Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM57_LEIBR

TriTrypDb:

LbrM.34.0220 , LBRM2903_340007200

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.386
CLV_NRD_NRD_1	166	168	PF00675	0.463
CLV_NRD_NRD_1	220	222	PF00675	0.554
CLV_NRD_NRD_1	500	502	PF00675	0.631
CLV_NRD_NRD_1	639	641	PF00675	0.527
CLV_NRD_NRD_1	684	686	PF00675	0.533
CLV_NRD_NRD_1	714	716	PF00675	0.513
CLV_NRD_NRD_1	782	784	PF00675	0.561
CLV_PCSK_KEX2_1	220	222	PF00082	0.363
CLV_PCSK_KEX2_1	245	247	PF00082	0.520
CLV_PCSK_KEX2_1	385	387	PF00082	0.432
CLV_PCSK_KEX2_1	638	640	PF00082	0.450
CLV_PCSK_KEX2_1	683	685	PF00082	0.536
CLV_PCSK_KEX2_1	782	784	PF00082	0.623
CLV_PCSK_KEX2_1	794	796	PF00082	0.491
CLV_PCSK_KEX2_1	852	854	PF00082	0.610
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.504
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.432
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.460
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.536
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.531
CLV_PCSK_PC1ET2_1	852	854	PF00082	0.601
CLV_PCSK_PC7_1	848	854	PF00082	0.594
CLV_PCSK_SKI1_1	208	212	PF00082	0.562
CLV_PCSK_SKI1_1	391	395	PF00082	0.552
CLV_PCSK_SKI1_1	407	411	PF00082	0.289
CLV_PCSK_SKI1_1	45	49	PF00082	0.469
CLV_PCSK_SKI1_1	751	755	PF00082	0.523
CLV_PCSK_SKI1_1	80	84	PF00082	0.568
CLV_PCSK_SKI1_1	853	857	PF00082	0.596
DEG_APCC_DBOX_1	500	508	PF00400	0.593
DEG_APCC_DBOX_1	542	550	PF00400	0.503
DEG_APCC_DBOX_1	65	73	PF00400	0.564
DEG_APCC_DBOX_1	732	740	PF00400	0.543
DEG_APCC_KENBOX_2	529	533	PF00400	0.538
DOC_CYCLIN_RxL_1	748	758	PF00134	0.476
DOC_MAPK_gen_1	37	46	PF00069	0.357
DOC_MAPK_gen_1	4	13	PF00069	0.395
DOC_MAPK_gen_1	700	708	PF00069	0.443
DOC_MAPK_gen_1	713	723	PF00069	0.321
DOC_MAPK_gen_1	818	825	PF00069	0.507
DOC_MAPK_MEF2A_6	591	599	PF00069	0.511
DOC_MAPK_MEF2A_6	794	801	PF00069	0.560
DOC_MAPK_NFAT4_5	794	802	PF00069	0.560
DOC_SPAK_OSR1_1	447	451	PF12202	0.309
DOC_USP7_MATH_1	194	198	PF00917	0.551
DOC_USP7_MATH_1	281	285	PF00917	0.646
DOC_USP7_MATH_1	402	406	PF00917	0.375
DOC_USP7_MATH_1	412	416	PF00917	0.410
DOC_USP7_MATH_1	651	655	PF00917	0.509
DOC_USP7_UBL2_3	80	84	PF12436	0.363
LIG_14-3-3_CanoR_1	102	108	PF00244	0.345
LIG_14-3-3_CanoR_1	15	23	PF00244	0.439
LIG_14-3-3_CanoR_1	178	182	PF00244	0.540
LIG_14-3-3_CanoR_1	220	227	PF00244	0.502
LIG_14-3-3_CanoR_1	246	254	PF00244	0.528
LIG_14-3-3_CanoR_1	257	265	PF00244	0.499
LIG_14-3-3_CanoR_1	489	498	PF00244	0.620
LIG_14-3-3_CanoR_1	501	507	PF00244	0.628
LIG_14-3-3_CanoR_1	591	599	PF00244	0.496
LIG_14-3-3_CanoR_1	733	737	PF00244	0.554
LIG_14-3-3_CanoR_1	742	750	PF00244	0.499
LIG_14-3-3_CanoR_1	811	817	PF00244	0.617
LIG_14-3-3_CanoR_1	839	847	PF00244	0.636
LIG_Actin_WH2_2	205	222	PF00022	0.356
LIG_Actin_WH2_2	504	521	PF00022	0.594
LIG_Actin_WH2_2	803	820	PF00022	0.497
LIG_Actin_WH2_2	9	26	PF00022	0.534
LIG_APCC_ABBA_1	706	711	PF00400	0.348
LIG_APCC_ABBA_1	821	826	PF00400	0.642
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BRCT_BRCA1_1	632	636	PF00533	0.500
LIG_BRCT_BRCA1_2	632	638	PF00533	0.424
LIG_CaM_IQ_9	450	466	PF13499	0.327
LIG_Clathr_ClatBox_1	360	364	PF01394	0.550
LIG_FHA_1	124	130	PF00498	0.573
LIG_FHA_1	221	227	PF00498	0.381
LIG_FHA_1	281	287	PF00498	0.608
LIG_FHA_1	408	414	PF00498	0.512
LIG_FHA_1	608	614	PF00498	0.443
LIG_FHA_2	289	295	PF00498	0.612
LIG_FHA_2	349	355	PF00498	0.483
LIG_FHA_2	357	363	PF00498	0.552
LIG_FHA_2	420	426	PF00498	0.373
LIG_FHA_2	494	500	PF00498	0.610
LIG_FHA_2	591	597	PF00498	0.464
LIG_FHA_2	614	620	PF00498	0.467
LIG_FHA_2	630	636	PF00498	0.430
LIG_FHA_2	694	700	PF00498	0.471
LIG_FHA_2	733	739	PF00498	0.538
LIG_FHA_2	747	753	PF00498	0.508
LIG_GBD_Chelix_1	789	797	PF00786	0.567
LIG_GBD_Chelix_1	89	97	PF00786	0.400
LIG_LIR_Gen_1	148	156	PF02991	0.525
LIG_LIR_Gen_1	170	177	PF02991	0.324
LIG_LIR_Gen_1	346	357	PF02991	0.470
LIG_LIR_Gen_1	372	382	PF02991	0.589
LIG_LIR_Gen_1	400	409	PF02991	0.520
LIG_LIR_Gen_1	445	455	PF02991	0.438
LIG_LIR_Gen_1	49	60	PF02991	0.543
LIG_LIR_Gen_1	673	680	PF02991	0.358
LIG_LIR_Gen_1	769	778	PF02991	0.405
LIG_LIR_Nem_3	148	152	PF02991	0.526
LIG_LIR_Nem_3	170	174	PF02991	0.317
LIG_LIR_Nem_3	346	352	PF02991	0.467
LIG_LIR_Nem_3	372	377	PF02991	0.536
LIG_LIR_Nem_3	379	384	PF02991	0.574
LIG_LIR_Nem_3	400	406	PF02991	0.525
LIG_LIR_Nem_3	445	451	PF02991	0.436
LIG_LIR_Nem_3	456	462	PF02991	0.438
LIG_LIR_Nem_3	49	55	PF02991	0.540
LIG_LIR_Nem_3	673	679	PF02991	0.358
LIG_LIR_Nem_3	769	774	PF02991	0.421
LIG_NRBOX	548	554	PF00104	0.580
LIG_NRBOX	749	755	PF00104	0.499
LIG_PCNA_yPIPBox_3	155	164	PF02747	0.326
LIG_PCNA_yPIPBox_3	4	12	PF02747	0.595
LIG_PCNA_yPIPBox_3	437	447	PF02747	0.364
LIG_Pex14_2	444	448	PF04695	0.414
LIG_PTB_Apo_2	485	492	PF02174	0.426
LIG_PTB_Phospho_1	485	491	PF10480	0.427
LIG_SH2_CRK	771	775	PF00017	0.404
LIG_SH2_STAP1	149	153	PF00017	0.470
LIG_SH2_STAP1	356	360	PF00017	0.433
LIG_SH2_STAT5	107	110	PF00017	0.408
LIG_SH2_STAT5	491	494	PF00017	0.535
LIG_SH2_STAT5	697	700	PF00017	0.520
LIG_SUMO_SIM_par_1	610	617	PF11976	0.436
LIG_TRAF2_1	260	263	PF00917	0.536
LIG_UBA3_1	163	169	PF00899	0.467
MOD_CK1_1	131	137	PF00069	0.357
MOD_CK1_1	197	203	PF00069	0.603
MOD_CK1_1	289	295	PF00069	0.562
MOD_CK1_1	401	407	PF00069	0.327
MOD_CK1_1	419	425	PF00069	0.499
MOD_CK1_1	428	434	PF00069	0.536
MOD_CK1_1	493	499	PF00069	0.507
MOD_CK1_1	509	515	PF00069	0.502
MOD_CK1_1	674	680	PF00069	0.496
MOD_CK1_1	745	751	PF00069	0.478
MOD_CK1_1	802	808	PF00069	0.501
MOD_CK2_1	14	20	PF00069	0.441
MOD_CK2_1	197	203	PF00069	0.517
MOD_CK2_1	258	264	PF00069	0.660
MOD_CK2_1	288	294	PF00069	0.699
MOD_CK2_1	348	354	PF00069	0.462
MOD_CK2_1	356	362	PF00069	0.533
MOD_CK2_1	402	408	PF00069	0.551
MOD_CK2_1	419	425	PF00069	0.349
MOD_CK2_1	493	499	PF00069	0.576
MOD_CK2_1	502	508	PF00069	0.481
MOD_CK2_1	590	596	PF00069	0.461
MOD_CK2_1	613	619	PF00069	0.406
MOD_CK2_1	67	73	PF00069	0.476
MOD_CK2_1	693	699	PF00069	0.401
MOD_CK2_1	732	738	PF00069	0.540
MOD_CK2_1	746	752	PF00069	0.486
MOD_GlcNHglycan	141	144	PF01048	0.389
MOD_GlcNHglycan	227	230	PF01048	0.515
MOD_GlcNHglycan	254	257	PF01048	0.713
MOD_GlcNHglycan	283	286	PF01048	0.781
MOD_GlcNHglycan	31	34	PF01048	0.544
MOD_GlcNHglycan	371	374	PF01048	0.342
MOD_GlcNHglycan	400	403	PF01048	0.555
MOD_GlcNHglycan	513	516	PF01048	0.511
MOD_GlcNHglycan	58	61	PF01048	0.551
MOD_GlcNHglycan	655	658	PF01048	0.446
MOD_GlcNHglycan	75	78	PF01048	0.562
MOD_GlcNHglycan	826	829	PF01048	0.645
MOD_GlcNHglycan	853	856	PF01048	0.594
MOD_GSK3_1	134	141	PF00069	0.520
MOD_GSK3_1	194	201	PF00069	0.382
MOD_GSK3_1	215	222	PF00069	0.388
MOD_GSK3_1	344	351	PF00069	0.419
MOD_GSK3_1	352	359	PF00069	0.454
MOD_GSK3_1	397	404	PF00069	0.625
MOD_GSK3_1	412	419	PF00069	0.323
MOD_GSK3_1	502	509	PF00069	0.494
MOD_GSK3_1	609	616	PF00069	0.454
MOD_GSK3_1	630	637	PF00069	0.500
MOD_GSK3_1	674	681	PF00069	0.483
MOD_GSK3_1	738	745	PF00069	0.542
MOD_GSK3_1	851	858	PF00069	0.743
MOD_LATS_1	849	855	PF00433	0.712
MOD_N-GLC_1	215	220	PF02516	0.423
MOD_N-GLC_1	397	402	PF02516	0.579
MOD_N-GLC_1	570	575	PF02516	0.741
MOD_N-GLC_1	628	633	PF02516	0.538
MOD_N-GLC_1	719	724	PF02516	0.356
MOD_N-GLC_1	840	845	PF02516	0.621
MOD_N-GLC_2	488	490	PF02516	0.518
MOD_NEK2_1	128	133	PF00069	0.595
MOD_NEK2_1	139	144	PF00069	0.462
MOD_NEK2_1	177	182	PF00069	0.541
MOD_NEK2_1	286	291	PF00069	0.655
MOD_NEK2_1	506	511	PF00069	0.677
MOD_NEK2_1	552	557	PF00069	0.589
MOD_NEK2_1	634	639	PF00069	0.539
MOD_NEK2_1	817	822	PF00069	0.604
MOD_NEK2_1	824	829	PF00069	0.659
MOD_NEK2_2	402	407	PF00069	0.328
MOD_PIKK_1	14	20	PF00454	0.441
MOD_PIKK_1	286	292	PF00454	0.645
MOD_PIKK_1	329	335	PF00454	0.671
MOD_PIKK_1	412	418	PF00454	0.336
MOD_PIKK_1	419	425	PF00454	0.464
MOD_PIKK_1	506	512	PF00454	0.548
MOD_PIKK_1	799	805	PF00454	0.503
MOD_PKA_1	220	226	PF00069	0.446
MOD_PKA_1	245	251	PF00069	0.478
MOD_PKA_1	385	391	PF00069	0.436
MOD_PKA_1	851	857	PF00069	0.663
MOD_PKA_2	101	107	PF00069	0.615
MOD_PKA_2	14	20	PF00069	0.435
MOD_PKA_2	177	183	PF00069	0.495
MOD_PKA_2	219	225	PF00069	0.432
MOD_PKA_2	245	251	PF00069	0.478
MOD_PKA_2	286	292	PF00069	0.678
MOD_PKA_2	329	335	PF00069	0.458
MOD_PKA_2	385	391	PF00069	0.562
MOD_PKA_2	428	434	PF00069	0.480
MOD_PKA_2	500	506	PF00069	0.643
MOD_PKA_2	524	530	PF00069	0.555
MOD_PKA_2	590	596	PF00069	0.515
MOD_PKA_2	732	738	PF00069	0.441
MOD_Plk_1	215	221	PF00069	0.511
MOD_Plk_1	347	353	PF00069	0.597
MOD_Plk_1	493	499	PF00069	0.608
MOD_Plk_1	570	576	PF00069	0.747
MOD_Plk_1	719	725	PF00069	0.356
MOD_Plk_1	745	751	PF00069	0.523
MOD_Plk_2-3	348	354	PF00069	0.438
MOD_Plk_2-3	746	752	PF00069	0.483
MOD_Plk_4	356	362	PF00069	0.360
MOD_Plk_4	428	434	PF00069	0.533
MOD_Plk_4	493	499	PF00069	0.507
MOD_Plk_4	502	508	PF00069	0.569
MOD_Plk_4	693	699	PF00069	0.364
MOD_Plk_4	812	818	PF00069	0.487
MOD_SUMO_for_1	212	215	PF00179	0.498
MOD_SUMO_for_1	47	50	PF00179	0.550
MOD_SUMO_for_1	625	628	PF00179	0.349
MOD_SUMO_for_1	830	833	PF00179	0.655
MOD_SUMO_for_1	93	96	PF00179	0.534
MOD_SUMO_rev_2	242	247	PF00179	0.490
MOD_SUMO_rev_2	304	313	PF00179	0.472
MOD_SUMO_rev_2	41	47	PF00179	0.494
MOD_SUMO_rev_2	667	677	PF00179	0.436
MOD_SUMO_rev_2	705	714	PF00179	0.506
MOD_SUMO_rev_2	734	741	PF00179	0.548
MOD_SUMO_rev_2	787	796	PF00179	0.532
TRG_DiLeu_BaEn_1	548	553	PF01217	0.579
TRG_DiLeu_BaEn_1	756	761	PF01217	0.479
TRG_DiLeu_BaEn_4	214	220	PF01217	0.504
TRG_DiLeu_BaEn_4	242	248	PF01217	0.437
TRG_DiLeu_BaEn_4	249	255	PF01217	0.654
TRG_DiLeu_BaEn_4	263	269	PF01217	0.495
TRG_DiLeu_BaEn_4	562	568	PF01217	0.741
TRG_DiLeu_BaLyEn_6	222	227	PF01217	0.434
TRG_ENDOCYTIC_2	149	152	PF00928	0.470
TRG_ENDOCYTIC_2	459	462	PF00928	0.337
TRG_ENDOCYTIC_2	641	644	PF00928	0.350
TRG_ENDOCYTIC_2	771	774	PF00928	0.405
TRG_ER_diArg_1	219	221	PF00400	0.451
TRG_ER_diArg_1	639	641	PF00400	0.502
TRG_ER_diArg_1	781	783	PF00400	0.621
TRG_NES_CRM1_1	791	804	PF08389	0.581
TRG_NLS_MonoExtN_4	848	855	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.661
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	460	464	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBM4	Leptomonas seymouri	53%	100%
A0A3Q8IHM9	Leishmania donovani	76%	100%
A0A422N7K6	Trypanosoma rangeli	30%	100%
A4IAR9	Leishmania infantum	76%	100%
D0A2E3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AEJ5	Leishmania major	76%	100%
E9B5Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BIR1	Trypanosoma cruzi	31%	99%