PF00018	0.459
LIG_SH3_4	227	234	PF00018	0.293
LIG_SUMO_SIM_anti_2	586	592	PF11976	0.294
LIG_SUMO_SIM_par_1	31	37	PF11976	0.307
LIG_TRAF2_1	503	506	PF00917	0.639
LIG_TRFH_1	134	138	PF08558	0.316
LIG_TYR_ITSM	448	455	PF00017	0.432
LIG_UBA3_1	207	215	PF00899	0.460
LIG_WRC_WIRS_1	121	126	PF05994	0.563
LIG_WRC_WIRS_1	623	628	PF05994	0.428
LIG_WW_3	236	240	PF00397	0.457
MOD_CK1_1	123	129	PF00069	0.634
MOD_CK1_1	183	189	PF00069	0.677
MOD_CK1_1	190	196	PF00069	0.537
MOD_CK1_1	518	524	PF00069	0.604
MOD_CK1_1	541	547	PF00069	0.467
MOD_CK1_1	621	627	PF00069	0.323
MOD_CK1_1	77	83	PF00069	0.677
MOD_CK2_1	621	627	PF00069	0.323
MOD_CK2_1	77	83	PF00069	0.484
MOD_GlcNHglycan	1	4	PF01048	0.382
MOD_GlcNHglycan	109	112	PF01048	0.447
MOD_GlcNHglycan	359	362	PF01048	0.501
MOD_GlcNHglycan	368	371	PF01048	0.480
MOD_GlcNHglycan	376	379	PF01048	0.499
MOD_GlcNHglycan	454	458	PF01048	0.598
MOD_GlcNHglycan	469	472	PF01048	0.712
MOD_GlcNHglycan	512	515	PF01048	0.621
MOD_GlcNHglycan	543	546	PF01048	0.468
MOD_GSK3_1	105	112	PF00069	0.412
MOD_GSK3_1	179	186	PF00069	0.766
MOD_GSK3_1	211	218	PF00069	0.505
MOD_GSK3_1	302	309	PF00069	0.449
MOD_GSK3_1	362	369	PF00069	0.442
MOD_GSK3_1	520	527	PF00069	0.427
MOD_GSK3_1	534	541	PF00069	0.358
MOD_GSK3_1	618	625	PF00069	0.403
MOD_GSK3_1	77	84	PF00069	0.666
MOD_N-GLC_1	467	472	PF02516	0.641
MOD_N-GLC_2	373	375	PF02516	0.581
MOD_NEK2_1	1	6	PF00069	0.425
MOD_NEK2_1	132	137	PF00069	0.453
MOD_NEK2_1	16	21	PF00069	0.225
MOD_NEK2_1	211	216	PF00069	0.519
MOD_NEK2_1	424	429	PF00069	0.362
MOD_NEK2_1	538	543	PF00069	0.327
MOD_NEK2_1	81	86	PF00069	0.691
MOD_NEK2_2	113	118	PF00069	0.330
MOD_OFUCOSY	334	341	PF10250	0.344
MOD_PIKK_1	279	285	PF00454	0.412
MOD_PIKK_1	538	544	PF00454	0.462
MOD_PK_1	215	221	PF00069	0.374
MOD_PKA_2	87	93	PF00069	0.621
MOD_PKB_1	445	453	PF00069	0.543
MOD_Plk_1	381	387	PF00069	0.396
MOD_Plk_1	538	544	PF00069	0.462
MOD_Plk_1	621	627	PF00069	0.323
MOD_Plk_2-3	622	628	PF00069	0.428
MOD_Plk_4	11	17	PF00069	0.305
MOD_Plk_4	132	138	PF00069	0.402
MOD_Plk_4	187	193	PF00069	0.661
MOD_Plk_4	589	595	PF00069	0.339
MOD_Plk_4	69	75	PF00069	0.566
MOD_ProDKin_1	105	111	PF00069	0.380
MOD_ProDKin_1	180	186	PF00069	0.573
MOD_ProDKin_1	469	475	PF00069	0.632
MOD_SUMO_rev_2	220	229	PF00179	0.647
TRG_DiLeu_BaEn_1	586	591	PF01217	0.279
TRG_DiLeu_BaEn_4	199	205	PF01217	0.484
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.409
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.421
TRG_DiLeu_LyEn_5	203	208	PF01217	0.278
TRG_ENDOCYTIC_2	134	137	PF00928	0.337
TRG_ENDOCYTIC_2	452	455	PF00928	0.485
TRG_ENDOCYTIC_2	484	487	PF00928	0.472
TRG_ENDOCYTIC_2	51	54	PF00928	0.441
TRG_ENDOCYTIC_2	552	555	PF00928	0.354
TRG_ER_diArg_1	147	150	PF00400	0.381
TRG_ER_diArg_1	256	258	PF00400	0.434
TRG_ER_diArg_1	259	262	PF00400	0.375
TRG_NLS_MonoExtN_4	665	672	PF00514	0.384
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV24	Leptomonas seymouri	62%	95%
A0A1X0NJK7	Trypanosomatidae	41%	91%
A0A3Q8IHZ3	Leishmania donovani	81%	100%
A0A3R7L3P1	Trypanosoma rangeli	47%	100%
A4IAT6	Leishmania infantum	82%	100%
D0A2C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AEL2	Leishmania major	82%	100%
E9B5S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BSU8	Trypanosoma cruzi	45%	100%