Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HM48_LEIBR

TriTrypDb:

LbrM.34.0130 , LBRM2903_340006300

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HM48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM48

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.523
CLV_NRD_NRD_1	13	15	PF00675	0.511
CLV_NRD_NRD_1	143	145	PF00675	0.550
CLV_NRD_NRD_1	171	173	PF00675	0.338
CLV_NRD_NRD_1	203	205	PF00675	0.526
CLV_NRD_NRD_1	221	223	PF00675	0.480
CLV_NRD_NRD_1	225	227	PF00675	0.461
CLV_PCSK_FUR_1	11	15	PF00082	0.534
CLV_PCSK_KEX2_1	13	15	PF00082	0.471
CLV_PCSK_KEX2_1	143	145	PF00082	0.516
CLV_PCSK_KEX2_1	171	173	PF00082	0.502
CLV_PCSK_KEX2_1	203	205	PF00082	0.567
CLV_PCSK_KEX2_1	221	223	PF00082	0.480
CLV_PCSK_KEX2_1	225	227	PF00082	0.461
CLV_PCSK_KEX2_1	252	254	PF00082	0.581
CLV_PCSK_KEX2_1	9	11	PF00082	0.515
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.543
CLV_PCSK_PC7_1	221	227	PF00082	0.380
CLV_PCSK_PC7_1	9	15	PF00082	0.508
CLV_PCSK_SKI1_1	112	116	PF00082	0.648
CLV_PCSK_SKI1_1	118	122	PF00082	0.588
CLV_PCSK_SKI1_1	14	18	PF00082	0.390
CLV_PCSK_SKI1_1	151	155	PF00082	0.627
CLV_PCSK_SKI1_1	70	74	PF00082	0.420
DOC_USP7_MATH_1	4	8	PF00917	0.615
DOC_USP7_UBL2_3	108	112	PF12436	0.469
DOC_WW_Pin1_4	276	281	PF00397	0.727
LIG_14-3-3_CanoR_1	13	19	PF00244	0.477
LIG_14-3-3_CanoR_1	203	209	PF00244	0.492
LIG_14-3-3_CanoR_1	275	280	PF00244	0.755
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_DLG_GKlike_1	260	267	PF00625	0.681
LIG_FHA_1	104	110	PF00498	0.621
LIG_FHA_2	15	21	PF00498	0.373
LIG_FHA_2	246	252	PF00498	0.702
LIG_LIR_Apic_2	257	262	PF02991	0.571
LIG_LIR_Nem_3	152	157	PF02991	0.460
LIG_LIR_Nem_3	266	271	PF02991	0.555
LIG_Pex14_1	132	136	PF04695	0.627
LIG_SH2_CRK	259	263	PF00017	0.544
LIG_SH2_CRK	268	272	PF00017	0.497
LIG_SH2_NCK_1	21	25	PF00017	0.523
LIG_SH2_STAT5	157	160	PF00017	0.536
LIG_SH3_3	111	117	PF00018	0.500
LIG_SUMO_SIM_anti_2	119	124	PF11976	0.531
LIG_TRAF2_1	72	75	PF00917	0.597
LIG_TRAF2_1	93	96	PF00917	0.530
MOD_CK1_1	160	166	PF00069	0.559
MOD_CK2_1	14	20	PF00069	0.460
MOD_CK2_1	245	251	PF00069	0.691
MOD_CK2_1	260	266	PF00069	0.457
MOD_CK2_1	90	96	PF00069	0.541
MOD_GlcNHglycan	237	240	PF01048	0.650
MOD_GlcNHglycan	39	42	PF01048	0.517
MOD_GlcNHglycan	6	9	PF01048	0.656
MOD_GSK3_1	108	115	PF00069	0.502
MOD_GSK3_1	156	163	PF00069	0.486
MOD_GSK3_1	23	30	PF00069	0.539
MOD_GSK3_1	237	244	PF00069	0.626
MOD_N-GLC_1	187	192	PF02516	0.339
MOD_NEK2_1	227	232	PF00069	0.622
MOD_NEK2_1	23	28	PF00069	0.390
MOD_NEK2_1	237	242	PF00069	0.518
MOD_NEK2_1	37	42	PF00069	0.358
MOD_PIKK_1	125	131	PF00454	0.416
MOD_PIKK_1	157	163	PF00454	0.347
MOD_PIKK_1	241	247	PF00454	0.625
MOD_PKA_2	202	208	PF00069	0.543
MOD_PKA_2	245	251	PF00069	0.581
MOD_PKA_2	274	280	PF00069	0.749
MOD_Plk_1	187	193	PF00069	0.530
MOD_Plk_4	160	166	PF00069	0.527
MOD_Plk_4	187	193	PF00069	0.484
MOD_Plk_4	245	251	PF00069	0.624
MOD_ProDKin_1	276	282	PF00069	0.733
MOD_SUMO_for_1	196	199	PF00179	0.352
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.491
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.516
TRG_ENDOCYTIC_2	268	271	PF00928	0.525
TRG_ER_diArg_1	12	14	PF00400	0.510
TRG_ER_diArg_1	225	227	PF00400	0.380
TRG_ER_diArg_1	9	11	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3Q7	Leptomonas seymouri	42%	100%
A0A3Q8IFY1	Leishmania donovani	72%	100%
A0A422N7M3	Trypanosoma rangeli	27%	93%
A4IAR0	Leishmania infantum	72%	100%
E9AEI6	Leishmania major	72%	100%
E9B5P7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%