Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM69_LEIBR

TriTrypDb:

LbrM.34.0340 , LBRM2903_340008300

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM69

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006260	DNA replication	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.476
CLV_NRD_NRD_1	295	297	PF00675	0.481
CLV_NRD_NRD_1	47	49	PF00675	0.592
CLV_PCSK_KEX2_1	225	227	PF00082	0.530
CLV_PCSK_KEX2_1	249	251	PF00082	0.465
CLV_PCSK_KEX2_1	295	297	PF00082	0.481
CLV_PCSK_KEX2_1	49	51	PF00082	0.592
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.530
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.465
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.592
CLV_PCSK_SKI1_1	104	108	PF00082	0.445
CLV_PCSK_SKI1_1	122	126	PF00082	0.354
CLV_PCSK_SKI1_1	250	254	PF00082	0.446
DOC_MAPK_gen_1	225	232	PF00069	0.538
DOC_USP7_MATH_1	155	159	PF00917	0.498
DOC_USP7_MATH_1	174	178	PF00917	0.685
DOC_USP7_MATH_1	180	184	PF00917	0.729
DOC_USP7_MATH_1	207	211	PF00917	0.615
DOC_USP7_MATH_1	33	37	PF00917	0.546
DOC_USP7_MATH_1	83	87	PF00917	0.583
DOC_USP7_UBL2_3	104	108	PF12436	0.441
DOC_USP7_UBL2_3	249	253	PF12436	0.440
DOC_WW_Pin1_4	58	63	PF00397	0.507
LIG_14-3-3_CanoR_1	208	212	PF00244	0.673
LIG_14-3-3_CanoR_1	276	286	PF00244	0.541
LIG_BRCT_BRCA1_1	102	106	PF00533	0.560
LIG_BRCT_BRCA1_1	25	29	PF00533	0.597
LIG_BRCT_BRCA1_1	60	64	PF00533	0.552
LIG_BRCT_BRCA1_2	102	108	PF00533	0.560
LIG_CaM_IQ_9	40	55	PF13499	0.474
LIG_FHA_1	232	238	PF00498	0.629
LIG_FHA_2	22	28	PF00498	0.573
LIG_FHA_2	237	243	PF00498	0.503
LIG_GBD_Chelix_1	2	10	PF00786	0.352
LIG_LIR_Nem_3	140	145	PF02991	0.502
LIG_LIR_Nem_3	26	32	PF02991	0.591
LIG_LIR_Nem_3	260	266	PF02991	0.581
LIG_LIR_Nem_3	280	286	PF02991	0.438
LIG_Pex14_2	259	263	PF04695	0.414
LIG_RPA_C_Fungi	158	170	PF08784	0.487
LIG_SH2_STAT3	131	134	PF00017	0.566
LIG_SH3_3	86	92	PF00018	0.607
MOD_CK1_1	137	143	PF00069	0.504
MOD_CK1_1	210	216	PF00069	0.579
MOD_CK1_1	36	42	PF00069	0.524
MOD_CK1_1	96	102	PF00069	0.604
MOD_CK2_1	137	143	PF00069	0.507
MOD_CK2_1	236	242	PF00069	0.545
MOD_CK2_1	258	264	PF00069	0.443
MOD_DYRK1A_RPxSP_1	58	62	PF00069	0.579
MOD_GlcNHglycan	167	170	PF01048	0.703
MOD_GlcNHglycan	177	180	PF01048	0.717
MOD_GlcNHglycan	196	199	PF01048	0.674
MOD_GlcNHglycan	85	88	PF01048	0.585
MOD_GSK3_1	15	22	PF00069	0.439
MOD_GSK3_1	155	162	PF00069	0.633
MOD_GSK3_1	175	182	PF00069	0.771
MOD_GSK3_1	188	195	PF00069	0.687
MOD_GSK3_1	231	238	PF00069	0.592
MOD_GSK3_1	244	251	PF00069	0.584
MOD_GSK3_1	32	39	PF00069	0.467
MOD_GSK3_1	4	11	PF00069	0.567
MOD_GSK3_1	96	103	PF00069	0.568
MOD_N-GLC_1	122	127	PF02516	0.361
MOD_NEK2_1	19	24	PF00069	0.453
MOD_NEK2_1	194	199	PF00069	0.772
MOD_NEK2_1	64	69	PF00069	0.429
MOD_PIKK_1	163	169	PF00454	0.644
MOD_PIKK_1	17	23	PF00454	0.456
MOD_PIKK_1	294	300	PF00454	0.530
MOD_PIKK_1	4	10	PF00454	0.511
MOD_PIKK_1	64	70	PF00454	0.526
MOD_PKA_2	145	151	PF00069	0.461
MOD_PKA_2	192	198	PF00069	0.734
MOD_PKA_2	207	213	PF00069	0.540
MOD_PKA_2	294	300	PF00069	0.471
MOD_PKA_2	96	102	PF00069	0.605
MOD_Plk_1	15	21	PF00069	0.533
MOD_Plk_1	155	161	PF00069	0.474
MOD_Plk_1	189	195	PF00069	0.717
MOD_Plk_1	235	241	PF00069	0.594
MOD_Plk_1	51	57	PF00069	0.572
MOD_Plk_2-3	236	242	PF00069	0.470
MOD_ProDKin_1	58	64	PF00069	0.504
MOD_SUMO_for_1	289	292	PF00179	0.445
MOD_SUMO_rev_2	129	137	PF00179	0.568
TRG_ENDOCYTIC_2	266	269	PF00928	0.615
TRG_ENDOCYTIC_2	286	289	PF00928	0.300
TRG_ER_diArg_1	48	51	PF00400	0.460
TRG_NES_CRM1_1	222	236	PF08389	0.634
TRG_Pf-PMV_PEXEL_1	139	143	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I316	Leptomonas seymouri	70%	91%
A0A0S4JRP8	Bodo saltans	33%	83%
A0A1X0NJS6	Trypanosomatidae	37%	74%
A0A3Q8IFZ2	Leishmania donovani	80%	90%
A0A3R7MJB6	Trypanosoma rangeli	38%	85%
A4IAT1	Leishmania infantum	81%	90%
D0A2C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9AEK7	Leishmania major	81%	100%
E9B5R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	90%
V5BSV2	Trypanosoma cruzi	39%	86%