Mitochondrial carrier protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM54_LEIBR

TriTrypDb:

LbrM.34.0190 , LBRM2903_340006900

Length:

290

Annotations

LeishMANIAdb annotations

A conserved mitochondrial transporter, might be an ADP/ATP translocase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HM54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM54

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	288	290	PF00675	0.511
CLV_PCSK_KEX2_1	288	290	PF00082	0.511
CLV_PCSK_KEX2_1	48	50	PF00082	0.660
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.668
CLV_PCSK_PC7_1	284	290	PF00082	0.588
CLV_PCSK_SKI1_1	238	242	PF00082	0.598
CLV_PCSK_SKI1_1	51	55	PF00082	0.640
DEG_SPOP_SBC_1	194	198	PF00917	0.300
DOC_PP2B_LxvP_1	186	189	PF13499	0.435
DOC_PP2B_LxvP_1	63	66	PF13499	0.392
DOC_USP7_MATH_1	10	14	PF00917	0.449
DOC_WW_Pin1_4	53	58	PF00397	0.286
LIG_14-3-3_CanoR_1	191	195	PF00244	0.374
LIG_14-3-3_CanoR_1	246	250	PF00244	0.369
LIG_14-3-3_CanoR_1	38	43	PF00244	0.317
LIG_APCC_ABBA_1	21	26	PF00400	0.406
LIG_BIR_II_1	1	5	PF00653	0.591
LIG_BRCT_BRCA1_1	12	16	PF00533	0.485
LIG_BRCT_BRCA1_1	165	169	PF00533	0.440
LIG_BRCT_BRCA1_1	251	255	PF00533	0.322
LIG_deltaCOP1_diTrp_1	171	177	PF00928	0.347
LIG_EH1_1	176	184	PF00400	0.391
LIG_FHA_1	185	191	PF00498	0.339
LIG_FHA_1	256	262	PF00498	0.348
LIG_FHA_1	4	10	PF00498	0.365
LIG_FHA_2	207	213	PF00498	0.294
LIG_LIR_Gen_1	110	120	PF02991	0.584
LIG_LIR_Gen_1	13	24	PF02991	0.471
LIG_LIR_Gen_1	171	182	PF02991	0.347
LIG_LIR_Gen_1	258	265	PF02991	0.344
LIG_LIR_Nem_3	110	115	PF02991	0.555
LIG_LIR_Nem_3	13	19	PF02991	0.420
LIG_LIR_Nem_3	171	177	PF02991	0.347
LIG_LIR_Nem_3	258	262	PF02991	0.344
LIG_LIR_Nem_3	276	280	PF02991	0.682
LIG_Pex14_2	72	76	PF04695	0.485
LIG_SH2_CRK	120	124	PF00017	0.563
LIG_SH2_CRK	134	138	PF00017	0.462
LIG_SH2_CRK	277	281	PF00017	0.604
LIG_SH2_STAP1	165	169	PF00017	0.460
LIG_SH2_STAP1	93	97	PF00017	0.639
LIG_SH2_STAT5	213	216	PF00017	0.453
LIG_SH2_STAT5	45	48	PF00017	0.468
LIG_SH2_STAT5	71	74	PF00017	0.401
LIG_SH2_STAT5	93	96	PF00017	0.638
LIG_SH3_3	54	60	PF00018	0.298
LIG_TRAF2_1	232	235	PF00917	0.394
LIG_UBA3_1	123	132	PF00899	0.600
LIG_WRC_WIRS_1	136	141	PF05994	0.401
LIG_WRC_WIRS_1	182	187	PF05994	0.352
MOD_CK1_1	14	20	PF00069	0.230
MOD_CK1_1	3	9	PF00069	0.401
MOD_CK2_1	165	171	PF00069	0.464
MOD_GlcNHglycan	120	123	PF01048	0.464
MOD_GlcNHglycan	129	132	PF01048	0.348
MOD_GlcNHglycan	146	149	PF01048	0.376
MOD_GlcNHglycan	202	206	PF01048	0.630
MOD_GSK3_1	10	17	PF00069	0.414
MOD_GSK3_1	161	168	PF00069	0.455
MOD_GSK3_1	190	197	PF00069	0.399
MOD_GSK3_1	244	251	PF00069	0.344
MOD_GSK3_1	93	100	PF00069	0.585
MOD_N-GLC_1	273	278	PF02516	0.491
MOD_NEK2_1	144	149	PF00069	0.412
MOD_NEK2_1	161	166	PF00069	0.249
MOD_NEK2_1	245	250	PF00069	0.360
MOD_NEK2_1	255	260	PF00069	0.324
MOD_NEK2_1	91	96	PF00069	0.524
MOD_NEK2_1	97	102	PF00069	0.615
MOD_NEK2_2	11	16	PF00069	0.452
MOD_NEK2_2	135	140	PF00069	0.369
MOD_NEK2_2	206	211	PF00069	0.307
MOD_PIKK_1	55	61	PF00454	0.381
MOD_PKA_2	190	196	PF00069	0.374
MOD_PKA_2	245	251	PF00069	0.371
MOD_PKA_2	37	43	PF00069	0.397
MOD_Plk_4	11	17	PF00069	0.364
MOD_Plk_4	135	141	PF00069	0.392
MOD_Plk_4	181	187	PF00069	0.383
MOD_Plk_4	93	99	PF00069	0.633
MOD_ProDKin_1	53	59	PF00069	0.286
TRG_ENDOCYTIC_2	112	115	PF00928	0.582
TRG_ENDOCYTIC_2	120	123	PF00928	0.565
TRG_ENDOCYTIC_2	134	137	PF00928	0.476
TRG_ENDOCYTIC_2	24	27	PF00928	0.353
TRG_ENDOCYTIC_2	259	262	PF00928	0.444
TRG_ENDOCYTIC_2	277	280	PF00928	0.752
TRG_ENDOCYTIC_2	50	53	PF00928	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JQQ1	Bodo saltans	37%	98%
A0A1X0NJA4	Trypanosomatidae	47%	100%
A0A3S7X8R5	Leishmania donovani	86%	100%
A4IAR6	Leishmania infantum	86%	100%
D0A2E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AEJ2	Leishmania major	85%	100%
E9B5Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BNB5	Trypanosoma cruzi	47%	100%