Ubiquinol-cytochrome C reductase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquinol-cytochrome c reductase complex 14kD subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HM49_LEIBR

TriTrypDb:

LbrM.34.0140 , LBRM2903_340006400

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005750	mitochondrial respiratory chain complex III	4	12
GO:0032991	protein-containing complex	1	12
GO:0045275	respiratory chain complex III	4	12
GO:0070069	cytochrome complex	3	12
GO:0098796	membrane protein complex	2	12
GO:0098798	mitochondrial protein-containing complex	2	12
GO:0098800	inner mitochondrial membrane protein complex	3	12
GO:0098803	respiratory chain complex	3	12
GO:1902494	catalytic complex	2	12
GO:1902495	transmembrane transporter complex	3	12
GO:1990204	oxidoreductase complex	3	12
GO:1990351	transporter complex	2	12

Expansion

Sequence features

A4HM49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM49

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	12
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	12
GO:0008152	metabolic process	1	12
GO:0009060	aerobic respiration	6	12
GO:0009987	cellular process	1	12
GO:0015980	energy derivation by oxidation of organic compounds	4	12
GO:0019646	aerobic electron transport chain	6	12
GO:0022900	electron transport chain	4	12
GO:0022904	respiratory electron transport chain	5	12
GO:0044237	cellular metabolic process	2	12
GO:0045333	cellular respiration	5	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.290
CLV_PCSK_KEX2_1	146	148	PF00082	0.290
CLV_PCSK_SKI1_1	152	156	PF00082	0.381
CLV_PCSK_SKI1_1	31	35	PF00082	0.511
CLV_PCSK_SKI1_1	50	54	PF00082	0.461
CLV_PCSK_SKI1_1	60	64	PF00082	0.470
DOC_MAPK_FxFP_2	24	27	PF00069	0.485
DOC_MAPK_MEF2A_6	60	67	PF00069	0.501
DOC_MAPK_NFAT4_5	60	68	PF00069	0.500
DOC_PP1_RVXF_1	87	94	PF00149	0.560
DOC_PP2B_LxvP_1	63	66	PF13499	0.496
DOC_PP4_FxxP_1	24	27	PF00568	0.485
DOC_WW_Pin1_4	2	7	PF00397	0.627
LIG_BRCT_BRCA1_1	4	8	PF00533	0.613
LIG_deltaCOP1_diTrp_1	185	194	PF00928	0.308
LIG_HP1_1	178	182	PF01393	0.289
LIG_LIR_Apic_2	164	169	PF02991	0.289
LIG_LIR_Gen_1	32	39	PF02991	0.519
LIG_LIR_Gen_1	77	88	PF02991	0.503
LIG_LIR_Nem_3	188	194	PF02991	0.500
LIG_LIR_Nem_3	32	36	PF02991	0.513
LIG_LIR_Nem_3	58	62	PF02991	0.507
LIG_LIR_Nem_3	77	83	PF02991	0.509
LIG_LYPXL_S_1	25	29	PF13949	0.491
LIG_LYPXL_yS_3	26	29	PF13949	0.492
LIG_Pex14_2	93	97	PF04695	0.560
LIG_PTB_Apo_2	169	176	PF02174	0.289
LIG_PTB_Phospho_1	169	175	PF10480	0.289
LIG_SH2_CRK	59	63	PF00017	0.526
LIG_SH2_STAP1	98	102	PF00017	0.274
LIG_SH2_STAT5	158	161	PF00017	0.274
LIG_SH2_STAT5	175	178	PF00017	0.274
LIG_SH2_STAT5	179	182	PF00017	0.274
LIG_SH2_STAT5	20	23	PF00017	0.440
LIG_TRAF2_1	195	198	PF00917	0.504
LIG_TYR_ITIM	57	62	PF00017	0.524
MOD_ProDKin_1	2	8	PF00069	0.622
TRG_ENDOCYTIC_2	106	109	PF00928	0.274
TRG_ENDOCYTIC_2	179	182	PF00928	0.274
TRG_ENDOCYTIC_2	26	29	PF00928	0.492
TRG_ENDOCYTIC_2	30	33	PF00928	0.498
TRG_ENDOCYTIC_2	59	62	PF00928	0.523
TRG_ER_diArg_1	146	148	PF00400	0.298
TRG_ER_diArg_1	149	152	PF00400	0.308
TRG_Pf-PMV_PEXEL_1	152	156	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB98	Leptomonas seymouri	97%	100%
A0A0S4JMJ5	Bodo saltans	84%	100%
A0A1X0NIZ5	Trypanosomatidae	91%	100%
A0A3R7N7A2	Trypanosoma rangeli	88%	100%
A0A3S7X8N8	Leishmania donovani	99%	100%
A4IAR1	Leishmania infantum	98%	100%
D0A2F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9AEI7	Leishmania major	99%	100%
E9B5P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5B398	Trypanosoma cruzi	90%	100%