Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM64_LEIBR

TriTrypDb:

LbrM.34.0290 , LBRM2903_340007900

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HM64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM64

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	333	335	PF00675	0.694
CLV_NRD_NRD_1	387	389	PF00675	0.725
CLV_NRD_NRD_1	6	8	PF00675	0.470
CLV_NRD_NRD_1	678	680	PF00675	0.593
CLV_PCSK_KEX2_1	333	335	PF00082	0.694
CLV_PCSK_KEX2_1	387	389	PF00082	0.672
CLV_PCSK_KEX2_1	394	396	PF00082	0.682
CLV_PCSK_KEX2_1	6	8	PF00082	0.470
CLV_PCSK_KEX2_1	712	714	PF00082	0.670
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.654

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L9	Leptomonas seymouri	63%	98%
A0A3Q8IJ18	Leishmania donovani	82%	100%
A4IAS6	Leishmania infantum	82%	100%
D0A2D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AEK2	Leishmania major	82%	100%
E9B5R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%

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