Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM72_LEIBR

TriTrypDb:

LbrM.34.0380 , LBRM2903_340008700

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HM72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.703
CLV_C14_Caspase3-7	167	171	PF00656	0.615
CLV_C14_Caspase3-7	457	461	PF00656	0.547
CLV_MEL_PAP_1	311	317	PF00089	0.570
CLV_NRD_NRD_1	320	322	PF00675	0.472
CLV_NRD_NRD_1	37	39	PF00675	0.613
CLV_NRD_NRD_1	471	473	PF00675	0.430
CLV_PCSK_FUR_1	35	39	PF00082	0.625
CLV_PCSK_KEX2_1	320	322	PF00082	0.472
CLV_PCSK_KEX2_1	34	36	PF00082	0.588
CLV_PCSK_KEX2_1	368	370	PF00082	0.533
CLV_PCSK_KEX2_1	37	39	PF00082	0.610
CLV_PCSK_KEX2_1	471	473	PF00082	0.417
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.666
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.610
CLV_PCSK_PC7_1	467	473	PF00082	0.425
CLV_PCSK_SKI1_1	130	134	PF00082	0.752
CLV_PCSK_SKI1_1	180	184	PF00082	0.636
CLV_PCSK_SKI1_1	222	226	PF00082	0.343
CLV_PCSK_SKI1_1	285	289	PF00082	0.586
CLV_PCSK_SKI1_1	388	392	PF00082	0.474
CLV_PCSK_SKI1_1	467	471	PF00082	0.510
CLV_PCSK_SKI1_1	61	65	PF00082	0.461
DEG_APCC_DBOX_1	179	187	PF00400	0.559
DEG_APCC_DBOX_1	200	208	PF00400	0.562
DOC_ANK_TNKS_1	183	190	PF00023	0.664
DOC_CDC14_PxL_1	215	223	PF14671	0.382
DOC_CDC14_PxL_1	458	466	PF14671	0.373
DOC_CDC14_PxL_1	5	13	PF14671	0.691
DOC_CYCLIN_RxL_1	219	226	PF00134	0.415
DOC_CYCLIN_RxL_1	368	379	PF00134	0.547
DOC_MAPK_gen_1	34	43	PF00069	0.572
DOC_MAPK_gen_1	368	378	PF00069	0.426
DOC_MAPK_gen_1	61	70	PF00069	0.530
DOC_MAPK_MEF2A_6	368	377	PF00069	0.433
DOC_PP2B_LxvP_1	175	178	PF13499	0.484
DOC_PP2B_LxvP_1	216	219	PF13499	0.393
DOC_PP2B_LxvP_1	229	232	PF13499	0.339
DOC_PP4_FxxP_1	411	414	PF00568	0.380
DOC_PP4_FxxP_1	6	9	PF00568	0.614
DOC_PP4_FxxP_1	73	76	PF00568	0.417
DOC_USP7_MATH_1	121	125	PF00917	0.698
DOC_USP7_MATH_1	132	136	PF00917	0.696
DOC_USP7_MATH_1	151	155	PF00917	0.438
DOC_USP7_MATH_1	165	169	PF00917	0.555
DOC_USP7_MATH_1	359	363	PF00917	0.508
DOC_USP7_MATH_1	389	393	PF00917	0.436
DOC_USP7_MATH_1	439	443	PF00917	0.556
DOC_USP7_MATH_1	59	63	PF00917	0.543
DOC_WW_Pin1_4	340	345	PF00397	0.616
DOC_WW_Pin1_4	401	406	PF00397	0.446
LIG_14-3-3_CanoR_1	142	151	PF00244	0.566
LIG_14-3-3_CanoR_1	201	205	PF00244	0.538
LIG_14-3-3_CanoR_1	261	270	PF00244	0.259
LIG_14-3-3_CanoR_1	320	326	PF00244	0.496
LIG_14-3-3_CanoR_1	388	398	PF00244	0.516
LIG_14-3-3_CanoR_1	400	404	PF00244	0.397
LIG_AP2alpha_1	377	381	PF02296	0.379
LIG_BRCT_BRCA1_1	391	395	PF00533	0.405
LIG_Clathr_ClatBox_1	267	271	PF01394	0.446
LIG_Clathr_ClatBox_1	375	379	PF01394	0.441
LIG_deltaCOP1_diTrp_1	323	326	PF00928	0.514
LIG_EVH1_1	175	179	PF00568	0.484
LIG_FHA_1	288	294	PF00498	0.550
LIG_FHA_1	358	364	PF00498	0.623
LIG_FHA_1	428	434	PF00498	0.294
LIG_FHA_2	201	207	PF00498	0.360
LIG_FHA_2	389	395	PF00498	0.529
LIG_FHA_2	455	461	PF00498	0.505
LIG_LIR_Apic_2	145	151	PF02991	0.376
LIG_LIR_Apic_2	3	9	PF02991	0.646
LIG_LIR_Apic_2	477	483	PF02991	0.529
LIG_LIR_Apic_2	72	76	PF02991	0.411
LIG_LIR_Gen_1	153	163	PF02991	0.422
LIG_LIR_Gen_1	191	200	PF02991	0.328
LIG_LIR_Gen_1	226	235	PF02991	0.414
LIG_LIR_Gen_1	374	382	PF02991	0.387
LIG_LIR_Gen_1	392	403	PF02991	0.405
LIG_LIR_Nem_3	153	159	PF02991	0.511
LIG_LIR_Nem_3	191	195	PF02991	0.344
LIG_LIR_Nem_3	226	231	PF02991	0.382
LIG_LIR_Nem_3	3	8	PF02991	0.623
LIG_LIR_Nem_3	374	380	PF02991	0.367
LIG_LIR_Nem_3	392	398	PF02991	0.416
LIG_LIR_Nem_3	404	409	PF02991	0.399
LIG_LIR_Nem_3	72	77	PF02991	0.479
LIG_LYPXL_SIV_4	405	413	PF13949	0.407
LIG_NRBOX	220	226	PF00104	0.381
LIG_PCNA_yPIPBox_3	276	288	PF02747	0.543
LIG_Pex14_2	377	381	PF04695	0.379
LIG_REV1ctd_RIR_1	3	8	PF16727	0.584
LIG_SH2_CRK	156	160	PF00017	0.517
LIG_SH2_CRK	192	196	PF00017	0.323
LIG_SH2_CRK	406	410	PF00017	0.268
LIG_SH2_CRK	434	438	PF00017	0.484
LIG_SH2_CRK	480	484	PF00017	0.481
LIG_SH2_NCK_1	484	488	PF00017	0.425
LIG_SH2_PTP2	74	77	PF00017	0.517
LIG_SH2_SRC	74	77	PF00017	0.545
LIG_SH2_STAP1	156	160	PF00017	0.517
LIG_SH2_STAT5	215	218	PF00017	0.376
LIG_SH2_STAT5	220	223	PF00017	0.347
LIG_SH2_STAT5	257	260	PF00017	0.447
LIG_SH2_STAT5	303	306	PF00017	0.456
LIG_SH2_STAT5	310	313	PF00017	0.456
LIG_SH2_STAT5	74	77	PF00017	0.443
LIG_SH3_3	157	163	PF00018	0.515
LIG_SH3_3	173	179	PF00018	0.693
LIG_SUMO_SIM_par_1	22	28	PF11976	0.627
LIG_SUMO_SIM_par_1	266	271	PF11976	0.444
LIG_TRFH_1	228	232	PF08558	0.375
LIG_WRC_WIRS_1	70	75	PF05994	0.515
LIG_WW_3	177	181	PF00397	0.460
MOD_CK1_1	164	170	PF00069	0.596
MOD_CK1_1	362	368	PF00069	0.587
MOD_CK1_1	401	407	PF00069	0.396
MOD_CK1_1	454	460	PF00069	0.443
MOD_CK2_1	388	394	PF00069	0.574
MOD_CK2_1	438	444	PF00069	0.556
MOD_CMANNOS	494	497	PF00535	0.458
MOD_GlcNHglycan	111	114	PF01048	0.656
MOD_GlcNHglycan	144	147	PF01048	0.612
MOD_GlcNHglycan	162	166	PF01048	0.503
MOD_GlcNHglycan	167	170	PF01048	0.634
MOD_GlcNHglycan	171	174	PF01048	0.659
MOD_GlcNHglycan	225	228	PF01048	0.359
MOD_GlcNHglycan	27	30	PF01048	0.588
MOD_GlcNHglycan	329	332	PF01048	0.711
MOD_GlcNHglycan	335	338	PF01048	0.713
MOD_GlcNHglycan	365	368	PF01048	0.605
MOD_GlcNHglycan	45	48	PF01048	0.337
MOD_GlcNHglycan	53	57	PF01048	0.481
MOD_GlcNHglycan	82	85	PF01048	0.570
MOD_GSK3_1	138	145	PF00069	0.543
MOD_GSK3_1	161	168	PF00069	0.527
MOD_GSK3_1	355	362	PF00069	0.653
MOD_GSK3_1	78	85	PF00069	0.585
MOD_NEK2_1	25	30	PF00069	0.632
MOD_NEK2_1	287	292	PF00069	0.548
MOD_NEK2_1	33	38	PF00069	0.639
MOD_NEK2_1	363	368	PF00069	0.436
MOD_NEK2_1	398	403	PF00069	0.340
MOD_NEK2_2	121	126	PF00069	0.500
MOD_NEK2_2	59	64	PF00069	0.317
MOD_PIKK_1	82	88	PF00454	0.673
MOD_PKA_2	165	171	PF00069	0.732
MOD_PKA_2	200	206	PF00069	0.536
MOD_PKA_2	319	325	PF00069	0.636
MOD_PKA_2	399	405	PF00069	0.527
MOD_PKA_2	454	460	PF00069	0.587
MOD_Plk_1	169	175	PF00069	0.491
MOD_Plk_4	144	150	PF00069	0.516
MOD_Plk_4	200	206	PF00069	0.495
MOD_Plk_4	346	352	PF00069	0.413
MOD_Plk_4	88	94	PF00069	0.679
MOD_ProDKin_1	340	346	PF00069	0.615
MOD_ProDKin_1	401	407	PF00069	0.441
MOD_SUMO_for_1	50	53	PF00179	0.578
MOD_SUMO_rev_2	28	36	PF00179	0.419
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.640
TRG_ENDOCYTIC_2	156	159	PF00928	0.389
TRG_ENDOCYTIC_2	192	195	PF00928	0.334
TRG_ENDOCYTIC_2	220	223	PF00928	0.386
TRG_ENDOCYTIC_2	406	409	PF00928	0.272
TRG_ENDOCYTIC_2	74	77	PF00928	0.466
TRG_ER_diArg_1	35	38	PF00400	0.559
TRG_ER_diArg_1	470	472	PF00400	0.427
TRG_NES_CRM1_1	372	385	PF08389	0.521
TRG_NLS_MonoExtC_3	33	38	PF00514	0.432
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M2	Leptomonas seymouri	59%	95%
A0A0S4JN24	Bodo saltans	35%	100%
A0A1X0NKI9	Trypanosomatidae	42%	100%
A0A3Q8ILR1	Leishmania donovani	79%	100%
A0A3R7NSD3	Trypanosoma rangeli	42%	100%
A4IAT5	Leishmania infantum	79%	100%
D0A2C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	96%
E9AEL1	Leishmania major	80%	100%
E9B5S2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BIP8	Trypanosoma cruzi	42%	100%