Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM64_LEIBR

TriTrypDb:

LbrM.34.0290 , LBRM2903_340007900

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HM64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM64

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	333	335	PF00675	0.694
CLV_NRD_NRD_1	387	389	PF00675	0.725
CLV_NRD_NRD_1	6	8	PF00675	0.470
CLV_NRD_NRD_1	678	680	PF00675	0.593
CLV_PCSK_KEX2_1	333	335	PF00082	0.694
CLV_PCSK_KEX2_1	387	389	PF00082	0.672
CLV_PCSK_KEX2_1	394	396	PF00082	0.682
CLV_PCSK_KEX2_1	6	8	PF00082	0.470
CLV_PCSK_KEX2_1	712	714	PF00082	0.670
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.654
CLV_PCSK_PC1ET2_1	712	714	PF00082	0.670
CLV_PCSK_SKI1_1	140	144	PF00082	0.531
CLV_PCSK_SKI1_1	239	243	PF00082	0.525
CLV_PCSK_SKI1_1	424	428	PF00082	0.500
DEG_SCF_FBW7_1	151	158	PF00400	0.510
DEG_SPOP_SBC_1	118	122	PF00917	0.518
DEG_SPOP_SBC_1	361	365	PF00917	0.556
DEG_SPOP_SBC_1	498	502	PF00917	0.733
DOC_ANK_TNKS_1	465	472	PF00023	0.473
DOC_CYCLIN_yClb3_PxF_3	598	606	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	636	642	PF00134	0.455
DOC_MAPK_MEF2A_6	616	624	PF00069	0.613
DOC_PP2B_LxvP_1	588	591	PF13499	0.694
DOC_PP2B_LxvP_1	620	623	PF13499	0.570
DOC_PP4_FxxP_1	193	196	PF00568	0.608
DOC_USP7_MATH_1	113	117	PF00917	0.447
DOC_USP7_MATH_1	118	122	PF00917	0.562
DOC_USP7_MATH_1	155	159	PF00917	0.691
DOC_USP7_MATH_1	258	262	PF00917	0.479
DOC_USP7_MATH_1	407	411	PF00917	0.726
DOC_USP7_MATH_1	420	424	PF00917	0.520
DOC_USP7_MATH_1	438	442	PF00917	0.670
DOC_USP7_MATH_1	498	502	PF00917	0.741
DOC_USP7_MATH_1	536	540	PF00917	0.613
DOC_WW_Pin1_4	129	134	PF00397	0.633
DOC_WW_Pin1_4	151	156	PF00397	0.736
DOC_WW_Pin1_4	192	197	PF00397	0.543
DOC_WW_Pin1_4	362	367	PF00397	0.765
DOC_WW_Pin1_4	557	562	PF00397	0.784
DOC_WW_Pin1_4	581	586	PF00397	0.633
DOC_WW_Pin1_4	591	596	PF00397	0.711
DOC_WW_Pin1_4	635	640	PF00397	0.662
LIG_14-3-3_CanoR_1	101	109	PF00244	0.525
LIG_14-3-3_CanoR_1	147	151	PF00244	0.744
LIG_14-3-3_CanoR_1	180	187	PF00244	0.499
LIG_14-3-3_CanoR_1	323	330	PF00244	0.632
LIG_14-3-3_CanoR_1	333	337	PF00244	0.648
LIG_14-3-3_CanoR_1	546	554	PF00244	0.627
LIG_14-3-3_CanoR_1	6	11	PF00244	0.522
LIG_14-3-3_CanoR_1	616	620	PF00244	0.696
LIG_14-3-3_CanoR_1	668	674	PF00244	0.583
LIG_Actin_WH2_2	530	548	PF00022	0.661
LIG_Actin_WH2_2	82	100	PF00022	0.588
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BRCT_BRCA1_1	133	137	PF00533	0.393
LIG_BRCT_BRCA1_1	422	426	PF00533	0.644
LIG_BRCT_BRCA1_1	596	600	PF00533	0.677
LIG_Clathr_ClatBox_1	461	465	PF01394	0.634
LIG_eIF4E_1	599	605	PF01652	0.727
LIG_FHA_1	101	107	PF00498	0.420
LIG_FHA_1	261	267	PF00498	0.517
LIG_FHA_1	279	285	PF00498	0.515
LIG_FHA_1	286	292	PF00498	0.480
LIG_FHA_1	3	9	PF00498	0.489
LIG_FHA_1	349	355	PF00498	0.719
LIG_FHA_1	45	51	PF00498	0.549
LIG_FHA_1	484	490	PF00498	0.617
LIG_FHA_1	507	513	PF00498	0.621
LIG_FHA_1	546	552	PF00498	0.490
LIG_FHA_1	616	622	PF00498	0.571
LIG_FHA_1	631	637	PF00498	0.637
LIG_FHA_2	126	132	PF00498	0.732
LIG_FHA_2	134	140	PF00498	0.562
LIG_FHA_2	207	213	PF00498	0.461
LIG_FHA_2	558	564	PF00498	0.745
LIG_GBD_Chelix_1	354	362	PF00786	0.547
LIG_LIR_Gen_1	261	272	PF02991	0.517
LIG_LIR_Gen_1	288	295	PF02991	0.488
LIG_LIR_Gen_1	509	517	PF02991	0.612
LIG_LIR_Nem_3	261	267	PF02991	0.517
LIG_LIR_Nem_3	288	293	PF02991	0.498
LIG_LIR_Nem_3	35	39	PF02991	0.464
LIG_LIR_Nem_3	423	429	PF02991	0.642
LIG_LIR_Nem_3	509	513	PF02991	0.584
LIG_LIR_Nem_3	597	603	PF02991	0.617
LIG_MAD2	701	709	PF02301	0.593
LIG_MLH1_MIPbox_1	596	600	PF16413	0.748
LIG_SH2_CRK	187	191	PF00017	0.393
LIG_SH2_CRK	457	461	PF00017	0.654
LIG_SH2_CRK	485	489	PF00017	0.671
LIG_SH2_CRK	656	660	PF00017	0.600
LIG_SH2_SRC	217	220	PF00017	0.476
LIG_SH2_STAP1	217	221	PF00017	0.478
LIG_SH2_STAP1	457	461	PF00017	0.654
LIG_SH2_STAP1	656	660	PF00017	0.547
LIG_SH2_STAT5	187	190	PF00017	0.422
LIG_SH2_STAT5	255	258	PF00017	0.499
LIG_SH2_STAT5	264	267	PF00017	0.491
LIG_SH2_STAT5	485	488	PF00017	0.492
LIG_SH2_STAT5	599	602	PF00017	0.624
LIG_SH3_3	112	118	PF00018	0.429
LIG_SH3_3	228	234	PF00018	0.532
LIG_SH3_3	254	260	PF00018	0.339
LIG_SH3_3	363	369	PF00018	0.740
LIG_SH3_3	486	492	PF00018	0.623
LIG_SH3_3	592	598	PF00018	0.742
LIG_SH3_3	655	661	PF00018	0.579
LIG_SUMO_SIM_anti_2	618	623	PF11976	0.683
LIG_TRAF2_1	136	139	PF00917	0.567
LIG_TRAF2_1	162	165	PF00917	0.590
LIG_TRFH_1	603	607	PF08558	0.719
MOD_CK1_1	120	126	PF00069	0.767
MOD_CK1_1	158	164	PF00069	0.595
MOD_CK1_1	2	8	PF00069	0.589
MOD_CK1_1	328	334	PF00069	0.641
MOD_CK1_1	406	412	PF00069	0.636
MOD_CK1_1	530	536	PF00069	0.651
MOD_CK1_1	594	600	PF00069	0.510
MOD_CK1_1	638	644	PF00069	0.554
MOD_CK1_1	9	15	PF00069	0.513
MOD_CK2_1	125	131	PF00069	0.719
MOD_CK2_1	133	139	PF00069	0.623
MOD_CK2_1	206	212	PF00069	0.457
MOD_CK2_1	536	542	PF00069	0.677
MOD_CK2_1	55	61	PF00069	0.433
MOD_GlcNHglycan	169	172	PF01048	0.565
MOD_GlcNHglycan	175	179	PF01048	0.511
MOD_GlcNHglycan	25	28	PF01048	0.482
MOD_GlcNHglycan	303	306	PF01048	0.643
MOD_GlcNHglycan	325	328	PF01048	0.651
MOD_GlcNHglycan	374	377	PF01048	0.731
MOD_GlcNHglycan	405	408	PF01048	0.710
MOD_GlcNHglycan	416	419	PF01048	0.713
MOD_GlcNHglycan	434	437	PF01048	0.679
MOD_GlcNHglycan	440	443	PF01048	0.693
MOD_GlcNHglycan	529	532	PF01048	0.636
MOD_GlcNHglycan	58	61	PF01048	0.524
MOD_GlcNHglycan	611	614	PF01048	0.498
MOD_GlcNHglycan	92	95	PF01048	0.567
MOD_GSK3_1	109	116	PF00069	0.641
MOD_GSK3_1	117	124	PF00069	0.667
MOD_GSK3_1	125	132	PF00069	0.715
MOD_GSK3_1	146	153	PF00069	0.761
MOD_GSK3_1	154	161	PF00069	0.661
MOD_GSK3_1	2	9	PF00069	0.556
MOD_GSK3_1	279	286	PF00069	0.503
MOD_GSK3_1	325	332	PF00069	0.611
MOD_GSK3_1	341	348	PF00069	0.686
MOD_GSK3_1	403	410	PF00069	0.675
MOD_GSK3_1	567	574	PF00069	0.671
MOD_GSK3_1	622	629	PF00069	0.581
MOD_GSK3_1	630	637	PF00069	0.502
MOD_GSK3_1	638	645	PF00069	0.479
MOD_N-GLC_1	278	283	PF02516	0.535
MOD_N-GLC_1	403	408	PF02516	0.706
MOD_N-GLC_1	45	50	PF02516	0.557
MOD_NEK2_1	1	6	PF00069	0.602
MOD_NEK2_1	109	114	PF00069	0.622
MOD_NEK2_1	229	234	PF00069	0.346
MOD_NEK2_1	283	288	PF00069	0.503
MOD_NEK2_1	291	296	PF00069	0.532
MOD_NEK2_1	322	327	PF00069	0.481
MOD_NEK2_1	349	354	PF00069	0.684
MOD_NEK2_1	545	550	PF00069	0.676
MOD_NEK2_1	564	569	PF00069	0.711
MOD_NEK2_1	609	614	PF00069	0.646
MOD_NEK2_1	615	620	PF00069	0.621
MOD_PIKK_1	667	673	PF00454	0.524
MOD_PK_1	6	12	PF00069	0.524
MOD_PKA_1	387	393	PF00069	0.803
MOD_PKA_1	6	12	PF00069	0.524
MOD_PKA_2	100	106	PF00069	0.549
MOD_PKA_2	146	152	PF00069	0.686
MOD_PKA_2	179	185	PF00069	0.490
MOD_PKA_2	322	328	PF00069	0.615
MOD_PKA_2	332	338	PF00069	0.649
MOD_PKA_2	349	355	PF00069	0.719
MOD_PKA_2	387	393	PF00069	0.747
MOD_PKA_2	545	551	PF00069	0.639
MOD_PKA_2	6	12	PF00069	0.524
MOD_PKA_2	615	621	PF00069	0.696
MOD_PKA_2	667	673	PF00069	0.582
MOD_Plk_1	138	144	PF00069	0.585
MOD_Plk_1	174	180	PF00069	0.479
MOD_Plk_1	278	284	PF00069	0.408
MOD_Plk_1	45	51	PF00069	0.549
MOD_Plk_2-3	626	632	PF00069	0.737
MOD_Plk_4	138	144	PF00069	0.585
MOD_Plk_4	212	218	PF00069	0.584
MOD_Plk_4	279	285	PF00069	0.543
MOD_Plk_4	615	621	PF00069	0.624
MOD_Plk_4	631	637	PF00069	0.667
MOD_Plk_4	638	644	PF00069	0.587
MOD_ProDKin_1	129	135	PF00069	0.614
MOD_ProDKin_1	151	157	PF00069	0.727
MOD_ProDKin_1	192	198	PF00069	0.543
MOD_ProDKin_1	362	368	PF00069	0.766
MOD_ProDKin_1	557	563	PF00069	0.786
MOD_ProDKin_1	581	587	PF00069	0.635
MOD_ProDKin_1	591	597	PF00069	0.709
MOD_ProDKin_1	635	641	PF00069	0.660
MOD_SUMO_rev_2	132	142	PF00179	0.591
TRG_DiLeu_BaEn_1	139	144	PF01217	0.590
TRG_DiLeu_BaEn_2	137	143	PF01217	0.577
TRG_DiLeu_BaLyEn_6	456	461	PF01217	0.655
TRG_ENDOCYTIC_2	187	190	PF00928	0.397
TRG_ENDOCYTIC_2	264	267	PF00928	0.491
TRG_ENDOCYTIC_2	31	34	PF00928	0.440
TRG_ENDOCYTIC_2	457	460	PF00928	0.661
TRG_ENDOCYTIC_2	656	659	PF00928	0.556
TRG_ER_diArg_1	6	8	PF00400	0.470
TRG_ER_diArg_1	70	73	PF00400	0.639
TRG_NES_CRM1_1	302	314	PF08389	0.418
TRG_NLS_MonoCore_2	711	716	PF00514	0.747
TRG_NLS_MonoExtN_4	709	716	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	701	706	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L9	Leptomonas seymouri	63%	98%
A0A3Q8IJ18	Leishmania donovani	82%	100%
A4IAS6	Leishmania infantum	82%	100%
D0A2D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AEK2	Leishmania major	82%	100%
E9B5R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%