Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM55_LEIBR

TriTrypDb:

LbrM.34.0200 , LBRM2903_340007000

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.269
CLV_NRD_NRD_1	145	147	PF00675	0.586
CLV_NRD_NRD_1	98	100	PF00675	0.287
CLV_PCSK_SKI1_1	147	151	PF00082	0.551
CLV_PCSK_SKI1_1	206	210	PF00082	0.581
CLV_PCSK_SKI1_1	43	47	PF00082	0.662
DEG_Nend_UBRbox_3	1	3	PF02207	0.454
DOC_CYCLIN_RxL_1	185	195	PF00134	0.552
DOC_PP2B_LxvP_1	231	234	PF13499	0.488
DOC_PP2B_LxvP_1	24	27	PF13499	0.577
DOC_PP4_FxxP_1	22	25	PF00568	0.535
DOC_PP4_FxxP_1	92	95	PF00568	0.287
DOC_USP7_MATH_1	247	251	PF00917	0.468
DOC_USP7_MATH_1	25	29	PF00917	0.629
DOC_WW_Pin1_4	15	20	PF00397	0.574
DOC_WW_Pin1_4	58	63	PF00397	0.568
DOC_WW_Pin1_4	91	96	PF00397	0.287
LIG_14-3-3_CanoR_1	21	25	PF00244	0.619
LIG_14-3-3_CanoR_1	240	244	PF00244	0.626
LIG_BRCT_BRCA1_1	69	73	PF00533	0.644
LIG_BRCT_BRCA1_1	92	96	PF00533	0.402
LIG_Clathr_ClatBox_1	217	221	PF01394	0.496
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.624
LIG_EH_1	178	182	PF12763	0.507
LIG_FHA_1	116	122	PF00498	0.496
LIG_FHA_1	171	177	PF00498	0.647
LIG_FHA_1	21	27	PF00498	0.554
LIG_FHA_2	158	164	PF00498	0.570
LIG_FHA_2	214	220	PF00498	0.652
LIG_LIR_Apic_2	20	25	PF02991	0.603
LIG_LIR_Apic_2	89	95	PF02991	0.287
LIG_LIR_Gen_1	106	114	PF02991	0.658
LIG_LIR_Gen_1	213	220	PF02991	0.533
LIG_LIR_Gen_1	221	231	PF02991	0.617
LIG_LIR_Nem_3	106	112	PF02991	0.597
LIG_LIR_Nem_3	213	218	PF02991	0.535
LIG_LIR_Nem_3	221	226	PF02991	0.621
LIG_LIR_Nem_3	249	255	PF02991	0.656
LIG_Pex14_2	4	8	PF04695	0.671
LIG_Pex14_2	92	96	PF04695	0.269
LIG_REV1ctd_RIR_1	43	51	PF16727	0.585
LIG_REV1ctd_RIR_1	71	80	PF16727	0.269
LIG_SH2_STAT5	109	112	PF00017	0.654
LIG_SH3_3	248	254	PF00018	0.627
LIG_SH3_3	59	65	PF00018	0.638
LIG_SUMO_SIM_par_1	117	124	PF11976	0.563
LIG_SUMO_SIM_par_1	216	221	PF11976	0.500
LIG_TRAF2_1	12	15	PF00917	0.698
LIG_TRAF2_1	75	78	PF00917	0.269
MOD_CDK_SPxK_1	15	21	PF00069	0.551
MOD_CK1_1	213	219	PF00069	0.434
MOD_CK1_1	33	39	PF00069	0.445
MOD_CK2_1	213	219	PF00069	0.559
MOD_GlcNHglycan	106	109	PF01048	0.675
MOD_GlcNHglycan	154	157	PF01048	0.698
MOD_GlcNHglycan	212	215	PF01048	0.419
MOD_GlcNHglycan	32	35	PF01048	0.670
MOD_GlcNHglycan	69	72	PF01048	0.680
MOD_GSK3_1	115	122	PF00069	0.553
MOD_GSK3_1	170	177	PF00069	0.533
MOD_GSK3_1	6	13	PF00069	0.540
MOD_N-GLC_1	115	120	PF02516	0.515
MOD_N-GLC_1	247	252	PF02516	0.649
MOD_NEK2_1	123	128	PF00069	0.561
MOD_NEK2_1	181	186	PF00069	0.530
MOD_NEK2_1	239	244	PF00069	0.662
MOD_NEK2_1	90	95	PF00069	0.424
MOD_NEK2_2	247	252	PF00069	0.555
MOD_PIKK_1	10	16	PF00454	0.712
MOD_PIKK_1	190	196	PF00454	0.504
MOD_PKA_2	20	26	PF00069	0.617
MOD_PKA_2	239	245	PF00069	0.582
MOD_Plk_1	115	121	PF00069	0.415
MOD_Plk_1	247	253	PF00069	0.558
MOD_Plk_2-3	132	138	PF00069	0.539
MOD_Plk_4	115	121	PF00069	0.603
MOD_Plk_4	123	129	PF00069	0.655
MOD_Plk_4	247	253	PF00069	0.518
MOD_ProDKin_1	15	21	PF00069	0.576
MOD_ProDKin_1	58	64	PF00069	0.566
MOD_ProDKin_1	91	97	PF00069	0.287
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.427
TRG_ENDOCYTIC_2	109	112	PF00928	0.657
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P611	Leptomonas seymouri	64%	78%
A0A1X0NJ57	Trypanosomatidae	47%	82%
A0A3R7LQI0	Trypanosoma rangeli	47%	82%
A0A3S7X8M8	Leishmania donovani	86%	81%
A4IAR7	Leishmania infantum	86%	81%
D0A2E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	83%
E9AEJ3	Leishmania major	85%	100%
E9B5Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	92%
V5DJR0	Trypanosoma cruzi	49%	82%