Trk system potassium uptake protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HM47_LEIBR

TriTrypDb:

LbrM.34.0120 , LBRM2903_340006200

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HM47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HM47

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006811	monoatomic ion transport	4	12
GO:0006812	monoatomic cation transport	5	12
GO:0006813	potassium ion transport	7	12
GO:0030001	metal ion transport	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	338	342	PF00656	0.526
CLV_NRD_NRD_1	159	161	PF00675	0.327
CLV_NRD_NRD_1	184	186	PF00675	0.380
CLV_NRD_NRD_1	284	286	PF00675	0.334
CLV_NRD_NRD_1	450	452	PF00675	0.397
CLV_NRD_NRD_1	57	59	PF00675	0.299
CLV_PCSK_FUR_1	157	161	PF00082	0.237
CLV_PCSK_KEX2_1	159	161	PF00082	0.327
CLV_PCSK_KEX2_1	179	181	PF00082	0.306
CLV_PCSK_KEX2_1	184	186	PF00082	0.322
CLV_PCSK_KEX2_1	284	286	PF00082	0.328
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.364
CLV_PCSK_PC7_1	180	186	PF00082	0.352
CLV_PCSK_SKI1_1	13	17	PF00082	0.449
CLV_PCSK_SKI1_1	131	135	PF00082	0.462
CLV_PCSK_SKI1_1	159	163	PF00082	0.364
CLV_PCSK_SKI1_1	454	458	PF00082	0.412
CLV_PCSK_SKI1_1	463	467	PF00082	0.268
CLV_PCSK_SKI1_1	501	505	PF00082	0.448
CLV_PCSK_SKI1_1	8	12	PF00082	0.414
DEG_SPOP_SBC_1	141	145	PF00917	0.417
DOC_CDC14_PxL_1	44	52	PF14671	0.619
DOC_CYCLIN_yCln2_LP_2	268	274	PF00134	0.240
DOC_MAPK_gen_1	546	554	PF00069	0.462
DOC_MAPK_gen_1	58	66	PF00069	0.500
DOC_MAPK_MEF2A_6	546	554	PF00069	0.462
DOC_PP1_RVXF_1	466	472	PF00149	0.335
DOC_PP2B_LxvP_1	134	137	PF13499	0.350
DOC_PP2B_LxvP_1	323	326	PF13499	0.713
DOC_PP2B_LxvP_1	517	520	PF13499	0.257
DOC_PP4_FxxP_1	45	48	PF00568	0.694
DOC_SPAK_OSR1_1	495	499	PF12202	0.339
DOC_USP7_MATH_1	106	110	PF00917	0.253
DOC_USP7_MATH_1	190	194	PF00917	0.417
DOC_USP7_MATH_1	287	291	PF00917	0.478
DOC_USP7_MATH_1	415	419	PF00917	0.291
DOC_USP7_MATH_1	520	524	PF00917	0.329
DOC_WW_Pin1_4	166	171	PF00397	0.604
DOC_WW_Pin1_4	193	198	PF00397	0.308
DOC_WW_Pin1_4	296	301	PF00397	0.700
DOC_WW_Pin1_4	566	571	PF00397	0.676
LIG_14-3-3_CanoR_1	310	318	PF00244	0.759
LIG_14-3-3_CanoR_1	328	334	PF00244	0.563
LIG_14-3-3_CanoR_1	39	45	PF00244	0.647
LIG_14-3-3_CanoR_1	458	462	PF00244	0.450
LIG_14-3-3_CanoR_1	463	472	PF00244	0.433
LIG_APCC_ABBA_1	478	483	PF00400	0.387
LIG_BRCT_BRCA1_1	234	238	PF00533	0.323
LIG_BRCT_BRCA1_1	363	367	PF00533	0.521
LIG_BRCT_BRCA1_1	466	470	PF00533	0.289
LIG_BRCT_BRCA1_1	522	526	PF00533	0.179
LIG_FHA_1	194	200	PF00498	0.346
LIG_FHA_1	249	255	PF00498	0.356
LIG_FHA_1	313	319	PF00498	0.702
LIG_FHA_1	364	370	PF00498	0.465
LIG_FHA_1	38	44	PF00498	0.712
LIG_FHA_1	457	463	PF00498	0.480
LIG_FHA_1	464	470	PF00498	0.331
LIG_FHA_1	472	478	PF00498	0.321
LIG_FHA_2	167	173	PF00498	0.589
LIG_FHA_2	347	353	PF00498	0.510
LIG_FHA_2	492	498	PF00498	0.202
LIG_FHA_2	500	506	PF00498	0.304
LIG_GBD_Chelix_1	203	211	PF00786	0.193
LIG_GBD_Chelix_1	461	469	PF00786	0.304
LIG_IRF3_LxIS_1	439	445	PF10401	0.372
LIG_LIR_Gen_1	101	110	PF02991	0.195
LIG_LIR_Gen_1	196	206	PF02991	0.370
LIG_LIR_Gen_1	221	231	PF02991	0.301
LIG_LIR_Gen_1	276	283	PF02991	0.546
LIG_LIR_Gen_1	341	348	PF02991	0.494
LIG_LIR_Gen_1	494	504	PF02991	0.272
LIG_LIR_Nem_3	101	107	PF02991	0.220
LIG_LIR_Nem_3	128	133	PF02991	0.339
LIG_LIR_Nem_3	143	149	PF02991	0.271
LIG_LIR_Nem_3	196	201	PF02991	0.335
LIG_LIR_Nem_3	221	226	PF02991	0.318
LIG_LIR_Nem_3	263	268	PF02991	0.284
LIG_LIR_Nem_3	276	280	PF02991	0.501
LIG_LIR_Nem_3	341	347	PF02991	0.477
LIG_LIR_Nem_3	355	359	PF02991	0.562
LIG_LIR_Nem_3	387	392	PF02991	0.339
LIG_LIR_Nem_3	397	403	PF02991	0.250
LIG_LIR_Nem_3	418	422	PF02991	0.345
LIG_LIR_Nem_3	467	473	PF02991	0.314
LIG_LIR_Nem_3	500	506	PF02991	0.238
LIG_LIR_Nem_3	523	529	PF02991	0.299
LIG_LIR_Nem_3	530	536	PF02991	0.368
LIG_LIR_Nem_3	555	561	PF02991	0.550
LIG_MYND_1	48	52	PF01753	0.585
LIG_MYND_3	420	424	PF01753	0.374
LIG_NRBOX	207	213	PF00104	0.462
LIG_Pex14_1	453	457	PF04695	0.595
LIG_Pex14_2	529	533	PF04695	0.290
LIG_Pex14_2	66	70	PF04695	0.539
LIG_PTB_Apo_2	490	497	PF02174	0.258
LIG_REV1ctd_RIR_1	64	73	PF16727	0.570
LIG_SH2_CRK	188	192	PF00017	0.368
LIG_SH2_GRB2like	214	217	PF00017	0.234
LIG_SH2_GRB2like	425	428	PF00017	0.303
LIG_SH2_SRC	214	217	PF00017	0.234
LIG_SH2_SRC	438	441	PF00017	0.417
LIG_SH2_STAP1	188	192	PF00017	0.306
LIG_SH2_STAT5	200	203	PF00017	0.313
LIG_SH2_STAT5	214	217	PF00017	0.302
LIG_SH2_STAT5	396	399	PF00017	0.409
LIG_SH2_STAT5	403	406	PF00017	0.351
LIG_SH2_STAT5	438	441	PF00017	0.403
LIG_SH2_STAT5	71	74	PF00017	0.289
LIG_SH2_STAT5	78	81	PF00017	0.289
LIG_SH3_3	158	164	PF00018	0.562
LIG_SH3_3	27	33	PF00018	0.766
LIG_SH3_3	324	330	PF00018	0.599
LIG_SH3_3	437	443	PF00018	0.289
LIG_SH3_3	46	52	PF00018	0.561
LIG_SH3_3	564	570	PF00018	0.670
LIG_SH3_3	89	95	PF00018	0.265
LIG_TRAF2_1	169	172	PF00917	0.521
LIG_TRAF2_1	343	346	PF00917	0.547
LIG_TYR_ITIM	186	191	PF00017	0.476
LIG_TYR_ITIM	212	217	PF00017	0.294
LIG_UBA3_1	60	69	PF00899	0.606
LIG_WRC_WIRS_1	230	235	PF05994	0.254
LIG_WW_3	325	329	PF00397	0.517
MOD_CK1_1	193	199	PF00069	0.417
MOD_CK1_1	218	224	PF00069	0.329
MOD_CK1_1	232	238	PF00069	0.296
MOD_CK1_1	38	44	PF00069	0.691
MOD_CK1_1	522	528	PF00069	0.271
MOD_CK1_1	560	566	PF00069	0.704
MOD_CK2_1	166	172	PF00069	0.624
MOD_CK2_1	346	352	PF00069	0.645
MOD_CK2_1	499	505	PF00069	0.237
MOD_GlcNHglycan	192	195	PF01048	0.360
MOD_GlcNHglycan	220	223	PF01048	0.544
MOD_GlcNHglycan	316	321	PF01048	0.516
MOD_GlcNHglycan	507	510	PF01048	0.448
MOD_GlcNHglycan	562	565	PF01048	0.486
MOD_GlcNHglycan	576	579	PF01048	0.559
MOD_GSK3_1	121	128	PF00069	0.331
MOD_GSK3_1	229	236	PF00069	0.251
MOD_GSK3_1	24	31	PF00069	0.708
MOD_GSK3_1	248	255	PF00069	0.362
MOD_GSK3_1	312	319	PF00069	0.746
MOD_GSK3_1	442	449	PF00069	0.506
MOD_GSK3_1	515	522	PF00069	0.264
MOD_GSK3_1	573	580	PF00069	0.812
MOD_N-GLC_1	215	220	PF02516	0.540
MOD_NEK2_1	18	23	PF00069	0.747
MOD_NEK2_1	215	220	PF00069	0.297
MOD_NEK2_1	226	231	PF00069	0.225
MOD_NEK2_1	233	238	PF00069	0.249
MOD_NEK2_1	260	265	PF00069	0.293
MOD_NEK2_1	402	407	PF00069	0.299
MOD_NEK2_1	423	428	PF00069	0.305
MOD_NEK2_1	456	461	PF00069	0.485
MOD_NEK2_1	464	469	PF00069	0.347
MOD_NEK2_1	491	496	PF00069	0.284
MOD_NEK2_1	499	504	PF00069	0.257
MOD_NEK2_1	515	520	PF00069	0.273
MOD_NEK2_1	529	534	PF00069	0.278
MOD_NEK2_2	363	368	PF00069	0.504
MOD_PIKK_1	24	30	PF00454	0.704
MOD_PIKK_1	38	44	PF00454	0.637
MOD_PKA_2	28	34	PF00069	0.675
MOD_PKA_2	309	315	PF00069	0.777
MOD_PKA_2	361	367	PF00069	0.573
MOD_PKA_2	38	44	PF00069	0.665
MOD_PKA_2	457	463	PF00069	0.469
MOD_Plk_1	215	221	PF00069	0.356
MOD_Plk_4	125	131	PF00069	0.371
MOD_Plk_4	207	213	PF00069	0.457
MOD_Plk_4	233	239	PF00069	0.291
MOD_Plk_4	329	335	PF00069	0.638
MOD_Plk_4	363	369	PF00069	0.488
MOD_Plk_4	374	380	PF00069	0.381
MOD_Plk_4	415	421	PF00069	0.280
MOD_Plk_4	430	436	PF00069	0.382
MOD_Plk_4	457	463	PF00069	0.459
MOD_Plk_4	522	528	PF00069	0.262
MOD_ProDKin_1	166	172	PF00069	0.601
MOD_ProDKin_1	193	199	PF00069	0.308
MOD_ProDKin_1	296	302	PF00069	0.702
MOD_ProDKin_1	566	572	PF00069	0.682
TRG_DiLeu_BaEn_1	46	51	PF01217	0.608
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.289
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.364
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.480
TRG_ENDOCYTIC_2	188	191	PF00928	0.328
TRG_ENDOCYTIC_2	200	203	PF00928	0.239
TRG_ENDOCYTIC_2	214	217	PF00928	0.302
TRG_ENDOCYTIC_2	403	406	PF00928	0.281
TRG_ER_diArg_1	156	159	PF00400	0.478
TRG_ER_diArg_1	184	186	PF00400	0.551
TRG_ER_diArg_1	283	285	PF00400	0.529
TRG_ER_diArg_1	5	8	PF00400	0.679
TRG_ER_diArg_1	546	549	PF00400	0.539
TRG_NLS_MonoExtN_4	448	455	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD62	Leptomonas seymouri	66%	100%
A0A0S4JPJ1	Bodo saltans	24%	100%
A0A1X0NIY1	Trypanosomatidae	54%	88%
A0A3Q8IIM6	Leishmania donovani	82%	100%
A0A3R7RF53	Trypanosoma rangeli	50%	98%
A4IAQ9	Leishmania infantum	82%	100%
D0A2F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9AEI5	Leishmania major	81%	100%
E9B5P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5B392	Trypanosoma cruzi	48%	98%