Putative short chain dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HM71_LEIBR

TriTrypDb:

LbrM.34.0370 , LBRM2903_340008600

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	1
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HM71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM71

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006643	membrane lipid metabolic process	4	10
GO:0006665	sphingolipid metabolic process	4	10
GO:0006666	3-keto-sphinganine metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0030148	sphingolipid biosynthetic process	5	10
GO:0042180	cellular ketone metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0046467	membrane lipid biosynthetic process	4	10
GO:0046519	sphingoid metabolic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:0006082	organic acid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0006633	fatty acid biosynthetic process	5	1
GO:0016053	organic acid biosynthetic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046394	carboxylic acid biosynthetic process	5	1
GO:0072330	monocarboxylic acid biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	10
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	10
GO:0047560	3-dehydrosphinganine reductase activity	5	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	323	325	PF00675	0.277
CLV_NRD_NRD_1	55	57	PF00675	0.273
CLV_NRD_NRD_1	67	69	PF00675	0.207
CLV_PCSK_KEX2_1	170	172	PF00082	0.162
CLV_PCSK_KEX2_1	67	69	PF00082	0.231
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.190
CLV_PCSK_SKI1_1	173	177	PF00082	0.208
CLV_PCSK_SKI1_1	251	255	PF00082	0.311
DEG_SPOP_SBC_1	175	179	PF00917	0.507
DOC_CKS1_1	225	230	PF01111	0.408
DOC_MAPK_DCC_7	56	64	PF00069	0.506
DOC_MAPK_gen_1	170	176	PF00069	0.362
DOC_MAPK_gen_1	56	64	PF00069	0.505
DOC_MAPK_JIP1_4	119	125	PF00069	0.512
DOC_MAPK_MEF2A_6	56	64	PF00069	0.506
DOC_MAPK_RevD_3	157	171	PF00069	0.353
DOC_PP4_FxxP_1	130	133	PF00568	0.408
DOC_USP7_MATH_1	243	247	PF00917	0.529
DOC_USP7_MATH_1	291	295	PF00917	0.489
DOC_USP7_MATH_1	329	333	PF00917	0.643
DOC_WW_Pin1_4	218	223	PF00397	0.426
DOC_WW_Pin1_4	224	229	PF00397	0.409
DOC_WW_Pin1_4	235	240	PF00397	0.478
LIG_14-3-3_CanoR_1	91	95	PF00244	0.524
LIG_Actin_WH2_2	296	311	PF00022	0.480
LIG_Actin_WH2_2	57	75	PF00022	0.451
LIG_BIR_II_1	1	5	PF00653	0.153
LIG_BRCT_BRCA1_1	1	5	PF00533	0.153
LIG_FHA_1	1	7	PF00498	0.315
LIG_FHA_1	208	214	PF00498	0.415
LIG_FHA_1	298	304	PF00498	0.448
LIG_FHA_1	34	40	PF00498	0.512
LIG_FHA_1	94	100	PF00498	0.459
LIG_GBD_Chelix_1	8	16	PF00786	0.391
LIG_LIR_Gen_1	2	12	PF02991	0.278
LIG_LIR_Gen_1	93	100	PF02991	0.475
LIG_LIR_Nem_3	2	8	PF02991	0.209
LIG_MLH1_MIPbox_1	1	5	PF16413	0.153
LIG_PCNA_yPIPBox_3	301	309	PF02747	0.533
LIG_PTB_Apo_2	124	131	PF02174	0.419
LIG_SH2_CRK	320	324	PF00017	0.476
LIG_SH2_STAP1	269	273	PF00017	0.511
LIG_SH2_STAT5	152	155	PF00017	0.451
LIG_SH2_STAT5	189	192	PF00017	0.506
LIG_SH2_STAT5	94	97	PF00017	0.419
LIG_SH3_3	216	222	PF00018	0.408
LIG_SH3_3	233	239	PF00018	0.580
LIG_SUMO_SIM_anti_2	155	160	PF11976	0.451
LIG_SUMO_SIM_par_1	33	40	PF11976	0.498
LIG_TYR_ITIM	318	323	PF00017	0.461
LIG_UBA3_1	166	170	PF00899	0.353
LIG_WRC_WIRS_1	1	6	PF05994	0.153
LIG_WRC_WIRS_1	244	249	PF05994	0.511
MOD_CK1_1	104	110	PF00069	0.509
MOD_CK1_1	93	99	PF00069	0.562
MOD_GlcNHglycan	192	195	PF01048	0.312
MOD_GlcNHglycan	285	288	PF01048	0.283
MOD_GlcNHglycan	332	335	PF01048	0.399
MOD_GSK3_1	267	274	PF00069	0.499
MOD_GSK3_1	33	40	PF00069	0.443
MOD_GSK3_1	330	337	PF00069	0.599
MOD_NEK2_1	12	17	PF00069	0.466
MOD_NEK2_1	136	141	PF00069	0.433
MOD_NEK2_1	176	181	PF00069	0.411
MOD_NEK2_1	208	213	PF00069	0.433
MOD_NEK2_1	258	263	PF00069	0.499
MOD_NEK2_1	271	276	PF00069	0.462
MOD_NEK2_1	299	304	PF00069	0.575
MOD_NEK2_2	187	192	PF00069	0.390
MOD_PIKK_1	297	303	PF00454	0.408
MOD_PKA_2	90	96	PF00069	0.512
MOD_Plk_1	101	107	PF00069	0.468
MOD_Plk_1	137	143	PF00069	0.502
MOD_Plk_1	208	214	PF00069	0.470
MOD_Plk_1	267	273	PF00069	0.465
MOD_Plk_1	32	38	PF00069	0.580
MOD_Plk_4	12	18	PF00069	0.433
MOD_Plk_4	187	193	PF00069	0.392
MOD_Plk_4	258	264	PF00069	0.383
MOD_Plk_4	299	305	PF00069	0.511
MOD_Plk_4	33	39	PF00069	0.512
MOD_Plk_4	90	96	PF00069	0.482
MOD_ProDKin_1	218	224	PF00069	0.426
MOD_ProDKin_1	235	241	PF00069	0.474
MOD_SUMO_rev_2	233	239	PF00179	0.519
TRG_ENDOCYTIC_2	320	323	PF00928	0.460
TRG_ENDOCYTIC_2	94	97	PF00928	0.419
TRG_ER_diArg_1	171	174	PF00400	0.363
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.280

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTS4	Leptomonas seymouri	28%	100%
A0A0N1I1P8	Leptomonas seymouri	76%	99%
A0A0N1I6F8	Leptomonas seymouri	27%	100%
A0A0N1I7L3	Leptomonas seymouri	31%	100%
A0A0S4JBE7	Bodo saltans	28%	100%
A0A0S4JMY7	Bodo saltans	50%	99%
A0A0S4JNE8	Bodo saltans	30%	100%
A0A1X0NFB1	Trypanosomatidae	27%	100%
A0A1X0NKR7	Trypanosomatidae	44%	91%
A0A3Q8IF11	Leishmania donovani	26%	100%
A0A3Q8IHN8	Leishmania donovani	89%	100%
A0A3Q8IIU6	Leishmania donovani	29%	100%
A0A3S7X6T1	Leishmania donovani	29%	100%
A0A3S7XB64	Leishmania donovani	30%	100%
A0A422NG64	Trypanosoma rangeli	30%	100%
A0A422NNE9	Trypanosoma rangeli	53%	100%
A4HDR5	Leishmania braziliensis	27%	100%
A4HLM0	Leishmania braziliensis	29%	100%
A4HME4	Leishmania braziliensis	29%	100%
A4HPK8	Leishmania braziliensis	30%	100%
A4I111	Leishmania infantum	26%	100%
A4I931	Leishmania infantum	29%	100%
A4IAT4	Leishmania infantum	89%	100%
A4IB16	Leishmania infantum	29%	100%
A4ID56	Leishmania infantum	30%	100%
A5DND6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	27%	99%
A5PJF6	Bos taurus	27%	100%
D0A2C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
D0A534	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D3U1D9	Klebsiella oxytoca	28%	100%
E9AEL0	Leishmania major	88%	100%
E9AEU5	Leishmania major	30%	100%
E9AX49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B3Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B5S1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B601	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
F4JZN6	Arabidopsis thaliana	33%	100%
O05730	Helicobacter pylori (strain ATCC 700392 / 26695)	26%	100%
O75452	Homo sapiens	28%	100%
O77667	Bos taurus	26%	84%
O88451	Mus musculus	29%	100%
O93868	Agaricus bisporus	25%	100%
P0CR36	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	25%	100%
P0CR37	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	25%	100%
P0DKC5	Arabidopsis thaliana	28%	97%
P0DKC6	Arabidopsis thaliana	28%	97%
P10528	Priestia megaterium	23%	100%
P25970	Myxococcus xanthus (strain DK1622)	31%	100%
P28845	Homo sapiens	28%	100%
P37694	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	26%	100%
P39482	Priestia megaterium	23%	100%
P39483	Priestia megaterium	25%	100%
P39484	Priestia megaterium	23%	100%
P39485	Priestia megaterium	23%	100%
P40288	Priestia megaterium	23%	100%
P41177	Streptomyces virginiae	28%	100%
P50168	Ovis aries	26%	79%
P80365	Homo sapiens	26%	84%
Q06136	Homo sapiens	35%	100%
Q0IH28	Xenopus laevis	29%	100%
Q0VFE7	Xenopus tropicalis	28%	100%
Q0WRJ2	Arabidopsis thaliana	29%	100%
Q13268	Homo sapiens	28%	100%
Q1R183	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	28%	100%
Q28IU1	Xenopus tropicalis	27%	100%
Q2KIJ5	Bos taurus	35%	100%
Q3T0R4	Bos taurus	29%	100%
Q3U0B3	Mus musculus	25%	100%
Q3ZBV9	Bos taurus	26%	100%
Q4L8Y1	Staphylococcus haemolyticus (strain JCSC1435)	27%	100%
Q4Q428	Leishmania major	29%	100%
Q4QAC7	Leishmania major	27%	100%
Q556J2	Dictyostelium discoideum	29%	100%
Q59RQ2	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	100%
Q5BE65	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	92%
Q5HLD8	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	29%	100%
Q5R6U1	Pongo abelii	26%	100%
Q5RJY4	Rattus norvegicus	29%	100%
Q5XGF7	Xenopus tropicalis	27%	99%
Q6BQK1	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	100%
Q6CE86	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	91%
Q6CVS4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	98%
Q6F7B8	Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)	29%	100%
Q6GV12	Mus musculus	33%	100%
Q6IAN0	Homo sapiens	26%	100%
Q6NRV4	Xenopus laevis	26%	99%
Q6PUF3	Danio rerio	27%	100%
Q6UWP2	Homo sapiens	25%	100%
Q71R50	Gallus gallus	27%	100%
Q758B6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q7Q732	Anopheles gambiae	31%	100%
Q7RZR2	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	94%
Q7T2D1	Danio rerio	26%	100%
Q83RE8	Shigella flexneri	26%	100%
Q8CN40	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	29%	100%
Q8U8I2	Agrobacterium fabrum (strain C58 / ATCC 33970)	30%	100%
Q8VCR2	Mus musculus	24%	100%
Q92781	Homo sapiens	28%	100%
Q99J47	Mus musculus	29%	100%
Q9FYL6	Arabidopsis thaliana	25%	100%
Q9GKX2	Oryctolagus cuniculus	26%	100%
Q9KWN1	Rhizobium radiobacter	30%	100%
Q9P7B4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9STY7	Arabidopsis thaliana	28%	100%
Q9X248	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	27%	100%
Q9Y140	Drosophila melanogaster	28%	100%
Q9ZKW1	Helicobacter pylori (strain J99 / ATCC 700824)	27%	100%
V5B376	Trypanosoma cruzi	52%	100%