Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM56_LEIBR

TriTrypDb:

LbrM.34.0210 , LBRM2903_340007100

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.412
CLV_NRD_NRD_1	72	74	PF00675	0.501
CLV_PCSK_KEX2_1	18	20	PF00082	0.584
CLV_PCSK_KEX2_1	85	87	PF00082	0.416
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.504
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.416
CLV_PCSK_SKI1_1	134	138	PF00082	0.547
CLV_PCSK_SKI1_1	15	19	PF00082	0.381
CLV_PCSK_SKI1_1	174	178	PF00082	0.588
CLV_PCSK_SKI1_1	288	292	PF00082	0.380
CLV_PCSK_SKI1_1	61	65	PF00082	0.385
DOC_CDC14_PxL_1	298	306	PF14671	0.367
DOC_CYCLIN_RxL_1	131	138	PF00134	0.487
DOC_CYCLIN_RxL_1	275	289	PF00134	0.343
DOC_MAPK_gen_1	243	253	PF00069	0.367
DOC_PP1_RVXF_1	45	52	PF00149	0.474
DOC_PP2B_LxvP_1	321	324	PF13499	0.561
DOC_USP7_MATH_1	297	301	PF00917	0.358
LIG_14-3-3_CanoR_1	215	219	PF00244	0.452
LIG_14-3-3_CanoR_1	224	230	PF00244	0.415
LIG_14-3-3_CanoR_1	98	108	PF00244	0.417
LIG_Actin_WH2_2	171	188	PF00022	0.464
LIG_Actin_WH2_2	278	294	PF00022	0.406
LIG_Actin_WH2_2	84	102	PF00022	0.374
LIG_BRCT_BRCA1_1	219	223	PF00533	0.366
LIG_eIF4E_1	245	251	PF01652	0.365
LIG_FHA_1	161	167	PF00498	0.711
LIG_FHA_1	203	209	PF00498	0.414
LIG_FHA_2	112	118	PF00498	0.509
LIG_FHA_2	188	194	PF00498	0.442
LIG_FHA_2	39	45	PF00498	0.412
LIG_FHA_2	78	84	PF00498	0.360
LIG_MLH1_MIPbox_1	219	223	PF16413	0.366
LIG_NRBOX	229	235	PF00104	0.407
LIG_NRBOX	65	71	PF00104	0.362
LIG_NRP_CendR_1	336	339	PF00754	0.530
LIG_PCNA_PIPBox_1	216	225	PF02747	0.415
LIG_PCNA_yPIPBox_3	212	223	PF02747	0.376
LIG_PCNA_yPIPBox_3	36	49	PF02747	0.483
LIG_REV1ctd_RIR_1	220	228	PF16727	0.423
LIG_SH2_GRB2like	229	232	PF00017	0.355
LIG_SH2_SRC	229	232	PF00017	0.355
LIG_SH2_STAP1	154	158	PF00017	0.460
LIG_SH2_STAT5	189	192	PF00017	0.497
LIG_SH2_STAT5	20	23	PF00017	0.476
LIG_SH2_STAT5	229	232	PF00017	0.388
LIG_SH2_STAT5	48	51	PF00017	0.473
LIG_SUMO_SIM_par_1	309	315	PF11976	0.483
LIG_WRC_WIRS_1	219	224	PF05994	0.505
MOD_CK1_1	144	150	PF00069	0.552
MOD_CK1_1	217	223	PF00069	0.369
MOD_CK1_1	326	332	PF00069	0.591
MOD_CK2_1	111	117	PF00069	0.511
MOD_CK2_1	191	197	PF00069	0.438
MOD_CK2_1	38	44	PF00069	0.412
MOD_GlcNHglycan	225	228	PF01048	0.387
MOD_GSK3_1	187	194	PF00069	0.482
MOD_GSK3_1	214	221	PF00069	0.559
MOD_N-GLC_1	144	149	PF02516	0.501
MOD_N-GLC_1	326	331	PF02516	0.494
MOD_N-GLC_2	330	332	PF02516	0.517
MOD_NEK2_1	130	135	PF00069	0.468
MOD_NEK2_1	141	146	PF00069	0.418
MOD_NEK2_1	158	163	PF00069	0.432
MOD_NEK2_1	185	190	PF00069	0.598
MOD_NEK2_1	218	223	PF00069	0.636
MOD_NEK2_1	256	261	PF00069	0.460
MOD_PKA_2	214	220	PF00069	0.511
MOD_PKA_2	223	229	PF00069	0.460
MOD_PKA_2	239	245	PF00069	0.422
MOD_PKA_2	99	105	PF00069	0.366
MOD_Plk_1	144	150	PF00069	0.534
MOD_Plk_1	158	164	PF00069	0.549
MOD_Plk_1	77	83	PF00069	0.384
MOD_Plk_4	191	197	PF00069	0.438
MOD_Plk_4	214	220	PF00069	0.444
MOD_Plk_4	225	231	PF00069	0.357
MOD_Plk_4	286	292	PF00069	0.357
MOD_Plk_4	77	83	PF00069	0.403
MOD_SUMO_rev_2	53	63	PF00179	0.407
TRG_DiLeu_BaEn_1	12	17	PF01217	0.495
TRG_DiLeu_BaEn_1	214	219	PF01217	0.521
TRG_DiLeu_BaLyEn_6	65	70	PF01217	0.386
TRG_ENDOCYTIC_2	48	51	PF00928	0.473
TRG_ER_diArg_1	98	101	PF00400	0.448
TRG_NES_CRM1_1	257	271	PF08389	0.527
TRG_NES_CRM1_1	89	103	PF08389	0.387
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M0	Leptomonas seymouri	34%	99%
A0A3Q8INY6	Leishmania donovani	60%	99%
A4IAR8	Leishmania infantum	60%	99%
E9AEJ4	Leishmania major	61%	100%
E9B5Q5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%