C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM62_LEIBR

TriTrypDb:

LbrM.34.0270 , LBRM2903_340007700

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM62

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.712
CLV_C14_Caspase3-7	94	98	PF00656	0.434
CLV_NRD_NRD_1	126	128	PF00675	0.657
CLV_PCSK_KEX2_1	126	128	PF00082	0.673
CLV_PCSK_KEX2_1	244	246	PF00082	0.478
CLV_PCSK_KEX2_1	329	331	PF00082	0.732
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.500
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.732
CLV_PCSK_SKI1_1	265	269	PF00082	0.426
CLV_PCSK_SKI1_1	91	95	PF00082	0.552
DEG_COP1_1	4	14	PF00400	0.457
DEG_SPOP_SBC_1	187	191	PF00917	0.507
DEG_SPOP_SBC_1	300	304	PF00917	0.669
DOC_ANK_TNKS_1	125	132	PF00023	0.755
DOC_MAPK_MEF2A_6	33	40	PF00069	0.415
DOC_USP7_MATH_1	152	156	PF00917	0.608
DOC_USP7_MATH_1	186	190	PF00917	0.572
DOC_USP7_MATH_1	208	212	PF00917	0.511
DOC_USP7_MATH_1	300	304	PF00917	0.623
DOC_USP7_MATH_1	47	51	PF00917	0.511
DOC_USP7_UBL2_3	240	244	PF12436	0.541
DOC_WW_Pin1_4	10	15	PF00397	0.668
DOC_WW_Pin1_4	174	179	PF00397	0.595
DOC_WW_Pin1_4	302	307	PF00397	0.719
LIG_14-3-3_CanoR_1	121	126	PF00244	0.700
LIG_14-3-3_CanoR_1	156	166	PF00244	0.710
LIG_14-3-3_CanoR_1	274	278	PF00244	0.306
LIG_BIR_II_1	1	5	PF00653	0.461
LIG_EVH1_2	79	83	PF00568	0.315
LIG_FHA_1	65	71	PF00498	0.372
LIG_FHA_2	188	194	PF00498	0.637
LIG_FHA_2	213	219	PF00498	0.428
LIG_FHA_2	92	98	PF00498	0.693
LIG_LIR_Gen_1	109	119	PF02991	0.509
LIG_LIR_Gen_1	215	222	PF02991	0.418
LIG_LIR_LC3C_4	133	138	PF02991	0.708
LIG_LIR_Nem_3	109	114	PF02991	0.694
LIG_LIR_Nem_3	215	220	PF02991	0.403
LIG_LIR_Nem_3	325	331	PF02991	0.524
LIG_PTAP_UEV_1	281	286	PF05743	0.555
LIG_SH2_CRK	111	115	PF00017	0.473
LIG_SH2_CRK	217	221	PF00017	0.429
LIG_SH2_CRK	328	332	PF00017	0.499
LIG_SH2_GRB2like	41	44	PF00017	0.525
LIG_SH2_NCK_1	111	115	PF00017	0.473
LIG_SH2_SRC	41	44	PF00017	0.525
LIG_SH2_STAP1	217	221	PF00017	0.528
LIG_SH2_STAP1	277	281	PF00017	0.436
LIG_SH2_STAT3	277	280	PF00017	0.544
LIG_SH2_STAT3	48	51	PF00017	0.351
LIG_SH2_STAT5	170	173	PF00017	0.581
LIG_SH3_2	282	287	PF14604	0.689
LIG_SH3_3	139	145	PF00018	0.730
LIG_SH3_3	279	285	PF00018	0.634
LIG_SH3_3	8	14	PF00018	0.589
LIG_SUMO_SIM_par_1	218	223	PF11976	0.308
MOD_CDK_SPxK_1	302	308	PF00069	0.744
MOD_CK1_1	154	160	PF00069	0.632
MOD_CK1_1	176	182	PF00069	0.592
MOD_CK1_1	227	233	PF00069	0.306
MOD_CK1_1	301	307	PF00069	0.713
MOD_CK1_1	315	321	PF00069	0.569
MOD_CK1_1	335	341	PF00069	0.760
MOD_CK1_1	4	10	PF00069	0.660
MOD_CK1_1	59	65	PF00069	0.426
MOD_CK1_1	74	80	PF00069	0.466
MOD_CK2_1	156	162	PF00069	0.682
MOD_CK2_1	313	319	PF00069	0.737
MOD_CK2_1	47	53	PF00069	0.566
MOD_GlcNHglycan	159	162	PF01048	0.754
MOD_GlcNHglycan	19	22	PF01048	0.695
MOD_GlcNHglycan	190	193	PF01048	0.447
MOD_GlcNHglycan	282	285	PF01048	0.604
MOD_GlcNHglycan	338	341	PF01048	0.513
MOD_GSK3_1	136	143	PF00069	0.612
MOD_GSK3_1	151	158	PF00069	0.645
MOD_GSK3_1	173	180	PF00069	0.652
MOD_GSK3_1	208	215	PF00069	0.507
MOD_GSK3_1	220	227	PF00069	0.489
MOD_GSK3_1	298	305	PF00069	0.676
MOD_GSK3_1	308	315	PF00069	0.638
MOD_GSK3_1	331	338	PF00069	0.648
MOD_LATS_1	89	95	PF00433	0.421
MOD_N-GLC_1	336	341	PF02516	0.776
MOD_NEK2_1	1	6	PF00069	0.464
MOD_NEK2_1	136	141	PF00069	0.603
MOD_NEK2_1	289	294	PF00069	0.520
MOD_NEK2_1	299	304	PF00069	0.760
MOD_NEK2_1	324	329	PF00069	0.690
MOD_NEK2_1	331	336	PF00069	0.726
MOD_NEK2_1	350	355	PF00069	0.503
MOD_NEK2_1	83	88	PF00069	0.506
MOD_PIKK_1	140	146	PF00454	0.473
MOD_PIKK_1	224	230	PF00454	0.493
MOD_PIKK_1	308	314	PF00454	0.761
MOD_PIKK_1	47	53	PF00454	0.493
MOD_PIKK_1	62	68	PF00454	0.441
MOD_PIKK_1	83	89	PF00454	0.547
MOD_PKA_2	109	115	PF00069	0.709
MOD_PKA_2	155	161	PF00069	0.643
MOD_PKA_2	273	279	PF00069	0.311
MOD_Plk_1	119	125	PF00069	0.720
MOD_Plk_1	324	330	PF00069	0.499
MOD_Plk_1	336	342	PF00069	0.775
MOD_Plk_1	59	65	PF00069	0.318
MOD_Plk_4	100	106	PF00069	0.434
MOD_Plk_4	109	115	PF00069	0.472
MOD_Plk_4	212	218	PF00069	0.414
MOD_Plk_4	227	233	PF00069	0.306
MOD_ProDKin_1	10	16	PF00069	0.669
MOD_ProDKin_1	174	180	PF00069	0.596
MOD_ProDKin_1	302	308	PF00069	0.721
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.308
TRG_ENDOCYTIC_2	111	114	PF00928	0.697
TRG_ENDOCYTIC_2	216	219	PF00928	0.397
TRG_ENDOCYTIC_2	328	331	PF00928	0.498
TRG_ER_diArg_1	125	127	PF00400	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P9	Leptomonas seymouri	56%	97%
A0A1X0NKL5	Trypanosomatidae	37%	97%
A0A3Q8IV00	Leishmania donovani	73%	98%
A0A422NNF8	Trypanosoma rangeli	35%	98%
A4IAS4	Leishmania infantum	74%	98%
E9AEK0	Leishmania major	73%	100%
E9B5R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
V5BNB0	Trypanosoma cruzi	36%	100%