LMBR1-like membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HM51_LEIBR

TriTrypDb:

LbrM.34.0160 , LBRM2903_340006600

Length:

450

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17
GO:0005794	Golgi apparatus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HM51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.410
CLV_C14_Caspase3-7	32	36	PF00656	0.511
CLV_NRD_NRD_1	218	220	PF00675	0.345
CLV_NRD_NRD_1	241	243	PF00675	0.408
CLV_NRD_NRD_1	340	342	PF00675	0.270
CLV_NRD_NRD_1	432	434	PF00675	0.362
CLV_PCSK_KEX2_1	218	220	PF00082	0.362
CLV_PCSK_KEX2_1	241	243	PF00082	0.395
CLV_PCSK_KEX2_1	340	342	PF00082	0.270
CLV_PCSK_KEX2_1	432	434	PF00082	0.360
CLV_PCSK_PC7_1	336	342	PF00082	0.231
CLV_PCSK_SKI1_1	340	344	PF00082	0.375
CLV_PCSK_SKI1_1	432	436	PF00082	0.438
CLV_PCSK_SKI1_1	77	81	PF00082	0.466
DEG_APCC_DBOX_1	112	120	PF00400	0.536
DEG_MDM2_SWIB_1	72	80	PF02201	0.212
DEG_Nend_Nbox_1	1	3	PF02207	0.362
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.315
DOC_MAPK_gen_1	203	210	PF00069	0.536
DOC_MAPK_gen_1	232	240	PF00069	0.570
DOC_MAPK_gen_1	340	347	PF00069	0.470
DOC_MAPK_MEF2A_6	113	122	PF00069	0.526
DOC_MAPK_MEF2A_6	149	156	PF00069	0.246
DOC_MAPK_MEF2A_6	340	347	PF00069	0.513
DOC_MAPK_MEF2A_6	40	49	PF00069	0.326
DOC_MAPK_NFAT4_5	340	348	PF00069	0.517
DOC_MAPK_RevD_3	417	433	PF00069	0.295
DOC_PP1_RVXF_1	301	308	PF00149	0.292
DOC_PP2B_LxvP_1	343	346	PF13499	0.666
DOC_PP2B_LxvP_1	422	425	PF13499	0.420
DOC_PP2B_LxvP_1	55	58	PF13499	0.315
DOC_WW_Pin1_4	99	104	PF00397	0.536
LIG_14-3-3_CanoR_1	113	117	PF00244	0.471
LIG_14-3-3_CanoR_1	241	245	PF00244	0.568
LIG_Actin_WH2_2	167	184	PF00022	0.312
LIG_BRCT_BRCA1_1	68	72	PF00533	0.212
LIG_BRCT_BRCA1_1	84	88	PF00533	0.312
LIG_CaM_NSCaTE_8	76	83	PF13499	0.420
LIG_Clathr_ClatBox_1	56	60	PF01394	0.326
LIG_CSL_BTD_1	36	39	PF09270	0.508
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.313
LIG_eIF4E_1	322	328	PF01652	0.290
LIG_FHA_1	292	298	PF00498	0.435
LIG_FHA_1	433	439	PF00498	0.491
LIG_FHA_1	44	50	PF00498	0.397
LIG_FHA_2	193	199	PF00498	0.463
LIG_GBD_Chelix_1	11	19	PF00786	0.400
LIG_LIR_Gen_1	107	117	PF02991	0.484
LIG_LIR_Gen_1	162	172	PF02991	0.351
LIG_LIR_Gen_1	370	380	PF02991	0.364
LIG_LIR_Gen_1	423	434	PF02991	0.466
LIG_LIR_Gen_1	82	92	PF02991	0.277
LIG_LIR_Nem_3	107	112	PF02991	0.457
LIG_LIR_Nem_3	162	168	PF02991	0.320
LIG_LIR_Nem_3	370	375	PF02991	0.335
LIG_LIR_Nem_3	381	385	PF02991	0.251
LIG_LIR_Nem_3	423	429	PF02991	0.353
LIG_LIR_Nem_3	82	87	PF02991	0.283
LIG_LIR_Nem_3	94	98	PF02991	0.326
LIG_NRBOX	356	362	PF00104	0.501
LIG_PCNA_PIPBox_1	301	310	PF02747	0.298
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.371
LIG_Pex14_1	165	169	PF04695	0.315
LIG_Pex14_1	426	430	PF04695	0.428
LIG_Pex14_2	126	130	PF04695	0.355
LIG_Pex14_2	163	167	PF04695	0.454
LIG_Pex14_2	2	6	PF04695	0.314
LIG_Pex14_2	72	76	PF04695	0.249
LIG_Pex14_2	93	97	PF04695	0.375
LIG_SH2_CRK	414	418	PF00017	0.420
LIG_SH2_CRK	84	88	PF00017	0.443
LIG_SH2_PTP2	52	55	PF00017	0.170
LIG_SH2_STAP1	320	324	PF00017	0.326
LIG_SH2_STAP1	414	418	PF00017	0.312
LIG_SH2_STAP1	84	88	PF00017	0.399
LIG_SH2_STAT3	407	410	PF00017	0.430
LIG_SH2_STAT5	155	158	PF00017	0.315
LIG_SH2_STAT5	22	25	PF00017	0.326
LIG_SH2_STAT5	264	267	PF00017	0.539
LIG_SH2_STAT5	322	325	PF00017	0.314
LIG_SH2_STAT5	326	329	PF00017	0.296
LIG_SH2_STAT5	407	410	PF00017	0.301
LIG_SH2_STAT5	52	55	PF00017	0.363
LIG_SH3_2	346	351	PF14604	0.536
LIG_SH3_3	185	191	PF00018	0.470
LIG_SH3_3	343	349	PF00018	0.581
LIG_SH3_3	394	400	PF00018	0.296
LIG_SH3_3	86	92	PF00018	0.349
LIG_Sin3_3	13	20	PF02671	0.312
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.341
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.377
LIG_SUMO_SIM_par_1	156	162	PF11976	0.230
LIG_SUMO_SIM_par_1	364	370	PF11976	0.374
LIG_SUMO_SIM_par_1	40	46	PF11976	0.417
LIG_TRAF2_1	28	31	PF00917	0.509
LIG_TYR_ITIM	412	417	PF00017	0.288
LIG_WRC_WIRS_1	160	165	PF05994	0.279
MOD_CK1_1	107	113	PF00069	0.560
MOD_CK1_1	381	387	PF00069	0.309
MOD_CK1_1	82	88	PF00069	0.399
MOD_CK2_1	192	198	PF00069	0.469
MOD_CK2_1	25	31	PF00069	0.509
MOD_Cter_Amidation	216	219	PF01082	0.374
MOD_GlcNHglycan	260	263	PF01048	0.405
MOD_GlcNHglycan	27	30	PF01048	0.318
MOD_GlcNHglycan	369	372	PF01048	0.399
MOD_GlcNHglycan	81	84	PF01048	0.325
MOD_GSK3_1	381	388	PF00069	0.317
MOD_GSK3_1	432	439	PF00069	0.691
MOD_GSK3_1	66	73	PF00069	0.353
MOD_GSK3_1	97	104	PF00069	0.563
MOD_NEK2_1	156	161	PF00069	0.339
MOD_NEK2_1	240	245	PF00069	0.590
MOD_NEK2_1	290	295	PF00069	0.387
MOD_NEK2_1	314	319	PF00069	0.352
MOD_NEK2_1	328	333	PF00069	0.363
MOD_NEK2_1	361	366	PF00069	0.354
MOD_NEK2_1	367	372	PF00069	0.323
MOD_NEK2_1	395	400	PF00069	0.349
MOD_NEK2_1	420	425	PF00069	0.397
MOD_NEK2_1	70	75	PF00069	0.316
MOD_NEK2_1	79	84	PF00069	0.363
MOD_NEK2_1	97	102	PF00069	0.528
MOD_NEK2_2	425	430	PF00069	0.376
MOD_PIKK_1	101	107	PF00454	0.563
MOD_PIKK_1	406	412	PF00454	0.265
MOD_PKA_1	432	438	PF00069	0.587
MOD_PKA_2	112	118	PF00069	0.459
MOD_PKA_2	240	246	PF00069	0.628
MOD_PKA_2	248	254	PF00069	0.644
MOD_PKA_2	25	31	PF00069	0.536
MOD_PKA_2	352	358	PF00069	0.581
MOD_PKA_2	432	438	PF00069	0.587
MOD_PKA_2	66	72	PF00069	0.259
MOD_Plk_1	70	76	PF00069	0.280
MOD_Plk_2-3	209	215	PF00069	0.408
MOD_Plk_2-3	436	442	PF00069	0.501
MOD_Plk_2-3	66	72	PF00069	0.358
MOD_Plk_4	104	110	PF00069	0.521
MOD_Plk_4	209	215	PF00069	0.516
MOD_Plk_4	279	285	PF00069	0.364
MOD_Plk_4	314	320	PF00069	0.370
MOD_Plk_4	328	334	PF00069	0.319
MOD_Plk_4	352	358	PF00069	0.505
MOD_Plk_4	361	367	PF00069	0.289
MOD_Plk_4	386	392	PF00069	0.339
MOD_Plk_4	425	431	PF00069	0.306
MOD_Plk_4	82	88	PF00069	0.411
MOD_ProDKin_1	99	105	PF00069	0.536
TRG_DiLeu_BaEn_1	209	214	PF01217	0.519
TRG_ENDOCYTIC_2	155	158	PF00928	0.269
TRG_ENDOCYTIC_2	22	25	PF00928	0.332
TRG_ENDOCYTIC_2	322	325	PF00928	0.309
TRG_ENDOCYTIC_2	414	417	PF00928	0.307
TRG_ENDOCYTIC_2	52	55	PF00928	0.380
TRG_ENDOCYTIC_2	84	87	PF00928	0.372
TRG_ER_diArg_1	218	220	PF00400	0.579
TRG_ER_diArg_1	240	242	PF00400	0.604
TRG_ER_diArg_1	340	342	PF00400	0.656
TRG_ER_diArg_1	350	353	PF00400	0.589
TRG_ER_diArg_1	431	433	PF00400	0.502
TRG_NES_CRM1_1	200	211	PF08389	0.357
TRG_Pf-PMV_PEXEL_1	218	223	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	25%	94%
A0A0N1I533	Leptomonas seymouri	63%	100%
A0A0S4IQ17	Bodo saltans	28%	93%
A0A0S4JTI8	Bodo saltans	33%	88%
A0A1X0NKT2	Trypanosomatidae	32%	100%
A0A1X0NM00	Trypanosomatidae	27%	96%
A0A3Q8IGK4	Leishmania donovani	24%	94%
A0A3S5H7Y2	Leishmania donovani	85%	100%
A0A422P212	Trypanosoma rangeli	28%	95%
A4HE60	Leishmania braziliensis	24%	100%
A4I1F8	Leishmania infantum	24%	94%
A4IAR3	Leishmania infantum	84%	100%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	94%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	96%
E9AEI9	Leishmania major	85%	100%
E9AXJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	94%
E9B5Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q9X7	Leishmania major	25%	100%
Q54QP7	Dictyostelium discoideum	24%	89%
Q9M028	Arabidopsis thaliana	24%	88%
Q9SR93	Arabidopsis thaliana	23%	88%