LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HM66_LEIBR
TriTrypDb:
LbrM.34.0310 , LBRM2903_340008100
Length:
77

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

A4HM66
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM66

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 75 77 PF00675 0.509
DEG_Nend_Nbox_1 1 3 PF02207 0.658
DOC_USP7_MATH_1 45 49 PF00917 0.501
DOC_USP7_UBL2_3 65 69 PF12436 0.589
LIG_Actin_WH2_2 49 67 PF00022 0.430
LIG_FHA_1 17 23 PF00498 0.355
LIG_FHA_1 2 8 PF00498 0.426
LIG_LIR_Gen_1 19 28 PF02991 0.562
LIG_LIR_Gen_1 4 13 PF02991 0.454
LIG_LIR_Nem_3 19 23 PF02991 0.355
LIG_LIR_Nem_3 4 8 PF02991 0.556
LIG_SH2_CRK 5 9 PF00017 0.249
LIG_SH2_CRK 60 64 PF00017 0.475
LIG_SH2_NCK_1 26 30 PF00017 0.335
LIG_SH2_SRC 26 29 PF00017 0.334
LIG_SH2_STAP1 34 38 PF00017 0.382
LIG_SH3_1 65 71 PF00018 0.632
LIG_SH3_3 65 71 PF00018 0.690
LIG_SUMO_SIM_par_1 13 19 PF11976 0.390
LIG_SUMO_SIM_par_1 27 33 PF11976 0.376
LIG_TYR_ITIM 3 8 PF00017 0.426
LIG_WRC_WIRS_1 17 22 PF05994 0.376
LIG_WW_3 69 73 PF00397 0.590
MOD_CK1_1 16 22 PF00069 0.430
MOD_GlcNHglycan 47 50 PF01048 0.501
MOD_GlcNHglycan 72 75 PF01048 0.491
MOD_NEK2_1 1 6 PF00069 0.687
MOD_NEK2_1 13 18 PF00069 0.430
MOD_Plk_4 13 19 PF00069 0.379
TRG_DiLeu_BaLyEn_6 50 55 PF01217 0.385
TRG_ENDOCYTIC_2 26 29 PF00928 0.334
TRG_ENDOCYTIC_2 5 8 PF00928 0.249
TRG_ENDOCYTIC_2 60 63 PF00928 0.255

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P608 Leptomonas seymouri 67% 100%
A0A3Q8IIN9 Leishmania donovani 79% 100%
A4IAS8 Leishmania infantum 79% 100%
D0A2D0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 97%
E9AEK4 Leishmania major 82% 100%
E9B5R5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 77% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS