Putative GTP-ase activating protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTP-ase activating protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM65_LEIBR

TriTrypDb:

LbrM.34.0300 , LBRM2903_340008000

Length:

625

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003924	GTPase activity	7	5
GO:0003925	G protein activity	2	5
GO:0005096	GTPase activator activity	4	10
GO:0005488	binding	1	10
GO:0005543	phospholipid binding	3	10
GO:0008047	enzyme activator activity	3	10
GO:0008289	lipid binding	2	10
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	5
GO:0030234	enzyme regulator activity	2	10
GO:0030695	GTPase regulator activity	4	10
GO:0060589	nucleoside-triphosphatase regulator activity	3	10
GO:0098772	molecular function regulator activity	1	10
GO:0140677	molecular function activator activity	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	242	244	PF00675	0.677
CLV_NRD_NRD_1	264	266	PF00675	0.756
CLV_NRD_NRD_1	28	30	PF00675	0.457
CLV_NRD_NRD_1	349	351	PF00675	0.439
CLV_NRD_NRD_1	434	436	PF00675	0.625
CLV_NRD_NRD_1	566	568	PF00675	0.533
CLV_PCSK_KEX2_1	28	30	PF00082	0.449
CLV_PCSK_KEX2_1	433	435	PF00082	0.485
CLV_PCSK_KEX2_1	440	442	PF00082	0.559
CLV_PCSK_KEX2_1	565	567	PF00082	0.365
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.422
CLV_PCSK_SKI1_1	138	142	PF00082	0.392
CLV_PCSK_SKI1_1	165	169	PF00082	0.504
CLV_PCSK_SKI1_1	456	460	PF00082	0.595
CLV_PCSK_SKI1_1	51	55	PF00082	0.384
CLV_PCSK_SKI1_1	532	536	PF00082	0.608
CLV_PCSK_SKI1_1	76	80	PF00082	0.488
DEG_Nend_UBRbox_2	1	3	PF02207	0.659
DEG_SPOP_SBC_1	458	462	PF00917	0.441
DOC_CKS1_1	606	611	PF01111	0.661
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.349
DOC_MAPK_gen_1	423	431	PF00069	0.485
DOC_MAPK_gen_1	51	59	PF00069	0.449
DOC_MAPK_MEF2A_6	494	503	PF00069	0.502
DOC_MAPK_RevD_3	228	244	PF00069	0.576
DOC_PP1_RVXF_1	136	143	PF00149	0.415
DOC_PP1_RVXF_1	592	598	PF00149	0.592
DOC_PP1_RVXF_1	612	618	PF00149	0.417
DOC_PP1_RVXF_1	74	81	PF00149	0.464
DOC_PP2B_LxvP_1	296	299	PF13499	0.441
DOC_PP4_FxxP_1	42	45	PF00568	0.443
DOC_PP4_MxPP_1	121	124	PF00568	0.502
DOC_USP7_MATH_1	115	119	PF00917	0.747
DOC_USP7_MATH_1	210	214	PF00917	0.734
DOC_USP7_MATH_1	327	331	PF00917	0.444
DOC_USP7_MATH_1	392	396	PF00917	0.381
DOC_USP7_MATH_1	408	412	PF00917	0.218
DOC_USP7_MATH_1	45	49	PF00917	0.461
DOC_USP7_MATH_1	609	613	PF00917	0.527
DOC_WW_Pin1_4	119	124	PF00397	0.585
DOC_WW_Pin1_4	302	307	PF00397	0.447
DOC_WW_Pin1_4	605	610	PF00397	0.673
LIG_14-3-3_CanoR_1	22	28	PF00244	0.580
LIG_14-3-3_CanoR_1	295	299	PF00244	0.576
LIG_14-3-3_CanoR_1	410	417	PF00244	0.233
LIG_14-3-3_CanoR_1	456	464	PF00244	0.441
LIG_14-3-3_CanoR_1	538	547	PF00244	0.544
LIG_APCC_ABBA_1	398	403	PF00400	0.233
LIG_APCC_ABBAyCdc20_2	54	60	PF00400	0.514
LIG_BRCT_BRCA1_1	155	159	PF00533	0.516
LIG_BRCT_BRCA1_1	394	398	PF00533	0.484
LIG_deltaCOP1_diTrp_1	363	372	PF00928	0.344
LIG_deltaCOP1_diTrp_1	575	583	PF00928	0.540
LIG_deltaCOP1_diTrp_1	611	617	PF00928	0.538
LIG_FHA_1	169	175	PF00498	0.688
LIG_FHA_1	22	28	PF00498	0.443
LIG_FHA_1	229	235	PF00498	0.657
LIG_FHA_1	391	397	PF00498	0.456
LIG_FHA_1	459	465	PF00498	0.645
LIG_FHA_1	494	500	PF00498	0.561
LIG_FHA_1	6	12	PF00498	0.438
LIG_FHA_1	72	78	PF00498	0.521
LIG_FHA_2	104	110	PF00498	0.495
LIG_FHA_2	213	219	PF00498	0.554
LIG_FHA_2	539	545	PF00498	0.429
LIG_FHA_2	606	612	PF00498	0.692
LIG_KLC1_Yacidic_2	55	60	PF13176	0.512
LIG_LIR_Gen_1	152	160	PF02991	0.575
LIG_LIR_Gen_1	236	242	PF02991	0.676
LIG_LIR_Gen_1	330	339	PF02991	0.344
LIG_LIR_Gen_1	386	396	PF02991	0.444
LIG_LIR_Gen_1	520	530	PF02991	0.428
LIG_LIR_Gen_1	619	625	PF02991	0.531
LIG_LIR_Nem_3	152	158	PF02991	0.573
LIG_LIR_Nem_3	236	240	PF02991	0.598
LIG_LIR_Nem_3	330	334	PF02991	0.328
LIG_LIR_Nem_3	386	391	PF02991	0.333
LIG_LIR_Nem_3	520	526	PF02991	0.414
LIG_LIR_Nem_3	619	624	PF02991	0.420
LIG_LYPXL_SIV_4	69	77	PF13949	0.530
LIG_MYND_1	206	210	PF01753	0.552
LIG_PDZ_Class_2	620	625	PF00595	0.331
LIG_Pex14_1	613	617	PF04695	0.508
LIG_PTB_Apo_2	80	87	PF02174	0.539
LIG_PTB_Phospho_1	80	86	PF10480	0.545
LIG_REV1ctd_RIR_1	484	491	PF16727	0.489
LIG_SH2_CRK	155	159	PF00017	0.467
LIG_SH2_CRK	495	499	PF00017	0.524
LIG_SH2_CRK	560	564	PF00017	0.485
LIG_SH2_CRK	621	625	PF00017	0.550
LIG_SH2_NCK_1	70	74	PF00017	0.604
LIG_SH2_SRC	58	61	PF00017	0.530
LIG_SH2_STAP1	155	159	PF00017	0.573
LIG_SH2_STAP1	308	312	PF00017	0.512
LIG_SH2_STAP1	426	430	PF00017	0.444
LIG_SH2_STAP1	86	90	PF00017	0.502
LIG_SH2_STAT3	129	132	PF00017	0.507
LIG_SH2_STAT5	129	132	PF00017	0.427
LIG_SH2_STAT5	388	391	PF00017	0.373
LIG_SH2_STAT5	40	43	PF00017	0.386
LIG_SH2_STAT5	469	472	PF00017	0.720
LIG_SH2_STAT5	495	498	PF00017	0.336
LIG_SH2_STAT5	560	563	PF00017	0.391
LIG_SH2_STAT5	58	61	PF00017	0.487
LIG_SH2_STAT5	99	102	PF00017	0.604
LIG_SH3_3	183	189	PF00018	0.780
LIG_SH3_3	386	392	PF00018	0.416
LIG_SH3_3	402	408	PF00018	0.225
LIG_SH3_3	439	445	PF00018	0.541
LIG_SH3_3	579	585	PF00018	0.485
LIG_SH3_4	315	322	PF00018	0.444
LIG_SUMO_SIM_anti_2	215	224	PF11976	0.749
LIG_SUMO_SIM_par_1	7	12	PF11976	0.394
LIG_TRAF2_1	239	242	PF00917	0.674
LIG_TRFH_1	398	402	PF08558	0.233
LIG_UBA3_1	144	153	PF00899	0.555
LIG_UBA3_1	498	504	PF00899	0.546
LIG_WRC_WIRS_1	409	414	PF05994	0.444
LIG_WW_1	492	495	PF00397	0.479
LIG_WW_3	491	495	PF00397	0.488
MOD_CK1_1	178	184	PF00069	0.750
MOD_CK1_1	21	27	PF00069	0.632
MOD_CK1_1	217	223	PF00069	0.721
MOD_CK1_1	411	417	PF00069	0.444
MOD_CK1_1	471	477	PF00069	0.730
MOD_CK1_1	5	11	PF00069	0.457
MOD_CK1_1	605	611	PF00069	0.691
MOD_CK2_1	210	216	PF00069	0.797
MOD_CK2_1	220	226	PF00069	0.685
MOD_CK2_1	266	272	PF00069	0.652
MOD_CK2_1	365	371	PF00069	0.477
MOD_CK2_1	410	416	PF00069	0.401
MOD_CK2_1	605	611	PF00069	0.705
MOD_GlcNHglycan	11	14	PF01048	0.355
MOD_GlcNHglycan	117	120	PF01048	0.610
MOD_GlcNHglycan	125	128	PF01048	0.531
MOD_GlcNHglycan	175	178	PF01048	0.637
MOD_GlcNHglycan	191	194	PF01048	0.707
MOD_GlcNHglycan	296	299	PF01048	0.453
MOD_GlcNHglycan	358	361	PF01048	0.441
MOD_GlcNHglycan	413	416	PF01048	0.436
MOD_GlcNHglycan	512	515	PF01048	0.340
MOD_GSK3_1	115	122	PF00069	0.646
MOD_GSK3_1	149	156	PF00069	0.478
MOD_GSK3_1	166	173	PF00069	0.714
MOD_GSK3_1	178	185	PF00069	0.679
MOD_GSK3_1	210	217	PF00069	0.743
MOD_GSK3_1	23	30	PF00069	0.448
MOD_GSK3_1	307	314	PF00069	0.399
MOD_GSK3_1	452	459	PF00069	0.619
MOD_GSK3_1	5	12	PF00069	0.438
MOD_GSK3_1	605	612	PF00069	0.655
MOD_GSK3_1	613	620	PF00069	0.478
MOD_LATS_1	212	218	PF00433	0.768
MOD_LATS_1	349	355	PF00433	0.441
MOD_LATS_1	536	542	PF00433	0.570
MOD_N-GLC_2	355	357	PF02516	0.444
MOD_NEK2_1	166	171	PF00069	0.641
MOD_NEK2_1	294	299	PF00069	0.613
MOD_NEK2_1	307	312	PF00069	0.295
MOD_NEK2_1	429	434	PF00069	0.245
MOD_NEK2_1	457	462	PF00069	0.603
MOD_NEK2_1	537	542	PF00069	0.558
MOD_NEK2_1	559	564	PF00069	0.529
MOD_NEK2_1	590	595	PF00069	0.492
MOD_NEK2_1	617	622	PF00069	0.400
MOD_NEK2_2	175	180	PF00069	0.581
MOD_NEK2_2	23	28	PF00069	0.551
MOD_NEK2_2	522	527	PF00069	0.527
MOD_PIKK_1	153	159	PF00454	0.516
MOD_PIKK_1	476	482	PF00454	0.513
MOD_PIKK_1	525	531	PF00454	0.541
MOD_PIKK_1	595	601	PF00454	0.568
MOD_PIKK_1	602	608	PF00454	0.686
MOD_PKA_2	149	155	PF00069	0.614
MOD_PKA_2	21	27	PF00069	0.576
MOD_PKA_2	294	300	PF00069	0.513
MOD_PKA_2	417	423	PF00069	0.444
MOD_PKA_2	493	499	PF00069	0.506
MOD_PKA_2	537	543	PF00069	0.550
MOD_PKB_1	433	441	PF00069	0.645
MOD_PKB_1	454	462	PF00069	0.635
MOD_Plk_1	153	159	PF00069	0.564
MOD_Plk_1	2	8	PF00069	0.468
MOD_Plk_1	217	223	PF00069	0.641
MOD_Plk_1	452	458	PF00069	0.607
MOD_Plk_1	471	477	PF00069	0.550
MOD_Plk_2-3	2	8	PF00069	0.579
MOD_Plk_4	217	223	PF00069	0.534
MOD_Plk_4	249	255	PF00069	0.776
MOD_Plk_4	417	423	PF00069	0.444
MOD_Plk_4	5	11	PF00069	0.445
MOD_Plk_4	559	565	PF00069	0.494
MOD_ProDKin_1	119	125	PF00069	0.582
MOD_ProDKin_1	302	308	PF00069	0.445
MOD_ProDKin_1	605	611	PF00069	0.666
MOD_SUMO_rev_2	43	48	PF00179	0.518
TRG_DiLeu_BaEn_1	530	535	PF01217	0.622
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.551
TRG_ENDOCYTIC_2	155	158	PF00928	0.629
TRG_ENDOCYTIC_2	237	240	PF00928	0.587
TRG_ENDOCYTIC_2	388	391	PF00928	0.369
TRG_ENDOCYTIC_2	426	429	PF00928	0.485
TRG_ENDOCYTIC_2	495	498	PF00928	0.431
TRG_ENDOCYTIC_2	560	563	PF00928	0.411
TRG_ENDOCYTIC_2	621	624	PF00928	0.467
TRG_ER_diArg_1	27	29	PF00400	0.466
TRG_ER_diArg_1	433	435	PF00400	0.485
TRG_ER_diArg_1	454	457	PF00400	0.651
TRG_ER_diArg_1	564	567	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE2	Leptomonas seymouri	59%	100%
A0A1X0NIZ1	Trypanosomatidae	33%	100%
A0A3S5IRI6	Trypanosoma rangeli	33%	100%
A0A3S7X8N7	Leishmania donovani	80%	100%
A4IAS7	Leishmania infantum	79%	100%
E9AEK3	Leishmania major	79%	100%
E9B5R4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
V5B380	Trypanosoma cruzi	34%	100%